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Protein

Selenide, water dikinase 2

Gene

SEPHS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Synthesizes selenophosphate from selenide and ATP.

Catalytic activityi

ATP + selenide + H2O = AMP + selenophosphate + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei60Sequence analysis1
Sitei63Important for catalytic activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi319 – 325ATPSequence analysis7

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • selenide, water dikinase activity Source: UniProtKB

GO - Biological processi

  • selenium compound metabolic process Source: Ensembl
  • selenocysteine biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Selenium

Enzyme and pathway databases

BioCyciZFISH:HS11405-MONOMER.
BRENDAi2.7.9.3. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Selenide, water dikinase 2 (EC:2.7.9.3)
Alternative name(s):
Selenium donor protein 2
Selenophosphate synthase 2
Gene namesi
Name:SEPHS2
Synonyms:SPS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:19686. SEPHS2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi22928.
OpenTargetsiENSG00000179918.
PharmGKBiPA134868765.

Polymorphism and mutation databases

DMDMi172044671.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001276502 – 448Selenide, water dikinase 2Add BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei46PhosphoserineBy similarity1
Modified residuei97PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99611.
MaxQBiQ99611.
PaxDbiQ99611.
PeptideAtlasiQ99611.
PRIDEiQ99611.

PTM databases

iPTMnetiQ99611.
PhosphoSitePlusiQ99611.

Expressioni

Gene expression databases

BgeeiENSG00000179918.
CleanExiHS_SEPHS2.
ExpressionAtlasiQ99611. baseline and differential.

Organism-specific databases

HPAiHPA047931.

Interactioni

Protein-protein interaction databases

BioGridi116588. 13 interactors.
IntActiQ99611. 2 interactors.
STRINGi9606.ENSP00000426234.

Structurei

3D structure databases

ProteinModelPortaliQ99611.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3939. Eukaryota.
COG0709. LUCA.
GeneTreeiENSGT00390000000950.
HOGENOMiHOG000219301.
HOVERGENiHBG001207.
InParanoidiQ99611.
KOiK01008.
PhylomeDBiQ99611.
TreeFamiTF313811.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR016188. PurM-like_N.
IPR004536. SPS/SelD.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00476. selD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEASATGAC GEAMAAAEGS SGPAGLTLGR SFSNYRPFEP QALGLSPSWR
60 70 80 90 100
LTGFSGMKGU GCKVPQEALL KLLAGLTRPD VRPPLGRGLV GGQEEASQEA
110 120 130 140 150
GLPAGAGPSP TFPALGIGMD SCVIPLRHGG LSLVQTTDFF YPLVEDPYMM
160 170 180 190 200
GRIACANVLS DLYAMGITEC DNMLMLLSVS QSMSEEEREK VTPLMVKGFR
210 220 230 240 250
DAAEEGGTAV TGGQTVVNPW IIIGGVATVV CQPNEFIMPD SAVVGDVLVL
260 270 280 290 300
TKPLGTQVAV NAHQWLDNPE RWNKVKMVVS REEVELAYQE AMFNMATLNR
310 320 330 340 350
TAAGLMHTFN AHAATDITGF GILGHSQNLA KQQRNEVSFV IHNLPIIAKM
360 370 380 390 400
AAVSKASGRF GLLQGTSAET SGGLLICLPR EQAARFCSEI KSSKYGEGHQ
410 420 430 440
AWIVGIVEKG NRTARIIDKP RVIEVLPRGA TAAVLAPDSS NASSEPSS
Length:448
Mass (Da):47,305
Last modified:February 26, 2008 - v3
Checksum:i309520C0CAE770F7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052345269P → A.Corresponds to variant rs1804600dbSNPEnsembl.1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei60Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43286 mRNA. Translation: AAC50958.2.
AC116348 Genomic DNA. No translation available.
BC002381 mRNA. Translation: AAH02381.3.
BC016643 mRNA. Translation: AAH16643.1.
CCDSiCCDS42150.1.
RefSeqiNP_036380.2. NM_012248.3.
UniGeneiHs.118725.

Genome annotation databases

EnsembliENST00000478753; ENSP00000418669; ENSG00000179918.
GeneIDi22928.
KEGGihsa:22928.

Keywords - Coding sequence diversityi

Polymorphism, Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43286 mRNA. Translation: AAC50958.2.
AC116348 Genomic DNA. No translation available.
BC002381 mRNA. Translation: AAH02381.3.
BC016643 mRNA. Translation: AAH16643.1.
CCDSiCCDS42150.1.
RefSeqiNP_036380.2. NM_012248.3.
UniGeneiHs.118725.

3D structure databases

ProteinModelPortaliQ99611.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116588. 13 interactors.
IntActiQ99611. 2 interactors.
STRINGi9606.ENSP00000426234.

PTM databases

iPTMnetiQ99611.
PhosphoSitePlusiQ99611.

Polymorphism and mutation databases

DMDMi172044671.

Proteomic databases

EPDiQ99611.
MaxQBiQ99611.
PaxDbiQ99611.
PeptideAtlasiQ99611.
PRIDEiQ99611.

Protocols and materials databases

DNASUi22928.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000478753; ENSP00000418669; ENSG00000179918.
GeneIDi22928.
KEGGihsa:22928.

Organism-specific databases

CTDi22928.
DisGeNETi22928.
GeneCardsiSEPHS2.
H-InvDBHIX0012959.
HGNCiHGNC:19686. SEPHS2.
HPAiHPA047931.
MIMi606218. gene.
neXtProtiNX_Q99611.
OpenTargetsiENSG00000179918.
PharmGKBiPA134868765.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3939. Eukaryota.
COG0709. LUCA.
GeneTreeiENSGT00390000000950.
HOGENOMiHOG000219301.
HOVERGENiHBG001207.
InParanoidiQ99611.
KOiK01008.
PhylomeDBiQ99611.
TreeFamiTF313811.

Enzyme and pathway databases

BioCyciZFISH:HS11405-MONOMER.
BRENDAi2.7.9.3. 2681.

Miscellaneous databases

ChiTaRSiSEPHS2. human.
GenomeRNAii22928.
PROiQ99611.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179918.
CleanExiHS_SEPHS2.
ExpressionAtlasiQ99611. baseline and differential.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR016188. PurM-like_N.
IPR004536. SPS/SelD.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00476. selD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPS2_HUMAN
AccessioniPrimary (citable) accession number: Q99611
Secondary accession number(s): Q9BUQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.