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Q99571

- P2RX4_HUMAN

UniProt

Q99571 - P2RX4_HUMAN

Protein

P2X purinoceptor 4

Gene

P2RX4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.1 Publication

    GO - Molecular functioni

    1. ATP binding Source: BHF-UCL
    2. cadherin binding Source: BHF-UCL
    3. copper ion binding Source: BHF-UCL
    4. extracellular ATP-gated cation channel activity Source: UniProtKB
    5. protein homodimerization activity Source: BHF-UCL
    6. purinergic nucleotide receptor activity Source: BHF-UCL
    7. receptor binding Source: BHF-UCL
    8. zinc ion binding Source: BHF-UCL

    GO - Biological processi

    1. apoptotic signaling pathway Source: BHF-UCL
    2. cation transport Source: GOC
    3. cellular response to ATP Source: UniProtKB
    4. endothelial cell activation Source: BHF-UCL
    5. ion transmembrane transport Source: UniProtKB
    6. membrane depolarization Source: BHF-UCL
    7. negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
    8. positive regulation of calcium ion transport Source: BHF-UCL
    9. positive regulation of calcium ion transport into cytosol Source: BHF-UCL
    10. positive regulation of calcium-mediated signaling Source: BHF-UCL
    11. positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
    12. positive regulation of prostaglandin secretion Source: BHF-UCL
    13. purinergic nucleotide receptor signaling pathway Source: BHF-UCL
    14. regulation of blood pressure Source: BHF-UCL
    15. regulation of cardiac muscle contraction Source: BHF-UCL
    16. regulation of sodium ion transport Source: BHF-UCL
    17. relaxation of cardiac muscle Source: BHF-UCL
    18. response to ATP Source: BHF-UCL
    19. response to fluid shear stress Source: BHF-UCL
    20. sensory perception of pain Source: BHF-UCL
    21. signal transduction Source: BHF-UCL
    22. tissue homeostasis Source: BHF-UCL
    23. transport Source: BHF-UCL

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Protein family/group databases

    TCDBi1.A.7.1.5. the atp-gated p2x receptor cation channel (p2x receptor) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2X purinoceptor 4
    Short name:
    P2X4
    Alternative name(s):
    ATP receptor
    Purinergic receptor
    Gene namesi
    Name:P2RX4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:8535. P2RX4.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cell junction Source: BHF-UCL
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of nuclear inner membrane Source: RefGenome
    4. integral component of plasma membrane Source: UniProtKB
    5. lysosomal membrane Source: UniProtKB
    6. membrane Source: UniProtKB
    7. perinuclear region of cytoplasm Source: BHF-UCL
    8. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32864.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388P2X purinoceptor 4PRO_0000161553Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi116 ↔ 165By similarity
    Disulfide bondi126 ↔ 149By similarity
    Disulfide bondi132 ↔ 159By similarity
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)1 Publication
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi217 ↔ 227By similarity
    Disulfide bondi261 ↔ 270By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ99571.
    PaxDbiQ99571.
    PRIDEiQ99571.

    PTM databases

    PhosphoSiteiQ99571.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99571.
    BgeeiQ99571.
    CleanExiHS_P2RX4.
    GenevestigatoriQ99571.

    Organism-specific databases

    HPAiHPA039494.

    Interactioni

    Subunit structurei

    Functional P2XRs are organized as homomeric and heteromeric trimers.By similarity

    Protein-protein interaction databases

    BioGridi111064. 2 interactions.
    IntActiQ99571. 3 interactions.
    STRINGi9606.ENSP00000336607.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99571.
    SMRiQ99571. Positions 31-358.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini55 – 338284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini360 – 38829CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei339 – 35921Helical; Name=2Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the P2X receptor family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47843.
    HOGENOMiHOG000232042.
    HOVERGENiHBG053086.
    InParanoidiQ99571.
    KOiK05218.
    OMAiTMINVGS.
    OrthoDBiEOG78PV92.
    PhylomeDBiQ99571.
    TreeFamiTF328633.

