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Protein

Nuclear pore complex protein Nup88

Gene

NUP88

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of nuclear pore complex.

GO - Molecular functioni

  • structural constituent of nuclear pore Source: InterPro
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup88
Alternative name(s):
88 kDa nucleoporin
Nucleoporin Nup88
Gene namesi
Name:NUP88
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108559.11
HGNCiHGNC:8067 NUP88
MIMi602552 gene
neXtProtiNX_Q99567

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4927
OpenTargetsiENSG00000108559
PharmGKBiPA31855

Polymorphism and mutation databases

BioMutaiNUP88
DMDMi25008854

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002048872 – 741Nuclear pore complex protein Nup88Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei379PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei442PhosphoserineCombined sources1
Modified residuei517PhosphoserineCombined sources1
Modified residuei525PhosphothreonineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei698PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99567
MaxQBiQ99567
PaxDbiQ99567
PeptideAtlasiQ99567
PRIDEiQ99567

PTM databases

iPTMnetiQ99567
PhosphoSitePlusiQ99567

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000108559
CleanExiHS_NUP88
ExpressionAtlasiQ99567 baseline and differential
GenevisibleiQ99567 HS

Organism-specific databases

HPAiCAB002209
HPA021816

Interactioni

Subunit structurei

Interacts with NUP214/CAN.1 Publication

Protein-protein interaction databases

BioGridi110981, 50 interactors
IntActiQ99567, 26 interactors
STRINGi9606.ENSP00000458954

Structurei

3D structure databases

ProteinModelPortaliQ99567
SMRiQ99567
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili585 – 651Sequence analysisAdd BLAST67

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4460 Eukaryota
ENOG410YC30 LUCA
GeneTreeiENSGT00390000015063
HOGENOMiHOG000234330
HOVERGENiHBG052700
InParanoidiQ99567
KOiK14318
OMAiLYENGET
OrthoDBiEOG091G0O97
PhylomeDBiQ99567
TreeFamiTF105307

Family and domain databases

InterProiView protein in InterPro
IPR019321 Nucleoporin_Nup88
IPR037700 NUP84
PANTHERiPTHR13257 PTHR13257, 1 hit
PfamiView protein in Pfam
PF10168 Nup88, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS
60 70 80 90 100
PPPQLLTRNV VFGLGGELFL WDGEDSSFLV VRLRGPSGGG EEPALSQYQR
110 120 130 140 150
LLCINPPLFE IYQVLLSPTQ HHVALIGIKG LMVLELPKRW GKNSEFEGGK
160 170 180 190 200
STVNCSTTPV AERFFTSSTS LTLKHAAWYP SEILDPHVVL LTSDNVIRIY
210 220 230 240 250
SLREPQTPTN VIILSEAEEE SLVLNKGRAY TASLGETAVA FDFGPLAAVP
260 270 280 290 300
KTLFGQNGKD EVVAYPLYIL YENGETFLTY ISLLHSPGNI GKLLGPLPMH
310 320 330 340 350
PAAEDNYGYD ACAVLCLPCV PNILVIATES GMLYHCVVLE GEEEDDHTSE
360 370 380 390 400
KSWDSRIDLI PSLYVFECVE LELALKLASG EDDPFDSDFS CPVKLHRDPK
410 420 430 440 450
CPSRYHCTHE AGVHSVGLTW IHKLHKFLGS DEEDKDSLQE LSTEQKCFVE
460 470 480 490 500
HILCTKPLPC RQPAPIRGFW IVPDILGPTM ICITSTYECL IWPLLSTVHP
510 520 530 540 550
ASPPLLCTRE DVEVAESPLR VLAETPDSFE KHIRSILQRS VANPAFLKAS
560 570 580 590 600
EKDIAPPPEE CLQLLSRATQ VFREQYILKQ DLAKEEIQRR VKLLCDQKKK
610 620 630 640 650
QLEDLSYCRE ERKSLREMAE RLADKYEEAK EKQEDIMNRM KKLLHSFHSE
660 670 680 690 700
LPVLSDSERD MKKELQLIPD QLRHLGNAIK QVTMKKDYQQ QKMEKVLSLP
710 720 730 740
KPTIILSAYQ RKCIQSILKE EGEHIREMVK QINDIRNHVN F
Length:741
Mass (Da):83,542
Last modified:November 8, 2002 - v2
Checksum:i954A8E2E203BC20B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247A → D in CAA69904 (PubMed:9049309).Curated1
Sequence conflicti291 – 301GKLLGPLPMHP → WKAVGSIAHAS in CAA69904 (PubMed:9049309).CuratedAdd BLAST11
Sequence conflicti456K → R in CAA69904 (PubMed:9049309).Curated1
Sequence conflicti518P → S in CAA69904 (PubMed:9049309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029340289N → S. Corresponds to variant dbSNP:rs1806245Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08612 mRNA Translation: CAA69904.1
CH471108 Genomic DNA Translation: EAW90340.1
CH471108 Genomic DNA Translation: EAW90342.1
BC000335 mRNA Translation: AAH00335.1
CCDSiCCDS11070.1
RefSeqiNP_001307582.1, NM_001320653.1
NP_002523.2, NM_002532.5
UniGeneiHs.584784
Hs.733301

Genome annotation databases

EnsembliENST00000573584; ENSP00000458954; ENSG00000108559
GeneIDi4927
KEGGihsa:4927
UCSCiuc002gbo.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNUP88_HUMAN
AccessioniPrimary (citable) accession number: Q99567
Secondary accession number(s): D3DTM2, Q9BWE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: May 23, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health