##gff-version 3 Q99607 UniProtKB Chain 1 663 . . . ID=PRO_0000204089;Note=ETS-related transcription factor Elf-4 Q99607 UniProtKB DNA binding 209 291 . . . Note=ETS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00237 Q99607 UniProtKB Region 87 206 . . . Note=RUNX1-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10207087;Dbxref=PMID:10207087 Q99607 UniProtKB Region 140 203 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99607 UniProtKB Region 302 353 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99607 UniProtKB Region 493 518 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99607 UniProtKB Region 582 605 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99607 UniProtKB Region 635 663 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99607 UniProtKB Compositional bias 147 172 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99607 UniProtKB Compositional bias 310 348 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99607 UniProtKB Site 25 26 . . . Note=Breakpoint for translocation to form ELF4-ERG oncogene Q99607 UniProtKB Modified residue 151 151 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q99607 UniProtKB Modified residue 188 188 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q99607 UniProtKB Modified residue 641 641 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q99607 UniProtKB Modified residue 648 648 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231 Q99607 UniProtKB Natural variant 95 95 . . . ID=VAR_087047;Note=No effect on transcriptional activity shown in IFNB1 promoter-driven luciferase assay. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=dbSNP:rs147410657,PMID:34326534 Q99607 UniProtKB Natural variant 147 147 . . . ID=VAR_087048;Note=No effect on transcriptional activity shown in IFNB1 promoter-driven luciferase assay. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=dbSNP:rs150084985,PMID:34326534 Q99607 UniProtKB Natural variant 177 177 . . . ID=VAR_087049;Note=No effect on transcriptional activity shown in IFNB1 promoter-driven luciferase assay. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=dbSNP:rs747352505,PMID:34326534 Q99607 UniProtKB Natural variant 187 187 . . . ID=VAR_087050;Note=No effect on transcriptional activity shown in IFNB1 promoter-driven luciferase assay. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=dbSNP:rs137884184,PMID:34326534 Q99607 UniProtKB Natural variant 231 231 . . . ID=VAR_087051;Note=In AIFBL2%3B loss of transcriptional activity shown in IFNB1 promoter-driven luciferase assay%3B decreased IFNB1 promoter binding%3B impaired binding to GPR35%2C GPR162 and PLCB2 promoters. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35266071;Dbxref=PMID:35266071 Q99607 UniProtKB Natural variant 251 251 . . . ID=VAR_087052;Note=In AIFBL2%3B elevated IL17A expression in patient colon biopsies%3B patient CD8+ T cells have reduced PRF1 expression when activated with IL-2 compared to CD8+ T cells from a healthy donor%3B severely decreased transcriptional activity shown in IFNB1 promoter-driven luciferase assay. W->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=PMID:34326534 Q99607 UniProtKB Natural variant 345 345 . . . ID=VAR_087053;Note=No effect on transcriptional activity shown in IFNB1 promoter-driven luciferase assay. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=dbSNP:rs141440727,PMID:34326534 Q99607 UniProtKB Natural variant 368 368 . . . ID=VAR_087054;Note=No effect on transcriptional activity shown in IFNB1 promoter-driven luciferase assay. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=dbSNP:rs576980542,PMID:34326534 Q99607 UniProtKB Natural variant 382 382 . . . ID=VAR_087055;Note=No effect on transcriptional activity shown in IFNB1 promoter-driven luciferase assay. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=dbSNP:rs148953158,PMID:34326534 Q99607 UniProtKB Natural variant 408 408 . . . ID=VAR_087056;Note=No effect on transcriptional activity shown in IFNB1 promoter-driven luciferase assay. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=dbSNP:rs199975202,PMID:34326534 Q99607 UniProtKB Natural variant 411 411 . . . ID=VAR_087057;Note=No effect on transcriptional activity shown in IFNB1 promoter-driven luciferase assay. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=dbSNP:rs145786527,PMID:34326534 Q99607 UniProtKB Natural variant 500 500 . . . ID=VAR_087058;Note=No effect on transcriptional activity shown in IFNB1 promoter-driven luciferase assay. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=dbSNP:rs145281864,PMID:34326534 Q99607 UniProtKB Natural variant 512 512 . . . ID=VAR_087059;Note=No effect on transcriptional activity shown in IFNB1 promoter-driven luciferase assay. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=dbSNP:rs370055472,PMID:34326534 Q99607 UniProtKB Natural variant 604 604 . . . ID=VAR_087060;Note=No effect on transcriptional activity shown in IFNB1 promoter-driven luciferase assay. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34326534;Dbxref=dbSNP:rs141284451,PMID:34326534 Q99607 UniProtKB Mutagenesis 211 211 . . . Note=Loss of transcriptional activity shown in IFNB1 promoter-driven luciferase assay. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35266071;Dbxref=PMID:35266071 Q99607 UniProtKB Mutagenesis 212 212 . . . Note=Loss of transcriptional activity shown in IFNB1 promoter-driven luciferase assay. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35266071;Dbxref=PMID:35266071 Q99607 UniProtKB Mutagenesis 219 219 . . . Note=Loss of transcriptional activity shown in IFNB1 promoter-driven luciferase assay. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35266071;Dbxref=PMID:35266071 Q99607 UniProtKB Mutagenesis 239 239 . . . Note=Loss of transcriptional activity shown in IFNB1 promoter-driven luciferase assay. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35266071;Dbxref=PMID:35266071 Q99607 UniProtKB Mutagenesis 251 251 . . . Note=Loss of transcriptional activity shown in IFNB1 promoter-driven luciferase assay. Loss of INFB1 promoter binding. Does not bind GPR35%2C GPR162 and PLCB2 promoters. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35266071;Dbxref=PMID:35266071 Q99607 UniProtKB Mutagenesis 252 252 . . . Note=Loss of transcriptional activity shown in IFNB1 promoter-driven luciferase assay. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35266071;Dbxref=PMID:35266071 Q99607 UniProtKB Mutagenesis 255 255 . . . Note=Loss of transcriptional activity shown in IFNB1 promoter-driven luciferase assay. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35266071;Dbxref=PMID:35266071 Q99607 UniProtKB Mutagenesis 260 260 . . . Note=Loss of transcriptional activity shown in IFNB1 promoter-driven luciferase assay. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35266071;Dbxref=PMID:35266071 Q99607 UniProtKB Sequence conflict 293 294 . . . Note=MP->IA;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q99607 UniProtKB Sequence conflict 499 499 . . . Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305