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Reviewed, UniProtKB/Swiss-Prot Q99567 (NUP88_HUMAN)

Last modified June 16, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Nuclear pore complex protein Nup88
Alternative name(s):
    Nucleoporin Nup88
    88 kDa nuclear pore complex protein
Gene names
Name: NUP88
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length741 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Essential component of nuclear pore complex.

Subunit structure

Interacts with NUP214/CAN. Ref.1

Subcellular location

Nucleusnuclear pore complex.

Tissue specificity

Ubiquitous.

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7

Ontologies

Keywords
   Biological processProtein transport
Translocation
Transport
mRNA transport
   Cellular componentNuclear pore complex
Nucleus
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological processintracellular protein transmembrane transport

Inferred from electronic annotation. Source: UniProtKB-KW

mRNA transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytosol

Inferred from Experiment. Source: Reactome

nuclear pore Ref.1

Traceable author statement. Source: ProtInc

   Molecular functiontransporter activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 741741Nuclear pore complex protein Nup88
PRO_0000204887

Regions

Coiled coil585 – 65167 Potential

Amino acid modifications

Modified residue351Phosphoserine Ref.6
Modified residue451Phosphoserine Ref.7
Modified residue501Phosphoserine Ref.6 Ref.7
Modified residue961Phosphoserine Ref.5
Modified residue4421Phosphoserine Ref.6
Modified residue5171Phosphoserine Ref.3 Ref.4 Ref.6 Ref.7
Modified residue5251Phosphothreonine Ref.4 Ref.6 Ref.7
Modified residue5401Phosphoserine Ref.7

Natural variations

Natural variant2891N → S: dbSNP rs1806245.
VAR_029340

Experimental info

Sequence conflict2471A → D in CAA69904. Ref.1
Sequence conflict291 – 30111GKLLGPLPMHP → WKAVGSIAHAS in CAA69904. Ref.1
Sequence conflict4561K → R in CAA69904. Ref.1
Sequence conflict5181P → S in CAA69904. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q99567-1 [UniParc].

Last modified November 8, 2002. Version 2.
Checksum: 954A8E2E203BC20B

FASTA74183,542
        10         20         30         40         50         60 
MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS PPPQLLTRNV 

        70         80         90        100        110        120 
VFGLGGELFL WDGEDSSFLV VRLRGPSGGG EEPALSQYQR LLCINPPLFE IYQVLLSPTQ 

       130        140        150        160        170        180 
HHVALIGIKG LMVLELPKRW GKNSEFEGGK STVNCSTTPV AERFFTSSTS LTLKHAAWYP 

       190        200        210        220        230        240 
SEILDPHVVL LTSDNVIRIY SLREPQTPTN VIILSEAEEE SLVLNKGRAY TASLGETAVA 

       250        260        270        280        290        300 
FDFGPLAAVP KTLFGQNGKD EVVAYPLYIL YENGETFLTY ISLLHSPGNI GKLLGPLPMH 

       310        320        330        340        350        360 
PAAEDNYGYD ACAVLCLPCV PNILVIATES GMLYHCVVLE GEEEDDHTSE KSWDSRIDLI 

       370        380        390        400        410        420 
PSLYVFECVE LELALKLASG EDDPFDSDFS CPVKLHRDPK CPSRYHCTHE AGVHSVGLTW 

       430        440        450        460        470        480 
IHKLHKFLGS DEEDKDSLQE LSTEQKCFVE HILCTKPLPC RQPAPIRGFW IVPDILGPTM 

       490        500        510        520        530        540 
ICITSTYECL IWPLLSTVHP ASPPLLCTRE DVEVAESPLR VLAETPDSFE KHIRSILQRS 

       550        560        570        580        590        600 
VANPAFLKAS EKDIAPPPEE CLQLLSRATQ VFREQYILKQ DLAKEEIQRR VKLLCDQKKK 

       610        620        630        640        650        660 
QLEDLSYCRE ERKSLREMAE RLADKYEEAK EKQEDIMNRM KKLLHSFHSE LPVLSDSERD 

       670        680        690        700        710        720 
MKKELQLIPD QLRHLGNAIK QVTMKKDYQQ QKMEKVLSLP KPTIILSAYQ RKCIQSILKE 

       730        740 
EGEHIREMVK QINDIRNHVN F 

« Hide

References

« Hide 'large scale' references
[1]"The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88."
Fornerod M., van Deursen J.M., van Baal S., Reynolds A., Davis D., Murti K.G., Fransen J., Grosveld G.
EMBO J. 16:807-816(1997) [PubMed: 9049309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH NUP214/CAN.
Tissue: Placenta.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, MASS SPECTROMETRY.
Tissue: Epithelium.
[4]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517 AND THR-525, MASS SPECTROMETRY.
Tissue: Epithelium.
[5]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, MASS SPECTROMETRY.
[6]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35; SER-50; SER-442; SER-517 AND THR-525, MASS SPECTROMETRY.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45; SER-50; SER-517; THR-525 AND SER-540, MASS SPECTROMETRY.
[8]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

Y08612 mRNA. Translation: CAA69904.1.
BC000335 mRNA. Translation: AAH00335.1.
IPIIPI00001738.
RefSeqNP_002523.2.
UniGeneHs.584784

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ99567. 1 interaction.

PTM databases

PhosphoSiteQ99567.

Proteomic databases

PeptideAtlasQ99567.
PRIDEQ99567.

Genome annotation databases

EnsemblENSG00000108559. Homo sapiens. [Contig view]
GeneID4927.
KEGGhsa:4927.
NMPDRfig|9606.3.peg.12953.

Organism-specific databases

GeneCardsGC17M005230.
H-InvDBHIX0013467.
HGNCHGNC:8067. NUP88.
HPACAB002209.
MIM602552. gene.
PharmGKBPA31855.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ99567.
HOVERGENQ99567.
OMAQ99567. LYENGET.

Enzyme and pathway databases

ReactomeREACT_6185. HIV Infection.

Gene expression databases

ArrayExpressQ99567.
BgeeQ99567.
CleanExHS_NUP88.
GermOnlineENSG00000108559. Homo sapiens.

Family and domain databases

InterProIPR019321. Nuclear_pore_Nup88.
[Graphical view]
PfamPF10168. Nup88. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio18975.
SOURCESearch...

Entry information

Entry nameNUP88_HUMAN
AccessionPrimary (citable) accession number: Q99567
Secondary accession number(s): Q9BWE5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: June 16, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents