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Protein

Max-binding protein MNT

Gene

MNT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • protein dimerization activity Source: InterPro
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: NTNU_SB
  • transcription coactivator activity Source: ProtInc
  • transcription corepressor activity Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • cell aging Source: Ensembl
  • multicellular organism development Source: ProtInc
  • negative regulation of apoptotic signaling pathway Source: Ensembl
  • negative regulation of cell proliferation Source: ProtInc
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of cell cycle Source: Ensembl
  • transcription from RNA polymerase II promoter Source: ProtInc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ99583.

Names & Taxonomyi

Protein namesi
Recommended name:
Max-binding protein MNT
Alternative name(s):
Class D basic helix-loop-helix protein 3
Short name:
bHLHd3
Myc antagonist MNT
Protein ROX
Gene namesi
Name:MNT
Synonyms:BHLHD3, ROX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:7188. MNT.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4335.
OpenTargetsiENSG00000070444.
PharmGKBiPA30898.

Polymorphism and mutation databases

BioMutaiMNT.
DMDMi3914034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001272812 – 582Max-binding protein MNTAdd BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99583.
MaxQBiQ99583.
PaxDbiQ99583.
PeptideAtlasiQ99583.
PRIDEiQ99583.

PTM databases

iPTMnetiQ99583.
PhosphoSitePlusiQ99583.

Expressioni

Gene expression databases

BgeeiENSG00000070444.
CleanExiHS_MNT.
ExpressionAtlasiQ99583. baseline and differential.
GenevisibleiQ99583. HS.

Organism-specific databases

HPAiHPA059532.
HPA067578.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110478. 15 interactors.
IntActiQ99583. 6 interactors.
MINTiMINT-7969172.
STRINGi9606.ENSP00000174618.

Structurei

3D structure databases

ProteinModelPortaliQ99583.
SMRiQ99583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 271bHLHPROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni271 – 299Leucine-zipperAdd BLAST29

Phylogenomic databases

eggNOGiKOG2483. Eukaryota.
ENOG4111VW9. LUCA.
GeneTreeiENSGT00510000048287.
HOGENOMiHOG000013115.
HOVERGENiHBG006379.
InParanoidiQ99583.
KOiK09115.
OMAiAVIPMVP.
OrthoDBiEOG091G0PW2.
PhylomeDBiQ99583.
TreeFamiTF315654.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 2 hits.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIETLLEAA RFLEWQAQQQ QRAREEQERL RLEQEREQEQ KKANSLARLA
60 70 80 90 100
HTLPVEEPRM EAPPLPLSPP APPPAPPPPL ATPAPLTVIP IPVVTNSPQP
110 120 130 140 150
LPPPPPLPAA AQPLPLAPRQ PALVGAPGLS IKEPAPLPSR PQVPTPAPLL
160 170 180 190 200
PDSKATIPPN GSPKPLQPLP TPVLTIAPHP GVQPQLAPQQ PPPPTLGTLK
210 220 230 240 250
LAPAEEVKSS EQKKRPGGIG TREVHNKLEK NRRAHLKECF ETLKRNIPNV
260 270 280 290 300
DDKKTSNLSV LRTALRYIQS LKRKEKEYEH EMERLAREKI ATQQRLAELK
310 320 330 340 350
HELSQWMDVL EIDRVLRQTG QPEDDQASTS TASEGEDNID EDMEEDRAGL
360 370 380 390 400
GPPKLSHRPQ PELLKSTLPP PSTTPAPLPP HPHPHPHSVA LPPAHLPVQQ
410 420 430 440 450
QQPQQKTPLP APPPPPAAPA QTLVPAPAHL VATAGGGSTV IAHTATTHAS
460 470 480 490 500
VIQTVNHVLQ GPGGKHIAHI APSAPSPAVQ LAPATPPIGH ITVHPATLNH
510 520 530 540 550
VAHLGSQLPL YPQPVAVSHI AHTLSHQQVN GTAGLGPPAT VMAKPAVGAQ
560 570 580
VVHHPQLVGQ TVLNPVTMVT MPSFPVSTLK LA
Length:582
Mass (Da):62,300
Last modified:May 1, 1997 - v1
Checksum:i06AC320D79BF18A0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061258109A → T. Corresponds to variant dbSNP:rs7207965Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96401 mRNA. Translation: CAA65265.1.
Y13440
, Y13441, Y13442, Y13443, Y13444 Genomic DNA. Translation: CAA73851.1.
AK291596 mRNA. Translation: BAF84285.1.
CH471108 Genomic DNA. Translation: EAW90541.1.
CH471108 Genomic DNA. Translation: EAW90542.1.
BC117563 mRNA. Translation: AAI17564.1.
CCDSiCCDS11018.1.
RefSeqiNP_064706.1. NM_020310.2.
UniGeneiHs.626579.
Hs.632239.

Genome annotation databases

EnsembliENST00000174618; ENSP00000174618; ENSG00000070444.
GeneIDi4335.
KEGGihsa:4335.
UCSCiuc002fur.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMNT_HUMAN
AccessioniPrimary (citable) accession number: Q99583
Secondary accession number(s): A8K6D1, D3DTI7, Q1ED38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: June 7, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot