##gff-version 3 Q99549 UniProtKB Chain 1 860 . . . ID=PRO_0000080244;Note=M-phase phosphoprotein 8 Q99549 UniProtKB Domain 59 118 . . . Note=Chromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00053 Q99549 UniProtKB Repeat 600 629 . . . Note=ANK 1 Q99549 UniProtKB Repeat 633 662 . . . Note=ANK 2 Q99549 UniProtKB Repeat 666 695 . . . Note=ANK 3 Q99549 UniProtKB Repeat 699 728 . . . Note=ANK 4 Q99549 UniProtKB Region 80 87 . . . Note=Histone H3K9me3 binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21419134;Dbxref=PMID:21419134 Q99549 UniProtKB Region 129 191 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99549 UniProtKB Region 206 440 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99549 UniProtKB Region 431 560 . . . Note=Interaction with humanin;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23532874;Dbxref=PMID:23532874 Q99549 UniProtKB Region 458 496 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99549 UniProtKB Compositional bias 159 187 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99549 UniProtKB Compositional bias 206 261 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99549 UniProtKB Compositional bias 276 329 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99549 UniProtKB Compositional bias 336 374 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99549 UniProtKB Compositional bias 389 440 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q99549 UniProtKB Site 59 59 . . . Note=Interaction with histone H3K9me3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21419134;Dbxref=PMID:21419134 Q99549 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:22814378;Dbxref=PMID:19413330,PMID:22814378 Q99549 UniProtKB Modified residue 51 51 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:18318008,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:17081983,PMID:18318008,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Q99549 UniProtKB Modified residue 85 85 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3TYA6 Q99549 UniProtKB Modified residue 136 136 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Q99549 UniProtKB Modified residue 138 138 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692 Q99549 UniProtKB Modified residue 144 144 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3TYA6 Q99549 UniProtKB Modified residue 149 149 . . . Note=Phosphoserine%3B by CDK1;Ontology_term=ECO:0000305,ECO:0007744,ECO:0007744;evidence=ECO:0000305|PubMed:23416073,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332,PMID:23416073 Q99549 UniProtKB Modified residue 164 164 . . . Note=Phosphoserine%3B by CDK1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23416073;Dbxref=PMID:23416073 Q99549 UniProtKB Modified residue 188 188 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Q99549 UniProtKB Modified residue 189 189 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332 Q99549 UniProtKB Modified residue 192 192 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Q99549 UniProtKB Modified residue 266 266 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3TYA6 Q99549 UniProtKB Modified residue 272 272 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q99549 UniProtKB Modified residue 279 279 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q99549 UniProtKB Modified residue 319 319 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:21406692;Dbxref=PMID:17081983,PMID:21406692 Q99549 UniProtKB Modified residue 334 334 . . . Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23416073;Dbxref=PMID:23416073 Q99549 UniProtKB Modified residue 385 385 . . . Note=Phosphothreonine%3B by CDK1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:23416073;Dbxref=PMID:23416073 Q99549 UniProtKB Modified residue 392 392 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692 Q99549 UniProtKB Modified residue 400 400 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Q99549 UniProtKB Modified residue 403 403 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Q99549 UniProtKB Modified residue 454 454 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 Q99549 UniProtKB Alternative sequence 820 860 . . . ID=VSP_031523;Note=In isoform 2. DSHFVYSFSPVAGPNKLFIRLTEAPSAKVKLLIGAYRVQLQ->TGSRSVVQAGVQWRGLQLTGVLTSQAQAILPPQPPNYLGLKMHATTSG;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17974005 Q99549 UniProtKB Mutagenesis 80 80 . . . Note=Abolishes interaction with histone H3K9me3 and prevents recruitment of the HUSH complex to heterochromatin. Impaired ability to mediate silencing of unintegrated retroviral DNA. W->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20871592,ECO:0000269|PubMed:26022416,ECO:0000269|PubMed:30487602;Dbxref=PMID:20871592,PMID:26022416,PMID:30487602 Q99549 UniProtKB Mutagenesis 149 149 . . . Note=In STA mutant%3B fails to dissociate from chromatin during early mitosis%3B when associated with A-164%3B A-334 and A-385. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23416073;Dbxref=PMID:23416073 Q99549 UniProtKB Mutagenesis 164 164 . . . Note=In STA mutant%3B fails to dissociate from chromatin during early mitosis%3B when associated with A-149%3B A-334 and A-385. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23416073;Dbxref=PMID:23416073 Q99549 UniProtKB Mutagenesis 334 334 . . . Note=In STA mutant%3B fails to dissociate from chromatin during early mitosis%3B when associated with A-149%3B A-164 and A-385. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23416073;Dbxref=PMID:23416073 Q99549 UniProtKB Mutagenesis 385 385 . . . Note=In STA mutant%3B fails to dissociate from chromatin during early mitosis%3B when associated with A-149%3B A-164%3B and A-334. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23416073;Dbxref=PMID:23416073 Q99549 UniProtKB Sequence conflict 526 530 . . . Note=DGRQQ->GEFGI;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q99549 UniProtKB Sequence conflict 860 860 . . . Note=Q->QPNRRDWAEFS;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q99549 UniProtKB Beta strand 61 70 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6V2S Q99549 UniProtKB Beta strand 73 80 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6V2S Q99549 UniProtKB Helix 85 87 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6V2S Q99549 UniProtKB Beta strand 89 92 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6V2S Q99549 UniProtKB Helix 93 96 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6V2S Q99549 UniProtKB Helix 100 113 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6V2S