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Q99584

- S10AD_HUMAN

UniProt

Q99584 - S10AD_HUMAN

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Protein

Protein S100-A13

Gene

S100A13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi24 – 37141Add
BLAST
Calcium bindingi64 – 75122Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. copper ion binding Source: UniProtKB
  3. fibroblast growth factor binding Source: UniProtKB
  4. lipid binding Source: UniProtKB-KW
  5. protein homodimerization activity Source: UniProtKB
  6. RAGE receptor binding Source: UniProtKB
  7. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cytokine secretion Source: UniProtKB
  2. interleukin-1 alpha secretion Source: UniProtKB
  3. mast cell degranulation Source: UniProtKB
  4. positive regulation of cell proliferation Source: Ensembl
  5. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  6. regulation of cell shape Source: Ensembl
  7. response to copper ion Source: Ensembl
  8. response to electrical stimulus Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Calcium, Copper, Lipid-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A13
Alternative name(s):
S100 calcium-binding protein A13
Gene namesi
Name:S100A13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10490. S100A13.

Subcellular locationi

Cytoplasm. Secreted
Note: Secretion is mediated by exposure to stress and requires copper ions.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProt
  5. mast cell granule Source: GOC
  6. nucleus Source: UniProtKB
  7. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34902.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Protein S100-A13PRO_0000144019Add
BLAST

Proteomic databases

MaxQBiQ99584.
PaxDbiQ99584.
PeptideAtlasiQ99584.
PRIDEiQ99584.

PTM databases

PhosphoSiteiQ99584.

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.

Gene expression databases

BgeeiQ99584.
CleanExiHS_S100A13.
ExpressionAtlasiQ99584. baseline.
GenevestigatoriQ99584.

Organism-specific databases

HPAiCAB025494.
HPA019592.

Interactioni

Subunit structurei

Homodimer. Part of a copper-dependent multiprotein complex containing S100A13, FGF1 and SYT1. Interacts with FGF1 and SYT1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi112192. 14 interactions.
IntActiQ99584. 4 interactions.
MINTiMINT-4537584.
STRINGi9606.ENSP00000344822.

Structurei

Secondary structure

98
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 33Combined sources
Helixi8 – 2417Combined sources
Beta strandi26 – 283Combined sources
Beta strandi32 – 343Combined sources
Helixi35 – 4511Combined sources
Turni47 – 526Combined sources
Beta strandi53 – 553Combined sources
Helixi56 – 638Combined sources
Beta strandi67 – 726Combined sources
Helixi73 – 8816Combined sources
Helixi93 – 953Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YURNMR-A/B1-98[»]
1YUSNMR-A/B1-98[»]
1YUTNMR-A/B1-98[»]
1YUUNMR-A/B1-98[»]
2EGDX-ray1.80A/B1-98[»]
2H2KX-ray2.00A/B1-98[»]
2K8MNMR-B/C1-98[»]
2KI4NMR-B/C1-98[»]
2KI6NMR-C/D1-98[»]
2KOTNMR-A/B1-98[»]
2L5XNMR-B/C1-98[»]
2LE9NMR-B/C2-98[»]
ProteinModelPortaliQ99584.
SMRiQ99584. Positions 6-96.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99584.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 5336EF-handAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 1 EF-hand domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG41858.
GeneTreeiENSGT00530000063972.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiQ99584.
OMAiKFANAMA.
OrthoDBiEOG71P2D8.
PhylomeDBiQ99584.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR013787. S100_Ca-bd_sub.
IPR028487. S100A13.
[Graphical view]
PANTHERiPTHR11639:SF57. PTHR11639:SF57. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99584-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAEPLTELE ESIETVVTTF FTFARQEGRK DSLSVNEFKE LVTQQLPHLL
60 70 80 90
KDVGSLDEKM KSLDVNQDSE LKFNEYWRLI GELAKEIRKK KDLKIRKK
Length:98
Mass (Da):11,471
Last modified:May 1, 1997 - v1
Checksum:i1D1BE57F3CD49E81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99920 mRNA. Translation: CAA68188.1.
CR542149 mRNA. Translation: CAG46946.1.
BT006724 mRNA. Translation: AAP35370.1.
BX470102 Genomic DNA. Translation: CAI14760.1.
BC000632 mRNA. Translation: AAH00632.1.
BC068064 mRNA. Translation: AAH68064.1.
BC070291 mRNA. Translation: AAH70291.1.
AY987392 mRNA. Translation: AAX89402.1.
CCDSiCCDS30874.1.
PIRiJC5064.
RefSeqiNP_001019381.1. NM_001024210.1.
NP_001019382.1. NM_001024211.1.
NP_001019383.1. NM_001024212.1.
NP_001019384.1. NM_001024213.1.
NP_005970.1. NM_005979.2.
XP_005245491.1. XM_005245434.2.
UniGeneiHs.516505.

Genome annotation databases

EnsembliENST00000339556; ENSP00000344822; ENSG00000189171.
ENST00000368699; ENSP00000357688; ENSG00000189171.
ENST00000392622; ENSP00000376398; ENSG00000189171.
ENST00000392623; ENSP00000376399; ENSG00000189171.
ENST00000440685; ENSP00000392767; ENSG00000189171.
GeneIDi6284.
KEGGihsa:6284.
UCSCiuc001fcf.4. human.

