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Q99558

- M3K14_HUMAN

UniProt

Q99558 - M3K14_HUMAN

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Protein
Mitogen-activated protein kinase kinase kinase 14
Gene
MAP3K14, NIK
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei429 – 4291ATP By similarity
Active sitei515 – 5151Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi406 – 4149ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: UniProtKB-EC
  3. NF-kappaB-inducing kinase activity Source: UniProtKB
  4. protein binding Source: UniProtKB
  5. protein kinase activity Source: MGI

GO - Biological processi

  1. I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  2. NIK/NF-kappaB signaling Source: GOC
  3. T cell costimulation Source: Reactome
  4. cellular response to mechanical stimulus Source: UniProtKB
  5. immune response Source: UniProtKB
  6. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_19358. CD28 dependent PI3K/Akt signaling.
SignaLinkiQ99558.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25)
Alternative name(s):
NF-kappa-beta-inducing kinase
Short name:
HsNIK
Serine/threonine-protein kinase NIK
Gene namesi
Name:MAP3K14
Synonyms:NIK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:6853. MAP3K14.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi429 – 4302KK → AA: Loss of autophosphorylation and 'Lys-63'-linked ubiquitination. 1 Publication
Mutagenesisi559 – 5591T → A: Abolishes 'Lys-63'-linked ubiquitination. 2 Publications

Organism-specific databases

PharmGKBiPA30597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 947947Mitogen-activated protein kinase kinase kinase 14
PRO_0000086266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei559 – 5591Phosphothreonine1 Publication

Post-translational modificationi

Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization.2 Publications
Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it.2 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ99558.
PRIDEiQ99558.

PTM databases

PhosphoSiteiQ99558.

Expressioni

Tissue specificityi

Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.1 Publication

Gene expression databases

CleanExiHS_MAP3K14.
GenevestigatoriQ99558.

Interactioni

Subunit structurei

Interacts with TRAF2, TRAF5, TRAF6, IKKA and NFKB2/P100 By similarity. Interacts with TRAF3 and PELI3. Interacts with NIBP; the interaction is direct. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with ZFP91.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ALPLP051864EBI-358011,EBI-1054354
CHUKO151115EBI-358011,EBI-81249
ChukQ60680-23EBI-358011,EBI-646264From a different organism.
HSP90AB1P082382EBI-358011,EBI-352572
IKBKBO149203EBI-358011,EBI-81266

Protein-protein interaction databases

BioGridi114487. 32 interactions.
DIPiDIP-27522N.
IntActiQ99558. 27 interactions.
MINTiMINT-88636.
STRINGi9606.ENSP00000342059.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi335 – 3417
Beta strandi345 – 3473
Helixi350 – 36314
Beta strandi364 – 3663
Beta strandi377 – 3815
Turni395 – 3973
Beta strandi398 – 40811
Beta strandi410 – 41910
Turni420 – 4223
Beta strandi425 – 4328
Helixi433 – 4353
Helixi439 – 4424
Turni443 – 4464
Beta strandi455 – 4617
Beta strandi464 – 4696
Helixi477 – 4848
Helixi489 – 50719
Turni508 – 5103
Helixi518 – 5203
Beta strandi521 – 5233
Beta strandi530 – 5323
Helixi535 – 5373
Beta strandi543 – 5475
Turni550 – 5534
Helixi560 – 5623
Helixi565 – 5684
Helixi576 – 59116
Turni595 – 5995
Helixi605 – 6106
Helixi614 – 6174
Helixi624 – 63310
Turni638 – 6403
Helixi644 – 65815

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DN5X-ray2.50A/B330-680[»]
4G3DX-ray2.90A/B/D/E308-673[»]
4IDTX-ray2.40A/B330-680[»]
4IDVX-ray2.90A/B/C/D330-680[»]
ProteinModelPortaliQ99558.
SMRiQ99558. Positions 333-675.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini400 – 655256Protein kinase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni401 – 653253Interaction with ZFP91
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000113436.
HOVERGENiHBG052384.
InParanoidiQ99558.
KOiK04466.
PhylomeDBiQ99558.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR017425. MAPKKK14.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF038175. MAPKKK14. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99558-1 [UniParc]FASTAAdd to Basket

