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Q99541

- PLIN2_HUMAN

UniProt

Q99541 - PLIN2_HUMAN

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Protein

Perilipin-2

Gene

PLIN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in development and maintenance of adipose tissue.By similarity

GO - Biological processi

  1. cellular lipid metabolic process Source: Reactome
  2. lipid storage Source: Ensembl
  3. long-chain fatty acid transport Source: Ensembl
  4. response to drug Source: Ensembl
  5. response to organic cyclic compound Source: Ensembl
  6. small molecule metabolic process Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-2
Alternative name(s):
Adipophilin
Adipose differentiation-related protein
Short name:
ADRP
Gene namesi
Name:PLIN2
Synonyms:ADFP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:248. PLIN2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. endoplasmic reticulum Source: ProtInc
  3. extracellular region Source: ProtInc
  4. lipid particle Source: UniProtKB
  5. nucleus Source: Ensembl
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 437436Perilipin-2PRO_0000099888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications

Post-translational modificationi

Acylated; primarily with C14, C16 and C18 fatty acids.

Keywords - PTMi

Acetylation, Lipoprotein

Proteomic databases

MaxQBiQ99541.
PaxDbiQ99541.
PeptideAtlasiQ99541.
PRIDEiQ99541.

PTM databases

PhosphoSiteiQ99541.

Expressioni

Tissue specificityi

Milk lipid globules.

Gene expression databases

BgeeiQ99541.
CleanExiHS_ADFP.
ExpressionAtlasiQ99541. baseline and differential.
GenevestigatoriQ99541.

Organism-specific databases

HPAiCAB037331.
HPA016607.

Interactioni

Protein-protein interaction databases

BioGridi106635. 3 interactions.
IntActiQ99541. 2 interactions.
STRINGi9606.ENSP00000276914.

Structurei

3D structure databases

ProteinModelPortaliQ99541.
SMRiQ99541. Positions 191-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the perilipin family.Curated

Phylogenomic databases

eggNOGiNOG68493.
GeneTreeiENSGT00500000044795.
HOGENOMiHOG000033816.
HOVERGENiHBG002935.
InParanoidiQ99541.
KOiK17284.
OMAiTKDNHPY.
OrthoDBiEOG7SN8CD.
PhylomeDBiQ99541.
TreeFamiTF328397.

Family and domain databases

InterProiIPR004279. Perilipin.
[Graphical view]
PANTHERiPTHR14024. PTHR14024. 1 hit.
PfamiPF03036. Perilipin. 1 hit.
[Graphical view]
PIRSFiPIRSF036881. PAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99541-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASVAVDPQP SVVTRVVNLP LVSSTYDLMS SAYLSTKDQY PYLKSVCEMA
60 70 80 90 100
ENGVKTITSV AMTSALPIIQ KLEPQIAVAN TYACKGLDRI EERLPILNQP
110 120 130 140 150
STQIVANAKG AVTGAKDAVT TTVTGAKDSV ASTITGVMDK TKGAVTGSVE
160 170 180 190 200
KTKSVVSGSI NTVLGSRMMQ LVSSGVENAL TKSELLVEQY LPLTEEELEK
210 220 230 240 250
EAKKVEGFDL VQKPSYYVRL GSLSTKLHSR AYQQALSRVK EAKQKSQQTI
260 270 280 290 300
SQLHSTVHLI EFARKNVYSA NQKIQDAQDK LYLSWVEWKR SIGYDDTDES
310 320 330 340 350
HCAEHIESRT LAIARNLTQQ LQTTCHTLLS NIQGVPQNIQ DQAKHMGVMA
360 370 380 390 400
GDIYSVFRNA ASFKEVSDSL LTSSKGQLQK MKESLDDVMD YLVNNTPLNW
410 420 430
LVGPFYPQLT ESQNAQDQGA EMDKSSQETQ RSEHKTH
Length:437
Mass (Da):48,075
Last modified:May 27, 2002 - v2
Checksum:i36411341619E53BF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti305 – 3062HI → QF in CAA65989. (PubMed:9003395)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti251 – 2511S → P.
Corresponds to variant rs35568725 [ dbSNP | Ensembl ].
VAR_061506

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97324 mRNA. Translation: CAA65989.1.
AF443203 mRNA. Translation: AAL35614.1.
BC005127 mRNA. Translation: AAH05127.1.
CCDSiCCDS6490.1.
RefSeqiNP_001113.2. NM_001122.3.
UniGeneiHs.3416.

Genome annotation databases

EnsembliENST00000276914; ENSP00000276914; ENSG00000147872.
GeneIDi123.
KEGGihsa:123.
UCSCiuc003zno.3. human.

Polymorphism databases

DMDMi21264409.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97324 mRNA. Translation: CAA65989.1 .
AF443203 mRNA. Translation: AAL35614.1 .
BC005127 mRNA. Translation: AAH05127.1 .
CCDSi CCDS6490.1.
RefSeqi NP_001113.2. NM_001122.3.
UniGenei Hs.3416.

3D structure databases

ProteinModelPortali Q99541.
SMRi Q99541. Positions 191-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106635. 3 interactions.
IntActi Q99541. 2 interactions.
STRINGi 9606.ENSP00000276914.

PTM databases

PhosphoSitei Q99541.

Polymorphism databases

DMDMi 21264409.

Proteomic databases

MaxQBi Q99541.
PaxDbi Q99541.
PeptideAtlasi Q99541.
PRIDEi Q99541.

Protocols and materials databases

DNASUi 123.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276914 ; ENSP00000276914 ; ENSG00000147872 .
GeneIDi 123.
KEGGi hsa:123.
UCSCi uc003zno.3. human.

Organism-specific databases

CTDi 123.
GeneCardsi GC09M019077.
HGNCi HGNC:248. PLIN2.
HPAi CAB037331.
HPA016607.
MIMi 103195. gene.
neXtProti NX_Q99541.
PharmGKBi PA24569.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68493.
GeneTreei ENSGT00500000044795.
HOGENOMi HOG000033816.
HOVERGENi HBG002935.
InParanoidi Q99541.
KOi K17284.
OMAi TKDNHPY.
OrthoDBi EOG7SN8CD.
PhylomeDBi Q99541.
TreeFami TF328397.

Enzyme and pathway databases

Reactomei REACT_116145. PPARA activates gene expression.

Miscellaneous databases

ChiTaRSi PLIN2. human.
GeneWikii Adipose_differentiation-related_protein.
GenomeRNAii 123.
NextBioi 491.
PROi Q99541.
SOURCEi Search...

Gene expression databases

Bgeei Q99541.
CleanExi HS_ADFP.
ExpressionAtlasi Q99541. baseline and differential.
Genevestigatori Q99541.

Family and domain databases

InterProi IPR004279. Perilipin.
[Graphical view ]
PANTHERi PTHR14024. PTHR14024. 1 hit.
Pfami PF03036. Perilipin. 1 hit.
[Graphical view ]
PIRSFi PIRSF036881. PAT. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane."
    Heid H.W., Schnolzer M., Keenan T.W.
    Biochem. J. 320:1025-1030(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Tangkeangsirisin W., Serrero G.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPLIN2_HUMAN
AccessioniPrimary (citable) accession number: Q99541
Secondary accession number(s): Q9BSC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 27, 2002
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3