Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Perilipin-2

Gene

PLIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in development and maintenance of adipose tissue.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-2
Alternative name(s):
Adipophilin
Adipose differentiation-related protein
Short name:
ADRP
Gene namesi
Name:PLIN2
Synonyms:ADFP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:248. PLIN2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • endoplasmic reticulum Source: ProtInc
  • extracellular region Source: ProtInc
  • lipid particle Source: UniProtKB
  • nucleus Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24569.

Polymorphism and mutation databases

BioMutaiPLIN2.
DMDMi21264409.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 437436Perilipin-2PRO_0000099888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications

Post-translational modificationi

Acylated; primarily with C14, C16 and C18 fatty acids.

Keywords - PTMi

Acetylation, Lipoprotein

Proteomic databases

MaxQBiQ99541.
PaxDbiQ99541.
PeptideAtlasiQ99541.
PRIDEiQ99541.

PTM databases

PhosphoSiteiQ99541.

Expressioni

Tissue specificityi

Milk lipid globules.

Gene expression databases

BgeeiQ99541.
CleanExiHS_ADFP.
ExpressionAtlasiQ99541. baseline and differential.
GenevestigatoriQ99541.

Organism-specific databases

HPAiCAB037331.
HPA016607.

Interactioni

Protein-protein interaction databases

BioGridi106635. 3 interactions.
IntActiQ99541. 2 interactions.
STRINGi9606.ENSP00000276914.

Structurei

3D structure databases

ProteinModelPortaliQ99541.
SMRiQ99541. Positions 191-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the perilipin family.Curated

Phylogenomic databases

eggNOGiNOG68493.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiQ99541.
KOiK17284.
OMAiTKDNHPY.
OrthoDBiEOG7SN8CD.
PhylomeDBiQ99541.
TreeFamiTF328397.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVAVDPQP SVVTRVVNLP LVSSTYDLMS SAYLSTKDQY PYLKSVCEMA
60 70 80 90 100
ENGVKTITSV AMTSALPIIQ KLEPQIAVAN TYACKGLDRI EERLPILNQP
110 120 130 140 150
STQIVANAKG AVTGAKDAVT TTVTGAKDSV ASTITGVMDK TKGAVTGSVE
160 170 180 190 200
KTKSVVSGSI NTVLGSRMMQ LVSSGVENAL TKSELLVEQY LPLTEEELEK
210 220 230 240 250
EAKKVEGFDL VQKPSYYVRL GSLSTKLHSR AYQQALSRVK EAKQKSQQTI
260 270 280 290 300
SQLHSTVHLI EFARKNVYSA NQKIQDAQDK LYLSWVEWKR SIGYDDTDES
310 320 330 340 350
HCAEHIESRT LAIARNLTQQ LQTTCHTLLS NIQGVPQNIQ DQAKHMGVMA
360 370 380 390 400
GDIYSVFRNA ASFKEVSDSL LTSSKGQLQK MKESLDDVMD YLVNNTPLNW
410 420 430
LVGPFYPQLT ESQNAQDQGA EMDKSSQETQ RSEHKTH
Length:437
Mass (Da):48,075
Last modified:May 27, 2002 - v2
Checksum:i36411341619E53BF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti305 – 3062HI → QF in CAA65989 (PubMed:9003395).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti251 – 2511S → P.
Corresponds to variant rs35568725 [ dbSNP | Ensembl ].
VAR_061506

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97324 mRNA. Translation: CAA65989.1.
AF443203 mRNA. Translation: AAL35614.1.
BC005127 mRNA. Translation: AAH05127.1.
CCDSiCCDS6490.1.
RefSeqiNP_001113.2. NM_001122.3.
UniGeneiHs.3416.

Genome annotation databases

EnsembliENST00000276914; ENSP00000276914; ENSG00000147872.
GeneIDi123.
KEGGihsa:123.
UCSCiuc003zno.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97324 mRNA. Translation: CAA65989.1.
AF443203 mRNA. Translation: AAL35614.1.
BC005127 mRNA. Translation: AAH05127.1.
CCDSiCCDS6490.1.
RefSeqiNP_001113.2. NM_001122.3.
UniGeneiHs.3416.

3D structure databases

ProteinModelPortaliQ99541.
SMRiQ99541. Positions 191-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106635. 3 interactions.
IntActiQ99541. 2 interactions.
STRINGi9606.ENSP00000276914.

PTM databases

PhosphoSiteiQ99541.

Polymorphism and mutation databases

BioMutaiPLIN2.
DMDMi21264409.

Proteomic databases

MaxQBiQ99541.
PaxDbiQ99541.
PeptideAtlasiQ99541.
PRIDEiQ99541.

Protocols and materials databases

DNASUi123.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276914; ENSP00000276914; ENSG00000147872.
GeneIDi123.
KEGGihsa:123.
UCSCiuc003zno.3. human.

Organism-specific databases

CTDi123.
GeneCardsiGC09M019077.
HGNCiHGNC:248. PLIN2.
HPAiCAB037331.
HPA016607.
MIMi103195. gene.
neXtProtiNX_Q99541.
PharmGKBiPA24569.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG68493.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiQ99541.
KOiK17284.
OMAiTKDNHPY.
OrthoDBiEOG7SN8CD.
PhylomeDBiQ99541.
TreeFamiTF328397.

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.

Miscellaneous databases

ChiTaRSiPLIN2. human.
GeneWikiiAdipose_differentiation-related_protein.
GenomeRNAii123.
NextBioi491.
PROiQ99541.
SOURCEiSearch...

Gene expression databases

BgeeiQ99541.
CleanExiHS_ADFP.
ExpressionAtlasiQ99541. baseline and differential.
GenevestigatoriQ99541.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane."
    Heid H.W., Schnolzer M., Keenan T.W.
    Biochem. J. 320:1025-1030(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Tangkeangsirisin W., Serrero G.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPLIN2_HUMAN
AccessioniPrimary (citable) accession number: Q99541
Secondary accession number(s): Q9BSC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 27, 2002
Last modified: April 29, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.