SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99569

- PKP4_HUMAN

UniProt

Q99569 - PKP4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Plakophilin-4
Gene
PKP4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. cell-cell junction assembly Source: UniProtKB
  2. cell-cell signaling Source: UniProtKB
  3. positive regulation of Rho GTPase activity Source: UniProtKB
  4. positive regulation of cytokinesis Source: UniProtKB
  5. positive regulation of gene expression Source: UniProtKB
  6. regulation of cell adhesion Source: UniProtKB
  7. single organismal cell-cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

SignaLinkiQ99569.

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-4
Alternative name(s):
p0071
Gene namesi
Name:PKP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:9026. PKP4.

Subcellular locationi

Cell junctiondesmosome. Cytoplasmcytoskeletonspindle. Cytoplasmcytoskeletonspindle pole. Midbody. Cell membrane; Peripheral membrane protein
Note: Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.1 Publication

GO - Cellular componenti

  1. cell-cell junction Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytoplasmic side of plasma membrane Source: UniProtKB
  4. cytoskeleton Source: UniProtKB
  5. desmosome Source: UniProtKB
  6. midbody Source: UniProtKB
  7. mitotic spindle Source: UniProtKB
  8. perinuclear region of cytoplasm Source: UniProtKB
  9. plasma membrane Source: UniProtKB
  10. spindle midzone Source: UniProtKB
  11. spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11921192Plakophilin-4
PRO_0000064289Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei221 – 2211Phosphoserine1 Publication
Modified residuei231 – 2311Phosphoserine1 Publication
Modified residuei273 – 2731Phosphoserine1 Publication
Modified residuei281 – 2811Phosphoserine1 Publication
Modified residuei314 – 3141Phosphoserine7 Publications
Modified residuei327 – 3271Phosphoserine1 Publication
Modified residuei372 – 3721Phosphotyrosine By similarity
Modified residuei403 – 4031Phosphoserine1 Publication
Modified residuei406 – 4061Phosphoserine2 Publications
Modified residuei415 – 4151Phosphotyrosine2 Publications
Modified residuei478 – 4781Phosphotyrosine By similarity
Cross-linki611 – 611Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei776 – 7761Phosphoserine1 Publication
Modified residuei1135 – 11351Phosphoserine By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ99569.
PaxDbiQ99569.
PRIDEiQ99569.

PTM databases

PhosphoSiteiQ99569.

Expressioni

Gene expression databases

ArrayExpressiQ99569.
BgeeiQ99569.
CleanExiHS_PKP4.
GenevestigatoriQ99569.

Organism-specific databases

HPAiCAB037334.

Interactioni

Subunit structurei

Interacts with PDZD2 By similarity. Interacts (via the C-terminus) with FRMPD2 (via the PDZ 2 domain). Interacts with RHOA; the interaction is detected at the midbody. Interacts with ECT2; the interaction is detected at the midbody.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ERBB2IPQ96RT13EBI-726447,EBI-993903
ERBB2IPQ96RT1-23EBI-726447,EBI-8449250

Protein-protein interaction databases

BioGridi114074. 16 interactions.
IntActiQ99569. 12 interactions.
MINTiMINT-88417.
STRINGi9606.ENSP00000374409.

Structurei

3D structure databases

ProteinModelPortaliQ99569.
SMRiQ99569. Positions 525-1011.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati415 – 45541ARM 1
Add
BLAST
Repeati518 – 55740ARM 2
Add
BLAST
Repeati560 – 59940ARM 3
Add
BLAST
Repeati604 – 64441ARM 4
Add
BLAST
Repeati660 – 70243ARM 5
Add
BLAST
Repeati706 – 75146ARM 6
Add
BLAST
Repeati815 – 85541ARM 7
Add
BLAST
Repeati862 – 90140ARM 8
Add
BLAST
Repeati950 – 99344ARM 9
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili36 – 7035 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi788 – 7947Poly-Lys

