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Protein

Plakophilin-4

Gene

PKP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.1 Publication

GO - Biological processi

  • cell-cell junction assembly Source: UniProtKB
  • cell-cell signaling Source: UniProtKB
  • positive regulation of cytokinesis Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • regulation of cell adhesion Source: UniProtKB
  • single organismal cell-cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144283-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.
SignaLinkiQ99569.

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-4
Alternative name(s):
p0071
Gene namesi
Name:PKP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:9026. PKP4.

Subcellular locationi

GO - Cellular componenti

  • cell-cell junction Source: UniProtKB
  • cell junction Source: HPA
  • cytoplasm Source: UniProtKB
  • cytoplasmic side of plasma membrane Source: UniProtKB
  • cytoskeleton Source: UniProtKB
  • desmosome Source: UniProtKB
  • midbody Source: UniProtKB
  • mitotic spindle Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • postsynaptic density Source: Ensembl
  • spindle midzone Source: UniProtKB
  • spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8502.
OpenTargetsiENSG00000144283.
PharmGKBiPA33359.

Polymorphism and mutation databases

BioMutaiPKP4.
DMDMi313104155.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642891 – 1192Plakophilin-4Add BLAST1192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineCombined sources1
Modified residuei84PhosphothreonineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei132PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei221PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei236PhosphoserineCombined sources1
Modified residuei254Omega-N-methylarginineBy similarity1
Modified residuei270Omega-N-methylarginineBy similarity1
Modified residuei273PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei372PhosphotyrosineBy similarity1
Modified residuei392PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei412PhosphothreonineBy similarity1
Modified residuei415PhosphotyrosineCombined sources1
Modified residuei422PhosphoserineBy similarity1
Modified residuei427PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei478PhosphotyrosineBy similarity1
Modified residuei510PhosphoserineBy similarity1
Modified residuei512PhosphoserineBy similarity1
Modified residuei515PhosphoserineBy similarity1
Modified residuei776PhosphoserineCombined sources1
Modified residuei1013PhosphothreonineBy similarity1
Modified residuei1017PhosphothreonineBy similarity1
Modified residuei1045PhosphoserineBy similarity1
Modified residuei1091PhosphoserineBy similarity1
Modified residuei1100PhosphoserineBy similarity1
Modified residuei1135PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ99569.
MaxQBiQ99569.
PaxDbiQ99569.
PeptideAtlasiQ99569.
PRIDEiQ99569.

PTM databases

iPTMnetiQ99569.
PhosphoSitePlusiQ99569.
SwissPalmiQ99569.

Expressioni

Gene expression databases

BgeeiENSG00000144283.
CleanExiHS_PKP4.
ExpressionAtlasiQ99569. baseline and differential.
GenevisibleiQ99569. HS.

Organism-specific databases

HPAiCAB037334.
HPA066647.

Interactioni

Subunit structurei

Interacts with PDZD2 (By similarity). Interacts (via the C-terminus) with FRMPD2 (via the PDZ 2 domain). Interacts with RHOA; the interaction is detected at the midbody. Interacts with ECT2; the interaction is detected at the midbody.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATPAF2Q8N5M13EBI-726447,EBI-1166928
ERBINQ96RT13EBI-726447,EBI-993903
ERBINQ96RT1-24EBI-726447,EBI-8449250
GOLGA2Q083793EBI-726447,EBI-618309
LZTS2Q9BRK43EBI-726447,EBI-741037
TRIM23P364063EBI-726447,EBI-740098

Protein-protein interaction databases

BioGridi114074. 51 interactors.
IntActiQ99569. 33 interactors.
MINTiMINT-88417.
STRINGi9606.ENSP00000374409.

Structurei

3D structure databases

ProteinModelPortaliQ99569.
SMRiQ99569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati415 – 455ARM 1Add BLAST41
Repeati518 – 557ARM 2Add BLAST40
Repeati560 – 599ARM 3Add BLAST40
Repeati604 – 644ARM 4Add BLAST41
Repeati660 – 702ARM 5Add BLAST43
Repeati706 – 751ARM 6Add BLAST46
Repeati815 – 855ARM 7Add BLAST41
Repeati862 – 901ARM 8Add BLAST40
Repeati950 – 993ARM 9Add BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili36 – 70Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi788 – 794Poly-Lys7

