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Q99594

- TEAD3_HUMAN

UniProt

Q99594 - TEAD3_HUMAN

Protein

Transcriptional enhancer factor TEF-5

Gene

TEAD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi30 – 9768TEAPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. RNA polymerase II transcription factor binding Source: WormBase
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. female pregnancy Source: ProtInc
    2. gene expression Source: Reactome
    3. hippo signaling Source: UniProtKB
    4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    6. transcription initiation from RNA polymerase II promoter Source: Reactome

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.
    REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional enhancer factor TEF-5
    Alternative name(s):
    DTEF-1
    TEA domain family member 3
    Short name:
    TEAD-3
    Gene namesi
    Name:TEAD3
    Synonyms:TEAD5, TEF5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:11716. TEAD3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36434.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 435434Transcriptional enhancer factor TEF-5PRO_0000205934Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ99594.
    PaxDbiQ99594.
    PRIDEiQ99594.

    PTM databases

    PhosphoSiteiQ99594.

    Expressioni

    Tissue specificityi

    Preferentially expressed in the placenta.

    Gene expression databases

    ArrayExpressiQ99594.
    BgeeiQ99594.
    CleanExiHS_TEAD3.
    GenevestigatoriQ99594.

    Organism-specific databases

    HPAiHPA028906.

    Interactioni

    Subunit structurei

    Interacts with YAP1 and WWTR1/TAZ.2 Publications

    Protein-protein interaction databases

    BioGridi112864. 12 interactions.
    IntActiQ99594. 14 interactions.
    STRINGi9606.ENSP00000345772.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99594.
    SMRiQ99594. Positions 27-104, 218-434.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni173 – 435263Transcriptional activationSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi146 – 21368Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 TEA DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG246992.
    HOGENOMiHOG000253933.
    HOVERGENiHBG056905.
    KOiK09448.
    PhylomeDBiQ99594.
    TreeFamiTF313443.

    Family and domain databases

    InterProiIPR000818. TEA/ATTS.
    IPR016361. TEF.
    IPR027253. TEF-5.
    [Graphical view]
    PANTHERiPTHR11834. PTHR11834. 1 hit.
    PfamiPF01285. TEA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002603. TEF. 1 hit.
    PIRSF500720. TEF-5. 1 hit.
    PRINTSiPR00065. TEADOMAIN.
    SMARTiSM00426. TEA. 1 hit.
    [Graphical view]
    PROSITEiPS00554. TEA_1. 1 hit.
    PS51088. TEA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99594-1 [UniParc]FASTAAdd to Basket

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    MASNSWNASS SPGEAREDGP EGLDKGLDND AEGVWSPDIE QSFQEALAIY    50
    PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARK 100
    KVREYQVGIK AMNLDQVSKD KALQSMASMS SAQIVSASVL QNKFSPPSPL 150
    PQAVFSTSSR FWSSPPLLGQ QPGPSQDIKP FAQPAYPIQP PLPPTLSSYE 200
    PLAPLPSAAA SVPVWQDRTI ASSRLRLLEY SAFMEVQRDP DTYSKHLFVH 250
    IGQTNPAFSD PPLEAVDVRQ IYDKFPEKKG GLKELYEKGP PNAFFLVKFW 300
    ADLNSTIQEG PGAFYGVSSQ YSSADSMTIS VSTKVCSFGK QVVEKVETEY 350
    ARLENGRFVY RIHRSPMCEY MINFIHKLKH LPEKYMMNSV LENFTILQVV 400
    TSRDSQETLL VIAFVFEVST SEHGAQHHVY KLVKD 435
    Length:435
    Mass (Da):48,676
    Last modified:November 1, 1997 - v2
    Checksum:i9F8E7900EB13D4DC
    GO

    Sequence cautioni

    The sequence AAH27877.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.
    The sequence AAH91488.2 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.
    The sequence CAA64213.2 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti254 – 2541T → M.
    Corresponds to variant rs35080860 [ dbSNP | Ensembl ].
    VAR_052278

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94439 mRNA. Translation: CAA64213.2. Sequence problems.
    AL022721 Genomic DNA. No translation available.
    BC027877 mRNA. Translation: AAH27877.1. Sequence problems.
    BC091488 mRNA. Translation: AAH91488.2. Sequence problems.
    CCDSiCCDS47414.1.
    RefSeqiNP_003205.2. NM_003214.3.
    UniGeneiHs.485205.

    Genome annotation databases

    EnsembliENST00000338863; ENSP00000345772; ENSG00000007866.
    GeneIDi7005.
    KEGGihsa:7005.
    UCSCiuc003okt.3. human.

    Polymorphism databases

    DMDMi2501157.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94439 mRNA. Translation: CAA64213.2 . Sequence problems.
    AL022721 Genomic DNA. No translation available.
    BC027877 mRNA. Translation: AAH27877.1 . Sequence problems.
    BC091488 mRNA. Translation: AAH91488.2 . Sequence problems.
    CCDSi CCDS47414.1.
    RefSeqi NP_003205.2. NM_003214.3.
    UniGenei Hs.485205.

    3D structure databases

    ProteinModelPortali Q99594.
    SMRi Q99594. Positions 27-104, 218-434.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112864. 12 interactions.
    IntActi Q99594. 14 interactions.
    STRINGi 9606.ENSP00000345772.

    PTM databases

    PhosphoSitei Q99594.

    Polymorphism databases

    DMDMi 2501157.

    Proteomic databases

    MaxQBi Q99594.
    PaxDbi Q99594.
    PRIDEi Q99594.

    Protocols and materials databases

    DNASUi 7005.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338863 ; ENSP00000345772 ; ENSG00000007866 .
    GeneIDi 7005.
    KEGGi hsa:7005.
    UCSCi uc003okt.3. human.

    Organism-specific databases

    CTDi 7005.
    GeneCardsi GC06M035441.
    HGNCi HGNC:11716. TEAD3.
    HPAi HPA028906.
    MIMi 603170. gene.
    neXtProti NX_Q99594.
    PharmGKBi PA36434.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG246992.
    HOGENOMi HOG000253933.
    HOVERGENi HBG056905.
    KOi K09448.
    PhylomeDBi Q99594.
    TreeFami TF313443.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.
    REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

    Miscellaneous databases

    GeneWikii TEAD3.
    GenomeRNAii 7005.
    NextBioi 27362.
    PROi Q99594.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99594.
    Bgeei Q99594.
    CleanExi HS_TEAD3.
    Genevestigatori Q99594.

    Family and domain databases

    InterProi IPR000818. TEA/ATTS.
    IPR016361. TEF.
    IPR027253. TEF-5.
    [Graphical view ]
    PANTHERi PTHR11834. PTHR11834. 1 hit.
    Pfami PF01285. TEA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002603. TEF. 1 hit.
    PIRSF500720. TEF-5. 1 hit.
    PRINTSi PR00065. TEADOMAIN.
    SMARTi SM00426. TEA. 1 hit.
    [Graphical view ]
    PROSITEi PS00554. TEA_1. 1 hit.
    PS51088. TEA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer."
      Jacquemin P., Martial J.A., Davidson I.
      J. Biol. Chem. 272:12928-12937(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and PNS.
    4. "TEAD mediates YAP-dependent gene induction and growth control."
      Zhao B., Ye X., Yu J., Li L., Li W., Li S., Yu J., Lin J.D., Wang C.Y., Chinnaiyan A.M., Lai Z.C., Guan K.L.
      Genes Dev. 22:1962-1971(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH YAP1.
    5. "TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition."
      Zhang H., Liu C.Y., Zha Z.Y., Zhao B., Yao J., Zhao S., Xiong Y., Lei Q.Y., Guan K.L.
      J. Biol. Chem. 284:13355-13362(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH WWTR1.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTEAD3_HUMAN
    AccessioniPrimary (citable) accession number: Q99594
    Secondary accession number(s): O95910, Q5BJG7, Q8N6Y4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3