Sequence similaritiesi

Belongs to the beta-catenin family.
Contains 9 ARM repeats.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG276924.
HOGENOMiHOG000231863.
HOVERGENiHBG004284.
InParanoidiQ99569.
OMAiGIGNLQR.
OrthoDBiEOG7X6KZB.
PhylomeDBiQ99569.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028443. Plakophilin-4.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF8. PTHR10372:SF8. 1 hit.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99569-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPAPEQASLV EEGQPQTRQE AASTGPGMEP ETTATTILAS VKEQELQFQR     50
LTRELEVERQ IVASQLERCR LGAESPSIAS TSSTEKSFPW RSTDVPNTGV 100
SKPRVSDAVQ PNNYLIRTEP EQGTLYSPEQ TSLHESEGSL GNSRSSTQMN 150
SYSDSGYQEA GSFHNSQNVS KADNRQQHSF IGSTNNHVVR NSRAEGQTLV 200
QPSVANRAMR RVSSVPSRAQ SPSYVISTGV SPSRGSLRTS LGSGFGSPSV 250
TDPRPLNPSA YSSTTLPAAR AASPYSQRPA SPTAIRRIGS VTSRQTSNPN 300
GPTPQYQTTA RVGSPLTLTD AQTRVASPSQ GQVGSSSPKR SGMTAVPQHL 350
GPSLQRTVHD MEQFGQQQYD IYERMVPPRP DSLTGLRSSY ASQHSQLGQD 400
LRSAVSPDLH ITPIYEGRTY YSPVYRSPNH GTVELQGSQT ALYRTGSVGI 450
GNLQRTSSQR STLTYQRNNY ALNTTATYAE PYRPIQYRVQ ECNYNRLQHA 500
VPADDGTTRS PSIDSIQKDP REFAWRDPEL PEVIHMLQHQ FPSVQANAAA 550
YLQHLCFGDN KVKMEVCRLG GIKHLVDLLD HRVLEVQKNA CGALRNLVFG 600
KSTDENKIAM KNVGGIPALL RLLRKSIDAE VRELVTGVLW NLSSCDAVKM 650
TIIRDALSTL TNTVIVPHSG WNNSSFDDDH KIKFQTSLVL RNTTGCLRNL 700
SSAGEEARKQ MRSCEGLVDS LLYVIHTCVN TSDYDSKTVE NCVCTLRNLS 750
YRLELEVPQA RLLGLNELDD LLGKESPSKD SEPSCWGKKK KKKKRTPQED 800
QWDGVGPIPG LSKSPKGVEM LWHPSVVKPY LTLLAESSNP ATLEGSAGSL 850
QNLSAGNWKF AAYIRAAVRK EKGLPILVEL LRMDNDRVVS SVATALRNMA 900
LDVRNKELIG KYAMRDLVNR LPGGNGPSVL SDETMAAICC ALHEVTSKNM 950
ENAKALADSG GIEKLVNITK GRGDRSSLKV VKAAAQVLNT LWQYRDLRSI 1000
YKKDGWNQNH FITPVSTLER DRFKSHPSLS TTNQQMSPII QSVGSTSSSP 1050
ALLGIRDPRS EYDRTQPPMQ YYNSQGDATH KGLYPGSSKP SPIYISSYSS 1100
PAREQNRRLQ HQQLYYSQDD SNRKNFDAYR LYLQSPHSYE DPYFDDRVHF 1150
PASTDYSTQY GLKSTTNYVD FYSTKRPSYR AEQYPGSPDS WV 1192
Length:1,192
Mass (Da):131,868
Last modified:November 30, 2010 - v2
Checksum:i48EA1579E323E019
GO
Isoform 2 (identifier: Q99569-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1043-1085: Missing.

Show »
Length:1,149
Mass (Da):127,144
Checksum:i060914C3E7947CB2
GO

Sequence cautioni

The sequence CAA57478.1 differs from that shown. Reason: Frameshift at positions 334, 337, 864 and 874.
The sequence CAA57478.1 differs from that shown. Reason: Erroneous termination at position 1193. Translated as stop.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1043 – 108543Missing in isoform 2.
VSP_006737Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411V → M in AAH50308. 1 Publication
Sequence conflicti223 – 2231S → Y in AAH50308. 1 Publication
Sequence conflicti235 – 2351G → W in AAH50308. 1 Publication
Sequence conflicti335 – 3351S → V in CAA57478. 1 Publication
Sequence conflicti336 – 3361S → V in CAA57478. 1 Publication
Sequence conflicti447 – 4471S → V in CAA57478. 1 Publication
Sequence conflicti448 – 4481V → S in CAA57478. 1 Publication
Sequence conflicti538 – 5381Q → E in CAA57478. 1 Publication
Sequence conflicti701 – 7011S → T in CAA57478. 1 Publication
Sequence conflicti766 – 7661N → D in AAH50308. 1 Publication
Sequence conflicti856 – 8561G → S in CAA57478. 1 Publication
Sequence conflicti865 – 8651R → G in CAA57478. 1 Publication
Sequence conflicti892 – 8921V → G in CAA57478. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81889 mRNA. Translation: CAA57478.1. Sequence problems.
AC005042 Genomic DNA. No translation available.
AC008070 Genomic DNA. No translation available.
BC050308 mRNA. Translation: AAH50308.1.
CCDSiCCDS33305.1. [Q99569-1]
CCDS33306.1. [Q99569-2]
RefSeqiNP_001005476.1. NM_001005476.1. [Q99569-2]
NP_003619.2. NM_003628.3. [Q99569-1]
UniGeneiHs.407580.

