Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial import inner membrane translocase subunit Tim17-A

Gene

TIMM17A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1268020. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim17-A
Alternative name(s):
Inner membrane preprotein translocase Tim17a
Gene namesi
Name:TIMM17A
Synonyms:MIMT17, TIM17, TIM17A, TIMM17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:17315. TIMM17A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of mitochondrial inner membrane Source: BHF-UCL
  • mitochondrial inner membrane Source: GO_Central
  • mitochondrial inner membrane presequence translocase complex Source: BHF-UCL
  • mitochondrion Source: HPA
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38228.

Polymorphism and mutation databases

BioMutaiTIMM17A.
DMDMi3219818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Mitochondrial import inner membrane translocase subunit Tim17-APRO_0000210284Add
BLAST

Proteomic databases

EPDiQ99595.
MaxQBiQ99595.
PaxDbiQ99595.
PeptideAtlasiQ99595.
PRIDEiQ99595.
TopDownProteomicsiQ99595.

PTM databases

iPTMnetiQ99595.
PhosphoSiteiQ99595.
SwissPalmiQ99595.

Expressioni

Gene expression databases

BgeeiQ99595.
CleanExiHS_TIMM17A.
GenevisibleiQ99595. HS.

Organism-specific databases

HPAiHPA010083.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.1 Publication

Protein-protein interaction databases

BioGridi115707. 8 interactions.
IntActiQ99595. 2 interactions.
MINTiMINT-1411052.
STRINGi9606.ENSP00000356256.

Structurei

3D structure databases

ProteinModelPortaliQ99595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1652. Eukaryota.
COG5596. LUCA.
GeneTreeiENSGT00390000017780.
HOGENOMiHOG000183190.
HOVERGENiHBG054233.
InParanoidiQ99595.
KOiK17795.
OMAiMLAGSTK.
OrthoDBiEOG7JX35C.
PhylomeDBiQ99595.
TreeFamiTF106195.

Family and domain databases

InterProiIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PANTHERiPTHR10485. PTHR10485. 1 hit.
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYAREPCP WRIVDDCGGA FTMGTIGGGI FQAIKGFRNS PVGVNHRLRG
60 70 80 90 100
SLTAIKTRAP QLGGSFAVWG GLFSMIDCSM VQVRGKEDPW NSITSGALTG
110 120 130 140 150
AILAARNGPV AMVGSAAMGG ILLALIEGAG ILLTRFASAQ FPNGPQFAED
160 170
PSQLPSTQLP SSPFGDYRQY Q
Length:171
Mass (Da):18,024
Last modified:May 1, 1997 - v1
Checksum:iAAC3C0875424416A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131V → I.
Corresponds to variant rs4648 [ dbSNP | Ensembl ].
VAR_052305

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97544 mRNA. Translation: CAA66146.1.
AF106622 mRNA. Translation: AAD19596.1.
AK315602 mRNA. Translation: BAG37972.1.
CH471067 Genomic DNA. Translation: EAW91384.1.
BC000294 mRNA. Translation: AAH00294.2.
BC004439 mRNA. Translation: AAH04439.1.
BC007106 mRNA. Translation: AAH07106.1.
BC009784 mRNA. Translation: AAH09784.1.
BC015098 mRNA. Translation: AAH15098.1.
BC020833 mRNA. Translation: AAH20833.1.
CCDSiCCDS1417.1.
RefSeqiNP_006326.1. NM_006335.2.
UniGeneiHs.20716.

Genome annotation databases

EnsembliENST00000367287; ENSP00000356256; ENSG00000134375.
GeneIDi10440.
KEGGihsa:10440.
UCSCiuc001gxc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97544 mRNA. Translation: CAA66146.1.
AF106622 mRNA. Translation: AAD19596.1.
AK315602 mRNA. Translation: BAG37972.1.
CH471067 Genomic DNA. Translation: EAW91384.1.
BC000294 mRNA. Translation: AAH00294.2.
BC004439 mRNA. Translation: AAH04439.1.
BC007106 mRNA. Translation: AAH07106.1.
BC009784 mRNA. Translation: AAH09784.1.
BC015098 mRNA. Translation: AAH15098.1.
BC020833 mRNA. Translation: AAH20833.1.
CCDSiCCDS1417.1.
RefSeqiNP_006326.1. NM_006335.2.
UniGeneiHs.20716.

3D structure databases

ProteinModelPortaliQ99595.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115707. 8 interactions.
IntActiQ99595. 2 interactions.
MINTiMINT-1411052.
STRINGi9606.ENSP00000356256.

PTM databases

iPTMnetiQ99595.
PhosphoSiteiQ99595.
SwissPalmiQ99595.

Polymorphism and mutation databases

BioMutaiTIMM17A.
DMDMi3219818.

Proteomic databases

EPDiQ99595.
MaxQBiQ99595.
PaxDbiQ99595.
PeptideAtlasiQ99595.
PRIDEiQ99595.
TopDownProteomicsiQ99595.

Protocols and materials databases

DNASUi10440.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367287; ENSP00000356256; ENSG00000134375.
GeneIDi10440.
KEGGihsa:10440.
UCSCiuc001gxc.3. human.

Organism-specific databases

CTDi10440.
GeneCardsiTIMM17A.
HGNCiHGNC:17315. TIMM17A.
HPAiHPA010083.
MIMi605057. gene.
neXtProtiNX_Q99595.
PharmGKBiPA38228.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1652. Eukaryota.
COG5596. LUCA.
GeneTreeiENSGT00390000017780.
HOGENOMiHOG000183190.
HOVERGENiHBG054233.
InParanoidiQ99595.
KOiK17795.
OMAiMLAGSTK.
OrthoDBiEOG7JX35C.
PhylomeDBiQ99595.
TreeFamiTF106195.

Enzyme and pathway databases

ReactomeiR-HSA-1268020. Mitochondrial protein import.

Miscellaneous databases

ChiTaRSiTIMM17A. human.
GeneWikiiTIMM17A.
GenomeRNAii10440.
NextBioi39573.
PROiQ99595.
SOURCEiSearch...

Gene expression databases

BgeeiQ99595.
CleanExiHS_TIMM17A.
GenevisibleiQ99595. HS.

Family and domain databases

InterProiIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PANTHERiPTHR10485. PTHR10485. 1 hit.
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00980. 3a0801so1tim17. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17."
    Boemer U., Rassow J., Zufall N., Pfanner N., Meijer M., Maarse A.C.
    J. Mol. Biol. 262:389-395(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genetic and structural characterization of the human mitochondrial inner membrane translocase."
    Bauer M.F., Gempel K., Reichert A.S., Rappold G.A., Lichtner P., Gerbitz K.-D., Neupert W., Brunner M., Hofmann S.
    J. Mol. Biol. 289:69-82(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow, Brain, Lung, Testis and Urinary bladder.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria."
    Schusdziarra C., Blamowska M., Azem A., Hell K.
    Hum. Mol. Genet. 22:1348-1357(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DNAJC15.

Entry informationi

Entry nameiTI17A_HUMAN
AccessioniPrimary (citable) accession number: Q99595
Secondary accession number(s): B2RDM5, Q9BWF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.