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Q99527

- GPER1_HUMAN

UniProt

Q99527 - GPER1_HUMAN

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Protein

G-protein coupled estrogen receptor 1

Gene
GPER1, CEPR, CMKRL2, DRY12, GPER, GPR30
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.14 Publications

Kineticsi

  1. KM=3.3 mM for 17-beta-estradiol (1 Publication)3 Publications
  2. KM=6.6 mM for 17-beta-estradiol (1 Publication)
  3. KM=3.3 mM for 17-beta-estradiol (1 Publication)

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. estrogen receptor activity Source: UniProtKB
  3. G-protein coupled receptor activity Source: ProtInc
  4. mineralocorticoid receptor activity Source: UniProtKB
  5. protein binding Source: UniProtKB
  6. steroid binding Source: UniProtKB

GO - Biological processi

  1. apoptotic chromosome condensation Source: UniProtKB
  2. cell cycle Source: UniProtKB-KW
  3. cellular response to estradiol stimulus Source: UniProtKB
  4. cellular response to glucose stimulus Source: UniProtKB
  5. cellular response to mineralocorticoid stimulus Source: UniProtKB
  6. cellular response to peptide hormone stimulus Source: UniProtKB
  7. cellular response to tumor necrosis factor Source: UniProtKB
  8. cytosolic calcium ion homeostasis Source: UniProtKB
  9. G-protein coupled receptor signaling pathway Source: ProtInc
  10. inflammatory response Source: UniProtKB-KW
  11. innate immune response Source: UniProtKB-KW
  12. intracellular steroid hormone receptor signaling pathway Source: UniProtKB
  13. mineralocorticoid receptor signaling pathway Source: GOC
  14. negative regulation of cell cycle arrest Source: UniProtKB
  15. negative regulation of cell proliferation Source: UniProtKB
  16. negative regulation of DNA metabolic process Source: UniProtKB
  17. negative regulation of fat cell differentiation Source: UniProtKB
  18. negative regulation of gene expression Source: UniProtKB
  19. negative regulation of inflammatory response Source: UniProtKB
  20. negative regulation of leukocyte activation Source: UniProtKB
  21. negative regulation of lipid biosynthetic process Source: UniProtKB
  22. neuronal action potential Source: UniProtKB
  23. nuclear fragmentation involved in apoptotic nuclear change Source: UniProtKB
  24. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: UniProtKB
  25. positive regulation of apoptotic process Source: UniProtKB
  26. positive regulation of cAMP biosynthetic process Source: UniProtKB
  27. positive regulation of cell migration Source: UniProtKB
  28. positive regulation of cell proliferation Source: UniProtKB
  29. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  30. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  31. positive regulation of endothelial cell apoptotic process Source: UniProtKB
  32. positive regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
  33. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  34. positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  35. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
  36. positive regulation of gene expression Source: UniProtKB
  37. positive regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
  38. positive regulation of inositol trisphosphate biosynthetic process Source: UniProtKB
  39. positive regulation of insulin secretion Source: UniProtKB
  40. positive regulation of MAPK cascade Source: UniProtKB
  41. positive regulation of neurogenesis Source: UniProtKB
  42. positive regulation of neurotransmitter secretion Source: UniProtKB
  43. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  44. positive regulation of protein phosphorylation Source: UniProtKB
  45. positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
  46. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  47. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  48. positive regulation of uterine smooth muscle contraction Source: UniProtKB
  49. positive regulation of vasodilation Source: UniProtKB
  50. steroid hormone mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Apoptosis, Cell cycle, Differentiation, Immunity, Inflammatory response, Innate immunity, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled estrogen receptor 1
Alternative name(s):
Chemoattractant receptor-like 2
Flow-induced endothelial G-protein coupled receptor 1
Short name:
FEG-1
G protein-coupled estrogen receptor 1
G-protein coupled receptor 30
GPCR-Br
IL8-related receptor DRY12
Lymphocyte-derived G-protein coupled receptor
Short name:
LYGPR
Membrane estrogen receptor
Short name:
mER
Gene namesi
Name:GPER1
Synonyms:CEPR, CMKRL2, DRY12, GPER, GPR30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:4485. GPER1.

