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Q99567

- NUP88_HUMAN

UniProt

Q99567 - NUP88_HUMAN

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Protein

Nuclear pore complex protein Nup88

Gene

NUP88

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential component of nuclear pore complex.

GO - Molecular functioni

  1. transporter activity Source: ProtInc

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. cytokine-mediated signaling pathway Source: Reactome
  3. glucose transport Source: Reactome
  4. hexose transport Source: Reactome
  5. mitotic cell cycle Source: Reactome
  6. mitotic nuclear envelope disassembly Source: Reactome
  7. mRNA transport Source: UniProtKB-KW
  8. protein transport Source: UniProtKB-KW
  9. regulation of glucose transport Source: Reactome
  10. small molecule metabolic process Source: Reactome
  11. transmembrane transport Source: Reactome
  12. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup88
Alternative name(s):
88 kDa nucleoporin
Nucleoporin Nup88
Gene namesi
Name:NUP88
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:8067. NUP88.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. nuclear pore Source: ProtInc
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31855.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 741740Nuclear pore complex protein Nup88PRO_0000204887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei35 – 351Phosphoserine1 Publication
Modified residuei50 – 501Phosphoserine1 Publication
Modified residuei517 – 5171Phosphoserine7 Publications
Modified residuei525 – 5251Phosphothreonine4 Publications
Modified residuei540 – 5401Phosphoserine1 Publication
Modified residuei698 – 6981PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ99567.
PaxDbiQ99567.
PeptideAtlasiQ99567.
PRIDEiQ99567.

PTM databases

PhosphoSiteiQ99567.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ99567.
CleanExiHS_NUP88.
ExpressionAtlasiQ99567. baseline and differential.
GenevestigatoriQ99567.

Organism-specific databases

HPAiCAB002209.
HPA021816.

Interactioni

Subunit structurei

Interacts with NUP214/CAN.1 Publication

Protein-protein interaction databases

BioGridi110981. 27 interactions.
IntActiQ99567. 13 interactions.
MINTiMINT-191368.
STRINGi9606.ENSP00000225696.

Structurei

3D structure databases

ProteinModelPortaliQ99567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili585 – 65167Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG274278.
GeneTreeiENSGT00390000015063.
HOGENOMiHOG000234330.
HOVERGENiHBG052700.
InParanoidiQ99567.
KOiK14318.
OMAiLYENGET.
OrthoDBiEOG72C500.
PhylomeDBiQ99567.
TreeFamiTF105307.

Family and domain databases

InterProiIPR019321. Nucleoporin_Nup88.
[Graphical view]
PfamiPF10168. Nup88. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99567-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS
60 70 80 90 100
PPPQLLTRNV VFGLGGELFL WDGEDSSFLV VRLRGPSGGG EEPALSQYQR
110 120 130 140 150
LLCINPPLFE IYQVLLSPTQ HHVALIGIKG LMVLELPKRW GKNSEFEGGK
160 170 180 190 200
STVNCSTTPV AERFFTSSTS LTLKHAAWYP SEILDPHVVL LTSDNVIRIY
210 220 230 240 250
SLREPQTPTN VIILSEAEEE SLVLNKGRAY TASLGETAVA FDFGPLAAVP
260 270 280 290 300
KTLFGQNGKD EVVAYPLYIL YENGETFLTY ISLLHSPGNI GKLLGPLPMH
310 320 330 340 350
PAAEDNYGYD ACAVLCLPCV PNILVIATES GMLYHCVVLE GEEEDDHTSE
360 370 380 390 400
KSWDSRIDLI PSLYVFECVE LELALKLASG EDDPFDSDFS CPVKLHRDPK
410 420 430 440 450
CPSRYHCTHE AGVHSVGLTW IHKLHKFLGS DEEDKDSLQE LSTEQKCFVE
460 470 480 490 500
HILCTKPLPC RQPAPIRGFW IVPDILGPTM ICITSTYECL IWPLLSTVHP
510 520 530 540 550
ASPPLLCTRE DVEVAESPLR VLAETPDSFE KHIRSILQRS VANPAFLKAS
560 570 580 590 600
EKDIAPPPEE CLQLLSRATQ VFREQYILKQ DLAKEEIQRR VKLLCDQKKK
610 620 630 640 650
QLEDLSYCRE ERKSLREMAE RLADKYEEAK EKQEDIMNRM KKLLHSFHSE
660 670 680 690 700
LPVLSDSERD MKKELQLIPD QLRHLGNAIK QVTMKKDYQQ QKMEKVLSLP
710 720 730 740
KPTIILSAYQ RKCIQSILKE EGEHIREMVK QINDIRNHVN F
Length:741
Mass (Da):83,542
Last modified:November 8, 2002 - v2
Checksum:i954A8E2E203BC20B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti247 – 2471A → D in CAA69904. (PubMed:9049309)Curated
Sequence conflicti291 – 30111GKLLGPLPMHP → WKAVGSIAHAS in CAA69904. (PubMed:9049309)CuratedAdd
BLAST
Sequence conflicti456 – 4561K → R in CAA69904. (PubMed:9049309)Curated
Sequence conflicti518 – 5181P → S in CAA69904. (PubMed:9049309)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti289 – 2891N → S.
Corresponds to variant rs1806245 [ dbSNP | Ensembl ].
VAR_029340

