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Q99607

- ELF4_HUMAN

UniProt

Q99607 - ELF4_HUMAN

Protein

ETS-related transcription factor Elf-4

Gene

ELF4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter By similarity. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 By similarity. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.By similarity6 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei25 – 262Breakpoint for translocation to form ELF4-ERG oncogene

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi209 – 29183ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. natural killer cell proliferation Source: UniProtKB
    3. NK T cell proliferation Source: UniProtKB
    4. positive regulation of transcription, DNA-templated Source: UniProtKB
    5. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    6. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS-related transcription factor Elf-4
    Alternative name(s):
    E74-like factor 4
    Myeloid Elf-1-like factor
    Gene namesi
    Name:ELF4Imported
    Synonyms:ELFRImported, MEFImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:3319. ELF4.

    Subcellular locationi

    NucleusPML body 1 Publication
    Note: Accumulation into PML nuclear bodies is mediated by PML.

    GO - Cellular componenti

    1. nucleus Source: HPA
    2. PML body Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    Orphaneti632. Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia.
    PharmGKBiPA27747.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 663663ETS-related transcription factor Elf-4PRO_0000204089Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511Phosphoserine1 Publication
    Modified residuei648 – 6481Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ99607.
    PaxDbiQ99607.
    PRIDEiQ99607.

    PTM databases

    PhosphoSiteiQ99607.

    Expressioni

    Tissue specificityi

    Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain.2 Publications

    Inductioni

    By ponisterone A in erythroleukemia cells.1 Publication

    Gene expression databases

    ArrayExpressiQ99607.
    BgeeiQ99607.
    CleanExiHS_ELF4.
    GenevestigatoriQ99607.

    Organism-specific databases

    HPAiHPA058595.

    Interactioni

    Subunit structurei

    Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ.2 Publications

    Protein-protein interaction databases

    BioGridi108315. 11 interactions.
    IntActiQ99607. 4 interactions.
    STRINGi9606.ENSP00000311280.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99607.
    SMRiQ99607. Positions 209-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni87 – 206120RUNX1-binding1 PublicationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Sequence Analysis
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG291231.
    HOGENOMiHOG000049253.
    HOVERGENiHBG007183.
    InParanoidiQ99607.
    KOiK09428.
    OMAiYLFPVSE.
    OrthoDBiEOG73RBD1.
    PhylomeDBiQ99607.
    TreeFamiTF318679.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR022084. TF_Elf_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF12310. Elf-1_N. 1 hit.
    PF00178. Ets. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99607-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAITLQPSDL IFEFASNGMD DDIHQLEDPS VFPAVIVEQV PYPDLLHLYS    50
    GLELDDVHNG IITDGTLCMT QDQILEGSFL LTDDNEATSH TMSTAEVLLN 100
    MESPSDILDE KQIFSTSEML PDSDPAPAVT LPNYLFPASE PDALNRAGDT 150
    SDQEGHSLEE KASREESAKK TGKSKKRIRK TKGNRSTSPV TDPSIPIRKK 200
    SKDGKGSTIY LWEFLLALLQ DRNTCPKYIK WTQREKGIFK LVDSKAVSKL 250
    WGKQKNKPDM NYETMGRALR YYYQRGILAK VEGQRLVYQF KEMPKDLVVI 300
    EDEDESSEAT AAPPQASTAS VASASTTRRT SSRVSSRSAP QGKGSSSWEK 350
    PKIQHVGLQP SASLELGPSL DEEIPTTSTM LVSPAEGQVK LTKAVSASSV 400
    PSNIHLGVAP VGSGSALTLQ TIPLTTVLTN GPPASTTAPT QLVLQSVPAA 450
    STFKDTFTLQ ASFPLNASFQ DSQVAAPGAP LILSGLPQLL AGANRPTNPA 500
    PPTVTGAGPA GPSSQPPGTV IAAFIRTSGT TAAPRVKEGP LRSSSYVQGM 550
    VTGAPMEGLL VPEETLRELL RDQAHLQPLP TQVVSRGSHN PSLLGNQTLS 600
    PPSRPTVGLT PVAELELSSG SGSLLMAEPS VTTSGSLLTR SPTPAPFSPF 650
    NPTSLIKMEP HDI 663
    Length:663
    Mass (Da):70,730
    Last modified:May 1, 1997 - v1
    Checksum:i1696085D31B09BC5
    GO

    Sequence cautioni

    The sequence AAC17452.1 differs from that shown. Reason: Frameshift at positions 334 and 412.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti293 – 2942MP → IA in AAC17452. (PubMed:9524226)Curated
    Sequence conflicti499 – 4991P → L in AAC17452. (PubMed:9524226)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32645 mRNA. Translation: AAB53693.1.
    AF000670 mRNA. Translation: AAC17452.1. Frameshift.
    AL136450, Z81363 Genomic DNA. Translation: CAI42882.1.
    Z81363, AL136450 Genomic DNA. Translation: CAI42371.1.
    CH471107 Genomic DNA. Translation: EAX11813.1.
    CH471107 Genomic DNA. Translation: EAX11814.1.
    BC017194 mRNA. Translation: AAH17194.1.
    CCDSiCCDS14617.1.
    RefSeqiNP_001120669.1. NM_001127197.1.
    NP_001412.1. NM_001421.3.
    XP_005262446.1. XM_005262389.1.
    UniGeneiHs.271940.

