SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99587

- Q99587_HUMAN

UniProt

Q99587 - Q99587_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Dopamine D4 receptor

Gene
dopamine D4 receptor
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. dopamine binding Source: Ensembl
  2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: Ensembl
  3. drug binding Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
  2. adult locomotory behavior Source: Ensembl
  3. behavioral fear response Source: Ensembl
  4. behavioral response to cocaine Source: Ensembl
  5. circadian rhythm Source: Ensembl
  6. olfactory learning Source: Ensembl
  7. photoperiodism Source: Ensembl
  8. positive regulation of excitatory postsynaptic membrane potential Source: Ensembl
  9. positive regulation of penile erection Source: Ensembl
  10. regulation of calcium-mediated signaling Source: Ensembl
  11. regulation of dopamine metabolic process Source: Ensembl
  12. regulation of inhibitory postsynaptic membrane potential Source: Ensembl
  13. regulation of neurotransmitter secretion Source: Ensembl
  14. response to amphetamine Source: Ensembl
  15. response to steroid hormone Source: Ensembl
  16. retina development in camera-type eye Source: Ensembl
  17. short-term memory Source: Ensembl
  18. synaptic transmission, dopaminergic Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Dopamine D4 receptorImported
Gene namesi
Name:dopamine D4 receptorImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. dendritic spine Source: Ensembl
  3. integral component of plasma membrane Source: InterPro
  4. neuronal cell body Source: Ensembl
  5. terminal bouton Source: Ensembl
  6. vesicle membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiQ99587.
BgeeiQ99587.

Structurei

3D structure databases

ProteinModelPortaliQ99587.

Family & Domainsi

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002185. Dopamine_D4_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24249:SF37. PTHR24249:SF37. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q99587-1 [UniParc]FASTAAdd to Basket

« Hide

MGNRSTADAD GLLAGRGPAA GASAGASAGL AGQGALLIGA VLAGNSLVCV   50
SVATERALQT PTNSFIVSLA AADLLLALLV LPLFVYSE 88
Length:88
Mass (Da):8,482
Last modified:May 1, 1997 - v1
Checksum:i314093AB4678CEDF
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S82918 Genomic DNA. Translation: AAB46803.1.
UniGeneiHs.99922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S82918 Genomic DNA. Translation: AAB46803.1 .
UniGenei Hs.99922.

3D structure databases

ProteinModelPortali Q99587.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

ArrayExpressi Q99587.
Bgeei Q99587.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002185. Dopamine_D4_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24249:SF37. PTHR24249:SF37. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of two novel polymorphisms and a rare deletion variant in the human dopamine D4 receptor gene."
    Cichon S., Nothen M.M., Catalano M., Di Bella D., Maier W., Lichtermann D., Minges J., Albus M., Borrmann M., Franzek E.
    Psychiatr. Genet. 5:97-103(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ99587_HUMAN
AccessioniPrimary (citable) accession number: Q99587
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi