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Q99571

- P2RX4_HUMAN

UniProt

Q99571 - P2RX4_HUMAN

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Protein

P2X purinoceptor 4

Gene

P2RX4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.1 Publication

GO - Molecular functioni

  1. ATP binding Source: BHF-UCL
  2. cadherin binding Source: BHF-UCL
  3. copper ion binding Source: BHF-UCL
  4. drug binding Source: Ensembl
  5. extracellular ATP-gated cation channel activity Source: UniProtKB
  6. protein homodimerization activity Source: BHF-UCL
  7. purinergic nucleotide receptor activity Source: BHF-UCL
  8. receptor binding Source: BHF-UCL
  9. zinc ion binding Source: BHF-UCL

GO - Biological processi

  1. apoptotic signaling pathway Source: BHF-UCL
  2. calcium ion transport Source: Ensembl
  3. cation transmembrane transport Source: GOC
  4. cellular response to ATP Source: UniProtKB
  5. endothelial cell activation Source: BHF-UCL
  6. ion transmembrane transport Source: UniProtKB
  7. membrane depolarization Source: BHF-UCL
  8. negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
  9. neuronal action potential Source: Ensembl
  10. nitric oxide biosynthetic process Source: Ensembl
  11. positive regulation of calcium ion transport Source: BHF-UCL
  12. positive regulation of calcium ion transport into cytosol Source: BHF-UCL
  13. positive regulation of calcium-mediated signaling Source: BHF-UCL
  14. positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
  15. positive regulation of prostaglandin secretion Source: BHF-UCL
  16. protein homooligomerization Source: Ensembl
  17. purinergic nucleotide receptor signaling pathway Source: BHF-UCL
  18. regulation of blood pressure Source: BHF-UCL
  19. regulation of cardiac muscle contraction Source: BHF-UCL
  20. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  21. regulation of sodium ion transport Source: BHF-UCL
  22. relaxation of cardiac muscle Source: BHF-UCL
  23. response to ATP Source: BHF-UCL
  24. response to fluid shear stress Source: BHF-UCL
  25. sensory perception of pain Source: BHF-UCL
  26. signal transduction Source: BHF-UCL
  27. tissue homeostasis Source: BHF-UCL
  28. transport Source: BHF-UCL
  29. vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.7.1.5. the atp-gated p2x receptor cation channel (p2x receptor) family.

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 4
Short name:
P2X4
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:8535. P2RX4.

Subcellular locationi

Membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini55 – 338284ExtracellularSequence AnalysisAdd
BLAST
Transmembranei339 – 35921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini360 – 38829CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. cell junction Source: BHF-UCL
  3. dendritic spine Source: Ensembl
  4. extracellular vesicular exosome Source: UniProtKB
  5. integral component of nuclear inner membrane Source: RefGenome
  6. integral component of plasma membrane Source: UniProtKB
  7. lysosomal membrane Source: UniProtKB
  8. membrane Source: UniProtKB
  9. neuronal cell body Source: Ensembl
  10. perinuclear region of cytoplasm Source: BHF-UCL
  11. plasma membrane Source: BHF-UCL
  12. postsynaptic density Source: Ensembl
  13. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388P2X purinoceptor 4PRO_0000161553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi116 ↔ 165By similarity
Disulfide bondi126 ↔ 149By similarity
Disulfide bondi132 ↔ 159By similarity
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)1 Publication
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi217 ↔ 227By similarity
Disulfide bondi261 ↔ 270By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ99571.
PaxDbiQ99571.
PRIDEiQ99571.

PTM databases

PhosphoSiteiQ99571.

Expressioni

Gene expression databases

BgeeiQ99571.
CleanExiHS_P2RX4.
ExpressionAtlasiQ99571. baseline and differential.
GenevestigatoriQ99571.

Organism-specific databases

HPAiHPA039494.

Interactioni

Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers.By similarity

Protein-protein interaction databases

BioGridi111064. 24 interactions.
IntActiQ99571. 3 interactions.
STRINGi9606.ENSP00000336607.