    Genome annotation databases

    EnsembliENST00000308167; ENSP00000311280; ENSG00000102034.
    ENST00000335997; ENSP00000338608; ENSG00000102034.
    GeneIDi2000.
    KEGGihsa:2000.
    UCSCiuc004evd.4. human.

    Polymorphism databases

    DMDMi68052244.

    Keywords - Coding sequence diversityi

    Chromosomal rearrangement

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U32645 mRNA. Translation: AAB53693.1 .
    AF000670 mRNA. Translation: AAC17452.1 . Frameshift.
    AL136450 , Z81363 Genomic DNA. Translation: CAI42882.1 .
    Z81363 , AL136450 Genomic DNA. Translation: CAI42371.1 .
    CH471107 Genomic DNA. Translation: EAX11813.1 .
    CH471107 Genomic DNA. Translation: EAX11814.1 .
    BC017194 mRNA. Translation: AAH17194.1 .
    CCDSi CCDS14617.1.
    RefSeqi NP_001120669.1. NM_001127197.1.
    NP_001412.1. NM_001421.3.
    XP_005262446.1. XM_005262389.1.
    UniGenei Hs.271940.

    3D structure databases

    ProteinModelPortali Q99607.
    SMRi Q99607. Positions 209-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108315. 11 interactions.
    IntActi Q99607. 4 interactions.
    STRINGi 9606.ENSP00000311280.

    PTM databases

    PhosphoSitei Q99607.

    Polymorphism databases

    DMDMi 68052244.

    Proteomic databases

    MaxQBi Q99607.
    PaxDbi Q99607.
    PRIDEi Q99607.

    Protocols and materials databases

    DNASUi 2000.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308167 ; ENSP00000311280 ; ENSG00000102034 .
    ENST00000335997 ; ENSP00000338608 ; ENSG00000102034 .
    GeneIDi 2000.
    KEGGi hsa:2000.
    UCSCi uc004evd.4. human.

    Organism-specific databases

    CTDi 2000.
    GeneCardsi GC0XM129198.
    HGNCi HGNC:3319. ELF4.
    HPAi HPA058595.
    MIMi 300775. gene.
    neXtProti NX_Q99607.
    Orphaneti 632. Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia.
    PharmGKBi PA27747.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291231.
    HOGENOMi HOG000049253.
    HOVERGENi HBG007183.
    InParanoidi Q99607.
    KOi K09428.
    OMAi YLFPVSE.
    OrthoDBi EOG73RBD1.
    PhylomeDBi Q99607.
    TreeFami TF318679.

    Miscellaneous databases

    GeneWikii ELF4.
    GenomeRNAii 2000.
    NextBioi 8091.
    PROi Q99607.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99607.
    Bgeei Q99607.
    CleanExi HS_ELF4.
    Genevestigatori Q99607.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR022084. TF_Elf_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF12310. Elf-1_N. 1 hit.
    PF00178. Ets. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties."
      Miyazaki Y., Sun X., Uchida H., Zhang J., Nimer S.
      Oncogene 13:1721-1729(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Promyelocytic leukemia1 Publication.
    2. "Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1."
      Aryee D.N.T., Petermann R., Kos K., Henn T., Haas O.A., Kovar H.
      Gene 210:71-78(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Ewing sarcoma1 Publication.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PlacentaImported.
    6. "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias."
      Mao S., Frank R.C., Zhang J., Miyazaki Y., Nimer S.D.
      Mol. Cell. Biol. 19:3635-3644(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RUNX1.
    7. "Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells."
      Hedvat C.V., Yao J., Sokolic R.A., Nimer S.D.
      J. Biol. Chem. 279:6395-6400(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    8. "Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein."
      Suico M.A., Yoshida H., Seki Y., Uchikawa T., Lu Z., Shuto T., Matsuzaki K., Nakao M., Li J.-D., Kai H.
      J. Biol. Chem. 279:19091-19098(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PML.
    9. "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)."
      Moore S.D., Offor O., Ferry J.A., Amrein P.C., Morton C.C., Dal Cin P.
      Leuk. Res. 30:1037-1042(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH ERG.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151 AND SER-648, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation."
      Sashida G., Liu Y., Elf S., Miyata Y., Ohyashiki K., Izumi M., Menendez S., Nimer S.D.
      Mol. Cell. Biol. 29:3687-3699(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-648, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-648, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiELF4_HUMAN
    AccessioniPrimary (citable) accession number: Q99607
    Secondary accession number(s): D3DTG1, O60435
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3