« Hide

MAVMEMACPG APGSAVGQQK ELPKAKEKTP PLGKKQSSVY KLEAVEKSPV    50
FCGKWEILND VITKGTAKEG SEAGPAAISI IAQAECENSQ EFSPTFSERI 100
FIAGSKQYSQ SESLDQIPNN VAHATEGKMA RVCWKGKRRS KARKKRKKKS 150
SKSLAHAGVA LAKPLPRTPE QESCTIPVQE DESPLGAPYV RNTPQFTKPL 200
KEPGLGQLCF KQLGEGLRPA LPRSELHKLI SPLQCLNHVW KLHHPQDGGP 250
LPLPTHPFPY SRLPHPFPFH PLQPWKPHPL ESFLGKLACV DSQKPLPDPH 300
LSKLACVDSP KPLPGPHLEP SCLSRGAHEK FSVEEYLVHA LQGSVSSGQA 350
HSLTSLAKTW AARGSRSREP SPKTEDNEGV LLTEKLKPVD YEYREEVHWA 400
THQLRLGRGS FGEVHRMEDK QTGFQCAVKK VRLEVFRAEE LMACAGLTSP 450
RIVPLYGAVR EGPWVNIFME LLEGGSLGQL VKEQGCLPED RALYYLGQAL 500
EGLEYLHSRR ILHGDVKADN VLLSSDGSHA ALCDFGHAVC LQPDGLGKSL 550
LTGDYIPGTE THMAPEVVLG RSCDAKVDVW SSCCMMLHML NGCHPWTQFF 600
RGPLCLKIAS EPPPVREIPP SCAPLTAQAI QEGLRKEPIH RVSAAELGGK 650
VNRALQQVGG LKSPWRGEYK EPRHPPPNQA NYHQTLHAQP RELSPRAPGP 700
RPAEETTGRA PKLQPPLPPE PPEPNKSPPL TLSKEESGMW EPLPLSSLEP 750
APARNPSSPE RKATVPEQEL QQLEIELFLN SLSQPFSLEE QEQILSCLSI 800
DSLSLSDDSE KNPSKASQSS RDTLSSGVHS WSSQAEARSS SWNMVLARGR 850
PTDTPSYFNG VKVQIQSLNG EHLHIREFHR VKVGDIATGI SSQIPAAAFS 900
LVTKDGQPVR YDMEVPDSGI DLQCTLAPDG SFAWSWRVKH GQLENRP 947
Length:947
Mass (Da):104,042
Last modified:April 4, 2006 - v2
Checksum:iC9D10F67FF7F48AC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401S → N.1 Publication
Corresponds to variant rs11574819 [ dbSNP | Ensembl ].
VAR_040711
Natural varianti255 – 2551T → M.
Corresponds to variant rs11574820 [ dbSNP | Ensembl ].
VAR_051641
Natural varianti514 – 5141G → K in a lung neuroendocrine carcinoma sample; somatic mutation; requires 2 nucleotide substitutions. 1 Publication
VAR_040712
Natural varianti674 – 6741H → Y.
Corresponds to variant rs11867907 [ dbSNP | Ensembl ].
VAR_051642
Natural varianti764 – 7641T → A.1 Publication
Corresponds to variant rs56302559 [ dbSNP | Ensembl ].
VAR_040713
Natural varianti852 – 8521T → I in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
VAR_040714
Natural varianti928 – 9281P → H.1 Publication
Corresponds to variant rs56036201 [ dbSNP | Ensembl ].
VAR_040715

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251A → P in CAA71306. 1 Publication
Sequence conflicti348 – 3481G → S in CAA71306. 1 Publication
Sequence conflicti880 – 8801R → G in BAF82892. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10256 mRNA. Translation: CAA71306.1.
AK290203 mRNA. Translation: BAF82892.1.
DQ314874 Genomic DNA. Translation: ABC40733.1.
CH471178 Genomic DNA. Translation: EAW51529.1.
CH471178 Genomic DNA. Translation: EAW51530.1.
BC035576 mRNA. Translation: AAH35576.1.
RefSeqiNP_003945.2. NM_003954.4.
UniGeneiHs.404183.
Hs.735695.

Genome annotation databases

GeneIDi9020.
KEGGihsa:9020.
UCSCiuc002iiv.1. human.

Polymorphism databases

DMDMi92090612.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10256 mRNA. Translation: CAA71306.1 .
AK290203 mRNA. Translation: BAF82892.1 .
DQ314874 Genomic DNA. Translation: ABC40733.1 .
CH471178 Genomic DNA. Translation: EAW51529.1 .
CH471178 Genomic DNA. Translation: EAW51530.1 .
BC035576 mRNA. Translation: AAH35576.1 .
RefSeqi NP_003945.2. NM_003954.4.
UniGenei Hs.404183.
Hs.735695.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DN5 X-ray 2.50 A/B 330-680 [» ]
4G3D X-ray 2.90 A/B/D/E 308-673 [» ]
4IDT X-ray 2.40 A/B 330-680 [» ]
4IDV X-ray 2.90 A/B/C/D 330-680 [» ]
ProteinModelPortali Q99558.
SMRi Q99558. Positions 333-675.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114487. 32 interactions.
DIPi DIP-27522N.
IntActi Q99558. 27 interactions.
MINTi MINT-88636.
STRINGi 9606.ENSP00000342059.

