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Q99598 (TSNAX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translin-associated protein X
Alternative name(s):
Translin-associated factor X
Gene names
Name:TSNAX
Synonyms:TRAX
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. Ref.7 Ref.13

Subunit structure

Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner. Ref.1 Ref.7 Ref.8 Ref.9 Ref.13

Subcellular location

Cytoplasmperinuclear region. Golgi apparatus By similarity. Nucleus. Note: Accumulate in the Golgi complex of mid-late pachytene spermatocytes By similarity. Expressed in the cytoplasm in the presence of TSN. Ref.7 Ref.8

Post-translational modification

Sumoylated with SUMO1. Ref.10

Sequence similarities

Belongs to the translin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Translin-associated protein X
PRO_0000191686

Regions

Region73 – 208136Interaction with C1D

Sites

Metal binding1291Magnesium
Metal binding1971Magnesium

Secondary structure

.................... 290
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q99598 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: D38B0DD96B50C0B9

FASTA29033,112
        10         20         30         40         50         60 
MSNKEGSGGF RKRKHDNFPH NQRREGKDVN SSSPVMLAFK SFQQELDARH DKYERLVKLS 

        70         80         90        100        110        120 
RDITVESKRT IFLLHRITSA PDMEDILTES EIKLDGVRQK IFQVAQELSG EDMHQFHRAI 

       130        140        150        160        170        180 
TTGLQEYVEA VSFQHFIKTR SLISMDEINK QLIFTTEDNG KENKTPSSDA QDKQFGTWRL 

       190        200        210        220        230        240 
RVTPVDYLLG VADLTGELMR MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS 

       250        260        270        280        290 
KKLYTLKQSL AKVENACYAL KVRGSEIPKH MLADVFSVKT EMIDQEEGIS 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a cDNA encoding a translin-like protein, TRAX."
Aoki K., Ishida R., Kasai M.
FEBS Lett. 401:109-112(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH TSN.
Tissue: Spleen.
[2]"Genomic structure of human translin-associated factor X (TRAX) gene."
Guyonnet Duperat V., Dupuy D., Stef M., Arveiler B.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Caudate nucleus.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Muscle.
[7]"Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X."
Bray J.D., Chennathukuzhi V.M., Hecht N.B.
Genomics 79:799-808(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TSN; GOLGA3; TSNAXIP1; SUN1 AND AKAP9.
Tissue: Testis.
[8]"DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)."
Erdemir T., Bilican B., Oncel D., Goding C.R., Yavuzer U.
J. Cell Sci. 115:207-216(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH C1D AND TSN.
[9]"Co-expressed recombinant human Translin-Trax complex binds DNA."
Gupta G.D., Makde R.D., Kamdar R.P., D'Souza J.S., Kulkarni M.G., Kumar V., Rao B.J.
FEBS Lett. 579:3141-3146(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: DNA-BINDING, SUBUNIT.
[10]"Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."
Gocke C.B., Yu H., Kang J.
J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUMOYLATION.
[11]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Structure of C3PO and mechanism of human RISC activation."
Ye X., Huang N., Liu Y., Paroo Z., Huerta C., Li P., Chen S., Liu Q., Zhang H.
Nat. Struct. Mol. Biol. 18:650-657(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS), SUBUNIT, MAGNESIUM-BINDING SITES, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X95073 mRNA. Translation: CAA64469.1.
AF271269, AF271267, AF271268 Genomic DNA. Translation: AAK58640.1.
AK313068 mRNA. Translation: BAG35896.1.
AL626763, AL445524 Genomic DNA. Translation: CAH70959.1.
AL445524, AL626763 Genomic DNA. Translation: CAH72107.1.
CH471098 Genomic DNA. Translation: EAW69963.1.
BC010376 mRNA. Translation: AAH10376.1.
BC011797 mRNA. Translation: AAH11797.1.
CCDSCCDS1596.1.
RefSeqNP_005990.1. NM_005999.2.
UniGeneHs.13318.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3PJAX-ray3.00J/K/L1-290[»]
3QB5X-ray2.95K1-290[»]
ProteinModelPortalQ99598.
SMRQ99598. Positions 31-272.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113108. 23 interactions.
DIPDIP-29463N.
IntActQ99598. 19 interactions.
MINTMINT-1347706.
STRING9606.ENSP00000355599.

PTM databases

PhosphoSiteQ99598.

Polymorphism databases

DMDM6136057.

Proteomic databases

MaxQBQ99598.
PaxDbQ99598.
PeptideAtlasQ99598.
PRIDEQ99598.

Protocols and materials databases

DNASU7257.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366639; ENSP00000355599; ENSG00000116918.
GeneID7257.
KEGGhsa:7257.
UCSCuc001huw.3. human.

Organism-specific databases

CTD7257.
GeneCardsGC01P231664.
HGNCHGNC:12380. TSNAX.
HPACAB034263.
HPA031054.
HPA031055.
MIM602964. gene.
neXtProtNX_Q99598.
PharmGKBPA37048.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2178.
HOGENOMHOG000008075.
HOVERGENHBG059067.
InParanoidQ99598.
OMACISSVGN.
OrthoDBEOG7XWPPR.
PhylomeDBQ99598.
TreeFamTF323633.

Gene expression databases

ArrayExpressQ99598.
BgeeQ99598.
CleanExHS_TSNAX.
GenevestigatorQ99598.

Family and domain databases

Gene3D1.20.58.190. 1 hit.
1.20.58.200. 1 hit.
InterProIPR002848. Translin.
IPR016069. Translin_C.
IPR016068. Translin_N.
[Graphical view]
PANTHERPTHR10741. PTHR10741. 1 hit.
PfamPF01997. Translin. 1 hit.
[Graphical view]
SUPFAMSSF74784. SSF74784. 1 hit.
ProtoNetSearch...

Other

ChiTaRSTSNAX. human.
GeneWikiTSNAX.
GenomeRNAi7257.
NextBio28373.
PROQ99598.
SOURCESearch...

Entry information

Entry nameTSNAX_HUMAN
AccessionPrimary (citable) accession number: Q99598
Secondary accession number(s): B1APC6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM