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Protein

Translin-associated protein X

Gene

TSNAX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi129Magnesium1
Metal bindingi197Magnesium1

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • protein transporter activity Source: ProtInc
  • RNA binding Source: UniProtKB
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-426486. Small interfering RNA (siRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Translin-associated protein X
Alternative name(s):
Translin-associated factor X
Gene namesi
Name:TSNAX
Synonyms:TRAX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116918.13.
HGNCiHGNC:12380. TSNAX.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7257.
OpenTargetsiENSG00000116918.
PharmGKBiPA37048.

Polymorphism and mutation databases

BioMutaiTSNAX.
DMDMi6136057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916861 – 290Translin-associated protein XAdd BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki279Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Sumoylated with SUMO1.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ99598.
MaxQBiQ99598.
PaxDbiQ99598.
PeptideAtlasiQ99598.
PRIDEiQ99598.

PTM databases

iPTMnetiQ99598.
PhosphoSitePlusiQ99598.

Expressioni

Gene expression databases

BgeeiENSG00000116918.
CleanExiHS_TSNAX.
ExpressionAtlasiQ99598. baseline and differential.
GenevisibleiQ99598. HS.

Organism-specific databases

HPAiCAB034263.
HPA031054.
HPA031055.

Interactioni

Subunit structurei

Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113108. 101 interactors.
DIPiDIP-29463N.
IntActiQ99598. 103 interactors.
MINTiMINT-1347706.
STRINGi9606.ENSP00000355599.

Structurei

Secondary structure

1290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 75Combined sources42
Helixi83 – 108Combined sources26
Beta strandi109 – 111Combined sources3
Turni114 – 116Combined sources3
Helixi117 – 119Combined sources3
Helixi121 – 139Combined sources19
Helixi145 – 150Combined sources6
Helixi184 – 207Combined sources24
Helixi213 – 231Combined sources19
Helixi232 – 234Combined sources3
Helixi237 – 263Combined sources27

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PJAX-ray3.00J/K/L1-290[»]
3QB5X-ray2.95K1-290[»]
ProteinModelPortaliQ99598.
SMRiQ99598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 208Interaction with C1D1 PublicationAdd BLAST136

Sequence similaritiesi

Belongs to the translin family.Curated

Phylogenomic databases

eggNOGiKOG3066. Eukaryota.
COG2178. LUCA.
GeneTreeiENSGT00390000014716.
HOGENOMiHOG000008075.
HOVERGENiHBG059067.
InParanoidiQ99598.
OMAiAYTYMEY.
OrthoDBiEOG091G0JHU.
PhylomeDBiQ99598.
TreeFamiTF323633.

Family and domain databases

Gene3Di1.20.58.190. 1 hit.
InterProiView protein in InterPro
IPR002848. Translin_fam.
IPR016068. Translin_N.
IPR036081. Translin_sf.
PANTHERiPTHR10741. PTHR10741. 1 hit.
PfamiView protein in Pfam
PF01997. Translin. 1 hit.
SUPFAMiSSF74784. SSF74784. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKEGSGGF RKRKHDNFPH NQRREGKDVN SSSPVMLAFK SFQQELDARH
60 70 80 90 100
DKYERLVKLS RDITVESKRT IFLLHRITSA PDMEDILTES EIKLDGVRQK
110 120 130 140 150
IFQVAQELSG EDMHQFHRAI TTGLQEYVEA VSFQHFIKTR SLISMDEINK
160 170 180 190 200
QLIFTTEDNG KENKTPSSDA QDKQFGTWRL RVTPVDYLLG VADLTGELMR
210 220 230 240 250
MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS KKLYTLKQSL
260 270 280 290
AKVENACYAL KVRGSEIPKH MLADVFSVKT EMIDQEEGIS
Length:290
Mass (Da):33,112
Last modified:May 1, 1997 - v1
Checksum:iD38B0DD96B50C0B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95073 mRNA. Translation: CAA64469.1.
AF271269, AF271267, AF271268 Genomic DNA. Translation: AAK58640.1.
AK313068 mRNA. Translation: BAG35896.1.
AL626763 Genomic DNA. No translation available.
AL445524 Genomic DNA. No translation available.
CH471098 Genomic DNA. Translation: EAW69963.1.
BC010376 mRNA. Translation: AAH10376.1.
BC011797 mRNA. Translation: AAH11797.1.
CCDSiCCDS1596.1.
RefSeqiNP_005990.1. NM_005999.2.
UniGeneiHs.13318.

Genome annotation databases

EnsembliENST00000366639; ENSP00000355599; ENSG00000116918.
GeneIDi7257.
KEGGihsa:7257.
UCSCiuc001huw.4. human.

Similar proteinsi

Entry informationi

Entry nameiTSNAX_HUMAN
AccessioniPrimary (citable) accession number: Q99598
Secondary accession number(s): B1APC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: November 22, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families