Genome annotation databases

EnsembliENST00000389757; ENSP00000374407; ENSG00000144283. [Q99569-2]
ENST00000389759; ENSP00000374409; ENSG00000144283. [Q99569-1]
GeneIDi8502.
KEGGihsa:8502.
UCSCiuc002tzt.1. human. [Q99569-1]
uc002tzw.3. human. [Q99569-2]

Polymorphism databases

DMDMi313104155.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81889 mRNA. Translation: CAA57478.1 . Sequence problems.
AC005042 Genomic DNA. No translation available.
AC008070 Genomic DNA. No translation available.
BC050308 mRNA. Translation: AAH50308.1 .
CCDSi CCDS33305.1. [Q99569-1 ]
CCDS33306.1. [Q99569-2 ]
RefSeqi NP_001005476.1. NM_001005476.1. [Q99569-2 ]
NP_003619.2. NM_003628.3. [Q99569-1 ]
UniGenei Hs.407580.

3D structure databases

ProteinModelPortali Q99569.
SMRi Q99569. Positions 525-1011.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114074. 16 interactions.
IntActi Q99569. 12 interactions.
MINTi MINT-88417.
STRINGi 9606.ENSP00000374409.

PTM databases

PhosphoSitei Q99569.

Polymorphism databases

DMDMi 313104155.

Proteomic databases

MaxQBi Q99569.
PaxDbi Q99569.
PRIDEi Q99569.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389757 ; ENSP00000374407 ; ENSG00000144283 . [Q99569-2 ]
ENST00000389759 ; ENSP00000374409 ; ENSG00000144283 . [Q99569-1 ]
GeneIDi 8502.
KEGGi hsa:8502.
UCSCi uc002tzt.1. human. [Q99569-1 ]
uc002tzw.3. human. [Q99569-2 ]

Organism-specific databases

CTDi 8502.
GeneCardsi GC02P159313.
H-InvDB HIX0002526.
HGNCi HGNC:9026. PKP4.
HPAi CAB037334.
MIMi 604276. gene.
neXtProti NX_Q99569.
PharmGKBi PA33359.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276924.
HOGENOMi HOG000231863.
HOVERGENi HBG004284.
InParanoidi Q99569.
OMAi GIGNLQR.
OrthoDBi EOG7X6KZB.
PhylomeDBi Q99569.
TreeFami TF321877.

Enzyme and pathway databases

SignaLinki Q99569.

Miscellaneous databases

ChiTaRSi PKP4. human.
GeneWikii PKP4.
GenomeRNAii 8502.
NextBioi 31815.
PROi Q99569.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99569.
Bgeei Q99569.
CleanExi HS_PKP4.
Genevestigatori Q99569.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028443. Plakophilin-4.
IPR028435. Plakophilin/d_Catenin.
[Graphical view ]
PANTHERi PTHR10372. PTHR10372. 1 hit.
PTHR10372:SF8. PTHR10372:SF8. 1 hit.
Pfami PF00514. Arm. 3 hits.
[Graphical view ]
SMARTi SM00185. ARM. 6 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins."
    Hatzfeld M., Nachtsheim C.
    J. Cell Sci. 109:2767-2778(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Frontal cortex.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314; SER-406 AND TYR-415, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "The armadillo protein p0071 regulates Rho signalling during cytokinesis."
    Wolf A., Keil R., Gotzl O., Mun A., Schwarze K., Lederer M., Huttelmaier S., Hatzfeld M.
    Nat. Cell Biol. 8:1432-1440(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ECT2 AND RHOA, SUBCELLULAR LOCATION.
  7. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-611.
    Tissue: Mammary cancer.
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314; SER-403 AND SER-406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; SER-281; SER-314 AND SER-327, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells."
    Stenzel N., Fetzer C.P., Heumann R., Erdmann K.S.
    J. Cell Sci. 122:3374-3384(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FRMPD2.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-415, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221; SER-231 AND SER-776, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPKP4_HUMAN
AccessioniPrimary (citable) accession number: Q99569
Secondary accession number(s): Q86W91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi