SCAF11

Functionⁱ

Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	41 – 82	RING-type; degeneratePROSITE-ProRule annotationAdd BLAST		42

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22658674
- 22681889
zinc ion binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

mRNA processing
Source: ProtInc
Traceable author statementⁱ
- 9447963
RNA splicing
Source: UniProtKB
Inferred from direct assayⁱ
- 9447963
RNA splicing, via transesterification reactions
Source: UniProtKB
Inferred from direct assayⁱ
- 9447963
spliceosomal complex assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 9447963

Complete GO annotation...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein SCAF11 Alternative name(s): CTD-associated SR protein 11 Renal carcinoma antigen NY-REN-40 SC35-interacting protein 1 SR-related and CTD-associated factor 11 SRSF2-interacting protein Serine/arginine-rich splicing factor 2-interacting protein Splicing factor, arginine/serine-rich 2-interacting protein Splicing regulatory protein 129 Short name: SRrp129
Gene namesⁱ	Name:SCAF11 Synonyms:CASP11, SFRS2IP, SIP1, SRSF2IP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10784. SCAF11.

HGNCⁱ

HGNC:10784. SCAF11.

Subcellular locationⁱ

Nucleus
1 Publication
Manual assertion based on experiment inⁱ
- Ref.2
  "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing."
  Zhang W.-J., Wu J.Y.
  Mol. Cell. Biol. 18:676-684(1998) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH SRSF2; U2AF2 AND SNRNP70, SUBCELLULAR LOCATION.

GO - Cellular componentⁱ

nuclear body Source: HPA
nucleolus Source: HPA
nucleoplasm Source: HPA
nucleus Source: HPA

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9169.
Open Targets More...OpenTargetsⁱ	ENSG00000139218.
PharmGKBⁱ	PA35700.

Polymorphism and mutation databases

BioMutaⁱ	SCAF11.
DMDMⁱ	251757337.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076314	1 – 1463	Protein SCAF11Add BLAST		1463

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	331	PhosphothreonineCombined sources	1
Modified residueⁱ	338	PhosphoserineCombined sources	1
Modified residueⁱ	341	PhosphoserineCombined sources	1
Modified residueⁱ	344	PhosphoserineCombined sources	1
Modified residueⁱ	400	PhosphoserineCombined sources	1
Modified residueⁱ	401	PhosphoserineCombined sources	1
Modified residueⁱ	402	PhosphoserineCombined sources	1
Modified residueⁱ	405	PhosphoserineCombined sources	1
Modified residueⁱ	410	PhosphothreonineCombined sources	1
Modified residueⁱ	413	PhosphoserineCombined sources	1
Modified residueⁱ	533	PhosphoserineCombined sources	1
Modified residueⁱ	588	PhosphoserineCombined sources	1
Cross-linkⁱ	601	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	608	PhosphoserineCombined sources	1
Cross-linkⁱ	610	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	614	PhosphoserineCombined sources	1
Cross-linkⁱ	676	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linkⁱ	676	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	680	PhosphoserineCombined sources	1
Modified residueⁱ	687	PhosphoserineCombined sources	1
Modified residueⁱ	694	PhosphoserineCombined sources	1
Modified residueⁱ	723	PhosphoserineCombined sources	1
Modified residueⁱ	726	PhosphoserineCombined sources	1
Modified residueⁱ	769	PhosphothreonineCombined sources	1
Modified residueⁱ	771	PhosphoserineCombined sources	1
Modified residueⁱ	776	PhosphoserineCombined sources	1
Modified residueⁱ	796	PhosphoserineCombined sources	1
Modified residueⁱ	798	PhosphoserineCombined sources	1
Modified residueⁱ	802	PhosphoserineCombined sources	1
Modified residueⁱ	807	PhosphothreonineCombined sources	1
Modified residueⁱ	816	PhosphoserineCombined sources	1
Modified residueⁱ	963	PhosphoserineCombined sources	1
Modified residueⁱ	1122	PhosphoserineCombined sources	1
Modified residueⁱ	1127	PhosphoserineCombined sources	1
Modified residueⁱ	1151	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	1153	PhosphothreonineCombined sources	1
Modified residueⁱ	1169	PhosphoserineCombined sources	1
Modified residueⁱ	1170	PhosphoserineCombined sources	1
Cross-linkⁱ	1178	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q99590.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99590.
PaxDbⁱ	Q99590.
PeptideAtlas More...PeptideAtlasⁱ	Q99590.
PRIDEⁱ	Q99590.

PTM databases

iPTMnetⁱ	Q99590.
PhosphoSitePlusⁱ	Q99590.
SwissPalmⁱ	Q99590.

Miscellaneous databases

PMAP-CutDBⁱ	Q99590.

PMAP-CutDBⁱ

Q99590.

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000139218.
CleanExⁱ	HS_SFRS2IP. HS_SIP1.
ExpressionAtlasⁱ	Q99590. baseline and differential.
Genevisibleⁱ	Q99590. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038862. HPA045456. HPA046345.

HPAⁱ

HPA038862.
HPA045456.
HPA046345.

Interactionⁱ

Subunit structureⁱ

Interacts with SRSF2/SFRS2, U2AF2 and SNRNP70.1 Publication

Protein-protein interaction databases

BioGridⁱ	114610. 38 interactors.
IntActⁱ	Q99590. 17 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-2866162.
STRINGⁱ	9606.ENSP00000358374.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99590.
SMRⁱ	Q99590.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	841 – 985	Arg-richAdd BLAST		145
Compositional biasⁱ	1225 – 1285	Pro-richAdd BLAST		61

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	41 – 82	RING-type; degeneratePROSITE-ProRule annotationAdd BLAST		42

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IMMV. Eukaryota. ENOG4111NG4. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063661.
HOVERGENⁱ	HBG101126.
InParanoidⁱ	Q99590.
OMAⁱ	YCTEFIE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05JH.
PhylomeDBⁱ	Q99590.
TreeFamⁱ	TF332183.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00162. RING. 1 hit.
Gene3Dⁱ	3.30.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13639. zf-RING_2. 1 hit.
SMARTⁱ	View protein in SMART SM00184. RING. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q99590-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKKTVCTLN MGDKKYEDME GEENGDNTIS TGLLYSEADR CPICLNCLLE 
        60         70         80         90        100
KEVGFPESCN HVFCMTCILK WAETLASCPI DRKPFQAVFK FSALEGYVKV 
       110        120        130        140        150
QVKKQLRETK DKKNENSFEK QVSCHENSKS CIRRKAIVRE DLLSAKVCDL 
       160        170        180        190        200
KWIHRNSLYS ETGGKKNAAI KINKPQRSNW STNQCFRNFF SNMFSSVSHS 
       210        220        230        240        250
GESSFTYRAY CTEFIEASEI SALIRQKRHE LELSWFPDTL PGIGRIGFIP 
       260        270        280        290        300
WNVETEVLPL ISSVLPRTIF PTSTISFEHF GTSCKGYALA HTQEGEEKKQ 
       310        320        330        340        350
TSGTSNTRGS RRKPAMTTPT RRSTRNTRAE TASQSQRSPI SDNSGCDAPG 
       360        370        380        390        400
NSNPSLSVPS SAESEKQTRQ APKRKSVRRG RKPPLLKKKL RSSVAAPEKS 
       410        420        430        440        450
