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Protein

Protein SCAF11

Gene

SCAF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri41 – 82RING-type; degeneratePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • mRNA processing Source: ProtInc
  • RNA splicing Source: UniProtKB
  • RNA splicing, via transesterification reactions Source: UniProtKB
  • spliceosomal complex assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139218-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SCAF11
Alternative name(s):
CTD-associated SR protein 11
Renal carcinoma antigen NY-REN-40
SC35-interacting protein 1
SR-related and CTD-associated factor 11
SRSF2-interacting protein
Serine/arginine-rich splicing factor 2-interacting protein
Splicing factor, arginine/serine-rich 2-interacting protein
Splicing regulatory protein 129
Short name:
SRrp129
Gene namesi
Name:SCAF11
Synonyms:CASP11, SFRS2IP, SIP1, SRSF2IP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:10784. SCAF11.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9169.
OpenTargetsiENSG00000139218.
PharmGKBiPA35700.

Polymorphism and mutation databases

BioMutaiSCAF11.
DMDMi251757337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763141 – 1463Protein SCAF11Add BLAST1463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei331PhosphothreonineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei401PhosphoserineCombined sources1
Modified residuei402PhosphoserineCombined sources1
Modified residuei405PhosphoserineCombined sources1
Modified residuei410PhosphothreonineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei588PhosphoserineCombined sources1
Cross-linki601Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei608PhosphoserineCombined sources1
Cross-linki610Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei614PhosphoserineCombined sources1
Cross-linki676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei680PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei694PhosphoserineCombined sources1
Modified residuei723PhosphoserineCombined sources1
Modified residuei726PhosphoserineCombined sources1
Modified residuei769PhosphothreonineCombined sources1
Modified residuei771PhosphoserineCombined sources1
Modified residuei776PhosphoserineCombined sources1
Modified residuei796PhosphoserineCombined sources1
Modified residuei798PhosphoserineCombined sources1
Modified residuei802PhosphoserineCombined sources1
Modified residuei807PhosphothreonineCombined sources1
Modified residuei816PhosphoserineCombined sources1
Modified residuei963PhosphoserineCombined sources1
Modified residuei1122PhosphoserineCombined sources1
Modified residuei1127PhosphoserineCombined sources1
Modified residuei1151Omega-N-methylarginineCombined sources1
Modified residuei1153PhosphothreonineCombined sources1
Modified residuei1169PhosphoserineCombined sources1
Modified residuei1170PhosphoserineCombined sources1
Cross-linki1178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99590.
MaxQBiQ99590.
PaxDbiQ99590.
PeptideAtlasiQ99590.
PRIDEiQ99590.

PTM databases

iPTMnetiQ99590.
PhosphoSitePlusiQ99590.
SwissPalmiQ99590.

Miscellaneous databases

PMAP-CutDBQ99590.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000139218.
CleanExiHS_SFRS2IP.
HS_SIP1.
ExpressionAtlasiQ99590. baseline and differential.
GenevisibleiQ99590. HS.

Organism-specific databases

HPAiHPA038862.
HPA045456.
HPA046345.

Interactioni

Subunit structurei

Interacts with SRSF2/SFRS2, U2AF2 and SNRNP70.1 Publication

Protein-protein interaction databases

BioGridi114610. 38 interactors.
IntActiQ99590. 17 interactors.
MINTiMINT-2866162.
STRINGi9606.ENSP00000358374.

Structurei

3D structure databases

ProteinModelPortaliQ99590.
SMRiQ99590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi841 – 985Arg-richAdd BLAST145
Compositional biasi1225 – 1285Pro-richAdd BLAST61

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri41 – 82RING-type; degeneratePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IMMV. Eukaryota.
ENOG4111NG4. LUCA.
GeneTreeiENSGT00530000063661.
HOVERGENiHBG101126.
InParanoidiQ99590.
OMAiYCTEFIE.
OrthoDBiEOG091G05JH.
PhylomeDBiQ99590.
TreeFamiTF332183.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99590-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKKTVCTLN MGDKKYEDME GEENGDNTIS TGLLYSEADR CPICLNCLLE
60 70 80 90 100
KEVGFPESCN HVFCMTCILK WAETLASCPI DRKPFQAVFK FSALEGYVKV
110 120 130 140 150
QVKKQLRETK DKKNENSFEK QVSCHENSKS CIRRKAIVRE DLLSAKVCDL
160 170 180 190 200
KWIHRNSLYS ETGGKKNAAI KINKPQRSNW STNQCFRNFF SNMFSSVSHS
210 220 230 240 250
GESSFTYRAY CTEFIEASEI SALIRQKRHE LELSWFPDTL PGIGRIGFIP
260 270 280 290 300
WNVETEVLPL ISSVLPRTIF PTSTISFEHF GTSCKGYALA HTQEGEEKKQ
310 320 330 340 350
TSGTSNTRGS RRKPAMTTPT RRSTRNTRAE TASQSQRSPI SDNSGCDAPG
360 370 380 390 400
NSNPSLSVPS SAESEKQTRQ APKRKSVRRG RKPPLLKKKL RSSVAAPEKS
410 420 430 440 450
SSNDSVDEET AESDTSPVLE KEHQPDVDSS NICTVQTHVE NQSANCLKSC
460 470 480 490 500
NEQIEESEKH TANYDTEERV GSSSSESCAQ DLPVLVGEEG EVKKLENTGI
510 520 530 540 550
EANVLCLESE ISENILEKGG DPLEKQDQIS GLSQSEVKTD VCTVHLPNDF
560 570 580 590 600
PTCLTSESKV YQPVSCPLSD LSENVESVVN EEKITESSLV EITEHKDFTL
610 620 630 640 650
KTEELIESPK LESSEGEIIQ TVDRQSVKSP EVQLLGHVET EDVEIIATCD
660 670 680 690 700
TFGNEDFNNI QDSENNLLKN NLLNTKLEKS LEEKNESLTE HPRSTELPKT
710 720 730 740 750
HIEQIQKHFS EDNNEMIPME CDSFCSDQNE SEVEPSVNAD LKQMNENSVT
760 770 780 790 800
HCSENNMPSS DLADEKVETV SQPSESPKDT IDKTKKPRTR RSRFHSPSTT
810 820 830 840 850
WSPNKDTPQE KKRPQSPSPR RETGKESRKS QSPSPKNESA RGRKKSRSQS
860 870 880 890 900
PKKDIARERR QSQSRSPKRD TTRESRRSES LSPRRETSRE NKRSQPRVKD
910 920 930 940 950
SSPGEKSRSQ SRERESDRDG QRRERERRTR KWSRSRSHSR SPSRCRTKSK
960 970 980 990 1000
SSSFGRIDRD SYSPRWKGRW ANDGWRCPRG NDRYRKNDPE KQNENTRKEK
1010 1020 1030 1040 1050
NDIHLDADDP NSADKHRNDC PNWITEKINS GPDPRTRNPE KLKESHWEEN
1060 1070 1080 1090 1100
RNENSGNSWN KNFGSGWVSN RGRGRGNRGR GTYRSSFAYK DQNENRWQNR
1110 1120 1130 1140 1150
KPLSGNSNSS GSESFKFVEQ QSYKRKSEQE FSFDTPADRS GWTSASSWAV
1160 1170 1180 1190 1200
RKTLPADVQN YYSRRGRNSS GPQSGWMKQE EETSGQDSSL KDQTNQQVDG
1210 1220 1230 1240 1250
SQLPINMMQP QMNVMQQQMN AQHQPMNIFP YPVGVHAPLM NIQRNPFNIH
1260 1270 1280 1290 1300
PQLPLHLHTG VPLMQVATPT SVSQGLPPPP PPPPPSQQVN YIASQPDGKQ
1310 1320 1330 1340 1350
LQGIPSSSHV SNNMSTPVLP APTAAPGNTG MVQGPSSGNT SSSSHSKASN
1360 1370 1380 1390 1400
AAVKLAESKV SVAVEASADS SKTDKKLQIQ EKAAQEVKLA IKPFYQNKDI
1410 1420 1430 1440 1450
TKEEYKEIVR KAVDKVCHSK SGEVNSTKVA NLVKAYVDKY KYSRKGSQKK
1460
TLEEPVSTEK NIG
Length:1,463
Mass (Da):164,652
Last modified:July 7, 2009 - v2
Checksum:i7170B88544BAF7D4
GO
Isoform 2 (identifier: Q99590-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-315: Missing.

