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Protein

Transcription termination factor 1, mitochondrial

Gene

MTERF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.1 Publication

GO - Molecular functioni

  • double-stranded DNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • DNA geometric change Source: UniProtKB
  • DNA-templated transcription, termination Source: UniProtKB
  • mitochondrion organization Source: Reactome
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • termination of mitochondrial transcription Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127989-MONOMER.
ReactomeiR-HSA-163316. Mitochondrial transcription termination.
R-HSA-2151201. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 1, mitochondrial
Alternative name(s):
Mitochondrial transcription termination factor 1
Short name:
mTERF
Short name:
mTERF1
Gene namesi
Name:MTERF1
Synonyms:MTERF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21463. MTERF1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: Reactome
  • mitochondrial nucleoid Source: BHF-UCL
  • mitochondrion Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi162R → A: Reduces affinity for cognate DNA; when associated with A-243 and A-288. 1 Publication1
Mutagenesisi169R → A: Strongly reduces affinity for DNA. Strongly reduces transcription termination. 1 Publication1
Mutagenesisi202R → A: Strongly reduces affinity for DNA. Strongly reduces transcription termination. 1 Publication1
Mutagenesisi243F → A: Reduces affinity for cognate DNA; when associated with A-162 and A-288. 1 Publication1
Mutagenesisi251R → A: Strongly reduces transcription termination. 1 Publication1
Mutagenesisi288Y → A: Reduces affinity for cognate DNA; when associated with A-162 and A-243. 1 Publication1
Mutagenesisi350R → A: Reduces transcription termination. 1 Publication1
Mutagenesisi387R → A: Strongly reduces affinity for cognate DNA. Strongly reduces transcription termination. 1 Publication1

Organism-specific databases

DisGeNETi7978.
OpenTargetsiENSG00000127989.
PharmGKBiPA142671308.

Polymorphism and mutation databases

BioMutaiMTERF.
DMDMi12644536.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 57MitochondrionSequence analysisAdd BLAST57
ChainiPRO_000002177958 – 399Transcription termination factor 1, mitochondrialAdd BLAST342

Post-translational modificationi

Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99551.
MaxQBiQ99551.
PaxDbiQ99551.
PeptideAtlasiQ99551.
PRIDEiQ99551.

PTM databases

iPTMnetiQ99551.
PhosphoSitePlusiQ99551.

Expressioni

Gene expression databases

BgeeiENSG00000127989.
CleanExiHS_MTERF.
ExpressionAtlasiQ99551. baseline and differential.

Organism-specific databases

HPAiHPA044894.
HPA069560.

Interactioni

Subunit structurei

Monomer.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei162Interaction with DNA1
Sitei202Interaction with DNA1
Sitei243Interaction with DNA1
Sitei288Interaction with DNA1
Sitei350Interaction with DNA1

Binary interactionsi

WithEntry#Exp.IntActNotes
DNAJC21Q5F1R62EBI-2690033,EBI-2654581

Protein-protein interaction databases

BioGridi113691. 9 interactors.
IntActiQ99551. 13 interactors.
MINTiMINT-8052274.
STRINGi9606.ENSP00000248643.

Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi75 – 82Combined sources8
Helixi86 – 92Combined sources7
Helixi94 – 98Combined sources5
Helixi104 – 113Combined sources10
Helixi118 – 127Combined sources10
Helixi129 – 133Combined sources5
Helixi136 – 146Combined sources11
Turni147 – 149Combined sources3
Helixi153 – 162Combined sources10
Helixi165 – 168Combined sources4
Helixi173 – 185Combined sources13
Helixi190 – 199Combined sources10
Helixi201 – 204Combined sources4
Helixi208 – 224Combined sources17
Helixi230 – 240Combined sources11
Helixi242 – 246Combined sources5
Helixi249 – 262Combined sources14
Helixi267 – 275Combined sources9
Turni276 – 278Combined sources3
Helixi279 – 283Combined sources5
Helixi288 – 301Combined sources14
Turni302 – 304Combined sources3
Helixi307 – 315Combined sources9
Helixi318 – 322Combined sources5
Helixi325 – 336Combined sources12
Turni337 – 339Combined sources3
Helixi342 – 347Combined sources6
Helixi349 – 353Combined sources5
Helixi356 – 367Combined sources12
Turni368 – 370Combined sources3
Beta strandi373 – 376Combined sources4
Helixi378 – 382Combined sources5
Helixi385 – 394Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MVAX-ray2.20O57-396[»]
3MVBX-ray2.79O57-396[»]
3N6SX-ray3.10A56-399[»]
3N7QX-ray2.40A99-399[»]
5CKYX-ray2.62O73-396[»]
5CO0X-ray2.65O73-396[»]
5CRJX-ray2.59O73-396[»]
5CRKX-ray2.48O73-396[»]
ProteinModelPortaliQ99551.
SMRiQ99551.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99551.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni169 – 170Interaction with DNA2
Regioni247 – 251Interaction with DNA5
Regioni324 – 331Interaction with DNA8
Regioni355 – 358Interaction with DNA4
Regioni384 – 391Interaction with DNA8

Domaini

Contains nine structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a left-handed superhelical assembly with a solenoid structure that wraps itself around DNA.2 Publications

Sequence similaritiesi

Belongs to the mTERF family.Curated

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG1267. Eukaryota.
ENOG410XT49. LUCA.
GeneTreeiENSGT00530000063817.
HOGENOMiHOG000252957.
HOVERGENiHBG052524.
InParanoidiQ99551.
KOiK15031.
OMAiFGSRCWM.
OrthoDBiEOG091G0AQ5.
PhylomeDBiQ99551.
TreeFamiTF330821.

Family and domain databases

InterProiIPR003690. MTERF.
[Graphical view]
PfamiPF02536. mTERF. 1 hit.
[Graphical view]
SMARTiSM00733. Mterf. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSLSLGQTS ISKGLNYLTI MAPGNLWHMR NNFLFGSRCW MTRFSAENIF
60 70 80 90 100
KSVSFRLFGV KCHNTDSEPL KNEDLLKNLL TMGVDIDMAR KRQPGVFHRM
110 120 130 140 150
ITNEQDLKMF LLSKGASKEV IASIISRYPR AITRTPENLS KRWDLWRKIV
160 170 180 190 200
TSDLEIVNIL ERSPESFFRS NNNLNLENNI KFLYSVGLTR KCLCRLLTNA
210 220 230 240 250
PRTFSNSLDL NKQMVEFLQA AGLSLGHNDP ADFVRKIIFK NPFILIQSTK
260 270 280 290 300
RVKANIEFLR STFNLNSEEL LVLICGPGAE ILDLSNDYAR RSYANIKEKL
310 320 330 340 350
FSLGCTEEEV QKFVLSYPDV IFLAEKKFND KIDCLMEENI SISQIIENPR
360 370 380 390
VLDSSISTLK SRIKELVNAG CNLSTLNITL LSWSKKRYEA KLKKLSRFA
Length:399
Mass (Da):45,778
Last modified:May 1, 1997 - v1
Checksum:iA0C6CE4A8498526E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053785231A → T.1 PublicationCorresponds to variant rs17856025dbSNPEnsembl.1
Natural variantiVAR_024237294A → T.1 PublicationCorresponds to variant rs10266424dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09615 mRNA. Translation: CAA70830.1.
AK222730 mRNA. Translation: BAD96450.1.
AC003086 Genomic DNA. Translation: AAB83941.1.
CH236949 Genomic DNA. Translation: EAL24159.1.
CH471091 Genomic DNA. Translation: EAW76869.1.
BC000965 mRNA. Translation: AAH00965.1.
BC108648 mRNA. Translation: AAI08649.1.
BC130389 mRNA. Translation: AAI30390.1.
BC130391 mRNA. Translation: AAI30392.1.
CCDSiCCDS5621.1.
RefSeqiNP_001288063.1. NM_001301134.1.
NP_001288064.1. NM_001301135.1.
NP_008911.1. NM_006980.4.
XP_005250650.1. XM_005250593.3.
XP_006716189.1. XM_006716126.3.
UniGeneiHs.532216.

