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Protein

M-phase phosphoprotein 6

Gene

MPHOSPH6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.1 Publication

GO - Molecular functioni

GO - Biological processi

  • maturation of 5.8S rRNA Source: UniProtKB
  • rRNA processing Source: Reactome
Complete GO annotation...

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135698-MONOMER.
ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase phosphoprotein 6
Gene namesi
Name:MPHOSPH6
Synonyms:MPP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7214. MPHOSPH6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • exosome (RNase complex) Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10200.
OpenTargetsiENSG00000135698.
PharmGKBiPA30920.

Polymorphism and mutation databases

BioMutaiMPHOSPH6.
DMDMi296438296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224371 – 160M-phase phosphoprotein 6Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphoserineCombined sources1
Modified residuei147PhosphothreonineCombined sources1
Cross-linki153Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Phosphorylated in M (mitotic) phase.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99547.
MaxQBiQ99547.
PaxDbiQ99547.
PeptideAtlasiQ99547.
PRIDEiQ99547.

PTM databases

iPTMnetiQ99547.
PhosphoSitePlusiQ99547.
SwissPalmiQ99547.

Expressioni

Gene expression databases

BgeeiENSG00000135698.
CleanExiHS_MPHOSPH6.
HS_MPP6.
ExpressionAtlasiQ99547. baseline and differential.
GenevisibleiQ99547. HS.

Organism-specific databases

HPAiCAB003674.
HPA026948.

Interactioni

Subunit structurei

Associates with the RNA exosome complex, probably mediated by EXOSC10. Interacts with ARHGAP18, EXOSC10 and SKIV2L2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EXOSC10Q017804EBI-373187,EBI-358236
EXOSC2Q138683EBI-373187,EBI-301735
SKIV2L2P422852EBI-373187,EBI-347612

Protein-protein interaction databases

BioGridi115495. 28 interactors.
DIPiDIP-31131N.
IntActiQ99547. 28 interactors.
MINTiMINT-1372240.
STRINGi9606.ENSP00000258169.

Structurei

3D structure databases

ProteinModelPortaliQ99547.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi116 – 133Nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 35Poly-Glu4

Sequence similaritiesi

Belongs to the MPP6 family.Curated

Phylogenomic databases

eggNOGiKOG4531. Eukaryota.
ENOG4111K5Z. LUCA.
GeneTreeiENSGT00390000009212.
HOGENOMiHOG000007728.
HOVERGENiHBG031714.
InParanoidiQ99547.
KOiK12593.
OMAiNGDITPI.
OrthoDBiEOG091G0T3X.
PhylomeDBiQ99547.
TreeFamiTF323810.

Family and domain databases

InterProiIPR019324. MPP6.
[Graphical view]
PANTHERiPTHR13582. PTHR13582. 1 hit.
PfamiPF10175. MPP6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAERKTRLS KNLLRMKFMQ RGLDSETKKQ LEEEEKKIIS EEHWYLDLPE
60 70 80 90 100
LKEKESFIIE EQSFLLCEDL LYGRMSFRGF NPEVEKLMLQ MNAKHKAEEV
110 120 130 140 150
EDETVELDVS DEEMARRYET LVGTIGKKFA RKRDHANYEE DENGDITPIK
160
AKKMFLKPQD
Length:160
Mass (Da):19,024
Last modified:May 18, 2010 - v2
Checksum:i506D5274C839BD7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8R → K in CAA66916 (PubMed:8885239).Curated1
Sequence conflicti8R → K in BAG36847 (PubMed:14702039).Curated1
Sequence conflicti8R → K in AAH05242 (PubMed:15489334).Curated1
Sequence conflicti8R → K in AAH11020 (PubMed:15489334).Curated1
Sequence conflicti8R → K in AAH31017 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05615058I → V.Corresponds to variant rs2303267dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98263 mRNA. Translation: CAA66916.1.
AK314163 mRNA. Translation: BAG36847.1.
AC138304 Genomic DNA. No translation available.
BC005242 mRNA. Translation: AAH05242.1.
BC011020 mRNA. Translation: AAH11020.1.
BC031017 mRNA. Translation: AAH31017.1.
CCDSiCCDS10937.1.
RefSeqiNP_005783.2. NM_005792.2.
UniGeneiHs.344400.

Genome annotation databases

EnsembliENST00000258169; ENSP00000258169; ENSG00000135698.
GeneIDi10200.
KEGGihsa:10200.
UCSCiuc002fgw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98263 mRNA. Translation: CAA66916.1.
AK314163 mRNA. Translation: BAG36847.1.
AC138304 Genomic DNA. No translation available.
BC005242 mRNA. Translation: AAH05242.1.
BC011020 mRNA. Translation: AAH11020.1.
BC031017 mRNA. Translation: AAH31017.1.
CCDSiCCDS10937.1.
RefSeqiNP_005783.2. NM_005792.2.
UniGeneiHs.344400.

3D structure databases

ProteinModelPortaliQ99547.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115495. 28 interactors.
DIPiDIP-31131N.
IntActiQ99547. 28 interactors.
MINTiMINT-1372240.
STRINGi9606.ENSP00000258169.

PTM databases

iPTMnetiQ99547.
PhosphoSitePlusiQ99547.
SwissPalmiQ99547.

Polymorphism and mutation databases

BioMutaiMPHOSPH6.
DMDMi296438296.

Proteomic databases

EPDiQ99547.
MaxQBiQ99547.
PaxDbiQ99547.
PeptideAtlasiQ99547.
PRIDEiQ99547.

Protocols and materials databases

DNASUi10200.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258169; ENSP00000258169; ENSG00000135698.
GeneIDi10200.
KEGGihsa:10200.
UCSCiuc002fgw.4. human.

Organism-specific databases

CTDi10200.
DisGeNETi10200.
GeneCardsiMPHOSPH6.
H-InvDBHIX0013281.
HGNCiHGNC:7214. MPHOSPH6.
HPAiCAB003674.
HPA026948.
MIMi605500. gene.
neXtProtiNX_Q99547.
OpenTargetsiENSG00000135698.
PharmGKBiPA30920.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4531. Eukaryota.
ENOG4111K5Z. LUCA.
GeneTreeiENSGT00390000009212.
HOGENOMiHOG000007728.
HOVERGENiHBG031714.
InParanoidiQ99547.
KOiK12593.
OMAiNGDITPI.
OrthoDBiEOG091G0T3X.
PhylomeDBiQ99547.
TreeFamiTF323810.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135698-MONOMER.
ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

GeneWikiiMPHOSPH6.
GenomeRNAii10200.
PROiQ99547.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135698.
CleanExiHS_MPHOSPH6.
HS_MPP6.
ExpressionAtlasiQ99547. baseline and differential.
GenevisibleiQ99547. HS.

Family and domain databases

InterProiIPR019324. MPP6.
[Graphical view]
PANTHERiPTHR13582. PTHR13582. 1 hit.
PfamiPF10175. MPP6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPH6_HUMAN
AccessioniPrimary (citable) accession number: Q99547
Secondary accession number(s): B2RAF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.