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Protein

Transcriptional enhancer factor TEF-5

Gene

TEAD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi30 – 97TEAPROSITE-ProRule annotationAdd BLAST68

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • RNA polymerase II transcription factor binding Source: WormBase
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • asymmetric neuroblast division Source: UniProtKB
  • female pregnancy Source: ProtInc
  • hippo signaling Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: InterPro
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000007866-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
SIGNORiQ99594.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional enhancer factor TEF-5
Alternative name(s):
DTEF-1
TEA domain family member 3
Short name:
TEAD-3
Gene namesi
Name:TEAD3
Synonyms:TEAD5, TEF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:11716. TEAD3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7005.
PharmGKBiPA36434.

Polymorphism and mutation databases

BioMutaiTEAD3.
DMDMi2501157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002059342 – 435Transcriptional enhancer factor TEF-5Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei148PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99594.
MaxQBiQ99594.
PaxDbiQ99594.
PeptideAtlasiQ99594.
PRIDEiQ99594.

PTM databases

iPTMnetiQ99594.
PhosphoSitePlusiQ99594.
SwissPalmiQ99594.

Expressioni

Tissue specificityi

Preferentially expressed in the placenta.

Gene expression databases

BgeeiENSG00000007866.
CleanExiHS_TEAD3.
ExpressionAtlasiQ99594. baseline and differential.
GenevisibleiQ99594. HS.

Organism-specific databases

HPAiHPA028906.

Interactioni

Subunit structurei

Interacts with YAP1 and WWTR1/TAZ.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VGLL2Q8N8G23EBI-746720,EBI-10267981

GO - Molecular functioni

  • RNA polymerase II transcription factor binding Source: WormBase

Protein-protein interaction databases

BioGridi112864. 20 interactors.
DIPiDIP-50657N.
IntActiQ99594. 19 interactors.
STRINGi9606.ENSP00000345772.

Structurei

Secondary structure

1435
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi226 – 239Combined sources14
Beta strandi242 – 251Combined sources10
Beta strandi264 – 267Combined sources4
Helixi268 – 270Combined sources3
Helixi272 – 274Combined sources3
Helixi282 – 288Combined sources7
Helixi291 – 293Combined sources3
Beta strandi294 – 301Combined sources8
Beta strandi314 – 325Combined sources12
Beta strandi328 – 337Combined sources10
Beta strandi340 – 350Combined sources11
Beta strandi352 – 354Combined sources3
Beta strandi357 – 366Combined sources10
Helixi369 – 379Combined sources11
Helixi384 – 391Combined sources8
Beta strandi394 – 402Combined sources9
Turni403 – 405Combined sources3
Beta strandi408 – 418Combined sources11
Beta strandi426 – 433Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EMWX-ray2.55A/B/C/D219-435[»]
ProteinModelPortaliQ99594.
SMRiQ99594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 435Transcriptional activationSequence analysisAdd BLAST263

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi146 – 213Pro-richAdd BLAST68

Sequence similaritiesi

Contains 1 TEA DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3841. Eukaryota.
ENOG410XQMP. LUCA.
HOGENOMiHOG000253933.
HOVERGENiHBG056905.
InParanoidiQ99594.
KOiK09448.
OrthoDBiEOG091G08YE.
PhylomeDBiQ99594.
TreeFamiTF313443.

Family and domain databases

InterProiIPR000818. TEA/ATTS_dom.
IPR027253. TEF-5.
IPR016361. TEF_metazoa.
[Graphical view]
PfamiPF01285. TEA. 1 hit.
[Graphical view]
PIRSFiPIRSF002603. TEF. 1 hit.
PIRSF500720. TEF-5. 1 hit.
PRINTSiPR00065. TEADOMAIN.
SMARTiSM00426. TEA. 1 hit.
[Graphical view]
PROSITEiPS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99594-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNSWNASS SPGEAREDGP EGLDKGLDND AEGVWSPDIE QSFQEALAIY
60 70 80 90 100
PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARK
110 120 130 140 150
KVREYQVGIK AMNLDQVSKD KALQSMASMS SAQIVSASVL QNKFSPPSPL
160 170 180 190 200
PQAVFSTSSR FWSSPPLLGQ QPGPSQDIKP FAQPAYPIQP PLPPTLSSYE
210 220 230 240 250
PLAPLPSAAA SVPVWQDRTI ASSRLRLLEY SAFMEVQRDP DTYSKHLFVH
260 270 280 290 300
IGQTNPAFSD PPLEAVDVRQ IYDKFPEKKG GLKELYEKGP PNAFFLVKFW
310 320 330 340 350
ADLNSTIQEG PGAFYGVSSQ YSSADSMTIS VSTKVCSFGK QVVEKVETEY
360 370 380 390 400
ARLENGRFVY RIHRSPMCEY MINFIHKLKH LPEKYMMNSV LENFTILQVV
410 420 430
TSRDSQETLL VIAFVFEVST SEHGAQHHVY KLVKD
Length:435
Mass (Da):48,676
Last modified:November 1, 1997 - v2
Checksum:i9F8E7900EB13D4DC
GO