Polymorphism databases

DMDMi2493416.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99920 mRNA. Translation: CAA68188.1 .
CR542149 mRNA. Translation: CAG46946.1 .
BT006724 mRNA. Translation: AAP35370.1 .
BX470102 Genomic DNA. Translation: CAI14760.1 .
BC000632 mRNA. Translation: AAH00632.1 .
BC068064 mRNA. Translation: AAH68064.1 .
BC070291 mRNA. Translation: AAH70291.1 .
AY987392 mRNA. Translation: AAX89402.1 .
CCDSi CCDS30874.1.
PIRi JC5064.
RefSeqi NP_001019381.1. NM_001024210.1.
NP_001019382.1. NM_001024211.1.
NP_001019383.1. NM_001024212.1.
NP_001019384.1. NM_001024213.1.
NP_005970.1. NM_005979.2.
XP_005245491.1. XM_005245434.2.
UniGenei Hs.516505.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YUR NMR - A/B 1-98 [» ]
1YUS NMR - A/B 1-98 [» ]
1YUT NMR - A/B 1-98 [» ]
1YUU NMR - A/B 1-98 [» ]
2EGD X-ray 1.80 A/B 1-98 [» ]
2H2K X-ray 2.00 A/B 1-98 [» ]
2K8M NMR - B/C 1-98 [» ]
2KI4 NMR - B/C 1-98 [» ]
2KI6 NMR - C/D 1-98 [» ]
2KOT NMR - A/B 1-98 [» ]
2L5X NMR - B/C 1-98 [» ]
2LE9 NMR - B/C 2-98 [» ]
ProteinModelPortali Q99584.
SMRi Q99584. Positions 6-96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112192. 14 interactions.
IntActi Q99584. 4 interactions.
MINTi MINT-4537584.
STRINGi 9606.ENSP00000344822.

Chemistry

DrugBanki DB01025. Amlexanox.
DB00768. Olopatadine.

PTM databases

PhosphoSitei Q99584.

Polymorphism databases

DMDMi 2493416.

Proteomic databases

MaxQBi Q99584.
PaxDbi Q99584.
PeptideAtlasi Q99584.
PRIDEi Q99584.

Protocols and materials databases

DNASUi 6284.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339556 ; ENSP00000344822 ; ENSG00000189171 .
ENST00000368699 ; ENSP00000357688 ; ENSG00000189171 .
ENST00000392622 ; ENSP00000376398 ; ENSG00000189171 .
ENST00000392623 ; ENSP00000376399 ; ENSG00000189171 .
ENST00000440685 ; ENSP00000392767 ; ENSG00000189171 .
GeneIDi 6284.
KEGGi hsa:6284.
UCSCi uc001fcf.4. human.

Organism-specific databases

CTDi 6284.
GeneCardsi GC01M153591.
HGNCi HGNC:10490. S100A13.
HPAi CAB025494.
HPA019592.
MIMi 601989. gene.
neXtProti NX_Q99584.
PharmGKBi PA34902.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41858.
GeneTreei ENSGT00530000063972.
HOGENOMi HOG000246968.
HOVERGENi HBG001479.
InParanoidi Q99584.
OMAi KFANAMA.
OrthoDBi EOG71P2D8.
PhylomeDBi Q99584.
TreeFami TF332727.

Miscellaneous databases

ChiTaRSi S100A13. human.
EvolutionaryTracei Q99584.
GeneWikii S100A13.
GenomeRNAii 6284.
NextBioi 24393.
PROi Q99584.
SOURCEi Search...

Gene expression databases

Bgeei Q99584.
CleanExi HS_S100A13.
ExpressionAtlasi Q99584. baseline.
Genevestigatori Q99584.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR013787. S100_Ca-bd_sub.
IPR028487. S100A13.
[Graphical view ]
PANTHERi PTHR11639:SF57. PTHR11639:SF57. 1 hit.
Pfami PF01023. S_100. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family."
    Wicki R., Schaefer B.W., Erne P., Heizmann C.W.
    Biochem. Biophys. Res. Commun. 227:594-599(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Skin.
  6. Wen G.B., Yang J., Cao R.X., Liu J.H., Peng Z.L.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-98.
    Tissue: Thyroid.
  7. "S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells."
    Mandinova A., Soldi R., Graziani I., Bagala C., Bellum S., Landriscina M., Tarantini F., Prudovsky I., Maciag T.
    J. Cell Sci. 116:2687-2696(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells."
    Cao R., Yan B., Yang H., Zu X., Wen G., Zhong J.
    J. Formos. Med. Assoc. 109:632-640(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Structural interplay between calcium(II) and copper(II) binding to S100A13 protein."
    Arnesano F., Banci L., Bertini I., Fantoni A., Tenori L., Viezzoli M.S.
    Angew. Chem. Int. Ed. 44:6341-6344(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR IN COMPLEX WITH CALCIUM IONS, COPPER-BINDING, SUBUNIT.
  11. "Crystal structure study on human S100A13 at 2.0 A resolution."
    Li M., Zhang P.F., Pan X.W., Chang W.R.
    Biochem. Biophys. Res. Commun. 356:616-621(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH CALCIUM IONS, SUBUNIT.
  12. "Structure of calcium-bound human S100A13 at pH 7.5 at 1.8 A resolution."
    Imai F.L., Nagata K., Yonezawa N., Nakano M., Tanokura M.
    Acta Crystallogr. F 64:70-76(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH CALCIUM IONS, SUBUNIT.
  13. "S100A13-C2A binary complex structure-a key component in the acidic fibroblast growth factor for the non-classical pathway."
    Mohan S.K., Rani S.G., Kumar S.M., Yu C.
    Biochem. Biophys. Res. Commun. 380:514-519(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR IN COMPLEX WITH SYT1, SUBUNIT.

Entry informationi

Entry nameiS10AD_HUMAN
AccessioniPrimary (citable) accession number: Q99584
Secondary accession number(s): Q52PI9, Q6FGF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3