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Q99598

- TSNAX_HUMAN

UniProt

Q99598 - TSNAX_HUMAN

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Protein

Translin-associated protein X

Gene

TSNAX

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi129 – 1291Magnesium
Metal bindingi197 – 1971Magnesium

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. metal ion binding Source: UniProtKB-KW
  3. poly(A) RNA binding Source: UniProtKB
  4. protein transporter activity Source: ProtInc
  5. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. protein transport Source: GOC
  4. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_118560. Small interfering RNA (siRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Translin-associated protein X
Alternative name(s):
Translin-associated factor X
Gene namesi
Name:TSNAX
Synonyms:TRAX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:12380. TSNAX.

Subcellular locationi

Cytoplasmperinuclear region. Golgi apparatus By similarity. Nucleus
Note: Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN.By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Translin-associated protein XPRO_0000191686Add
BLAST

Post-translational modificationi

Sumoylated with SUMO1.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ99598.
PaxDbiQ99598.
PeptideAtlasiQ99598.
PRIDEiQ99598.

PTM databases

PhosphoSiteiQ99598.

Expressioni

Gene expression databases

BgeeiQ99598.
CleanExiHS_TSNAX.
ExpressionAtlasiQ99598. baseline and differential.
GenevestigatoriQ99598.

Organism-specific databases

HPAiCAB034263.
HPA031054.
HPA031055.

Interactioni

Subunit structurei

Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner.5 Publications

Protein-protein interaction databases

BioGridi113108. 34 interactions.
DIPiDIP-29463N.
IntActiQ99598. 19 interactions.
MINTiMINT-1347706.
STRINGi9606.ENSP00000355599.

Structurei

Secondary structure

1
290
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi34 – 7542Combined sources
Helixi83 – 10826Combined sources
Beta strandi109 – 1113Combined sources
Turni114 – 1163Combined sources
Helixi117 – 1193Combined sources
Helixi121 – 13919Combined sources
Helixi145 – 1506Combined sources
Helixi184 – 20724Combined sources
Helixi213 – 23119Combined sources
Helixi232 – 2343Combined sources
Helixi237 – 26327Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PJAX-ray3.00J/K/L1-290[»]
3QB5X-ray2.95K1-290[»]
ProteinModelPortaliQ99598.
SMRiQ99598. Positions 31-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni73 – 208136Interaction with C1DAdd
BLAST

Sequence similaritiesi

Belongs to the translin family.Curated

Phylogenomic databases

eggNOGiCOG2178.
GeneTreeiENSGT00390000014716.
HOGENOMiHOG000008075.
HOVERGENiHBG059067.
InParanoidiQ99598.
OMAiCISSVGN.
OrthoDBiEOG7XWPPR.
PhylomeDBiQ99598.
TreeFamiTF323633.

Family and domain databases

Gene3Di1.20.58.190. 1 hit.
1.20.58.200. 1 hit.
InterProiIPR002848. Translin.
IPR016069. Translin_C.
IPR016068. Translin_N.
[Graphical view]
PANTHERiPTHR10741. PTHR10741. 1 hit.
PfamiPF01997. Translin. 1 hit.
[Graphical view]
SUPFAMiSSF74784. SSF74784. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99598-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNKEGSGGF RKRKHDNFPH NQRREGKDVN SSSPVMLAFK SFQQELDARH
60 70 80 90 100
DKYERLVKLS RDITVESKRT IFLLHRITSA PDMEDILTES EIKLDGVRQK
110 120 130 140 150
IFQVAQELSG EDMHQFHRAI TTGLQEYVEA VSFQHFIKTR SLISMDEINK
160 170 180 190 200
QLIFTTEDNG KENKTPSSDA QDKQFGTWRL RVTPVDYLLG VADLTGELMR
210 220 230 240 250
MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS KKLYTLKQSL
260 270 280 290
AKVENACYAL KVRGSEIPKH MLADVFSVKT EMIDQEEGIS
Length:290
Mass (Da):33,112
Last modified:May 1, 1997 - v1
Checksum:iD38B0DD96B50C0B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95073 mRNA. Translation: CAA64469.1.
AF271269, AF271267, AF271268 Genomic DNA. Translation: AAK58640.1.
AK313068 mRNA. Translation: BAG35896.1.
AL626763, AL445524 Genomic DNA. Translation: CAH70959.1.
AL445524, AL626763 Genomic DNA. Translation: CAH72107.1.
CH471098 Genomic DNA. Translation: EAW69963.1.
BC010376 mRNA. Translation: AAH10376.1.
BC011797 mRNA. Translation: AAH11797.1.
CCDSiCCDS1596.1.
RefSeqiNP_005990.1. NM_005999.2.
UniGeneiHs.13318.

Genome annotation databases

EnsembliENST00000366639; ENSP00000355599; ENSG00000116918.
GeneIDi7257.
KEGGihsa:7257.
UCSCiuc001huw.3. human.