    Family and domain databases

    Gene3Di2.60.490.10. 1 hit.
    InterProiIPR003047. P2X4_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view]
    PANTHERiPTHR10125. PTHR10125. 1 hit.
    PTHR10125:SF18. PTHR10125:SF18. 1 hit.
    PfamiPF00864. P2X_receptor. 1 hit.
    [Graphical view]
    PRINTSiPR01311. P2X4RECEPTOR.
    PR01307. P2XRECEPTOR.
    TIGRFAMsiTIGR00863. P2X. 1 hit.
    PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99571-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGCCAALAA FLFEYDTPRI VLIRSRKVGL MNRAVQLLIL AYVIGWVFVW    50
    EKGYQETDSV VSSVTTKVKG VAVTNTSKLG FRIWDVADYV IPAQEENSLF 100
    VMTNVILTMN QTQGLCPEIP DATTVCKSDA SCTAGSAGTH SNGVSTGRCV 150
    AFNGSVKTCE VAAWCPVEDD THVPQPAFLK AAENFTLLVK NNIWYPKFNF 200
    SKRNILPNIT TTYLKSCIYD AKTDPFCPIF RLGKIVENAG HSFQDMAVEG 250
    GIMGIQVNWD CNLDRAASLC LPRYSFRRLD TRDVEHNVSP GYNFRFAKYY 300
    RDLAGNEQRT LIKAYGIRFD IIVFGKAGKF DIIPTMINIG SGLALLGMAT 350
    VLCDIIVLYC MKKRLYYREK KYKYVEDYEQ GLASELDQ 388
    Length:388
    Mass (Da):43,369
    Last modified:October 17, 2006 - v2
    Checksum:iBA3BE7F30114C2A5
    GO
    Isoform 2 (identifier: Q99571-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         45-45: G → GCYHPHLAEVEMESPRR

    Note: No experimental confirmation available.

    Show »
    Length:404
    Mass (Da):45,305
    Checksum:i0A8CB40D3D899F21
    GO
    Isoform 3 (identifier: Q99571-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         149-175: Missing.

    Show »
    Length:361
    Mass (Da):40,481
    Checksum:i9D09FA497870DDB1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti121 – 1211D → S in AAB66834. 1 PublicationCurated
    Sequence conflicti148 – 1481R → W in AAB66834. 1 PublicationCurated
    Sequence conflicti179 – 1791L → F in AAB66834. 1 PublicationCurated
    Sequence conflicti238 – 2381N → I in AAB66834. 1 PublicationCurated
    Sequence conflicti315 – 3151Y → C in AAB58405. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61A → S.3 Publications
    Corresponds to variant rs1044249 [ dbSNP | Ensembl ].
    VAR_028307
    Natural varianti242 – 2421S → G.1 Publication
    Corresponds to variant rs25644 [ dbSNP | Ensembl ].
    VAR_014942

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei45 – 451G → GCYHPHLAEVEMESPRR in isoform 2. CuratedVSP_053812
    Alternative sequencei149 – 17527Missing in isoform 3. 1 PublicationVSP_053813Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07684 mRNA. Translation: CAA68948.1.
    U87270
    , U85971, U85972, U85973, U85974, U85975 Genomic DNA. Translation: AAD00556.1.
    U83993 mRNA. Translation: AAD00553.1.
    AF191093 Genomic DNA. Translation: AAF06661.1.
    BT019738 mRNA. Translation: AAV38543.1.
    BT019739 mRNA. Translation: AAV38544.1.
    AC069209 Genomic DNA. No translation available.
    BC033826 mRNA. Translation: AAH33826.1.
    AF000234 mRNA. Translation: AAB58405.1.
    AF012903 mRNA. Translation: AAB66834.1.
    CCDSiCCDS58282.1. [Q99571-2]
    CCDS9214.1. [Q99571-1]
    RefSeqiNP_001243725.1. NM_001256796.1. [Q99571-2]
    NP_001248326.1. NM_001261397.1. [Q99571-3]
    NP_002551.2. NM_002560.2. [Q99571-1]
    UniGeneiHs.321709.

    Genome annotation databases

    EnsembliENST00000337233; ENSP00000336607; ENSG00000135124. [Q99571-1]
    ENST00000359949; ENSP00000353032; ENSG00000135124. [Q99571-2]
    ENST00000542067; ENSP00000438329; ENSG00000135124. [Q99571-3]
    GeneIDi5025.
    KEGGihsa:5025.
    UCSCiuc001tzr.3. human. [Q99571-1]

    Polymorphism databases

    DMDMi116242696.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    P2X receptor entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07684 mRNA. Translation: CAA68948.1 .
    U87270
    , U85971 , U85972 , U85973 , U85974 , U85975 Genomic DNA. Translation: AAD00556.1 .
    U83993 mRNA. Translation: AAD00553.1 .
    AF191093 Genomic DNA. Translation: AAF06661.1 .
    BT019738 mRNA. Translation: AAV38543.1 .
    BT019739 mRNA. Translation: AAV38544.1 .
    AC069209 Genomic DNA. No translation available.
    BC033826 mRNA. Translation: AAH33826.1 .
    AF000234 mRNA. Translation: AAB58405.1 .
    AF012903 mRNA. Translation: AAB66834.1 .
    CCDSi CCDS58282.1. [Q99571-2 ]
    CCDS9214.1. [Q99571-1 ]
    RefSeqi NP_001243725.1. NM_001256796.1. [Q99571-2 ]
    NP_001248326.1. NM_001261397.1. [Q99571-3 ]
    NP_002551.2. NM_002560.2. [Q99571-1 ]
    UniGenei Hs.321709.

