Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial import inner membrane translocase subunit Tim17-A

Gene

TIMM17A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim17-A
Alternative name(s):
Inner membrane preprotein translocase Tim17a
Gene namesi
Name:TIMM17A
Synonyms:MIMT17, TIM17, TIM17A, TIMM17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134375.10
HGNCiHGNC:17315 TIMM17A
MIMi605057 gene
neXtProtiNX_Q99595

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei63 – 77HelicalSequence analysisAdd BLAST15
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10440
OpenTargetsiENSG00000134375
PharmGKBiPA38228

Polymorphism and mutation databases

BioMutaiTIMM17A
DMDMi3219818

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102841 – 171Mitochondrial import inner membrane translocase subunit Tim17-AAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi9 ↔ 78By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ99595
MaxQBiQ99595
PaxDbiQ99595
PeptideAtlasiQ99595
PRIDEiQ99595
ProteomicsDBi78350
TopDownProteomicsiQ99595

PTM databases

iPTMnetiQ99595
PhosphoSitePlusiQ99595
SwissPalmiQ99595

Expressioni

Gene expression databases

BgeeiENSG00000134375
CleanExiHS_TIMM17A
GenevisibleiQ99595 HS

Organism-specific databases

HPAiHPA010083

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.1 Publication

Protein-protein interaction databases

BioGridi115707, 13 interactors
CORUMiQ99595
IntActiQ99595, 4 interactors
MINTiQ99595
STRINGi9606.ENSP00000356256

Structurei

3D structure databases

ProteinModelPortaliQ99595
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1652 Eukaryota
COG5596 LUCA
GeneTreeiENSGT00390000017780
HOGENOMiHOG000183190
HOVERGENiHBG054233
InParanoidiQ99595
KOiK17795
OMAiFASTQFP
OrthoDBiEOG091G0PGZ
PhylomeDBiQ99595
TreeFamiTF106195

Family and domain databases

InterProiView protein in InterPro
IPR005678 Tim17
TIGRFAMsiTIGR00980 3a0801so1tim17, 1 hit

Sequencei

Sequence statusi: Complete.

Q99595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYAREPCP WRIVDDCGGA FTMGTIGGGI FQAIKGFRNS PVGVNHRLRG
60 70 80 90 100
SLTAIKTRAP QLGGSFAVWG GLFSMIDCSM VQVRGKEDPW NSITSGALTG
110 120 130 140 150
AILAARNGPV AMVGSAAMGG ILLALIEGAG ILLTRFASAQ FPNGPQFAED
160 170
PSQLPSTQLP SSPFGDYRQY Q
Length:171
Mass (Da):18,024
Last modified:May 1, 1997 - v1
Checksum:iAAC3C0875424416A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052305113V → I. Corresponds to variant dbSNP:rs4648Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97544 mRNA Translation: CAA66146.1
AF106622 mRNA Translation: AAD19596.1
AK315602 mRNA Translation: BAG37972.1
CH471067 Genomic DNA Translation: EAW91384.1
BC000294 mRNA Translation: AAH00294.2
BC004439 mRNA Translation: AAH04439.1
BC007106 mRNA Translation: AAH07106.1
BC009784 mRNA Translation: AAH09784.1
BC015098 mRNA Translation: AAH15098.1
BC020833 mRNA Translation: AAH20833.1
CCDSiCCDS1417.1
RefSeqiNP_006326.1, NM_006335.2
UniGeneiHs.20716

Genome annotation databases

EnsembliENST00000367287; ENSP00000356256; ENSG00000134375
GeneIDi10440
KEGGihsa:10440
UCSCiuc001gxc.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTI17A_HUMAN
AccessioniPrimary (citable) accession number: Q99595
Secondary accession number(s): B2RDM5, Q9BWF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: June 20, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health