Chemistry

BindingDBi Q99558.
ChEMBLi CHEMBL5888.
GuidetoPHARMACOLOGYi 2074.

PTM databases

PhosphoSitei Q99558.

Polymorphism databases

DMDMi 92090612.

Proteomic databases

PaxDbi Q99558.
PRIDEi Q99558.

Protocols and materials databases

DNASUi 9020.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9020.
KEGGi hsa:9020.
UCSCi uc002iiv.1. human.

Organism-specific databases

CTDi 9020.
GeneCardsi GC17M043466.
HGNCi HGNC:6853. MAP3K14.
MIMi 604655. gene.
neXtProti NX_Q99558.
PharmGKBi PA30597.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000113436.
HOVERGENi HBG052384.
InParanoidi Q99558.
KOi K04466.
PhylomeDBi Q99558.

Enzyme and pathway databases

Reactomei REACT_19358. CD28 dependent PI3K/Akt signaling.
SignaLinki Q99558.

Miscellaneous databases

ChiTaRSi MAP3K14. human.
GeneWikii MAP3K14.
GenomeRNAii 9020.
NextBioi 33793.
PROi Q99558.
SOURCEi Search...

Gene expression databases

CleanExi HS_MAP3K14.
Genevestigatori Q99558.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR017425. MAPKKK14.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF038175. MAPKKK14. 1 hit.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1."
    Malinin N.L., Boldin M.P., Kovalenko A.V., Wallach D.
    Nature 385:540-544(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF 429-LYS-LYS-430, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  3. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  6. "Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein."
    Jensen L.E., Whitehead A.S.
    J. Immunol. 171:1500-1506(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PELI3.
  7. "NIK is a component of the EGF/heregulin receptor signaling complexes."
    Chen D., Xu L.G., Chen L., Li L., Zhai Z., Shu H.B.
    Oncogene 22:4348-4355(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRB10.
  8. "Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation."
    Liao G., Zhang M., Harhaj E.W., Sun S.C.
    J. Biol. Chem. 279:26243-26250(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, UBIQUITINATION, INTERACTION WITH TRAF3.
  9. "beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha."
    Witherow D.S., Garrison T.R., Miller W.E., Lefkowitz R.J.
    Proc. Natl. Acad. Sci. U.S.A. 101:8603-8607(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARRB1 AND ARRB2.
  10. "NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation."
    Hu W.-H., Pendergast J.S., Mo X.-M., Brambilla R., Bracchi-Ricard V., Li F., Walters W.M., Blits B., He L., Schaal S.M., Bethea J.R.
    J. Biol. Chem. 280:29233-29241(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NIBP.
  11. "Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation."
    Razani B., Zarnegar B., Ytterberg A.J., Shiba T., Dempsey P.W., Ware C.F., Loo J.A., Cheng G.
    Sci. Signal. 3:RA41-RA41(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY CHUK/IKKA.
  12. "Structure of the nuclear factor kappaB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation."
    Liu J., Sudom A., Min X., Cao Z., Gao X., Ayres M., Lee F., Cao P., Johnstone S., Plotnikova O., Walker N., Chen G., Wang Z.
    J. Biol. Chem. 287:27326-27334(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 330-680.
  13. "The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site."
    de Leon-Boenig G., Bowman K.K., Feng J.A., Crawford T., Everett C., Franke Y., Oh A., Stanley M., Staben S.T., Starovasnik M.A., Wallweber H.J., Wu J., Wu L.C., Johnson A.R., Hymowitz S.G.
    Structure 20:1704-1714(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 308-673.
  14. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-140; LYS-514; ALA-764; ILE-852 AND HIS-928.
  15. "An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination."
    Jin X., Jin H.R., Jung H.S., Lee S.J., Lee J.H., Lee J.J.
    J. Biol. Chem. 285:30539-30547(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-559, UBIQUITINATION, INTERACTION WITH ZFP91, MUTAGENESIS OF 429-LYS-LYS-430 AND THR-559.

Entry informationi

Entry nameiM3K14_HUMAN
AccessioniPrimary (citable) accession number: Q99558
Secondary accession number(s): A8K2D8, D3DX67, Q8IYN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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