SSNDSVDEET AESDTSPVLE KEHQPDVDSS NICTVQTHVE NQSANCLKSC 
       460        470        480        490        500
NEQIEESEKH TANYDTEERV GSSSSESCAQ DLPVLVGEEG EVKKLENTGI 
       510        520        530        540        550
EANVLCLESE ISENILEKGG DPLEKQDQIS GLSQSEVKTD VCTVHLPNDF 
       560        570        580        590        600
PTCLTSESKV YQPVSCPLSD LSENVESVVN EEKITESSLV EITEHKDFTL 
       610        620        630        640        650
KTEELIESPK LESSEGEIIQ TVDRQSVKSP EVQLLGHVET EDVEIIATCD 
       660        670        680        690        700
TFGNEDFNNI QDSENNLLKN NLLNTKLEKS LEEKNESLTE HPRSTELPKT 
       710        720        730        740        750
HIEQIQKHFS EDNNEMIPME CDSFCSDQNE SEVEPSVNAD LKQMNENSVT 
       760        770        780        790        800
HCSENNMPSS DLADEKVETV SQPSESPKDT IDKTKKPRTR RSRFHSPSTT 
       810        820        830        840        850
WSPNKDTPQE KKRPQSPSPR RETGKESRKS QSPSPKNESA RGRKKSRSQS 
       860        870        880        890        900
PKKDIARERR QSQSRSPKRD TTRESRRSES LSPRRETSRE NKRSQPRVKD 
       910        920        930        940        950
SSPGEKSRSQ SRERESDRDG QRRERERRTR KWSRSRSHSR SPSRCRTKSK 
       960        970        980        990       1000
SSSFGRIDRD SYSPRWKGRW ANDGWRCPRG NDRYRKNDPE KQNENTRKEK 
      1010       1020       1030       1040       1050
NDIHLDADDP NSADKHRNDC PNWITEKINS GPDPRTRNPE KLKESHWEEN 
      1060       1070       1080       1090       1100
RNENSGNSWN KNFGSGWVSN RGRGRGNRGR GTYRSSFAYK DQNENRWQNR 
      1110       1120       1130       1140       1150
KPLSGNSNSS GSESFKFVEQ QSYKRKSEQE FSFDTPADRS GWTSASSWAV 
      1160       1170       1180       1190       1200
RKTLPADVQN YYSRRGRNSS GPQSGWMKQE EETSGQDSSL KDQTNQQVDG 
      1210       1220       1230       1240       1250
SQLPINMMQP QMNVMQQQMN AQHQPMNIFP YPVGVHAPLM NIQRNPFNIH 
      1260       1270       1280       1290       1300
PQLPLHLHTG VPLMQVATPT SVSQGLPPPP PPPPPSQQVN YIASQPDGKQ 
      1310       1320       1330       1340       1350
LQGIPSSSHV SNNMSTPVLP APTAAPGNTG MVQGPSSGNT SSSSHSKASN 
      1360       1370       1380       1390       1400
AAVKLAESKV SVAVEASADS SKTDKKLQIQ EKAAQEVKLA IKPFYQNKDI 
      1410       1420       1430       1440       1450
TKEEYKEIVR KAVDKVCHSK SGEVNSTKVA NLVKAYVDKY KYSRKGSQKK 
      1460 
TLEEPVSTEK NIG

Length:1,463

Mass (Da):164,652

Last modified:July 7, 2009 - v2

Checksum:ⁱ7170B88544BAF7D4

GO

Isoform 2 (identifier: Q99590-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-315: Missing.

« Hide

        10         20         30         40         50
MTTPTRRSTR NTRAETASQS QRSPISDNSG CDAPGNSNPS LSVPSSAESE 
        60         70         80         90        100
KQTRQAPKRK SVRRGRKPPL LKKKLRSSVA APEKSSSNDS VDEETAESDT 
       110        120        130        140        150
SPVLEKEHQP DVDSSNICTV QTHVENQSAN CLKSCNEQIE ESEKHTANYD 
       160        170        180        190        200
TEERVGSSSS ESCAQDLPVL VGEEGEVKKL ENTGIEANVL CLESEISENI 
       210        220        230        240        250
LEKGGDPLEK QDQISGLSQS EVKTDVCTVH LPNDFPTCLT SESKVYQPVS 
       260        270        280        290        300
CPLSDLSENV ESVVNEEKIT ESSLVEITEH KDFTLKTEEL IESPKLESSE 
       310        320        330        340        350
GEIIQTVDRQ SVKSPEVQLL GHVETEDVEI IATCDTFGNE DFNNIQDSEN 
       360        370        380        390        400
NLLKNNLLNT KLEKSLEEKN ESLTEHPRST ELPKTHIEQI QKHFSEDNNE 
       410        420        430        440        450
MIPMECDSFC SDQNESEVEP SVNADLKQMN ENSVTHCSEN NMPSSDLADE 
       460        470        480        490        500
KVETVSQPSE SPKDTIDKTK KPRTRRSRFH SPSTTWSPNK DTPQEKKRPQ 
       510        520        530        540        550
SPSPRRETGK ESRKSQSPSP KNESARGRKK SRSQSPKKDI ARERRQSQSR 
       560        570        580        590        600
SPKRDTTRES RRSESLSPRR ETSRENKRSQ PRVKDSSPGE KSRSQSRERE 
       610        620        630        640        650
SDRDGQRRER ERRTRKWSRS RSHSRSPSRC RTKSKSSSFG RIDRDSYSPR 
       660        670        680        690        700
WKGRWANDGW RCPRGNDRYR KNDPEKQNEN TRKEKNDIHL DADDPNSADK 
       710        720        730        740        750
HRNDCPNWIT EKINSGPDPR TRNPEKLKES HWEENRNENS GNSWNKNFGS 
       760        770        780        790        800
GWVSNRGRGR GNRGRGTYRS SFAYKDQNEN RWQNRKPLSG NSNSSGSESF 
       810        820        830        840        850
KFVEQQSYKR KSEQEFSFDT PADRSGWTSA SSWAVRKTLP ADVQNYYSRR 
       860        870        880        890        900
GRNSSGPQSG WMKQEEETSG QDSSLKDQTN QQVDGSQLPI NMMQPQMNVM 
       910        920        930        940        950
QQQMNAQHQP MNIFPYPVGV HAPLMNIQRN PFNIHPQLPL HLHTGVPLMQ 
       960        970        980        990       1000
VATPTSVSQG LPPPPPPPPP SQQVNYIASQ PDGKQLQGIP SSSHVSNNMS 
      1010       1020       1030       1040       1050
TPVLPAPTAA PGNTGMVQGP SSGNTSSSSH SKASNAAVKL AESKVSVAVE 
      1060       1070       1080       1090       1100
ASADSSKTDK KLQIQEKAAQ EVKLAIKPFY QNKDITKEEY KEIVRKAVDK 
      1110       1120       1130       1140 
VCHSKSGEVN STKVANLVKA YVDKYKYSRK GSQKKTLEEP VSTEKNIG

Show »

Length:1,148

Mass (Da):128,875

Checksum:ⁱB57FD40EE5E4C48C

GO

Sequence cautionⁱ

The sequence AAC39565 differs from that shown. Reason: Frameshift at position 62.Curated

The sequence AAC39565 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH40951 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

The sequence AAH40951 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	584	I → M in AAH40951 (PubMed:15489334).Curated		1
Sequence conflictⁱ	623	D → G in AAH40951 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059722	657	F → Y. Corresponds to variant dbSNP:rs7315731Ensembl.		1
Natural variantⁱVAR_059723	1261	V → L. Corresponds to variant dbSNP:rs11574973Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037665	1 – 315	Missing in isoform 2. 1 PublicationAdd BLAST		315

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y11251 mRNA. Translation: CAA72121.1. AF030234 mRNA. Translation: AAC39565.1. Sequence problems. AC000015 Genomic DNA. No translation available. CH471111 Genomic DNA. Translation: EAW57892.1. CH471111 Genomic DNA. Translation: EAW57894.1. BC040951 mRNA. Translation: AAH40951.1. Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8748.2. [Q99590-1]
PIRⁱ	T09073.
NCBI Reference Sequences More...RefSeqⁱ	NP_004710.2. NM_004719.2. [Q99590-1] XP_005269287.2. XM_005269230.2. [Q99590-1] XP_011537287.1. XM_011538985.1. [Q99590-1]
UniGeneⁱ	Hs.210367.

