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Protein

Protein FEV

Gene

FEV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei18 – 19Breakpoint for insertion to form EWS-FEV fusion protein2

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 127ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163497-MONOMER.
SIGNORiQ99581.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FEV
Alternative name(s):
Fifth Ewing variant protein
PC12 ETS domain-containing transcription factor 1
Short name:
PC12 ETS factor 1
Short name:
Pet-1
Gene namesi
Name:FEV
Synonyms:PET1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:18562. FEV.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Sudden infant death syndrome (SIDS)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionSIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.
See also OMIM:272120

A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.

Organism-specific databases

DisGeNETi54738.
MIMi272120. phenotype.
OpenTargetsiENSG00000163497.
PharmGKBiPA134875093.

Polymorphism and mutation databases

BioMutaiFEV.
DMDMi74762701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003442041 – 238Protein FEVAdd BLAST238

Proteomic databases

PaxDbiQ99581.
PeptideAtlasiQ99581.
PRIDEiQ99581.

PTM databases

iPTMnetiQ99581.
PhosphoSitePlusiQ99581.

Expressioni

Tissue specificityi

In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.3 Publications

Gene expression databases

BgeeiENSG00000163497.
CleanExiHS_FEV.
GenevisibleiQ99581. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000295727.

Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi49 – 57Combined sources9
Helixi60 – 62Combined sources3
Turni63 – 65Combined sources3
Beta strandi67 – 71Combined sources5
Beta strandi74 – 76Combined sources3
Helixi80 – 91Combined sources12
Helixi98 – 107Combined sources10
Turni108 – 112Combined sources5
Beta strandi113 – 116Combined sources4
Beta strandi123 – 126Combined sources4
Helixi128 – 134Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPRX-ray2.64A/B42-141[»]
3ZP5X-ray2.00A42-141[»]
ProteinModelPortaliQ99581.
SMRiQ99581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 238May mediate active transcriptional repressionAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 210Ala-richAdd BLAST79

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000234879.
HOVERGENiHBG095796.
InParanoidiQ99581.
KOiK09437.
OMAiLMFNMYL.
OrthoDBiEOG091G0HJF.
PhylomeDBiQ99581.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQSGASQPL LINMYLPDPV GDGLFKDGKN PSWGPLSPAV QKGSGQIQLW
60 70 80 90 100
QFLLELLADR ANAGCIAWEG GHGEFKLTDP DEVARRWGER KSKPNMNYDK
110 120 130 140 150
LSRALRYYYD KNIMSKVHGK RYAYRFDFQG LAQACQPPPA HAHAAAAAAA
160 170 180 190 200
AAAAAQDGAL YKLPAGLAPL PFPGLSKLNL MAASAGVAPA GFSYWPGPGP
210 220 230
AATAAAATAA LYPSPSLQPP PGPFGAVAAA SHLGGHYH
Length:238
Mass (Da):25,030
Last modified:May 1, 1997 - v1
Checksum:i057E4A76FBDD6E0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08976 mRNA. Translation: CAA70169.1.
AC097468 Genomic DNA. Translation: AAX88917.1.
CH471063 Genomic DNA. Translation: EAW70664.1.
BC023511 mRNA. Translation: AAH23511.1.
CCDSiCCDS2428.1.
RefSeqiNP_059991.1. NM_017521.2.
UniGeneiHs.234759.

Genome annotation databases

EnsembliENST00000295727; ENSP00000295727; ENSG00000163497.
GeneIDi54738.
KEGGihsa:54738.
UCSCiuc002vji.1. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08976 mRNA. Translation: CAA70169.1.
AC097468 Genomic DNA. Translation: AAX88917.1.
CH471063 Genomic DNA. Translation: EAW70664.1.
BC023511 mRNA. Translation: AAH23511.1.
CCDSiCCDS2428.1.
RefSeqiNP_059991.1. NM_017521.2.
UniGeneiHs.234759.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPRX-ray2.64A/B42-141[»]
3ZP5X-ray2.00A42-141[»]
ProteinModelPortaliQ99581.
SMRiQ99581.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000295727.

PTM databases

iPTMnetiQ99581.
PhosphoSitePlusiQ99581.

Polymorphism and mutation databases

BioMutaiFEV.
DMDMi74762701.

Proteomic databases

PaxDbiQ99581.
PeptideAtlasiQ99581.
PRIDEiQ99581.

Protocols and materials databases

DNASUi54738.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295727; ENSP00000295727; ENSG00000163497.
GeneIDi54738.
KEGGihsa:54738.
UCSCiuc002vji.1. human.

Organism-specific databases

CTDi54738.
DisGeNETi54738.
GeneCardsiFEV.
HGNCiHGNC:18562. FEV.
MIMi272120. phenotype.
607150. gene.
neXtProtiNX_Q99581.
OpenTargetsiENSG00000163497.
PharmGKBiPA134875093.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000234879.
HOVERGENiHBG095796.
InParanoidiQ99581.
KOiK09437.
OMAiLMFNMYL.
OrthoDBiEOG091G0HJF.
PhylomeDBiQ99581.
TreeFamiTF316214.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163497-MONOMER.
SIGNORiQ99581.

Miscellaneous databases

GenomeRNAii54738.
PROiQ99581.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163497.
CleanExiHS_FEV.
GenevisibleiQ99581. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEV_HUMAN
AccessioniPrimary (citable) accession number: Q99581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.