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Protein

GTP-binding protein Rit2

Gene

RIT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator.By similarity

Miscellaneous

Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 34GTPBy similarity8
Nucleotide bindingi74 – 78GTPBy similarity5
Nucleotide bindingi133 – 136GTPBy similarity4

GO - Molecular functioni

  • calmodulin binding Source: ParkinsonsUK-UCL
  • chromatin binding Source: Ensembl
  • GTPase activity Source: ParkinsonsUK-UCL
  • GTP binding Source: ParkinsonsUK-UCL
  • semaphorin receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  • chemical synaptic transmission Source: ProtInc
  • intracellular signal transduction Source: ParkinsonsUK-UCL
  • maintenance of protein location in cell Source: ParkinsonsUK-UCL
  • negative regulation of neuron projection development Source: Ensembl
  • positive regulation of MAPK cascade Source: ParkinsonsUK-UCL
  • positive regulation of neuron projection development Source: ParkinsonsUK-UCL
  • positive regulation of transcription by RNA polymerase II Source: Ensembl
  • Ras protein signal transduction Source: ParkinsonsUK-UCL
  • regulation of calcium-mediated signaling Source: ParkinsonsUK-UCL
  • regulation of Cdc42 protein signal transduction Source: ParkinsonsUK-UCL
  • regulation of endocytosis Source: ParkinsonsUK-UCL
  • small GTPase mediated signal transduction Source: UniProtKB

Keywordsi

Molecular functionCalmodulin-binding
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-187706 Signalling to p38 via RIT and RIN
SIGNORiQ99578

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rit2
Alternative name(s):
Ras-like protein expressed in neurons
Ras-like without CAAX protein 2
Gene namesi
Name:RIT2
Synonyms:RIN, ROC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000152214.12
HGNCiHGNC:10017 RIT2
MIMi609592 gene
neXtProtiNX_Q99578

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6014
OpenTargetsiENSG00000152214
PharmGKBiPA35527

Polymorphism and mutation databases

DMDMi38258639

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827271 – 217GTP-binding protein Rit2Add BLAST217

Proteomic databases

PaxDbiQ99578
PeptideAtlasiQ99578
PRIDEiQ99578

PTM databases

iPTMnetiQ99578
PhosphoSitePlusiQ99578

Expressioni

Tissue specificityi

Neuron-specific.

Gene expression databases

BgeeiENSG00000152214
CleanExiHS_RIT2
ExpressionAtlasiQ99578 baseline and differential
GenevisibleiQ99578 HS

Interactioni

Subunit structurei

Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3. Interacts with POU4F1 (via N-terminus); the interaction controls POU4F1 transactivation activity on some neuronal target genes (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC6A3Q019595EBI-365914,EBI-6661445

GO - Molecular functioni

  • calmodulin binding Source: ParkinsonsUK-UCL
  • semaphorin receptor binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi111946, 10 interactors
IntActiQ99578, 3 interactors
STRINGi9606.ENSP00000321805

Structurei

3D structure databases

ProteinModelPortaliQ99578
SMRiQ99578
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ99578
KOiK07833
OMAiRFLDYHD
OrthoDBiEOG091G0UAU
PhylomeDBiQ99578
TreeFamiTF315072

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99578-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVENEASCS PGSASGGSRE YKVVMLGAGG VGKSAMTMQF ISHQFPDYHD
60 70 80 90 100
PTIEDAYKTQ VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS
110 120 130 140 150
VTDRQSFQEA AKFKELIFQV RHTYEIPLVL VGNKIDLEQF RQVSTEEGLS
160 170 180 190 200
LAQEYNCGFF ETSAALRFCI DDAFHGLVRE IRKKESMPSL MEKKLKRKDS
210
LWKKLKGSLK KKRENMT
Length:217
Mass (Da):24,668
Last modified:May 1, 1997 - v1
Checksum:iCD2A9ECE4AEAA792
GO
Isoform 2 (identifier: Q99578-2) [UniParc]FASTAAdd to basket
Also known as: RIBA

The sequence of this isoform differs from the canonical sequence as follows:
     143-153: VSTEEGLSLAQ → PTLKEFGREEF
     154-217: Missing.

Show »
Length:153
Mass (Da):17,308
Checksum:i9820326EF5FCA223
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39Q → L in AAM12636 (Ref. 4) Curated1
Sequence conflicti76A → D in AAB42214 (PubMed:8824319).Curated1
Sequence conflicti200S → C in AAH18060 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018102143 – 153VSTEEGLSLAQ → PTLKEFGREEF in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_018103154 – 217Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71204 mRNA Translation: AAB42214.1
Y07565 mRNA Translation: CAA68850.1
U78164 mRNA Translation: AAB64245.1
U78166 mRNA Translation: AAB64247.1
AF493922 mRNA Translation: AAM12636.1
AY563951 mRNA Translation: AAS75332.1
AK313823 mRNA Translation: BAG36558.1
CH471088 Genomic DNA Translation: EAX01432.1
BC018060 mRNA Translation: AAH18060.1
CCDSiCCDS11921.1 [Q99578-1]
CCDS62431.1 [Q99578-2]
RefSeqiNP_001259006.1, NM_001272077.1 [Q99578-2]
NP_002921.1, NM_002930.3 [Q99578-1]
UniGeneiHs.464985

Genome annotation databases

EnsembliENST00000326695; ENSP00000321805; ENSG00000152214 [Q99578-1]
ENST00000589109; ENSP00000467217; ENSG00000152214 [Q99578-2]
GeneIDi6014
KEGGihsa:6014
UCSCiuc002lav.5 human [Q99578-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRIT2_HUMAN
AccessioniPrimary (citable) accession number: Q99578
Secondary accession number(s): B2R9L1
, O15295, Q8TD69, Q8WVF6, Q92964
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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