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Q99587 (Q99587_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:dopamine D4 receptor EMBL AAB46803.1
OrganismHomo sapiens (Human) EMBL AAB46803.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length88 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Molecular functionReceptor EMBL AAB46803.1
Gene Ontology (GO)
   Biological_processadenylate cyclase-inhibiting dopamine receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

adult locomotory behavior

Inferred from electronic annotation. Source: Ensembl

behavioral fear response

Inferred from electronic annotation. Source: Ensembl

behavioral response to cocaine

Inferred from electronic annotation. Source: Ensembl

circadian rhythm

Inferred from electronic annotation. Source: Ensembl

olfactory learning

Inferred from electronic annotation. Source: Ensembl

photoperiodism

Inferred from electronic annotation. Source: Ensembl

positive regulation of excitatory postsynaptic membrane potential

Inferred from electronic annotation. Source: Ensembl

positive regulation of penile erection

Inferred from electronic annotation. Source: Ensembl

regulation of calcium-mediated signaling

Inferred from electronic annotation. Source: Ensembl

regulation of dopamine metabolic process

Inferred from electronic annotation. Source: Ensembl

regulation of inhibitory postsynaptic membrane potential

Inferred from electronic annotation. Source: Ensembl

regulation of neurotransmitter secretion

Inferred from electronic annotation. Source: Ensembl

response to amphetamine

Inferred from electronic annotation. Source: Ensembl

response to steroid hormone

Inferred from electronic annotation. Source: Ensembl

retina development in camera-type eye

Inferred from electronic annotation. Source: Ensembl

short-term memory

Inferred from electronic annotation. Source: Ensembl

synaptic transmission, dopaminergic

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell cortex

Inferred from electronic annotation. Source: Ensembl

dendritic spine

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred from electronic annotation. Source: InterPro

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

terminal bouton

Inferred from electronic annotation. Source: Ensembl

vesicle membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functiondopamine binding

Inferred from electronic annotation. Source: Ensembl

dopamine neurotransmitter receptor activity, coupled via Gi/Go

Inferred from electronic annotation. Source: Ensembl

drug binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAB46803.1

Sequences

Sequence LengthMass (Da)Tools
Q99587 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 314093AB4678CEDF

FASTA888,482
        10         20         30         40         50         60 
MGNRSTADAD GLLAGRGPAA GASAGASAGL AGQGALLIGA VLAGNSLVCV SVATERALQT 

        70         80 
PTNSFIVSLA AADLLLALLV LPLFVYSE 

« Hide

References

[1]"Identification of two novel polymorphisms and a rare deletion variant in the human dopamine D4 receptor gene."
Cichon S., Nothen M.M., Catalano M., Di Bella D., Maier W., Lichtermann D., Minges J., Albus M., Borrmann M., Franzek E.
Psychiatr. Genet. 5:97-103(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S82918 Genomic DNA. Translation: AAB46803.1.
UniGeneHs.99922.

3D structure databases

ProteinModelPortalQ99587.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Gene expression databases

ArrayExpressQ99587.
BgeeQ99587.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002185. Dopamine_D4_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24249:SF37. PTHR24249:SF37. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ99587_HUMAN
AccessionPrimary (citable) accession number: Q99587
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.