ID   Q99587_HUMAN            Unreviewed;        88 AA.
AC   Q99587;
DT   01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1997, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   SubName: Full=Dopamine D4 receptor {ECO:0000313|EMBL:AAB46803.1};
DE   Flags: Fragment;
GN   Name=dopamine D4 receptor {ECO:0000313|EMBL:AAB46803.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAB46803.1};
RN   [1] {ECO:0000313|EMBL:AAB46803.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8746407;
RA   Cichon S., Nothen M.M., Catalano M., Di Bella D., Maier W., Lichtermann D.,
RA   Minges J., Albus M., Borrmann M., Franzek E.;
RT   "Identification of two novel polymorphisms and a rare deletion variant in
RT   the human dopamine D4 receptor gene.";
RL   Psychiatr. Genet. 5:97-103(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; S82918; AAB46803.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q99587; -.
DR   ChiTaRS; ARHGDIB; human.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24248:SF143; D(4) DOPAMINE RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:AAB46803.1};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        34..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        65..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          44..88
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAB46803.1"
SQ   SEQUENCE   88 AA;  8482 MW;  314093AB4678CEDF CRC64;
     MGNRSTADAD GLLAGRGPAA GASAGASAGL AGQGALLIGA VLAGNSLVCV SVATERALQT
     PTNSFIVSLA AADLLLALLV LPLFVYSE
//