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Protein

Nuclear pore complex protein Nup88

Gene

NUP88

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of nuclear pore complex.

GO - Molecular functioni

  • transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108559-MONOMER.
ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-159227. Transport of the SLBP independent Mature mRNA.
R-HSA-159230. Transport of the SLBP Dependant Mature mRNA.
R-HSA-159231. Transport of Mature mRNA Derived from an Intronless Transcript.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-165054. Rev-mediated nuclear export of HIV RNA.
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-168325. Viral Messenger RNA Synthesis.
R-HSA-168333. NEP/NS2 Interacts with the Cellular Export Machinery.
R-HSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
R-HSA-191859. snRNP Assembly.
R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-HSA-3371453. Regulation of HSF1-mediated heat shock response.
R-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-4615885. SUMOylation of DNA replication proteins.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-6784531. tRNA processing in the nucleus.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup88
Alternative name(s):
88 kDa nucleoporin
Nucleoporin Nup88
Gene namesi
Name:NUP88
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8067. NUP88.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • nuclear pore Source: MGI
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4927.
OpenTargetsiENSG00000108559.
PharmGKBiPA31855.

Polymorphism and mutation databases

BioMutaiNUP88.
DMDMi25008854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002048872 – 741Nuclear pore complex protein Nup88Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei379PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei442PhosphoserineCombined sources1
Modified residuei517PhosphoserineCombined sources1
Modified residuei525PhosphothreonineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei698PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99567.
MaxQBiQ99567.
PaxDbiQ99567.
PeptideAtlasiQ99567.
PRIDEiQ99567.

PTM databases

iPTMnetiQ99567.
PhosphoSitePlusiQ99567.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000108559.
CleanExiHS_NUP88.
ExpressionAtlasiQ99567. baseline and differential.
GenevisibleiQ99567. HS.

Organism-specific databases

HPAiCAB002209.
HPA021816.

Interactioni

Subunit structurei

Interacts with NUP214/CAN.1 Publication

Protein-protein interaction databases

BioGridi110981. 42 interactors.
IntActiQ99567. 25 interactors.
MINTiMINT-191368.
STRINGi9606.ENSP00000458954.

Structurei

3D structure databases

ProteinModelPortaliQ99567.
SMRiQ99567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili585 – 651Sequence analysisAdd BLAST67

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4460. Eukaryota.
ENOG410YC30. LUCA.
GeneTreeiENSGT00390000015063.
HOGENOMiHOG000234330.
HOVERGENiHBG052700.
InParanoidiQ99567.
KOiK14318.
OMAiAWYPSEI.
OrthoDBiEOG091G0O97.
PhylomeDBiQ99567.
TreeFamiTF105307.

Family and domain databases

InterProiIPR019321. Nucleoporin_Nup88.
[Graphical view]
PfamiPF10168. Nup88. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS
60 70 80 90 100
PPPQLLTRNV VFGLGGELFL WDGEDSSFLV VRLRGPSGGG EEPALSQYQR
110 120 130 140 150
LLCINPPLFE IYQVLLSPTQ HHVALIGIKG LMVLELPKRW GKNSEFEGGK
160 170 180 190 200
STVNCSTTPV AERFFTSSTS LTLKHAAWYP SEILDPHVVL LTSDNVIRIY
210 220 230 240 250
SLREPQTPTN VIILSEAEEE SLVLNKGRAY TASLGETAVA FDFGPLAAVP
260 270 280 290 300
KTLFGQNGKD EVVAYPLYIL YENGETFLTY ISLLHSPGNI GKLLGPLPMH
310 320 330 340 350
PAAEDNYGYD ACAVLCLPCV PNILVIATES GMLYHCVVLE GEEEDDHTSE
360 370 380 390 400
KSWDSRIDLI PSLYVFECVE LELALKLASG EDDPFDSDFS CPVKLHRDPK
410 420 430 440 450
CPSRYHCTHE AGVHSVGLTW IHKLHKFLGS DEEDKDSLQE LSTEQKCFVE
460 470 480 490 500
HILCTKPLPC RQPAPIRGFW IVPDILGPTM ICITSTYECL IWPLLSTVHP
510 520 530 540 550
ASPPLLCTRE DVEVAESPLR VLAETPDSFE KHIRSILQRS VANPAFLKAS
560 570 580 590 600
EKDIAPPPEE CLQLLSRATQ VFREQYILKQ DLAKEEIQRR VKLLCDQKKK
610 620 630 640 650
QLEDLSYCRE ERKSLREMAE RLADKYEEAK EKQEDIMNRM KKLLHSFHSE
660 670 680 690 700
LPVLSDSERD MKKELQLIPD QLRHLGNAIK QVTMKKDYQQ QKMEKVLSLP
710 720 730 740
KPTIILSAYQ RKCIQSILKE EGEHIREMVK QINDIRNHVN F
Length:741
Mass (Da):83,542
Last modified:November 8, 2002 - v2
Checksum:i954A8E2E203BC20B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247A → D in CAA69904 (PubMed:9049309).Curated1
Sequence conflicti291 – 301GKLLGPLPMHP → WKAVGSIAHAS in CAA69904 (PubMed:9049309).CuratedAdd BLAST11
Sequence conflicti456K → R in CAA69904 (PubMed:9049309).Curated1
Sequence conflicti518P → S in CAA69904 (PubMed:9049309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029340289N → S.Corresponds to variant rs1806245dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08612 mRNA. Translation: CAA69904.1.
CH471108 Genomic DNA. Translation: EAW90340.1.
CH471108 Genomic DNA. Translation: EAW90342.1.
BC000335 mRNA. Translation: AAH00335.1.
CCDSiCCDS11070.1.
RefSeqiNP_001307582.1. NM_001320653.1.
NP_002523.2. NM_002532.5.
UniGeneiHs.584784.
Hs.733301.