Show »
Length:1,148
Mass (Da):128,875
Checksum:iB57FD40EE5E4C48C
GO

Sequence cautioni

The sequence AAC39565 differs from that shown. Reason: Frameshift at position 62.Curated
The sequence AAC39565 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH40951 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH40951 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti584I → M in AAH40951 (PubMed:15489334).Curated1
Sequence conflicti623D → G in AAH40951 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059722657F → Y.Corresponds to variant rs7315731dbSNPEnsembl.1
Natural variantiVAR_0597231261V → L.Corresponds to variant rs11574973dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0376651 – 315Missing in isoform 2. 1 PublicationAdd BLAST315

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11251 mRNA. Translation: CAA72121.1.
AF030234 mRNA. Translation: AAC39565.1. Sequence problems.
AC000015 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW57892.1.
CH471111 Genomic DNA. Translation: EAW57894.1.
BC040951 mRNA. Translation: AAH40951.1. Sequence problems.
CCDSiCCDS8748.2. [Q99590-1]
PIRiT09073.
RefSeqiNP_004710.2. NM_004719.2. [Q99590-1]
XP_005269287.2. XM_005269230.2. [Q99590-1]
XP_011537287.1. XM_011538985.1. [Q99590-1]
UniGeneiHs.210367.

Genome annotation databases

EnsembliENST00000369367; ENSP00000358374; ENSG00000139218. [Q99590-1]
ENST00000465950; ENSP00000449812; ENSG00000139218. [Q99590-2]
GeneIDi9169.
KEGGihsa:9169.
UCSCiuc001row.4. human. [Q99590-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11251 mRNA. Translation: CAA72121.1.
AF030234 mRNA. Translation: AAC39565.1. Sequence problems.
AC000015 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW57892.1.
CH471111 Genomic DNA. Translation: EAW57894.1.
BC040951 mRNA. Translation: AAH40951.1. Sequence problems.
CCDSiCCDS8748.2. [Q99590-1]
PIRiT09073.
RefSeqiNP_004710.2. NM_004719.2. [Q99590-1]
XP_005269287.2. XM_005269230.2. [Q99590-1]
XP_011537287.1. XM_011538985.1. [Q99590-1]
UniGeneiHs.210367.

3D structure databases

ProteinModelPortaliQ99590.
SMRiQ99590.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114610. 38 interactors.
IntActiQ99590. 17 interactors.
MINTiMINT-2866162.
STRINGi9606.ENSP00000358374.

PTM databases

iPTMnetiQ99590.
PhosphoSitePlusiQ99590.
SwissPalmiQ99590.

Polymorphism and mutation databases

BioMutaiSCAF11.
DMDMi251757337.

Proteomic databases

EPDiQ99590.
MaxQBiQ99590.
PaxDbiQ99590.
PeptideAtlasiQ99590.
PRIDEiQ99590.

Protocols and materials databases

DNASUi9169.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369367; ENSP00000358374; ENSG00000139218. [Q99590-1]
ENST00000465950; ENSP00000449812; ENSG00000139218. [Q99590-2]
GeneIDi9169.
KEGGihsa:9169.
UCSCiuc001row.4. human. [Q99590-1]

Organism-specific databases

CTDi9169.
DisGeNETi9169.
GeneCardsiSCAF11.
H-InvDBHIX0010567.
HGNCiHGNC:10784. SCAF11.
HPAiHPA038862.
HPA045456.
HPA046345.
MIMi603668. gene.
neXtProtiNX_Q99590.
OpenTargetsiENSG00000139218.
PharmGKBiPA35700.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMMV. Eukaryota.
ENOG4111NG4. LUCA.
GeneTreeiENSGT00530000063661.
HOVERGENiHBG101126.
InParanoidiQ99590.
OMAiYCTEFIE.
OrthoDBiEOG091G05JH.
PhylomeDBiQ99590.
TreeFamiTF332183.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139218-MONOMER.

Miscellaneous databases

ChiTaRSiSCAF11. human.
GeneWikiiSFRS2IP.
GenomeRNAii9169.
PMAP-CutDBQ99590.
PROiQ99590.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139218.
CleanExiHS_SFRS2IP.
HS_SIP1.
ExpressionAtlasiQ99590. baseline and differential.
GenevisibleiQ99590. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCAFB_HUMAN
AccessioniPrimary (citable) accession number: Q99590
Secondary accession number(s): A6NEU9, A6NLW5, Q8IW59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: July 7, 2009
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.