Q99541 (PLIN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Perilipin-2

Alternative name(s):
Adipophilin
Adipose differentiation-related protein
Short name=ADRP

Gene names

Name:	PLIN2
Synonyms:	ADFP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in development and maintenance of adipose tissue By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Tissue specificity	Milk lipid globules.
Post-translational modification	Acylated; primarily with C14, C16 and C18 fatty acids.
Sequence similarities	Belongs to the perilipin family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
PTM	Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular lipid metabolic process Traceable author statement. Source: Reactome lipid storage Inferred from electronic annotation. Source: Compara long-chain fatty acid transport Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to organic cyclic compound Inferred from electronic annotation. Source: Compara small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum Traceable author statement Ref.1. Source: ProtInc extracellular region Traceable author statement Ref.1. Source: ProtInc lipid particle Inferred from direct assay PubMed 14741744. Source: UniProtKB nucleus Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Perilipin-2		PRO_0000099888
Natural variations
	Natural variant	251	1	S → P. Corresponds to variant rs35568725 [ dbSNP | Ensembl ].		VAR_061506
Experimental info
	Sequence conflict	305 – 306	2	HI → QF in CAA65989. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q99541 [UniParc]. Last modified May 27, 2002. Version 2. Checksum: 36411341619E53BF	FASTA	437	48,075
	10 20 30 40 50 60 MASVAVDPQP SVVTRVVNLP LVSSTYDLMS SAYLSTKDQY PYLKSVCEMA ENGVKTITSV 70 80 90 100 110 120 AMTSALPIIQ KLEPQIAVAN TYACKGLDRI EERLPILNQP STQIVANAKG AVTGAKDAVT 130 140 150 160 170 180 TTVTGAKDSV ASTITGVMDK TKGAVTGSVE KTKSVVSGSI NTVLGSRMMQ LVSSGVENAL 190 200 210 220 230 240 TKSELLVEQY LPLTEEELEK EAKKVEGFDL VQKPSYYVRL GSLSTKLHSR AYQQALSRVK 250 260 270 280 290 300 EAKQKSQQTI SQLHSTVHLI EFARKNVYSA NQKIQDAQDK LYLSWVEWKR SIGYDDTDES 310 320 330 340 350 360 HCAEHIESRT LAIARNLTQQ LQTTCHTLLS NIQGVPQNIQ DQAKHMGVMA GDIYSVFRNA 370 380 390 400 410 420 ASFKEVSDSL LTSSKGQLQK MKESLDDVMD YLVNNTPLNW LVGPFYPQLT ESQNAQDQGA 430 EMDKSSQETQ RSEHKTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane." Heid H.W., Schnolzer M., Keenan T.W. Biochem. J. 320:1025-1030(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Tangkeangsirisin W., Serrero G. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97324 mRNA. Translation: CAA65989.1. AF443203 mRNA. Translation: AAL35614.1. BC005127 mRNA. Translation: AAH05127.1.
IPI	IPI00293307.
RefSeq	NP_001113.2. NM_001122.3.
UniGene	Hs.3416.
3D structure databases
ProteinModelPortal	Q99541.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99541. 2 interactions.
STRING	9606.ENSP00000276914.
PTM databases
PhosphoSite	Q99541.
Polymorphism databases
DMDM	21264409.
Proteomic databases
PaxDb	Q99541.
PeptideAtlas	Q99541.
PRIDE	Q99541.
Protocols and materials databases
DNASU	123.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000276914; ENSP00000276914; ENSG00000147872.
GeneID	123.
KEGG	hsa:123.
UCSC	uc003zno.3. human.
Organism-specific databases
CTD	123.
GeneCards	GC09M019077.
HGNC	HGNC:248. PLIN2.
MIM	103195. gene.
neXtProt	NX_Q99541.
PharmGKB	PA24569.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG68493.
HOGENOM	HOG000033816.
HOVERGEN	HBG002935.
InParanoid	Q99541.
OMA	VMDKTKG.
OrthoDB	EOG4CZBGS.
PhylomeDB	Q99541.
Enzyme and pathway databases
Pathway_Interaction_DB	hif1_tfpathway. HIF-1-alpha transcription factor network.
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q99541.
Bgee	Q99541.
CleanEx	HS_ADFP.
Genevestigator	Q99541.
GermOnline	ENSG00000147872. Homo sapiens.
Family and domain databases
InterPro	IPR004279. Perilipin. [Graphical view]
PANTHER	PTHR14024. PTHR14024. 1 hit.
Pfam	PF03036. Perilipin. 1 hit. [Graphical view]
PIRSF	PIRSF036881. PAT. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	PLIN2. human.
GenomeRNAi	123.
NextBio	491.
SOURCE	Search...

Entry information

Entry name

PLIN2_HUMAN

Accession

Primary (citable) accession number: Q99541
Secondary accession number(s): Q9BSC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 27, 2002
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.