Genome annotation databases

EnsembliENST00000573584; ENSP00000458954; ENSG00000108559.
GeneIDi4927.
KEGGihsa:4927.
UCSCiuc002gbo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08612 mRNA. Translation: CAA69904.1.
CH471108 Genomic DNA. Translation: EAW90340.1.
CH471108 Genomic DNA. Translation: EAW90342.1.
BC000335 mRNA. Translation: AAH00335.1.
CCDSiCCDS11070.1.
RefSeqiNP_001307582.1. NM_001320653.1.
NP_002523.2. NM_002532.5.
UniGeneiHs.584784.
Hs.733301.

3D structure databases

ProteinModelPortaliQ99567.
SMRiQ99567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110981. 42 interactors.
IntActiQ99567. 25 interactors.
MINTiMINT-191368.
STRINGi9606.ENSP00000458954.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiQ99567.
PhosphoSitePlusiQ99567.

Polymorphism and mutation databases

BioMutaiNUP88.
DMDMi25008854.

Proteomic databases

EPDiQ99567.
MaxQBiQ99567.
PaxDbiQ99567.
PeptideAtlasiQ99567.
PRIDEiQ99567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000573584; ENSP00000458954; ENSG00000108559.
GeneIDi4927.
KEGGihsa:4927.
UCSCiuc002gbo.3. human.

Organism-specific databases

CTDi4927.
DisGeNETi4927.
GeneCardsiNUP88.
HGNCiHGNC:8067. NUP88.
HPAiCAB002209.
HPA021816.
MIMi602552. gene.
neXtProtiNX_Q99567.
OpenTargetsiENSG00000108559.
PharmGKBiPA31855.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4460. Eukaryota.
ENOG410YC30. LUCA.
GeneTreeiENSGT00390000015063.
HOGENOMiHOG000234330.
HOVERGENiHBG052700.
InParanoidiQ99567.
KOiK14318.
OMAiAWYPSEI.
OrthoDBiEOG091G0O97.
PhylomeDBiQ99567.
TreeFamiTF105307.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108559-MONOMER.
ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
R-HSA-159227. Transport of the SLBP independent Mature mRNA.
R-HSA-159230. Transport of the SLBP Dependant Mature mRNA.
R-HSA-159231. Transport of Mature mRNA Derived from an Intronless Transcript.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-165054. Rev-mediated nuclear export of HIV RNA.
R-HSA-168271. Transport of Ribonucleoproteins into the Host Nucleus.
R-HSA-168276. NS1 Mediated Effects on Host Pathways.
R-HSA-168325. Viral Messenger RNA Synthesis.
R-HSA-168333. NEP/NS2 Interacts with the Cellular Export Machinery.
R-HSA-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-HSA-180746. Nuclear import of Rev protein.
R-HSA-180910. Vpr-mediated nuclear import of PICs.
R-HSA-191859. snRNP Assembly.
R-HSA-3108214. SUMOylation of DNA damage response and repair proteins.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-HSA-3371453. Regulation of HSF1-mediated heat shock response.
R-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-4615885. SUMOylation of DNA replication proteins.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-6784531. tRNA processing in the nucleus.

Miscellaneous databases

ChiTaRSiNUP88. human.
GeneWikiiNUP88.
GenomeRNAii4927.
PROiQ99567.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108559.
CleanExiHS_NUP88.
ExpressionAtlasiQ99567. baseline and differential.
GenevisibleiQ99567. HS.

Family and domain databases

InterProiIPR019321. Nucleoporin_Nup88.
[Graphical view]
PfamiPF10168. Nup88. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUP88_HUMAN
AccessioniPrimary (citable) accession number: Q99567
Secondary accession number(s): D3DTM2, Q9BWE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: November 30, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.