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Reviewed, UniProtKB/Swiss-Prot Q99584 (S10AD_HUMAN)

Last modified June 16, 2009. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein S100-A13
Alternative name(s):
    S100 calcium-binding protein A13
Gene names
Name: S100A13
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Tissue specificity

Expressed in heart and skeletal muscle.

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

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Ontologies

Keywords
   DomainRepeat
   LigandCalcium
   Technical term3D-structure
Gene Ontology (GO)
   Biological processcell differentiation

Non-traceable author statement. Source: UniProtKB

   Molecular functioncalcium ion binding Ref.1

Traceable author statement. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9898Protein S100-A13
PRO_0000144019

Regions

Domain18 – 5336EF-hand 1
Calcium binding24 – 37141; low affinity By similarity
Calcium binding64 – 75122; high affinity By similarity

Secondary structure

1 ............... 98
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q99584-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 1D1BE57F3CD49E81

FASTA9811,471
        10         20         30         40         50         60 
MAAEPLTELE ESIETVVTTF FTFARQEGRK DSLSVNEFKE LVTQQLPHLL KDVGSLDEKM 

        70         80         90 
KSLDVNQDSE LKFNEYWRLI GELAKEIRKK KDLKIRKK

« Hide

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References

« Hide 'large scale' references
[1]"Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family."
Wicki R., Schaefer B.W., Erne P., Heizmann C.W.
Biochem. Biophys. Res. Commun. 227:594-599(1996) [PubMed: 8878558] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Skin.
[6]Wen G.B., Yang J., Cao R.X., Liu J.H., Peng Z.L.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-98.
Tissue: Thyroid.
[7]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X99920 mRNA. Translation: CAA68188.1.
CR542149 mRNA. Translation: CAG46946.1.
BT006724 mRNA. Translation: AAP35370.1.
BX470102 Genomic DNA. Translation: CAI14760.1.
BC000632 mRNA. Translation: AAH00632.1.
BC068064 mRNA. Translation: AAH68064.1.
BC070291 mRNA. Translation: AAH70291.1.
AY987392 mRNA. Translation: AAX89402.1.
IPIIPI00016179.
PIRJC5064.
RefSeqNP_001019381.1.
NP_001019382.1.
NP_001019383.1.
NP_001019384.1.
NP_005970.1.
UniGeneHs.516505

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1YURNMR-A/B1-98[»]
1YUSNMR-A/B1-98[»]
1YUTNMR-A/B1-98[»]
1YUUNMR-A/B1-98[»]
2EGDX-ray1.80A/B1-98[»]
2H2KX-ray2.00A/B1-98[»]
2K8MNMR-B/C1-98[»]
ModBaseSearch...

Protein-protein interaction databases

IntActQ99584. 1 interaction.

PTM databases

PhosphoSiteQ99584.

Proteomic databases

PeptideAtlasQ99584.
PRIDEQ99584.

Genome annotation databases

EnsemblENSG00000189171. Homo sapiens. [Contig view]
GeneID6284.
KEGGhsa:6284.
NMPDRfig|9606.3.peg.2109.

Organism-specific databases

GeneCardsGC01M151857.
H-InvDBHIX0001084.
HGNCHGNC:10490. S100A13.
MIM601989. gene.
PharmGKBPA34902.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ99584.
HOVERGENQ99584.
OMAQ99584. FTFAGRE.

Gene expression databases

ArrayExpressQ99584.
BgeeQ99584.
CleanExHS_S100A13.
GermOnlineENSG00000189171. Homo sapiens.

Family and domain databases

InterProIPR011992. EF-Hand_type.
IPR018247. EF_HAND_1.
IPR001751. S100_Ca_bd.
IPR013787. S100_Ca_bd_sub.
[Graphical view]
Gene3DG3DSA:1.10.238.10. EF-Hand_type. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
ProDomPD003407. CaBP_S100. 1 hit.
PD000012. EF-hand. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00018. EF_HAND_1. False negative.
PS50222. EF_HAND_2. False negative.
PS00303. S100_CABP. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB01025. Amlexanox.
NextBio24393.
SOURCESearch...

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Entry information

Entry nameS10AD_HUMAN
AccessionPrimary (citable) accession number: Q99584
Secondary accession number(s): Q52PI9, Q6FGF8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 16, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents