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Protein

GTP-binding protein Rit2

Gene

RIT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 34GTPBy similarity8
Nucleotide bindingi74 – 78GTPBy similarity5
Nucleotide bindingi133 – 136GTPBy similarity4

GO - Molecular functioni

  • calmodulin binding Source: ParkinsonsUK-UCL
  • chromatin binding Source: Ensembl
  • GTPase activity Source: UniProtKB
  • GTP binding Source: ParkinsonsUK-UCL
  • semaphorin receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • intracellular signal transduction Source: ParkinsonsUK-UCL
  • maintenance of protein location in cell Source: ParkinsonsUK-UCL
  • negative regulation of neuron projection development Source: Ensembl
  • positive regulation of MAPK cascade Source: ParkinsonsUK-UCL
  • positive regulation of neuron projection development Source: ParkinsonsUK-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • Ras protein signal transduction Source: ParkinsonsUK-UCL
  • regulation of calcium-mediated signaling Source: ParkinsonsUK-UCL
  • regulation of Cdc42 protein signal transduction Source: ParkinsonsUK-UCL
  • regulation of endocytosis Source: ParkinsonsUK-UCL
  • small GTPase mediated signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152214-MONOMER.
ReactomeiR-HSA-187706. Signalling to p38 via RIT and RIN.
SIGNORiQ99578.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rit2
Alternative name(s):
Ras-like protein expressed in neurons
Ras-like without CAAX protein 2
Gene namesi
Name:RIT2
Synonyms:RIN, ROC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:10017. RIT2.

Subcellular locationi

GO - Cellular componenti

  • cell body Source: ParkinsonsUK-UCL
  • cytoplasm Source: ParkinsonsUK-UCL
  • dendritic tree Source: ParkinsonsUK-UCL
  • membrane raft Source: ParkinsonsUK-UCL
  • neuron projection Source: ParkinsonsUK-UCL
  • nucleus Source: ParkinsonsUK-UCL
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6014.
OpenTargetsiENSG00000152214.
PharmGKBiPA35527.

Polymorphism and mutation databases

DMDMi38258639.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827271 – 217GTP-binding protein Rit2Add BLAST217

Proteomic databases

PaxDbiQ99578.
PeptideAtlasiQ99578.
PRIDEiQ99578.

PTM databases

iPTMnetiQ99578.
PhosphoSitePlusiQ99578.

Expressioni

Tissue specificityi

Neuron-specific.

Gene expression databases

BgeeiENSG00000152214.
CleanExiHS_RIT2.
ExpressionAtlasiQ99578. baseline and differential.
GenevisibleiQ99578. HS.

Interactioni

Subunit structurei

Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3. Interacts with POU4F1 (via N-terminus); the interation controls POU4F1 transactivation activity on some neuronal target genes (By similarity).By similarity1 Publication

GO - Molecular functioni

  • calmodulin binding Source: ParkinsonsUK-UCL
  • semaphorin receptor binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi111946. 9 interactors.
IntActiQ99578. 2 interactors.
STRINGi9606.ENSP00000321805.

Structurei

3D structure databases

ProteinModelPortaliQ99578.
SMRiQ99578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133678.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ99578.
KOiK07833.
OMAiRCGEGFM.
OrthoDBiEOG091G0UAU.
PhylomeDBiQ99578.
TreeFamiTF315072.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99578-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVENEASCS PGSASGGSRE YKVVMLGAGG VGKSAMTMQF ISHQFPDYHD
60 70 80 90 100
PTIEDAYKTQ VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS
110 120 130 140 150
VTDRQSFQEA AKFKELIFQV RHTYEIPLVL VGNKIDLEQF RQVSTEEGLS
160 170 180 190 200
LAQEYNCGFF ETSAALRFCI DDAFHGLVRE IRKKESMPSL MEKKLKRKDS
210
LWKKLKGSLK KKRENMT
Length:217
Mass (Da):24,668
Last modified:May 1, 1997 - v1
Checksum:iCD2A9ECE4AEAA792
GO
Isoform 2 (identifier: Q99578-2) [UniParc]FASTAAdd to basket
Also known as: RIBA

The sequence of this isoform differs from the canonical sequence as follows:
     143-153: VSTEEGLSLAQ → PTLKEFGREEF
     154-217: Missing.

Show »
Length:153
Mass (Da):17,308
Checksum:i9820326EF5FCA223
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39Q → L in AAM12636 (Ref. 4) Curated1
Sequence conflicti76A → D in AAB42214 (PubMed:8824319).Curated1
Sequence conflicti200S → C in AAH18060 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018102143 – 153VSTEEGLSLAQ → PTLKEFGREEF in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_018103154 – 217Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71204 mRNA. Translation: AAB42214.1.
Y07565 mRNA. Translation: CAA68850.1.
U78164 mRNA. Translation: AAB64245.1.
U78166 mRNA. Translation: AAB64247.1.
AF493922 mRNA. Translation: AAM12636.1.
AY563951 mRNA. Translation: AAS75332.1.
AK313823 mRNA. Translation: BAG36558.1.
CH471088 Genomic DNA. Translation: EAX01432.1.
BC018060 mRNA. Translation: AAH18060.1.
CCDSiCCDS11921.1. [Q99578-1]
CCDS62431.1. [Q99578-2]
RefSeqiNP_001259006.1. NM_001272077.1. [Q99578-2]
NP_002921.1. NM_002930.3. [Q99578-1]
UniGeneiHs.464985.

Genome annotation databases

EnsembliENST00000326695; ENSP00000321805; ENSG00000152214. [Q99578-1]
ENST00000589109; ENSP00000467217; ENSG00000152214. [Q99578-2]
GeneIDi6014.
KEGGihsa:6014.
UCSCiuc002lav.5. human. [Q99578-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71204 mRNA. Translation: AAB42214.1.
Y07565 mRNA. Translation: CAA68850.1.
U78164 mRNA. Translation: AAB64245.1.
U78166 mRNA. Translation: AAB64247.1.
AF493922 mRNA. Translation: AAM12636.1.
AY563951 mRNA. Translation: AAS75332.1.
AK313823 mRNA. Translation: BAG36558.1.
CH471088 Genomic DNA. Translation: EAX01432.1.
BC018060 mRNA. Translation: AAH18060.1.
CCDSiCCDS11921.1. [Q99578-1]
CCDS62431.1. [Q99578-2]
RefSeqiNP_001259006.1. NM_001272077.1. [Q99578-2]
NP_002921.1. NM_002930.3. [Q99578-1]
UniGeneiHs.464985.

3D structure databases

ProteinModelPortaliQ99578.
SMRiQ99578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111946. 9 interactors.
IntActiQ99578. 2 interactors.
STRINGi9606.ENSP00000321805.

PTM databases

iPTMnetiQ99578.
PhosphoSitePlusiQ99578.

Polymorphism and mutation databases

DMDMi38258639.

Proteomic databases

PaxDbiQ99578.
PeptideAtlasiQ99578.
PRIDEiQ99578.

Protocols and materials databases

DNASUi6014.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326695; ENSP00000321805; ENSG00000152214. [Q99578-1]
ENST00000589109; ENSP00000467217; ENSG00000152214. [Q99578-2]
GeneIDi6014.
KEGGihsa:6014.
UCSCiuc002lav.5. human. [Q99578-1]

Organism-specific databases

CTDi6014.
DisGeNETi6014.
GeneCardsiRIT2.
H-InvDBHIX0014415.
HGNCiHGNC:10017. RIT2.
MIMi609592. gene.
neXtProtiNX_Q99578.
OpenTargetsiENSG00000152214.
PharmGKBiPA35527.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133678.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ99578.
KOiK07833.
OMAiRCGEGFM.
OrthoDBiEOG091G0UAU.
PhylomeDBiQ99578.
TreeFamiTF315072.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152214-MONOMER.
ReactomeiR-HSA-187706. Signalling to p38 via RIT and RIN.
SIGNORiQ99578.

Miscellaneous databases

GeneWikiiRIT2.
GenomeRNAii6014.
PROiQ99578.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152214.
CleanExiHS_RIT2.
ExpressionAtlasiQ99578. baseline and differential.
GenevisibleiQ99578. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIT2_HUMAN
AccessioniPrimary (citable) accession number: Q99578
Secondary accession number(s): B2R9L1
, O15295, Q8TD69, Q8WVF6, Q92964
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.