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Q99581

- FEV_HUMAN

UniProt

Q99581 - FEV_HUMAN

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Protein

Protein FEV

Gene

FEV

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei18 – 192Breakpoint for insertion to form EWS-FEV fusion protein

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi47 – 12781ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. double-stranded DNA binding Source: Ensembl
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc
  5. transcription corepressor activity Source: ProtInc

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. neuron fate specification Source: Ensembl
  3. neuron maturation Source: Ensembl
  4. positive regulation of transcription, DNA-templated Source: Ensembl
  5. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  6. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FEV
Alternative name(s):
Fifth Ewing variant protein
PC12 ETS domain-containing transcription factor 1
Short name:
PC12 ETS factor 1
Short name:
Pet-1
Gene namesi
Name:FEV
Synonyms:PET1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:18562. FEV.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Sudden infant death syndrome (SIDS) [MIM:272120]: SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.1 Publication
Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.
A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.

Organism-specific databases

MIMi272120. phenotype.
PharmGKBiPA134875093.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Protein FEVPRO_0000344204Add
BLAST

Proteomic databases

PaxDbiQ99581.
PRIDEiQ99581.

PTM databases

PhosphoSiteiQ99581.

Expressioni

Tissue specificityi

In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.3 Publications

Gene expression databases

BgeeiQ99581.
CleanExiHS_FEV.
GenevestigatoriQ99581.

Interactioni

Protein-protein interaction databases

BioGridi120120. 1 interaction.
STRINGi9606.ENSP00000295727.

Structurei

Secondary structure

1
238
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi49 – 579
Helixi60 – 623
Turni63 – 653
Beta strandi67 – 715
Beta strandi74 – 763
Helixi80 – 9112
Helixi98 – 10710
Turni108 – 1125
Beta strandi113 – 1164
Beta strandi123 – 1264
Helixi128 – 1347

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YPRX-ray2.64A/B42-141[»]
3ZP5X-ray2.00A42-141[»]
ProteinModelPortaliQ99581.
SMRiQ99581. Positions 44-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 238110May mediate active transcriptional repressionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi132 – 21079Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG287001.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000234879.
HOVERGENiHBG095796.
InParanoidiQ99581.
KOiK09437.
OMAiLMFNMYL.
OrthoDBiEOG73V6K8.
PhylomeDBiQ99581.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99581-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQSGASQPL LINMYLPDPV GDGLFKDGKN PSWGPLSPAV QKGSGQIQLW
60 70 80 90 100
QFLLELLADR ANAGCIAWEG GHGEFKLTDP DEVARRWGER KSKPNMNYDK
110 120 130 140 150
LSRALRYYYD KNIMSKVHGK RYAYRFDFQG LAQACQPPPA HAHAAAAAAA
160 170 180 190 200
AAAAAQDGAL YKLPAGLAPL PFPGLSKLNL MAASAGVAPA GFSYWPGPGP
210 220 230
AATAAAATAA LYPSPSLQPP PGPFGAVAAA SHLGGHYH
Length:238
Mass (Da):25,030
Last modified:May 1, 1997 - v1
Checksum:i057E4A76FBDD6E0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08976 mRNA. Translation: CAA70169.1.
AC097468 Genomic DNA. Translation: AAX88917.1.
CH471063 Genomic DNA. Translation: EAW70664.1.
BC023511 mRNA. Translation: AAH23511.1.
CCDSiCCDS2428.1.
RefSeqiNP_059991.1. NM_017521.2.
UniGeneiHs.234759.

Genome annotation databases

EnsembliENST00000295727; ENSP00000295727; ENSG00000163497.
GeneIDi54738.
KEGGihsa:54738.
UCSCiuc002vji.1. human.

Polymorphism databases

DMDMi74762701.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08976 mRNA. Translation: CAA70169.1 .
AC097468 Genomic DNA. Translation: AAX88917.1 .
CH471063 Genomic DNA. Translation: EAW70664.1 .
BC023511 mRNA. Translation: AAH23511.1 .
CCDSi CCDS2428.1.
RefSeqi NP_059991.1. NM_017521.2.
UniGenei Hs.234759.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YPR X-ray 2.64 A/B 42-141 [» ]
3ZP5 X-ray 2.00 A 42-141 [» ]
ProteinModelPortali Q99581.
SMRi Q99581. Positions 44-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120120. 1 interaction.
STRINGi 9606.ENSP00000295727.

PTM databases

PhosphoSitei Q99581.

Polymorphism databases

DMDMi 74762701.

Proteomic databases

PaxDbi Q99581.
PRIDEi Q99581.

Protocols and materials databases

DNASUi 54738.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295727 ; ENSP00000295727 ; ENSG00000163497 .
GeneIDi 54738.
KEGGi hsa:54738.
UCSCi uc002vji.1. human.

Organism-specific databases

CTDi 54738.
GeneCardsi GC02M219845.
HGNCi HGNC:18562. FEV.
MIMi 272120. phenotype.
607150. gene.
neXtProti NX_Q99581.
PharmGKBi PA134875093.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287001.
GeneTreei ENSGT00760000118907.
HOGENOMi HOG000234879.
HOVERGENi HBG095796.
InParanoidi Q99581.
KOi K09437.
OMAi LMFNMYL.
OrthoDBi EOG73V6K8.
PhylomeDBi Q99581.
TreeFami TF316214.

Miscellaneous databases

GenomeRNAii 54738.
NextBioi 57329.
PROi Q99581.
SOURCEi Search...

Gene expression databases

Bgeei Q99581.
CleanExi HS_FEV.
Genevestigatori Q99581.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL TRANSLOCATION WITH EWSR1, TISSUE SPECIFICITY.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain."
    Maurer P., T'Sas F., Coutte L., Callens N., Brenner C., Van Lint C., de Launoit Y., Baert J.-L.
    Oncogene 22:3319-3329(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "The Ets transcription factor Fev is specifically expressed in the human central serotonergic neurons."
    Maurer P., Rorive S., de Kerchove d'Exaerde A., Schiffmann S.N., Salmon I., de Launoit Y.
    Neurosci. Lett. 357:215-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain."
    Iyo A.H., Porter B., Deneris E.S., Austin M.C.
    Synapse 57:223-228(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma."
    Braunreiter C.L., Hancock J.D., Coffin C.M., Boucher K.M., Lessnick S.L.
    Cell Cycle 5:2753-2759(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF THE EWSR1-FEV FUSION PROTEIN.
  9. "Sudden infant death syndrome: rare mutation in the serotonin system FEV gene."
    Rand C.M., Berry-Kravis E.M., Zhou L., Fan W., Weese-Mayer D.E.
    Pediatr. Res. 62:180-182(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SIDS.

Entry informationi

Entry nameiFEV_HUMAN
AccessioniPrimary (citable) accession number: Q99581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3