Structurei

3D structure databases

ProteinModelPortaliQ99571.
SMRiQ99571. Positions 31-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47843.
GeneTreeiENSGT00390000016028.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiQ99571.
KOiK05218.
OMAiTMINVGS.
OrthoDBiEOG78PV92.
PhylomeDBiQ99571.
TreeFamiTF328633.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003047. P2X4_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF18. PTHR10125:SF18. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01311. P2X4RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99571-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGCCAALAA FLFEYDTPRI VLIRSRKVGL MNRAVQLLIL AYVIGWVFVW
60 70 80 90 100
EKGYQETDSV VSSVTTKVKG VAVTNTSKLG FRIWDVADYV IPAQEENSLF
110 120 130 140 150
VMTNVILTMN QTQGLCPEIP DATTVCKSDA SCTAGSAGTH SNGVSTGRCV
160 170 180 190 200
AFNGSVKTCE VAAWCPVEDD THVPQPAFLK AAENFTLLVK NNIWYPKFNF
210 220 230 240 250
SKRNILPNIT TTYLKSCIYD AKTDPFCPIF RLGKIVENAG HSFQDMAVEG
260 270 280 290 300
GIMGIQVNWD CNLDRAASLC LPRYSFRRLD TRDVEHNVSP GYNFRFAKYY
310 320 330 340 350
RDLAGNEQRT LIKAYGIRFD IIVFGKAGKF DIIPTMINIG SGLALLGMAT
360 370 380
VLCDIIVLYC MKKRLYYREK KYKYVEDYEQ GLASELDQ
Length:388
Mass (Da):43,369
Last modified:October 17, 2006 - v2
Checksum:iBA3BE7F30114C2A5
GO
Isoform 2 (identifier: Q99571-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-45: G → GCYHPHLAEVEMESPRR

Note: No experimental confirmation available.

Show »
Length:404
Mass (Da):45,305
Checksum:i0A8CB40D3D899F21
GO
Isoform 3 (identifier: Q99571-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-175: Missing.

Show »
Length:361
Mass (Da):40,481
Checksum:i9D09FA497870DDB1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211D → S in AAB66834. 1 PublicationCurated
Sequence conflicti148 – 1481R → W in AAB66834. 1 PublicationCurated
Sequence conflicti179 – 1791L → F in AAB66834. 1 PublicationCurated
Sequence conflicti238 – 2381N → I in AAB66834. 1 PublicationCurated
Sequence conflicti315 – 3151Y → C in AAB58405. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61A → S.3 Publications
Corresponds to variant rs1044249 [ dbSNP | Ensembl ].
VAR_028307
Natural varianti242 – 2421S → G.1 Publication
Corresponds to variant rs25644 [ dbSNP | Ensembl ].
VAR_014942

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei45 – 451G → GCYHPHLAEVEMESPRR in isoform 2. CuratedVSP_053812
Alternative sequencei149 – 17527Missing in isoform 3. 1 PublicationVSP_053813Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07684 mRNA. Translation: CAA68948.1.
U87270
, U85971, U85972, U85973, U85974, U85975 Genomic DNA. Translation: AAD00556.1.
U83993 mRNA. Translation: AAD00553.1.
AF191093 Genomic DNA. Translation: AAF06661.1.
BT019738 mRNA. Translation: AAV38543.1.
BT019739 mRNA. Translation: AAV38544.1.
AC069209 Genomic DNA. No translation available.
BC033826 mRNA. Translation: AAH33826.1.
AF000234 mRNA. Translation: AAB58405.1.
AF012903 mRNA. Translation: AAB66834.1.
CCDSiCCDS58282.1. [Q99571-2]
CCDS9214.1. [Q99571-1]
RefSeqiNP_001243725.1. NM_001256796.1. [Q99571-2]
NP_001248326.1. NM_001261397.1. [Q99571-3]
NP_002551.2. NM_002560.2. [Q99571-1]
UniGeneiHs.321709.

Genome annotation databases

EnsembliENST00000337233; ENSP00000336607; ENSG00000135124. [Q99571-1]
ENST00000359949; ENSP00000353032; ENSG00000135124. [Q99571-2]
ENST00000542067; ENSP00000438329; ENSG00000135124. [Q99571-3]
GeneIDi5025.
KEGGihsa:5025.
UCSCiuc001tzr.3. human. [Q99571-1]

Polymorphism databases

DMDMi116242696.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

P2X receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07684 mRNA. Translation: CAA68948.1 .
U87270
, U85971 , U85972 , U85973 , U85974 , U85975 Genomic DNA. Translation: AAD00556.1 .
U83993 mRNA. Translation: AAD00553.1 .
AF191093 Genomic DNA. Translation: AAF06661.1 .
BT019738 mRNA. Translation: AAV38543.1 .
BT019739 mRNA. Translation: AAV38544.1 .
AC069209 Genomic DNA. No translation available.
BC033826 mRNA. Translation: AAH33826.1 .
AF000234 mRNA. Translation: AAB58405.1 .
AF012903 mRNA. Translation: AAB66834.1 .
CCDSi CCDS58282.1. [Q99571-2 ]
CCDS9214.1. [Q99571-1 ]
RefSeqi NP_001243725.1. NM_001256796.1. [Q99571-2 ]
NP_001248326.1. NM_001261397.1. [Q99571-3 ]
NP_002551.2. NM_002560.2. [Q99571-1 ]
UniGenei Hs.321709.

