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Q99583

- MNT_HUMAN

UniProt

Q99583 - MNT_HUMAN

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Protein
Max-binding protein MNT
Gene
MNT, BHLHD3, ROX
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. chromatin binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc
  4. transcription coactivator activity Source: ProtInc
  5. transcription corepressor activity Source: ProtInc

GO - Biological processi

  1. cell aging Source: Ensembl
  2. multicellular organismal development Source: ProtInc
  3. negative regulation of apoptotic signaling pathway Source: Ensembl
  4. negative regulation of cell proliferation Source: ProtInc
  5. regulation of cell cycle Source: Ensembl
  6. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Max-binding protein MNT
Alternative name(s):
Class D basic helix-loop-helix protein 3
Short name:
bHLHd3
Myc antagonist MNT
Protein ROX
Gene namesi
Name:MNT
Synonyms:BHLHD3, ROX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7188. MNT.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30898.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 582581Max-binding protein MNT
PRO_0000127281Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ99583.
PaxDbiQ99583.
PRIDEiQ99583.

PTM databases

PhosphoSiteiQ99583.

Expressioni

Gene expression databases

ArrayExpressiQ99583.
BgeeiQ99583.
CleanExiHS_MNT.
GenevestigatoriQ99583.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.

Protein-protein interaction databases

BioGridi110478. 11 interactions.
IntActiQ99583. 2 interactions.
MINTiMINT-7969172.
STRINGi9606.ENSP00000174618.

Structurei

3D structure databases

ProteinModelPortaliQ99583.
SMRiQ99583. Positions 221-296.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 27152bHLH
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni271 – 29929Leucine-zipper
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG314808.
HOGENOMiHOG000013115.
HOVERGENiHBG006379.
InParanoidiQ99583.
KOiK09115.
OMAiGPPKLNH.
OrthoDBiEOG74R1QW.
PhylomeDBiQ99583.
TreeFamiTF315654.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99583-1 [UniParc]FASTAAdd to Basket

« Hide

MSIETLLEAA RFLEWQAQQQ QRAREEQERL RLEQEREQEQ KKANSLARLA    50
HTLPVEEPRM EAPPLPLSPP APPPAPPPPL ATPAPLTVIP IPVVTNSPQP 100
LPPPPPLPAA AQPLPLAPRQ PALVGAPGLS IKEPAPLPSR PQVPTPAPLL 150
PDSKATIPPN GSPKPLQPLP TPVLTIAPHP GVQPQLAPQQ PPPPTLGTLK 200
LAPAEEVKSS EQKKRPGGIG TREVHNKLEK NRRAHLKECF ETLKRNIPNV 250
DDKKTSNLSV LRTALRYIQS LKRKEKEYEH EMERLAREKI ATQQRLAELK 300
HELSQWMDVL EIDRVLRQTG QPEDDQASTS TASEGEDNID EDMEEDRAGL 350
GPPKLSHRPQ PELLKSTLPP PSTTPAPLPP HPHPHPHSVA LPPAHLPVQQ 400
QQPQQKTPLP APPPPPAAPA QTLVPAPAHL VATAGGGSTV IAHTATTHAS 450
VIQTVNHVLQ GPGGKHIAHI APSAPSPAVQ LAPATPPIGH ITVHPATLNH 500
VAHLGSQLPL YPQPVAVSHI AHTLSHQQVN GTAGLGPPAT VMAKPAVGAQ 550
VVHHPQLVGQ TVLNPVTMVT MPSFPVSTLK LA 582
Length:582
Mass (Da):62,300
Last modified:May 1, 1997 - v1
Checksum:i06AC320D79BF18A0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091A → T.
Corresponds to variant rs7207965 [ dbSNP | Ensembl ].
VAR_061258

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96401 mRNA. Translation: CAA65265.1.
Y13440
, Y13441, Y13442, Y13443, Y13444 Genomic DNA. Translation: CAA73851.1.
AK291596 mRNA. Translation: BAF84285.1.
CH471108 Genomic DNA. Translation: EAW90541.1.
CH471108 Genomic DNA. Translation: EAW90542.1.
BC117563 mRNA. Translation: AAI17564.1.
CCDSiCCDS11018.1.
RefSeqiNP_064706.1. NM_020310.2.
UniGeneiHs.626579.
Hs.632239.

Genome annotation databases

EnsembliENST00000174618; ENSP00000174618; ENSG00000070444.
GeneIDi4335.
KEGGihsa:4335.
UCSCiuc002fur.3. human.

Polymorphism databases

DMDMi3914034.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96401 mRNA. Translation: CAA65265.1 .
Y13440
, Y13441 , Y13442 , Y13443 , Y13444 Genomic DNA. Translation: CAA73851.1 .
AK291596 mRNA. Translation: BAF84285.1 .
CH471108 Genomic DNA. Translation: EAW90541.1 .
CH471108 Genomic DNA. Translation: EAW90542.1 .
BC117563 mRNA. Translation: AAI17564.1 .
CCDSi CCDS11018.1.
RefSeqi NP_064706.1. NM_020310.2.
UniGenei Hs.626579.
Hs.632239.

3D structure databases

ProteinModelPortali Q99583.
SMRi Q99583. Positions 221-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110478. 11 interactions.
IntActi Q99583. 2 interactions.
MINTi MINT-7969172.
STRINGi 9606.ENSP00000174618.

PTM databases

PhosphoSitei Q99583.

Polymorphism databases

DMDMi 3914034.

Proteomic databases

MaxQBi Q99583.
PaxDbi Q99583.
PRIDEi Q99583.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000174618 ; ENSP00000174618 ; ENSG00000070444 .
GeneIDi 4335.
KEGGi hsa:4335.
UCSCi uc002fur.3. human.

Organism-specific databases

CTDi 4335.
GeneCardsi GC17M002287.
HGNCi HGNC:7188. MNT.
MIMi 603039. gene.
neXtProti NX_Q99583.
PharmGKBi PA30898.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314808.
HOGENOMi HOG000013115.
HOVERGENi HBG006379.
InParanoidi Q99583.
KOi K09115.
OMAi GPPKLNH.
OrthoDBi EOG74R1QW.
PhylomeDBi Q99583.
TreeFami TF315654.

Miscellaneous databases

ChiTaRSi MNT. human.
GeneWikii MNT_(gene).
GenomeRNAii 4335.
NextBioi 17053.
PROi Q99583.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99583.
Bgeei Q99583.
CleanExi HS_MNT.
Genevestigatori Q99583.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor."
    Meroni G., Reymond A., Alcalay M., Borsani G., Tanigami A., Tonlorenzi R., Lo Nigro C., Messali S., Zollo M., Ledbetter D.H., Brent R., Ballabio A., Carrozzo R.
    EMBO J. 16:2892-2906(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "The human ROX gene: genomic structure and mutation analysis in human breast tumors."
    Nigro C.L., Venesio T., Reymond A., Meroni G., Alberici P., Cainarca S., Enrico F., Stack M., Ledbetter D.H., Liscia D.S., Ballabio A., Carrozzo R.
    Genomics 49:275-282(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMNT_HUMAN
AccessioniPrimary (citable) accession number: Q99583
Secondary accession number(s): A8K6D1, D3DTI7, Q1ED38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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