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Q99541

- PLIN2_HUMAN

UniProt

Q99541 - PLIN2_HUMAN

Protein

Perilipin-2

Gene

PLIN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (27 May 2002)
      Previous versions | rss
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    Functioni

    May be involved in development and maintenance of adipose tissue.By similarity

    GO - Biological processi

    1. cellular lipid metabolic process Source: Reactome
    2. lipid storage Source: Ensembl
    3. long-chain fatty acid transport Source: Ensembl
    4. response to drug Source: Ensembl
    5. response to organic cyclic compound Source: Ensembl
    6. small molecule metabolic process Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Perilipin-2
    Alternative name(s):
    Adipophilin
    Adipose differentiation-related protein
    Short name:
    ADRP
    Gene namesi
    Name:PLIN2
    Synonyms:ADFP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:248. PLIN2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: ProtInc
    2. extracellular region Source: ProtInc
    3. lipid particle Source: UniProtKB
    4. nucleus Source: Ensembl
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24569.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 437436Perilipin-2PRO_0000099888Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications

    Post-translational modificationi

    Acylated; primarily with C14, C16 and C18 fatty acids.

    Keywords - PTMi

    Acetylation, Lipoprotein

    Proteomic databases

    MaxQBiQ99541.
    PaxDbiQ99541.
    PeptideAtlasiQ99541.
    PRIDEiQ99541.

    PTM databases

    PhosphoSiteiQ99541.

    Expressioni

    Tissue specificityi

    Milk lipid globules.

    Gene expression databases

    ArrayExpressiQ99541.
    BgeeiQ99541.
    CleanExiHS_ADFP.
    GenevestigatoriQ99541.

    Organism-specific databases

    HPAiCAB037331.
    HPA016607.

    Interactioni

    Protein-protein interaction databases

    BioGridi106635. 3 interactions.
    IntActiQ99541. 2 interactions.
    STRINGi9606.ENSP00000276914.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99541.
    SMRiQ99541. Positions 191-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the perilipin family.Curated

    Phylogenomic databases

    eggNOGiNOG68493.
    HOGENOMiHOG000033816.
    HOVERGENiHBG002935.
    InParanoidiQ99541.
    KOiK17284.
    OMAiTKDNHPY.
    OrthoDBiEOG7SN8CD.
    PhylomeDBiQ99541.
    TreeFamiTF328397.

    Family and domain databases

    InterProiIPR004279. Perilipin.
    [Graphical view]
    PANTHERiPTHR14024. PTHR14024. 1 hit.
    PfamiPF03036. Perilipin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036881. PAT. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99541-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASVAVDPQP SVVTRVVNLP LVSSTYDLMS SAYLSTKDQY PYLKSVCEMA    50
    ENGVKTITSV AMTSALPIIQ KLEPQIAVAN TYACKGLDRI EERLPILNQP 100
    STQIVANAKG AVTGAKDAVT TTVTGAKDSV ASTITGVMDK TKGAVTGSVE 150
    KTKSVVSGSI NTVLGSRMMQ LVSSGVENAL TKSELLVEQY LPLTEEELEK 200
    EAKKVEGFDL VQKPSYYVRL GSLSTKLHSR AYQQALSRVK EAKQKSQQTI 250
    SQLHSTVHLI EFARKNVYSA NQKIQDAQDK LYLSWVEWKR SIGYDDTDES 300
    HCAEHIESRT LAIARNLTQQ LQTTCHTLLS NIQGVPQNIQ DQAKHMGVMA 350
    GDIYSVFRNA ASFKEVSDSL LTSSKGQLQK MKESLDDVMD YLVNNTPLNW 400
    LVGPFYPQLT ESQNAQDQGA EMDKSSQETQ RSEHKTH 437
    Length:437
    Mass (Da):48,075
    Last modified:May 27, 2002 - v2
    Checksum:i36411341619E53BF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti305 – 3062HI → QF in CAA65989. (PubMed:9003395)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti251 – 2511S → P.
    Corresponds to variant rs35568725 [ dbSNP | Ensembl ].
    VAR_061506

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97324 mRNA. Translation: CAA65989.1.
    AF443203 mRNA. Translation: AAL35614.1.
    BC005127 mRNA. Translation: AAH05127.1.
    CCDSiCCDS6490.1.
    RefSeqiNP_001113.2. NM_001122.3.
    UniGeneiHs.3416.

    Genome annotation databases

    EnsembliENST00000276914; ENSP00000276914; ENSG00000147872.
    GeneIDi123.
    KEGGihsa:123.
    UCSCiuc003zno.3. human.

    Polymorphism databases

    DMDMi21264409.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97324 mRNA. Translation: CAA65989.1 .
    AF443203 mRNA. Translation: AAL35614.1 .
    BC005127 mRNA. Translation: AAH05127.1 .
    CCDSi CCDS6490.1.
    RefSeqi NP_001113.2. NM_001122.3.
    UniGenei Hs.3416.

    3D structure databases

    ProteinModelPortali Q99541.
    SMRi Q99541. Positions 191-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106635. 3 interactions.
    IntActi Q99541. 2 interactions.
    STRINGi 9606.ENSP00000276914.

    PTM databases

    PhosphoSitei Q99541.

    Polymorphism databases

    DMDMi 21264409.

    Proteomic databases

    MaxQBi Q99541.
    PaxDbi Q99541.
    PeptideAtlasi Q99541.
    PRIDEi Q99541.

    Protocols and materials databases

    DNASUi 123.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276914 ; ENSP00000276914 ; ENSG00000147872 .
    GeneIDi 123.
    KEGGi hsa:123.
    UCSCi uc003zno.3. human.

    Organism-specific databases

    CTDi 123.
    GeneCardsi GC09M019077.
    HGNCi HGNC:248. PLIN2.
    HPAi CAB037331.
    HPA016607.
    MIMi 103195. gene.
    neXtProti NX_Q99541.
    PharmGKBi PA24569.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68493.
    HOGENOMi HOG000033816.
    HOVERGENi HBG002935.
    InParanoidi Q99541.
    KOi K17284.
    OMAi TKDNHPY.
    OrthoDBi EOG7SN8CD.
    PhylomeDBi Q99541.
    TreeFami TF328397.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.

    Miscellaneous databases

    ChiTaRSi PLIN2. human.
    GeneWikii Adipose_differentiation-related_protein.
    GenomeRNAii 123.
    NextBioi 491.
    PROi Q99541.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99541.
    Bgeei Q99541.
    CleanExi HS_ADFP.
    Genevestigatori Q99541.

    Family and domain databases

    InterProi IPR004279. Perilipin.
    [Graphical view ]
    PANTHERi PTHR14024. PTHR14024. 1 hit.
    Pfami PF03036. Perilipin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036881. PAT. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane."
      Heid H.W., Schnolzer M., Keenan T.W.
      Biochem. J. 320:1025-1030(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Tangkeangsirisin W., Serrero G.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPLIN2_HUMAN
    AccessioniPrimary (citable) accession number: Q99541
    Secondary accession number(s): Q9BSC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 27, 2002
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3