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Q99607

- ELF4_HUMAN

UniProt

Q99607 - ELF4_HUMAN

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Protein

ETS-related transcription factor Elf-4

Gene

ELF4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.By similarity6 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei25 – 262Breakpoint for translocation to form ELF4-ERG oncogene

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi209 – 29183ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. natural killer cell proliferation Source: UniProtKB
  3. NK T cell proliferation Source: UniProtKB
  4. positive regulation of transcription, DNA-templated Source: UniProtKB
  5. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  6. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-4
Alternative name(s):
E74-like factor 4
Myeloid Elf-1-like factor
Gene namesi
Name:ELF4Imported
Synonyms:ELFRImported, MEFImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:3319. ELF4.

Subcellular locationi

NucleusPML body 1 Publication
Note: Accumulation into PML nuclear bodies is mediated by PML.

GO - Cellular componenti

  1. nucleus Source: HPA
  2. PML body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

Orphaneti632. Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia.
PharmGKBiPA27747.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 663663ETS-related transcription factor Elf-4PRO_0000204089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphoserine1 Publication
Modified residuei648 – 6481Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99607.
PaxDbiQ99607.
PRIDEiQ99607.

PTM databases

PhosphoSiteiQ99607.

Expressioni

Tissue specificityi

Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain.2 Publications

Inductioni

By ponisterone A in erythroleukemia cells.1 Publication

Gene expression databases

BgeeiQ99607.
CleanExiHS_ELF4.
ExpressionAtlasiQ99607. baseline and differential.
GenevestigatoriQ99607.

Organism-specific databases

HPAiHPA058595.

Interactioni

Subunit structurei

Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ.2 Publications

Protein-protein interaction databases

BioGridi108315. 12 interactions.
IntActiQ99607. 4 interactions.
STRINGi9606.ENSP00000311280.

Structurei

3D structure databases

ProteinModelPortaliQ99607.
SMRiQ99607. Positions 209-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni87 – 206120RUNX1-binding1 PublicationAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Sequence Analysis
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG291231.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000049253.
HOVERGENiHBG007183.
InParanoidiQ99607.
KOiK09428.
OMAiYLFPVSE.
OrthoDBiEOG73RBD1.
PhylomeDBiQ99607.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR022084. TF_Elf_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF12310. Elf-1_N. 1 hit.
PF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99607-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAITLQPSDL IFEFASNGMD DDIHQLEDPS VFPAVIVEQV PYPDLLHLYS
60 70 80 90 100
GLELDDVHNG IITDGTLCMT QDQILEGSFL LTDDNEATSH TMSTAEVLLN
110 120 130 140 150
MESPSDILDE KQIFSTSEML PDSDPAPAVT LPNYLFPASE PDALNRAGDT
160 170 180 190 200
SDQEGHSLEE KASREESAKK TGKSKKRIRK TKGNRSTSPV TDPSIPIRKK
210 220 230 240 250
SKDGKGSTIY LWEFLLALLQ DRNTCPKYIK WTQREKGIFK LVDSKAVSKL
260 270 280 290 300
WGKQKNKPDM NYETMGRALR YYYQRGILAK VEGQRLVYQF KEMPKDLVVI
310 320 330 340 350
EDEDESSEAT AAPPQASTAS VASASTTRRT SSRVSSRSAP QGKGSSSWEK
360 370 380 390 400
PKIQHVGLQP SASLELGPSL DEEIPTTSTM LVSPAEGQVK LTKAVSASSV
410 420 430 440 450
PSNIHLGVAP VGSGSALTLQ TIPLTTVLTN GPPASTTAPT QLVLQSVPAA
460 470 480 490 500
STFKDTFTLQ ASFPLNASFQ DSQVAAPGAP LILSGLPQLL AGANRPTNPA
510 520 530 540 550
PPTVTGAGPA GPSSQPPGTV IAAFIRTSGT TAAPRVKEGP LRSSSYVQGM
560 570 580 590 600
VTGAPMEGLL VPEETLRELL RDQAHLQPLP TQVVSRGSHN PSLLGNQTLS
610 620 630 640 650
PPSRPTVGLT PVAELELSSG SGSLLMAEPS VTTSGSLLTR SPTPAPFSPF
660
NPTSLIKMEP HDI
Length:663
Mass (Da):70,730
Last modified:May 1, 1997 - v1
Checksum:i1696085D31B09BC5
GO

Sequence cautioni

The sequence AAC17452.1 differs from that shown. Reason: Frameshift at positions 334 and 412.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti293 – 2942MP → IA in AAC17452. (PubMed:9524226)Curated
Sequence conflicti499 – 4991P → L in AAC17452. (PubMed:9524226)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32645 mRNA. Translation: AAB53693.1.
AF000670 mRNA. Translation: AAC17452.1. Frameshift.
AL136450, Z81363 Genomic DNA. Translation: CAI42882.1.
Z81363, AL136450 Genomic DNA. Translation: CAI42371.1.
CH471107 Genomic DNA. Translation: EAX11813.1.
CH471107 Genomic DNA. Translation: EAX11814.1.
BC017194 mRNA. Translation: AAH17194.1.
CCDSiCCDS14617.1.
RefSeqiNP_001120669.1. NM_001127197.1.
NP_001412.1. NM_001421.3.
XP_005262446.1. XM_005262389.1.
UniGeneiHs.271940.

Genome annotation databases

EnsembliENST00000308167; ENSP00000311280; ENSG00000102034.
ENST00000335997; ENSP00000338608; ENSG00000102034.
GeneIDi2000.
KEGGihsa:2000.
UCSCiuc004evd.4. human.

Polymorphism databases

DMDMi68052244.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U32645 mRNA. Translation: AAB53693.1 .
AF000670 mRNA. Translation: AAC17452.1 . Frameshift.
AL136450 , Z81363 Genomic DNA. Translation: CAI42882.1 .
Z81363 , AL136450 Genomic DNA. Translation: CAI42371.1 .
CH471107 Genomic DNA. Translation: EAX11813.1 .
CH471107 Genomic DNA. Translation: EAX11814.1 .
BC017194 mRNA. Translation: AAH17194.1 .
CCDSi CCDS14617.1.
RefSeqi NP_001120669.1. NM_001127197.1.
NP_001412.1. NM_001421.3.
XP_005262446.1. XM_005262389.1.
UniGenei Hs.271940.

3D structure databases

ProteinModelPortali Q99607.
SMRi Q99607. Positions 209-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108315. 12 interactions.
IntActi Q99607. 4 interactions.
STRINGi 9606.ENSP00000311280.

PTM databases

PhosphoSitei Q99607.

Polymorphism databases

DMDMi 68052244.

Proteomic databases

MaxQBi Q99607.
PaxDbi Q99607.
PRIDEi Q99607.

Protocols and materials databases

DNASUi 2000.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308167 ; ENSP00000311280 ; ENSG00000102034 .
ENST00000335997 ; ENSP00000338608 ; ENSG00000102034 .
GeneIDi 2000.
KEGGi hsa:2000.
UCSCi uc004evd.4. human.

Organism-specific databases

CTDi 2000.
GeneCardsi GC0XM129198.
HGNCi HGNC:3319. ELF4.
HPAi HPA058595.
MIMi 300775. gene.
neXtProti NX_Q99607.
Orphaneti 632. Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia.
PharmGKBi PA27747.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291231.
GeneTreei ENSGT00760000118996.
HOGENOMi HOG000049253.
HOVERGENi HBG007183.
InParanoidi Q99607.
KOi K09428.
OMAi YLFPVSE.
OrthoDBi EOG73RBD1.
PhylomeDBi Q99607.
TreeFami TF318679.

Miscellaneous databases

GeneWikii ELF4.
GenomeRNAii 2000.
NextBioi 8091.
PROi Q99607.
SOURCEi Search...

Gene expression databases

Bgeei Q99607.
CleanExi HS_ELF4.
ExpressionAtlasi Q99607. baseline and differential.
Genevestigatori Q99607.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR022084. TF_Elf_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF12310. Elf-1_N. 1 hit.
PF00178. Ets. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties."
    Miyazaki Y., Sun X., Uchida H., Zhang J., Nimer S.
    Oncogene 13:1721-1729(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Promyelocytic leukemia1 Publication.
  2. "Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1."
    Aryee D.N.T., Petermann R., Kos K., Henn T., Haas O.A., Kovar H.
    Gene 210:71-78(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Ewing sarcoma1 Publication.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PlacentaImported.
  6. "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias."
    Mao S., Frank R.C., Zhang J., Miyazaki Y., Nimer S.D.
    Mol. Cell. Biol. 19:3635-3644(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RUNX1.
  7. "Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells."
    Hedvat C.V., Yao J., Sokolic R.A., Nimer S.D.
    J. Biol. Chem. 279:6395-6400(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  8. "Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein."
    Suico M.A., Yoshida H., Seki Y., Uchikawa T., Lu Z., Shuto T., Matsuzaki K., Nakao M., Li J.-D., Kai H.
    J. Biol. Chem. 279:19091-19098(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PML.
  9. "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)."
    Moore S.D., Offor O., Ferry J.A., Amrein P.C., Morton C.C., Dal Cin P.
    Leuk. Res. 30:1037-1042(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH ERG.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151 AND SER-648, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation."
    Sashida G., Liu Y., Elf S., Miyata Y., Ohyashiki K., Izumi M., Menendez S., Nimer S.D.
    Mol. Cell. Biol. 29:3687-3699(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-648, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-648, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiELF4_HUMAN
AccessioniPrimary (citable) accession number: Q99607
Secondary accession number(s): D3DTG1, O60435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3