Polymorphism databases

DMDMi6136057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95073 mRNA. Translation: CAA64469.1 .
AF271269 , AF271267 , AF271268 Genomic DNA. Translation: AAK58640.1 .
AK313068 mRNA. Translation: BAG35896.1 .
AL626763 , AL445524 Genomic DNA. Translation: CAH70959.1 .
AL445524 , AL626763 Genomic DNA. Translation: CAH72107.1 .
CH471098 Genomic DNA. Translation: EAW69963.1 .
BC010376 mRNA. Translation: AAH10376.1 .
BC011797 mRNA. Translation: AAH11797.1 .
CCDSi CCDS1596.1.
RefSeqi NP_005990.1. NM_005999.2.
UniGenei Hs.13318.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3PJA X-ray 3.00 J/K/L 1-290 [» ]
3QB5 X-ray 2.95 K 1-290 [» ]
ProteinModelPortali Q99598.
SMRi Q99598. Positions 31-272.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113108. 34 interactions.
DIPi DIP-29463N.
IntActi Q99598. 19 interactions.
MINTi MINT-1347706.
STRINGi 9606.ENSP00000355599.

PTM databases

PhosphoSitei Q99598.

Polymorphism databases

DMDMi 6136057.

Proteomic databases

MaxQBi Q99598.
PaxDbi Q99598.
PeptideAtlasi Q99598.
PRIDEi Q99598.

Protocols and materials databases

DNASUi 7257.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366639 ; ENSP00000355599 ; ENSG00000116918 .
GeneIDi 7257.
KEGGi hsa:7257.
UCSCi uc001huw.3. human.

Organism-specific databases

CTDi 7257.
GeneCardsi GC01P231664.
HGNCi HGNC:12380. TSNAX.
HPAi CAB034263.
HPA031054.
HPA031055.
MIMi 602964. gene.
neXtProti NX_Q99598.
PharmGKBi PA37048.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2178.
GeneTreei ENSGT00390000014716.
HOGENOMi HOG000008075.
HOVERGENi HBG059067.
InParanoidi Q99598.
OMAi CISSVGN.
OrthoDBi EOG7XWPPR.
PhylomeDBi Q99598.
TreeFami TF323633.

Enzyme and pathway databases

Reactomei REACT_118560. Small interfering RNA (siRNA) biogenesis.

Miscellaneous databases

ChiTaRSi TSNAX. human.
GeneWikii TSNAX.
GenomeRNAii 7257.
NextBioi 28373.
PROi Q99598.
SOURCEi Search...

Gene expression databases

Bgeei Q99598.
CleanExi HS_TSNAX.
ExpressionAtlasi Q99598. baseline and differential.
Genevestigatori Q99598.

Family and domain databases

Gene3Di 1.20.58.190. 1 hit.
1.20.58.200. 1 hit.
InterProi IPR002848. Translin.
IPR016069. Translin_C.
IPR016068. Translin_N.
[Graphical view ]
PANTHERi PTHR10741. PTHR10741. 1 hit.
Pfami PF01997. Translin. 1 hit.
[Graphical view ]
SUPFAMi SSF74784. SSF74784. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a cDNA encoding a translin-like protein, TRAX."
    Aoki K., Ishida R., Kasai M.
    FEBS Lett. 401:109-112(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH TSN.
    Tissue: Spleen.
  2. "Genomic structure of human translin-associated factor X (TRAX) gene."
    Guyonnet Duperat V., Dupuy D., Stef M., Arveiler B.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Caudate nucleus.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Muscle.
  7. "Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X."
    Bray J.D., Chennathukuzhi V.M., Hecht N.B.
    Genomics 79:799-808(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TSN; GOLGA3; TSNAXIP1; SUN1 AND AKAP9.
    Tissue: Testis.
  8. "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)."
    Erdemir T., Bilican B., Oncel D., Goding C.R., Yavuzer U.
    J. Cell Sci. 115:207-216(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH C1D AND TSN.
  9. "Co-expressed recombinant human Translin-Trax complex binds DNA."
    Gupta G.D., Makde R.D., Kamdar R.P., D'Souza J.S., Kulkarni M.G., Kumar V., Rao B.J.
    FEBS Lett. 579:3141-3146(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING, SUBUNIT.
  10. "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."
    Gocke C.B., Yu H., Kang J.
    J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION.
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Structure of C3PO and mechanism of human RISC activation."
    Ye X., Huang N., Liu Y., Paroo Z., Huerta C., Li P., Chen S., Liu Q., Zhang H.
    Nat. Struct. Mol. Biol. 18:650-657(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS), SUBUNIT, MAGNESIUM-BINDING SITES, FUNCTION.

Entry informationi

Entry nameiTSNAX_HUMAN
AccessioniPrimary (citable) accession number: Q99598
Secondary accession number(s): B1APC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3