Genome annotation databases

EnsembliENST00000351870; ENSP00000248643; ENSG00000127989.
GeneIDi7978.
KEGGihsa:7978.
UCSCiuc003ulc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09615 mRNA. Translation: CAA70830.1.
AK222730 mRNA. Translation: BAD96450.1.
AC003086 Genomic DNA. Translation: AAB83941.1.
CH236949 Genomic DNA. Translation: EAL24159.1.
CH471091 Genomic DNA. Translation: EAW76869.1.
BC000965 mRNA. Translation: AAH00965.1.
BC108648 mRNA. Translation: AAI08649.1.
BC130389 mRNA. Translation: AAI30390.1.
BC130391 mRNA. Translation: AAI30392.1.
CCDSiCCDS5621.1.
RefSeqiNP_001288063.1. NM_001301134.1.
NP_001288064.1. NM_001301135.1.
NP_008911.1. NM_006980.4.
XP_005250650.1. XM_005250593.3.
XP_006716189.1. XM_006716126.3.
UniGeneiHs.532216.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MVAX-ray2.20O57-396[»]
3MVBX-ray2.79O57-396[»]
3N6SX-ray3.10A56-399[»]
3N7QX-ray2.40A99-399[»]
5CKYX-ray2.62O73-396[»]
5CO0X-ray2.65O73-396[»]
5CRJX-ray2.59O73-396[»]
5CRKX-ray2.48O73-396[»]
ProteinModelPortaliQ99551.
SMRiQ99551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113691. 9 interactors.
IntActiQ99551. 13 interactors.
MINTiMINT-8052274.
STRINGi9606.ENSP00000248643.

PTM databases

iPTMnetiQ99551.
PhosphoSitePlusiQ99551.

Polymorphism and mutation databases

BioMutaiMTERF.
DMDMi12644536.

Proteomic databases

EPDiQ99551.
MaxQBiQ99551.
PaxDbiQ99551.
PeptideAtlasiQ99551.
PRIDEiQ99551.

Protocols and materials databases

DNASUi7978.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351870; ENSP00000248643; ENSG00000127989.
GeneIDi7978.
KEGGihsa:7978.
UCSCiuc003ulc.2. human.

Organism-specific databases

CTDi7978.
DisGeNETi7978.
GeneCardsiMTERF1.
HGNCiHGNC:21463. MTERF1.
HPAiHPA044894.
HPA069560.
MIMi602318. gene.
neXtProtiNX_Q99551.
OpenTargetsiENSG00000127989.
PharmGKBiPA142671308.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1267. Eukaryota.
ENOG410XT49. LUCA.
GeneTreeiENSGT00530000063817.
HOGENOMiHOG000252957.
HOVERGENiHBG052524.
InParanoidiQ99551.
KOiK15031.
OMAiFGSRCWM.
OrthoDBiEOG091G0AQ5.
PhylomeDBiQ99551.
TreeFamiTF330821.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127989-MONOMER.
ReactomeiR-HSA-163316. Mitochondrial transcription termination.
R-HSA-2151201. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

ChiTaRSiMTERF. human.
EvolutionaryTraceiQ99551.
GeneWikiiMTERF.
GenomeRNAii7978.
PROiQ99551.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127989.
CleanExiHS_MTERF.
ExpressionAtlasiQ99551. baseline and differential.

Family and domain databases

InterProiIPR003690. MTERF.
[Graphical view]
PfamiPF02536. mTERF. 1 hit.
[Graphical view]
SMARTiSM00733. Mterf. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTEF1_HUMAN
AccessioniPrimary (citable) accession number: Q99551
Secondary accession number(s): A4D1E3
, Q32NF8, Q53H51, Q9BVR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.