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Q99587

- Q99587_HUMAN

UniProt

Q99587 - Q99587_HUMAN

Protein
Submitted name:

Dopamine D4 receptor

Gene

dopamine D4 receptor

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. dopamine binding Source: Ensembl
    2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: Ensembl
    3. drug binding Source: Ensembl

    GO - Biological processi

    1. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
    2. adult locomotory behavior Source: Ensembl
    3. behavioral fear response Source: Ensembl
    4. behavioral response to cocaine Source: Ensembl
    5. circadian rhythm Source: Ensembl
    6. olfactory learning Source: Ensembl
    7. photoperiodism Source: Ensembl
    8. positive regulation of excitatory postsynaptic membrane potential Source: Ensembl
    9. positive regulation of penile erection Source: Ensembl
    10. regulation of calcium-mediated signaling Source: Ensembl
    11. regulation of dopamine metabolic process Source: Ensembl
    12. regulation of inhibitory postsynaptic membrane potential Source: Ensembl
    13. regulation of neurotransmitter secretion Source: Ensembl
    14. response to amphetamine Source: Ensembl
    15. response to steroid hormone Source: Ensembl
    16. retina development in camera-type eye Source: Ensembl
    17. short-term memory Source: Ensembl
    18. synaptic transmission, dopaminergic Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Dopamine D4 receptorImported
    Gene namesi
    Name:dopamine D4 receptorImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. dendritic spine Source: Ensembl
    3. integral component of plasma membrane Source: InterPro
    4. neuronal cell body Source: Ensembl
    5. terminal bouton Source: Ensembl
    6. vesicle membrane Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ99587.
    BgeeiQ99587.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99587.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002185. Dopamine_D4_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24249:SF37. PTHR24249:SF37. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q99587-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNRSTADAD GLLAGRGPAA GASAGASAGL AGQGALLIGA VLAGNSLVCV   50
    SVATERALQT PTNSFIVSLA AADLLLALLV LPLFVYSE 88
    Length:88
    Mass (Da):8,482
    Last modified:May 1, 1997 - v1
    Checksum:i314093AB4678CEDF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82918 Genomic DNA. Translation: AAB46803.1.
    UniGeneiHs.99922.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82918 Genomic DNA. Translation: AAB46803.1 .
    UniGenei Hs.99922.

    3D structure databases

    ProteinModelPortali Q99587.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q99587.
    Bgeei Q99587.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002185. Dopamine_D4_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24249:SF37. PTHR24249:SF37. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two novel polymorphisms and a rare deletion variant in the human dopamine D4 receptor gene."
      Cichon S., Nothen M.M., Catalano M., Di Bella D., Maier W., Lichtermann D., Minges J., Albus M., Borrmann M., Franzek E.
      Psychiatr. Genet. 5:97-103(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ99587_HUMAN
    AccessioniPrimary (citable) accession number: Q99587
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.