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08612 mRNA. Translation: CAA69904.1.
CH471108 Genomic DNA. Translation: EAW90340.1.
CH471108 Genomic DNA. Translation: EAW90342.1.
BC000335 mRNA. Translation: AAH00335.1.
CCDSiCCDS11070.1.
RefSeqiNP_002523.2. NM_002532.4.
UniGeneiHs.584784.

Genome annotation databases

EnsembliENST00000573584; ENSP00000458954; ENSG00000108559.
GeneIDi4927.
KEGGihsa:4927.
UCSCiuc002gbo.2. human.

Polymorphism databases

DMDMi25008854.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08612 mRNA. Translation: CAA69904.1 .
CH471108 Genomic DNA. Translation: EAW90340.1 .
CH471108 Genomic DNA. Translation: EAW90342.1 .
BC000335 mRNA. Translation: AAH00335.1 .
CCDSi CCDS11070.1.
RefSeqi NP_002523.2. NM_002532.4.
UniGenei Hs.584784.

3D structure databases

ProteinModelPortali Q99567.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110981. 27 interactions.
IntActi Q99567. 13 interactions.
MINTi MINT-191368.
STRINGi 9606.ENSP00000225696.

PTM databases

PhosphoSitei Q99567.

Polymorphism databases

DMDMi 25008854.

Proteomic databases

MaxQBi Q99567.
PaxDbi Q99567.
PeptideAtlasi Q99567.
PRIDEi Q99567.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000573584 ; ENSP00000458954 ; ENSG00000108559 .
GeneIDi 4927.
KEGGi hsa:4927.
UCSCi uc002gbo.2. human.

Organism-specific databases

CTDi 4927.
GeneCardsi GC17M005180.
HGNCi HGNC:8067. NUP88.
HPAi CAB002209.
HPA021816.
MIMi 602552. gene.
neXtProti NX_Q99567.
PharmGKBi PA31855.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG274278.
GeneTreei ENSGT00390000015063.
HOGENOMi HOG000234330.
HOVERGENi HBG052700.
InParanoidi Q99567.
KOi K14318.
OMAi LYENGET.
OrthoDBi EOG72C500.
PhylomeDBi Q99567.
TreeFami TF105307.

Enzyme and pathway databases

Reactomei REACT_115831. ISG15 antiviral mechanism.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.

Miscellaneous databases

ChiTaRSi NUP88. human.
GeneWikii NUP88.
GenomeRNAii 4927.
NextBioi 18975.
PROi Q99567.
SOURCEi Search...

Gene expression databases

Bgeei Q99567.
CleanExi HS_NUP88.
ExpressionAtlasi Q99567. baseline and differential.
Genevestigatori Q99567.

Family and domain databases

InterProi IPR019321. Nucleoporin_Nup88.
[Graphical view ]
Pfami PF10168. Nup88. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88."
    Fornerod M., van Deursen J.M., van Baal S., Reynolds A., Davis D., Murti K.G., Fransen J., Grosveld G.
    EMBO J. 16:807-816(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH NUP214/CAN.
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517 AND THR-525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517 AND THR-525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35; SER-50; SER-517 AND THR-525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517; THR-525 AND SER-540, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNUP88_HUMAN
AccessioniPrimary (citable) accession number: Q99567
Secondary accession number(s): D3DTM2, Q9BWE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3