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000231863.
HOVERGENiHBG004284.
InParanoidiQ99569.
PhylomeDBiQ99569.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028443. Plakophilin-4.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 2 hits.
PTHR10372:SF8. PTHR10372:SF8. 2 hits.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99569-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAPEQASLV EEGQPQTRQE AASTGPGMEP ETTATTILAS VKEQELQFQR
60 70 80 90 100
LTRELEVERQ IVASQLERCR LGAESPSIAS TSSTEKSFPW RSTDVPNTGV
110 120 130 140 150
SKPRVSDAVQ PNNYLIRTEP EQGTLYSPEQ TSLHESEGSL GNSRSSTQMN
160 170 180 190 200
SYSDSGYQEA GSFHNSQNVS KADNRQQHSF IGSTNNHVVR NSRAEGQTLV
210 220 230 240 250
QPSVANRAMR RVSSVPSRAQ SPSYVISTGV SPSRGSLRTS LGSGFGSPSV
260 270 280 290 300
TDPRPLNPSA YSSTTLPAAR AASPYSQRPA SPTAIRRIGS VTSRQTSNPN
310 320 330 340 350
GPTPQYQTTA RVGSPLTLTD AQTRVASPSQ GQVGSSSPKR SGMTAVPQHL
360 370 380 390 400
GPSLQRTVHD MEQFGQQQYD IYERMVPPRP DSLTGLRSSY ASQHSQLGQD
410 420 430 440 450
LRSAVSPDLH ITPIYEGRTY YSPVYRSPNH GTVELQGSQT ALYRTGSVGI
460 470 480 490 500
GNLQRTSSQR STLTYQRNNY ALNTTATYAE PYRPIQYRVQ ECNYNRLQHA
510 520 530 540 550
VPADDGTTRS PSIDSIQKDP REFAWRDPEL PEVIHMLQHQ FPSVQANAAA
560 570 580 590 600
YLQHLCFGDN KVKMEVCRLG GIKHLVDLLD HRVLEVQKNA CGALRNLVFG
610 620 630 640 650
KSTDENKIAM KNVGGIPALL RLLRKSIDAE VRELVTGVLW NLSSCDAVKM
660 670 680 690 700
TIIRDALSTL TNTVIVPHSG WNNSSFDDDH KIKFQTSLVL RNTTGCLRNL
710 720 730 740 750
SSAGEEARKQ MRSCEGLVDS LLYVIHTCVN TSDYDSKTVE NCVCTLRNLS
760 770 780 790 800
YRLELEVPQA RLLGLNELDD LLGKESPSKD SEPSCWGKKK KKKKRTPQED
810 820 830 840 850
QWDGVGPIPG LSKSPKGVEM LWHPSVVKPY LTLLAESSNP ATLEGSAGSL
860 870 880 890 900
QNLSAGNWKF AAYIRAAVRK EKGLPILVEL LRMDNDRVVS SVATALRNMA
910 920 930 940 950
LDVRNKELIG KYAMRDLVNR LPGGNGPSVL SDETMAAICC ALHEVTSKNM
960 970 980 990 1000
ENAKALADSG GIEKLVNITK GRGDRSSLKV VKAAAQVLNT LWQYRDLRSI
1010 1020 1030 1040 1050
YKKDGWNQNH FITPVSTLER DRFKSHPSLS TTNQQMSPII QSVGSTSSSP
1060 1070 1080 1090 1100
ALLGIRDPRS EYDRTQPPMQ YYNSQGDATH KGLYPGSSKP SPIYISSYSS
1110 1120 1130 1140 1150
PAREQNRRLQ HQQLYYSQDD SNRKNFDAYR LYLQSPHSYE DPYFDDRVHF
1160 1170 1180 1190
PASTDYSTQY GLKSTTNYVD FYSTKRPSYR AEQYPGSPDS WV
Length:1,192
Mass (Da):131,868
Last modified:November 30, 2010 - v2
Checksum:i48EA1579E323E019
GO
Isoform 2 (identifier: Q99569-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1043-1085: Missing.

Show »
Length:1,149
Mass (Da):127,144
Checksum:i060914C3E7947CB2
GO

Sequence cautioni

The sequence CAA57478 differs from that shown. Reason: Frameshift at positions 334, 337, 864 and 874.Curated
The sequence CAA57478 differs from that shown. Reason: Erroneous termination at position 1193. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41V → M in AAH50308 (PubMed:15489334).Curated1
Sequence conflicti223S → Y in AAH50308 (PubMed:15489334).Curated1
Sequence conflicti235G → W in AAH50308 (PubMed:15489334).Curated1
Sequence conflicti335S → V in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti336S → V in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti447S → V in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti448V → S in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti538Q → E in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti701S → T in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti766N → D in AAH50308 (PubMed:15489334).Curated1
Sequence conflicti856G → S in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti865R → G in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti892V → G in CAA57478 (PubMed:8937994).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0067371043 – 1085Missing in isoform 2. 2 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81889 mRNA. Translation: CAA57478.1. Sequence problems.
AC005042 Genomic DNA. No translation available.
AC008070 Genomic DNA. No translation available.
BC050308 mRNA. Translation: AAH50308.1.
CCDSiCCDS33305.1. [Q99569-1]
CCDS33306.1. [Q99569-2]
RefSeqiNP_001005476.1. NM_001005476.2. [Q99569-2]
NP_001291898.1. NM_001304969.1.
NP_001291899.1. NM_001304970.1.
NP_003619.2. NM_003628.4. [Q99569-1]
XP_011510318.1. XM_011512016.1. [Q99569-1]
UniGeneiHs.407580.

Genome annotation databases

EnsembliENST00000389757; ENSP00000374407; ENSG00000144283. [Q99569-2]
ENST00000389759; ENSP00000374409; ENSG00000144283. [Q99569-1]
GeneIDi8502.
KEGGihsa:8502.
UCSCiuc002tzv.4. human. [Q99569-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81889 mRNA. Translation: CAA57478.1. Sequence problems.
AC005042 Genomic DNA. No translation available.
AC008070 Genomic DNA. No translation available.
BC050308 mRNA. Translation: AAH50308.1.
CCDSiCCDS33305.1. [Q99569-1]
CCDS33306.1. [Q99569-2]
RefSeqiNP_001005476.1. NM_001005476.2. [Q99569-2]
NP_001291898.1. NM_001304969.1.
NP_001291899.1. NM_001304970.1.
NP_003619.2. NM_003628.4. [Q99569-1]
XP_011510318.1. XM_011512016.1. [Q99569-1]
UniGeneiHs.407580.

3D structure databases

ProteinModelPortaliQ99569.
SMRiQ99569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114074. 51 interactors.
IntActiQ99569. 33 interactors.
MINTiMINT-88417.
STRINGi9606.ENSP00000374409.

PTM databases

iPTMnetiQ99569.
PhosphoSitePlusiQ99569.
SwissPalmiQ99569.

Polymorphism and mutation databases

BioMutaiPKP4.
DMDMi313104155.

Proteomic databases

EPDiQ99569.
MaxQBiQ99569.
PaxDbiQ99569.
PeptideAtlasiQ99569.
PRIDEiQ99569.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389757; ENSP00000374407; ENSG00000144283. [Q99569-2]
ENST00000389759; ENSP00000374409; ENSG00000144283. [Q99569-1]
GeneIDi8502.
KEGGihsa:8502.
UCSCiuc002tzv.4. human. [Q99569-1]

Organism-specific databases

CTDi8502.
DisGeNETi8502.
GeneCardsiPKP4.
H-InvDBHIX0002526.
HGNCiHGNC:9026. PKP4.
HPAiCAB037334.
HPA066647.
MIMi604276. gene.
neXtProtiNX_Q99569.
OpenTargetsiENSG00000144283.
PharmGKBiPA33359.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000231863.
HOVERGENiHBG004284.
InParanoidiQ99569.
PhylomeDBiQ99569.
TreeFamiTF321877.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144283-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.
SignaLinkiQ99569.

Miscellaneous databases

ChiTaRSiPKP4. human.
GeneWikiiPKP4.
GenomeRNAii8502.
PROiQ99569.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144283.
CleanExiHS_PKP4.
ExpressionAtlasiQ99569. baseline and differential.
GenevisibleiQ99569. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028443. Plakophilin-4.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 2 hits.
PTHR10372:SF8. PTHR10372:SF8. 2 hits.
PfamiPF00514. Arm. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKP4_HUMAN
AccessioniPrimary (citable) accession number: Q99569
Secondary accession number(s): Q86W91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.