3D structure databases

ProteinModelPortali Q99571.
SMRi Q99571. Positions 31-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111064. 24 interactions.
IntActi Q99571. 3 interactions.
STRINGi 9606.ENSP00000336607.

Chemistry

BindingDBi Q99571.
ChEMBLi CHEMBL2104.
GuidetoPHARMACOLOGYi 481.

Protein family/group databases

TCDBi 1.A.7.1.5. the atp-gated p2x receptor cation channel (p2x receptor) family.

PTM databases

PhosphoSitei Q99571.

Polymorphism databases

DMDMi 116242696.

Proteomic databases

MaxQBi Q99571.
PaxDbi Q99571.
PRIDEi Q99571.

Protocols and materials databases

DNASUi 5025.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337233 ; ENSP00000336607 ; ENSG00000135124 . [Q99571-1 ]
ENST00000359949 ; ENSP00000353032 ; ENSG00000135124 . [Q99571-2 ]
ENST00000542067 ; ENSP00000438329 ; ENSG00000135124 . [Q99571-3 ]
GeneIDi 5025.
KEGGi hsa:5025.
UCSCi uc001tzr.3. human. [Q99571-1 ]

Organism-specific databases

CTDi 5025.
GeneCardsi GC12P121647.
HGNCi HGNC:8535. P2RX4.
HPAi HPA039494.
MIMi 600846. gene.
neXtProti NX_Q99571.
PharmGKBi PA32864.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47843.
GeneTreei ENSGT00390000016028.
HOGENOMi HOG000232042.
HOVERGENi HBG053086.
InParanoidi Q99571.
KOi K05218.
OMAi TMINVGS.
OrthoDBi EOG78PV92.
PhylomeDBi Q99571.
TreeFami TF328633.

Miscellaneous databases

ChiTaRSi P2RX4. human.
GeneWikii P2RX4.
GenomeRNAii 5025.
NextBioi 19346.
PROi Q99571.
SOURCEi Search...

Gene expression databases

Bgeei Q99571.
CleanExi HS_P2RX4.
ExpressionAtlasi Q99571. baseline and differential.
Genevestigatori Q99571.

Family and domain databases

Gene3Di 2.60.490.10. 1 hit.
InterProi IPR003047. P2X4_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view ]
PANTHERi PTHR10125. PTHR10125. 1 hit.
PTHR10125:SF18. PTHR10125:SF18. 1 hit.
Pfami PF00864. P2X_receptor. 1 hit.
[Graphical view ]
PRINTSi PR01311. P2X4RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsi TIGR00863. P2X. 1 hit.
PROSITEi PS01212. P2X_RECEPTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue."
    Garcia-Guzman M., Soto F., Gomez-Hernandez J.M., Lund P.E., Stuhmer W.
    Mol. Pharmacol. 51:109-118(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-6.
    Tissue: Brain.
  2. "Transcription map of the 5cM region surrounding the hepatocyte nuclear factor-1a/MODY3 gene on chromosome 12."
    Yamagata K., Oda N., Furuta H., Vaxillaire M., Southam L., Boriraj V., Chen X., Oda Y., Takeda J., Yamada S., Nishigori H., Lebeau M.M., Lathrop M., Cox R.D., Bell G.I.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  3. "Shear stress downregulates the expression of P2X4 receptor by human endothelial cells."
    Korenaga R., Yamamoto K., Kamiya A., Ando J.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT SER-6.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-6.
  5. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-242.
    Tissue: Blood.
  7. "Human P2X purinoceptor."
    Takahashi K., Korenaga R., Kamiya A., Ando J.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-388 (ISOFORM 1).
  8. "Cloning of P2X4 cDNA from human embryonic kidney (HEK) 293 cells."
    Chang A.S., Chang S.M.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-326 (ISOFORM 1).
    Tissue: Kidney.
  9. Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-184.
    Tissue: Liver.

Entry informationi

Entry nameiP2RX4_HUMAN
AccessioniPrimary (citable) accession number: Q99571
Secondary accession number(s): E7EPF7
, F6RU17, O00450, O14722, Q5U089, Q5U090, Q8N4N1, Q9UBG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3