Sequence cautioni

The sequence AAH27877 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence AAH91488 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence CAA64213 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052278254T → M.Corresponds to variant rs35080860dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94439 mRNA. Translation: CAA64213.2. Sequence problems.
AL022721 Genomic DNA. No translation available.
BC027877 mRNA. Translation: AAH27877.1. Sequence problems.
BC091488 mRNA. Translation: AAH91488.2. Sequence problems.
CCDSiCCDS47414.1.
RefSeqiNP_003205.2. NM_003214.3.
UniGeneiHs.485205.

Genome annotation databases

EnsembliENST00000338863; ENSP00000345772; ENSG00000007866.
GeneIDi7005.
KEGGihsa:7005.
UCSCiuc063obu.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94439 mRNA. Translation: CAA64213.2. Sequence problems.
AL022721 Genomic DNA. No translation available.
BC027877 mRNA. Translation: AAH27877.1. Sequence problems.
BC091488 mRNA. Translation: AAH91488.2. Sequence problems.
CCDSiCCDS47414.1.
RefSeqiNP_003205.2. NM_003214.3.
UniGeneiHs.485205.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EMWX-ray2.55A/B/C/D219-435[»]
ProteinModelPortaliQ99594.
SMRiQ99594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112864. 20 interactors.
DIPiDIP-50657N.
IntActiQ99594. 19 interactors.
STRINGi9606.ENSP00000345772.

PTM databases

iPTMnetiQ99594.
PhosphoSitePlusiQ99594.
SwissPalmiQ99594.

Polymorphism and mutation databases

BioMutaiTEAD3.
DMDMi2501157.

Proteomic databases

EPDiQ99594.
MaxQBiQ99594.
PaxDbiQ99594.
PeptideAtlasiQ99594.
PRIDEiQ99594.

Protocols and materials databases

DNASUi7005.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338863; ENSP00000345772; ENSG00000007866.
GeneIDi7005.
KEGGihsa:7005.
UCSCiuc063obu.1. human.

Organism-specific databases

CTDi7005.
DisGeNETi7005.
GeneCardsiTEAD3.
HGNCiHGNC:11716. TEAD3.
HPAiHPA028906.
MIMi603170. gene.
neXtProtiNX_Q99594.
PharmGKBiPA36434.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3841. Eukaryota.
ENOG410XQMP. LUCA.
HOGENOMiHOG000253933.
HOVERGENiHBG056905.
InParanoidiQ99594.
KOiK09448.
OrthoDBiEOG091G08YE.
PhylomeDBiQ99594.
TreeFamiTF313443.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000007866-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
SIGNORiQ99594.

Miscellaneous databases

ChiTaRSiTEAD3. human.
GeneWikiiTEAD3.
GenomeRNAii7005.
PROiQ99594.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000007866.
CleanExiHS_TEAD3.
ExpressionAtlasiQ99594. baseline and differential.
GenevisibleiQ99594. HS.

Family and domain databases

InterProiIPR000818. TEA/ATTS_dom.
IPR027253. TEF-5.
IPR016361. TEF_metazoa.
[Graphical view]
PfamiPF01285. TEA. 1 hit.
[Graphical view]
PIRSFiPIRSF002603. TEF. 1 hit.
PIRSF500720. TEF-5. 1 hit.
PRINTSiPR00065. TEADOMAIN.
SMARTiSM00426. TEA. 1 hit.
[Graphical view]
PROSITEiPS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEAD3_HUMAN
AccessioniPrimary (citable) accession number: Q99594
Secondary accession number(s): O95910, Q5BJG7, Q8N6Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.