    3D structure databases

    ProteinModelPortali Q99571.
    SMRi Q99571. Positions 31-358.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111064. 2 interactions.
    IntActi Q99571. 3 interactions.
    STRINGi 9606.ENSP00000336607.

    Chemistry

    BindingDBi Q99571.
    ChEMBLi CHEMBL2104.
    GuidetoPHARMACOLOGYi 481.

    Protein family/group databases

    TCDBi 1.A.7.1.5. the atp-gated p2x receptor cation channel (p2x receptor) family.

    PTM databases

    PhosphoSitei Q99571.

    Polymorphism databases

    DMDMi 116242696.

    Proteomic databases

    MaxQBi Q99571.
    PaxDbi Q99571.
    PRIDEi Q99571.

    Protocols and materials databases

    DNASUi 5025.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337233 ; ENSP00000336607 ; ENSG00000135124 . [Q99571-1 ]
    ENST00000359949 ; ENSP00000353032 ; ENSG00000135124 . [Q99571-2 ]
    ENST00000542067 ; ENSP00000438329 ; ENSG00000135124 . [Q99571-3 ]
    GeneIDi 5025.
    KEGGi hsa:5025.
    UCSCi uc001tzr.3. human. [Q99571-1 ]

    Organism-specific databases

    CTDi 5025.
    GeneCardsi GC12P121647.
    HGNCi HGNC:8535. P2RX4.
    HPAi HPA039494.
    MIMi 600846. gene.
    neXtProti NX_Q99571.
    PharmGKBi PA32864.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47843.
    HOGENOMi HOG000232042.
    HOVERGENi HBG053086.
    InParanoidi Q99571.
    KOi K05218.
    OMAi TMINVGS.
    OrthoDBi EOG78PV92.
    PhylomeDBi Q99571.
    TreeFami TF328633.

    Miscellaneous databases

    ChiTaRSi P2RX4. human.
    GeneWikii P2RX4.
    GenomeRNAii 5025.
    NextBioi 19346.
    PROi Q99571.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99571.
    Bgeei Q99571.
    CleanExi HS_P2RX4.
    Genevestigatori Q99571.

    Family and domain databases

    Gene3Di 2.60.490.10. 1 hit.
    InterProi IPR003047. P2X4_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view ]
    PANTHERi PTHR10125. PTHR10125. 1 hit.
    PTHR10125:SF18. PTHR10125:SF18. 1 hit.
    Pfami PF00864. P2X_receptor. 1 hit.
    [Graphical view ]
    PRINTSi PR01311. P2X4RECEPTOR.
    PR01307. P2XRECEPTOR.
    TIGRFAMsi TIGR00863. P2X. 1 hit.
    PROSITEi PS01212. P2X_RECEPTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue."
      Garcia-Guzman M., Soto F., Gomez-Hernandez J.M., Lund P.E., Stuhmer W.
      Mol. Pharmacol. 51:109-118(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-6.
      Tissue: Brain.
    2. "Transcription map of the 5cM region surrounding the hepatocyte nuclear factor-1a/MODY3 gene on chromosome 12."
      Yamagata K., Oda N., Furuta H., Vaxillaire M., Southam L., Boriraj V., Chen X., Oda Y., Takeda J., Yamada S., Nishigori H., Lebeau M.M., Lathrop M., Cox R.D., Bell G.I.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    3. "Shear stress downregulates the expression of P2X4 receptor by human endothelial cells."
      Korenaga R., Yamamoto K., Kamiya A., Ando J.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT SER-6.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-6.
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-242.
      Tissue: Blood.
    7. "Human P2X purinoceptor."
      Takahashi K., Korenaga R., Kamiya A., Ando J.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-388 (ISOFORM 1).
    8. "Cloning of P2X4 cDNA from human embryonic kidney (HEK) 293 cells."
      Chang A.S., Chang S.M.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-326 (ISOFORM 1).
      Tissue: Kidney.
    9. Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
    10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-184.
      Tissue: Liver.

    Entry informationi

    Entry nameiP2RX4_HUMAN
    AccessioniPrimary (citable) accession number: Q99571
    Secondary accession number(s): E7EPF7
    , F6RU17, O00450, O14722, Q5U089, Q5U090, Q8N4N1, Q9UBG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3