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Q99541 (PLIN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Perilipin-2
Alternative name(s):
Adipophilin
Adipose differentiation-related protein
Short name=ADRP
Gene names
Name:PLIN2
Synonyms:ADFP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in development and maintenance of adipose tissue By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Tissue specificity

Milk lipid globules.

Post-translational modification

Acylated; primarily with C14, C16 and C18 fatty acids.

Sequence similarities

Belongs to the perilipin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 437436Perilipin-2
PRO_0000099888

Amino acid modifications

Modified residue21N-acetylalanine Ref.5 Ref.6

Natural variations

Natural variant2511S → P.
Corresponds to variant rs35568725 [ dbSNP | Ensembl ].
VAR_061506

Experimental info

Sequence conflict305 – 3062HI → QF in CAA65989. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q99541 [UniParc].

Last modified May 27, 2002. Version 2.
Checksum: 36411341619E53BF

FASTA43748,075
        10         20         30         40         50         60 
MASVAVDPQP SVVTRVVNLP LVSSTYDLMS SAYLSTKDQY PYLKSVCEMA ENGVKTITSV 

        70         80         90        100        110        120 
AMTSALPIIQ KLEPQIAVAN TYACKGLDRI EERLPILNQP STQIVANAKG AVTGAKDAVT 

       130        140        150        160        170        180 
TTVTGAKDSV ASTITGVMDK TKGAVTGSVE KTKSVVSGSI NTVLGSRMMQ LVSSGVENAL 

       190        200        210        220        230        240 
TKSELLVEQY LPLTEEELEK EAKKVEGFDL VQKPSYYVRL GSLSTKLHSR AYQQALSRVK 

       250        260        270        280        290        300 
EAKQKSQQTI SQLHSTVHLI EFARKNVYSA NQKIQDAQDK LYLSWVEWKR SIGYDDTDES 

       310        320        330        340        350        360 
HCAEHIESRT LAIARNLTQQ LQTTCHTLLS NIQGVPQNIQ DQAKHMGVMA GDIYSVFRNA 

       370        380        390        400        410        420 
ASFKEVSDSL LTSSKGQLQK MKESLDDVMD YLVNNTPLNW LVGPFYPQLT ESQNAQDQGA 

       430 
EMDKSSQETQ RSEHKTH 

« Hide

References

« Hide 'large scale' references
[1]"Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane."
Heid H.W., Schnolzer M., Keenan T.W.
Biochem. J. 320:1025-1030(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Tangkeangsirisin W., Serrero G.
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X97324 mRNA. Translation: CAA65989.1.
AF443203 mRNA. Translation: AAL35614.1.
BC005127 mRNA. Translation: AAH05127.1.
CCDSCCDS6490.1.
RefSeqNP_001113.2. NM_001122.3.
UniGeneHs.3416.

3D structure databases

ProteinModelPortalQ99541.
SMRQ99541. Positions 191-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106635. 3 interactions.
IntActQ99541. 2 interactions.
STRING9606.ENSP00000276914.

PTM databases

PhosphoSiteQ99541.

Polymorphism databases

DMDM21264409.

Proteomic databases

MaxQBQ99541.
PaxDbQ99541.
PeptideAtlasQ99541.
PRIDEQ99541.

Protocols and materials databases

DNASU123.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000276914; ENSP00000276914; ENSG00000147872.
GeneID123.
KEGGhsa:123.
UCSCuc003zno.3. human.

Organism-specific databases

CTD123.
GeneCardsGC09M019077.
HGNCHGNC:248. PLIN2.
HPACAB037331.
HPA016607.
MIM103195. gene.
neXtProtNX_Q99541.
PharmGKBPA24569.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68493.
HOGENOMHOG000033816.
HOVERGENHBG002935.
InParanoidQ99541.
KOK17284.
OMATKDNHPY.
OrthoDBEOG7SN8CD.
PhylomeDBQ99541.
TreeFamTF328397.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressQ99541.
BgeeQ99541.
CleanExHS_ADFP.
GenevestigatorQ99541.

Family and domain databases

InterProIPR004279. Perilipin.
[Graphical view]
PANTHERPTHR14024. PTHR14024. 1 hit.
PfamPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFPIRSF036881. PAT. 1 hit.
ProtoNetSearch...

Other

ChiTaRSPLIN2. human.
GeneWikiAdipose_differentiation-related_protein.
GenomeRNAi123.
NextBio491.
PROQ99541.
SOURCESearch...

Entry information

Entry namePLIN2_HUMAN
AccessionPrimary (citable) accession number: Q99541
Secondary accession number(s): Q9BSC3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 27, 2002
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM