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Q99583

- MNT_HUMAN

UniProt

Q99583 - MNT_HUMAN

Protein

Max-binding protein MNT

Gene

MNT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc
    5. transcription coactivator activity Source: ProtInc
    6. transcription corepressor activity Source: ProtInc

    GO - Biological processi

    1. cell aging Source: Ensembl
    2. multicellular organismal development Source: ProtInc
    3. negative regulation of apoptotic signaling pathway Source: Ensembl
    4. negative regulation of cell proliferation Source: ProtInc
    5. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    6. regulation of cell cycle Source: Ensembl
    7. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Max-binding protein MNT
    Alternative name(s):
    Class D basic helix-loop-helix protein 3
    Short name:
    bHLHd3
    Myc antagonist MNT
    Protein ROX
    Gene namesi
    Name:MNT
    Synonyms:BHLHD3, ROX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:7188. MNT.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30898.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 582581Max-binding protein MNTPRO_0000127281Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ99583.
    PaxDbiQ99583.
    PRIDEiQ99583.

    PTM databases

    PhosphoSiteiQ99583.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99583.
    BgeeiQ99583.
    CleanExiHS_MNT.
    GenevestigatoriQ99583.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.

    Protein-protein interaction databases

    BioGridi110478. 11 interactions.
    IntActiQ99583. 2 interactions.
    MINTiMINT-7969172.
    STRINGi9606.ENSP00000174618.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99583.
    SMRiQ99583. Positions 221-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini220 – 27152bHLHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni271 – 29929Leucine-zipperAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG314808.
    HOGENOMiHOG000013115.
    HOVERGENiHBG006379.
    InParanoidiQ99583.
    KOiK09115.
    OMAiGPPKLNH.
    OrthoDBiEOG74R1QW.
    PhylomeDBiQ99583.
    TreeFamiTF315654.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99583-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIETLLEAA RFLEWQAQQQ QRAREEQERL RLEQEREQEQ KKANSLARLA    50
    HTLPVEEPRM EAPPLPLSPP APPPAPPPPL ATPAPLTVIP IPVVTNSPQP 100
    LPPPPPLPAA AQPLPLAPRQ PALVGAPGLS IKEPAPLPSR PQVPTPAPLL 150
    PDSKATIPPN GSPKPLQPLP TPVLTIAPHP GVQPQLAPQQ PPPPTLGTLK 200
    LAPAEEVKSS EQKKRPGGIG TREVHNKLEK NRRAHLKECF ETLKRNIPNV 250
    DDKKTSNLSV LRTALRYIQS LKRKEKEYEH EMERLAREKI ATQQRLAELK 300
    HELSQWMDVL EIDRVLRQTG QPEDDQASTS TASEGEDNID EDMEEDRAGL 350
    GPPKLSHRPQ PELLKSTLPP PSTTPAPLPP HPHPHPHSVA LPPAHLPVQQ 400
    QQPQQKTPLP APPPPPAAPA QTLVPAPAHL VATAGGGSTV IAHTATTHAS 450
    VIQTVNHVLQ GPGGKHIAHI APSAPSPAVQ LAPATPPIGH ITVHPATLNH 500
    VAHLGSQLPL YPQPVAVSHI AHTLSHQQVN GTAGLGPPAT VMAKPAVGAQ 550
    VVHHPQLVGQ TVLNPVTMVT MPSFPVSTLK LA 582
    Length:582
    Mass (Da):62,300
    Last modified:May 1, 1997 - v1
    Checksum:i06AC320D79BF18A0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti109 – 1091A → T.
    Corresponds to variant rs7207965 [ dbSNP | Ensembl ].
    VAR_061258

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96401 mRNA. Translation: CAA65265.1.
    Y13440
    , Y13441, Y13442, Y13443, Y13444 Genomic DNA. Translation: CAA73851.1.
    AK291596 mRNA. Translation: BAF84285.1.
    CH471108 Genomic DNA. Translation: EAW90541.1.
    CH471108 Genomic DNA. Translation: EAW90542.1.
    BC117563 mRNA. Translation: AAI17564.1.
    CCDSiCCDS11018.1.
    RefSeqiNP_064706.1. NM_020310.2.
    UniGeneiHs.626579.
    Hs.632239.

    Genome annotation databases

    EnsembliENST00000174618; ENSP00000174618; ENSG00000070444.
    GeneIDi4335.
    KEGGihsa:4335.
    UCSCiuc002fur.3. human.

    Polymorphism databases

    DMDMi3914034.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96401 mRNA. Translation: CAA65265.1 .
    Y13440
    , Y13441 , Y13442 , Y13443 , Y13444 Genomic DNA. Translation: CAA73851.1 .
    AK291596 mRNA. Translation: BAF84285.1 .
    CH471108 Genomic DNA. Translation: EAW90541.1 .
    CH471108 Genomic DNA. Translation: EAW90542.1 .
    BC117563 mRNA. Translation: AAI17564.1 .
    CCDSi CCDS11018.1.
    RefSeqi NP_064706.1. NM_020310.2.
    UniGenei Hs.626579.
    Hs.632239.

    3D structure databases

    ProteinModelPortali Q99583.
    SMRi Q99583. Positions 221-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110478. 11 interactions.
    IntActi Q99583. 2 interactions.
    MINTi MINT-7969172.
    STRINGi 9606.ENSP00000174618.

    PTM databases

    PhosphoSitei Q99583.

    Polymorphism databases

    DMDMi 3914034.

    Proteomic databases

    MaxQBi Q99583.
    PaxDbi Q99583.
    PRIDEi Q99583.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000174618 ; ENSP00000174618 ; ENSG00000070444 .
    GeneIDi 4335.
    KEGGi hsa:4335.
    UCSCi uc002fur.3. human.

    Organism-specific databases

    CTDi 4335.
    GeneCardsi GC17M002287.
    HGNCi HGNC:7188. MNT.
    MIMi 603039. gene.
    neXtProti NX_Q99583.
    PharmGKBi PA30898.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314808.
    HOGENOMi HOG000013115.
    HOVERGENi HBG006379.
    InParanoidi Q99583.
    KOi K09115.
    OMAi GPPKLNH.
    OrthoDBi EOG74R1QW.
    PhylomeDBi Q99583.
    TreeFami TF315654.

    Miscellaneous databases

    ChiTaRSi MNT. human.
    GeneWikii MNT_(gene).
    GenomeRNAii 4335.
    NextBioi 17053.
    PROi Q99583.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99583.
    Bgeei Q99583.
    CleanExi HS_MNT.
    Genevestigatori Q99583.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor."
      Meroni G., Reymond A., Alcalay M., Borsani G., Tanigami A., Tonlorenzi R., Lo Nigro C., Messali S., Zollo M., Ledbetter D.H., Brent R., Ballabio A., Carrozzo R.
      EMBO J. 16:2892-2906(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "The human ROX gene: genomic structure and mutation analysis in human breast tumors."
      Nigro C.L., Venesio T., Reymond A., Meroni G., Alberici P., Cainarca S., Enrico F., Stack M., Ledbetter D.H., Liscia D.S., Ballabio A., Carrozzo R.
      Genomics 49:275-282(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMNT_HUMAN
    AccessioniPrimary (citable) accession number: Q99583
    Secondary accession number(s): A8K6D1, D3DTI7, Q1ED38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3