Genome annotation databases

Ensemblⁱ	ENST00000369367; ENSP00000358374; ENSG00000139218. [Q99590-1] ENST00000465950; ENSP00000449812; ENSG00000139218. [Q99590-2]
GeneIDⁱ	9169.
KEGGⁱ	hsa:9169.
UCSC genome browser More...UCSCⁱ	uc001row.4. human. [Q99590-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y11251 mRNA. Translation: CAA72121.1. AF030234 mRNA. Translation: AAC39565.1. Sequence problems. AC000015 Genomic DNA. No translation available. CH471111 Genomic DNA. Translation: EAW57892.1. CH471111 Genomic DNA. Translation: EAW57894.1. BC040951 mRNA. Translation: AAH40951.1. Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8748.2. [Q99590-1]
PIRⁱ	T09073.
NCBI Reference Sequences More...RefSeqⁱ	NP_004710.2. NM_004719.2. [Q99590-1] XP_005269287.2. XM_005269230.2. [Q99590-1] XP_011537287.1. XM_011538985.1. [Q99590-1]
UniGeneⁱ	Hs.210367.

3D structure databases

ProteinModelPortalⁱ	Q99590.
SMRⁱ	Q99590.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114610. 38 interactors.
IntActⁱ	Q99590. 17 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-2866162.
STRINGⁱ	9606.ENSP00000358374.

PTM databases

iPTMnetⁱ	Q99590.
PhosphoSitePlusⁱ	Q99590.
SwissPalmⁱ	Q99590.

Polymorphism and mutation databases

BioMutaⁱ	SCAF11.
DMDMⁱ	251757337.

Proteomic databases

EPDⁱ	Q99590.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99590.
PaxDbⁱ	Q99590.
PeptideAtlas More...PeptideAtlasⁱ	Q99590.
PRIDEⁱ	Q99590.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9169.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369367; ENSP00000358374; ENSG00000139218. [Q99590-1] ENST00000465950; ENSP00000449812; ENSG00000139218. [Q99590-2]
GeneIDⁱ	9169.
KEGGⁱ	hsa:9169.
UCSC genome browser More...UCSCⁱ	uc001row.4. human. [Q99590-1]

Organism-specific databases

CTDⁱ	9169.
DisGeNET More...DisGeNETⁱ	9169.
GeneCardsⁱ	SCAF11.
H-InvDBⁱ	HIX0010567.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10784. SCAF11.
Human Protein Atlas More...HPAⁱ	HPA038862. HPA045456. HPA046345.
MIMⁱ	603668. gene.
neXtProtⁱ	NX_Q99590.
Open Targets More...OpenTargetsⁱ	ENSG00000139218.
PharmGKBⁱ	PA35700.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IMMV. Eukaryota. ENOG4111NG4. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063661.
HOVERGENⁱ	HBG101126.
InParanoidⁱ	Q99590.
OMAⁱ	YCTEFIE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05JH.
PhylomeDBⁱ	Q99590.
TreeFamⁱ	TF332183.

Miscellaneous databases

ChiTaRSⁱ	SCAF11. human.
GeneWikiⁱ	SFRS2IP.
GenomeRNAiⁱ	9169.
PMAP-CutDBⁱ	Q99590.
Protein Ontology More...PROⁱ	PR:Q99590.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139218.
CleanExⁱ	HS_SFRS2IP. HS_SIP1.
ExpressionAtlasⁱ	Q99590. baseline and differential.
Genevisibleⁱ	Q99590. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00162. RING. 1 hit.
Gene3Dⁱ	3.30.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13639. zf-RING_2. 1 hit.
SMARTⁱ	View protein in SMART SM00184. RING. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SCAFB_HUMAN
Accessionⁱ	Q99590Primary (citable) accession number: Q99590 Secondary accession number(s): A6NEU9, A6NLW5, Q8IW59
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
	Last sequence update:	July 7, 2009
	Last modified:	May 10, 2017
	This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99590 (SCAFB_HUMAN)

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Protein SCAF11

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Zinc finger

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (2)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