Subcellular locationi

Nucleus. Cytoplasm By similarity. Cytoplasmperinuclear region. Cytoplasmcytoskeleton. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Golgi apparatustrans-Golgi network. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projectiondendrite By similarity. Cell projectiondendritic spine membrane; Multi-pass membrane protein By similarity. Cell projectionaxon By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Mitochondrion membrane; Multi-pass membrane protein By similarity
Note: Colocalized with BSN to the active zone of presynaptic density. Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes By similarity. Endocytosed in a agonist- and arrestin-independent manner. Colocalized with RAMP3 and clathrin-coated pits at the plasma membrane. Colocalized with transferrin receptor at the plasma membrane and perinuclear region. Accumulated and colocalized with RAB11 proteins in recycling endosomes and trans-Golgi network (TGN), but does neither recycle back to the cell surface nor traffics to late endosome or lysosome. Colocalized with calnexin in the endoplasmic reticulum. Traffics to intracellular sites via cytokeratin intermediate filaments like KRT7 and KRT8 after constitutive endocytosis in epithelial cells. Colocalized with EGFR in the nucleus of agonist-induced cancer-associated fibroblasts (CAF).12 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262Extracellular Reviewed predictionAdd
BLAST
Transmembranei63 – 8422Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini85 – 9612Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei97 – 12024Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini121 – 13212Extracellular Reviewed predictionAdd
BLAST
Transmembranei133 – 15321Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini154 – 17522Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei176 – 19419Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini195 – 22026Extracellular Reviewed predictionAdd
BLAST
Transmembranei221 – 23616Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini237 – 25923Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei260 – 28021Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini281 – 30626Extracellular Reviewed predictionAdd
BLAST
Transmembranei307 – 32721Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini328 – 37548Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. axon terminus Source: UniProtKB
  3. cell junction Source: UniProtKB-KW
  4. cytoplasm Source: UniProtKB
  5. cytoplasmic vesicle membrane Source: UniProtKB
  6. dendrite Source: UniProtKB
  7. dendritic shaft Source: UniProtKB
  8. dendritic spine head Source: UniProtKB
  9. dendritic spine membrane Source: UniProtKB
  10. early endosome Source: UniProtKB
  11. endoplasmic reticulum Source: UniProtKB
  12. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  13. Golgi apparatus Source: UniProtKB
  14. Golgi membrane Source: UniProtKB-SubCell
  15. integral component of plasma membrane Source: ProtInc
  16. intracellular Source: UniProtKB
  17. keratin filament Source: UniProtKB
  18. mitochondrial membrane Source: UniProtKB
  19. neuronal postsynaptic density Source: UniProtKB
  20. nuclear envelope Source: UniProtKB
  21. nucleus Source: UniProtKB
  22. perinuclear region of cytoplasm Source: UniProtKB
  23. plasma membrane Source: UniProtKB
  24. postsynaptic density Source: UniProtKB
  25. presynaptic active zone Source: UniProtKB
  26. presynaptic membrane Source: UniProtKB
  27. recycling endosome Source: UniProtKB
  28. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Mitochondrion, Nucleus, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375G-protein coupled estrogen receptor 1PRO_0000069310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Glycosylationi25 – 251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi32 – 321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi44 – 441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi130 ↔ 207 Reviewed prediction

Post-translational modificationi

Ubiquitinated; ubiquitination occurs at the plasma membrane and leads to proteasome-mediated degradation.1 Publication
Glycosylated.1 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ99527.
PaxDbiQ99527.
PRIDEiQ99527.

Expressioni

Tissue specificityi

Expressed in placenta, endothelial and epithelial cells, non laboring and laboring term myometrium, fibroblasts and cancer-associated fibroblasts (CAF), prostate cancer cells and invasive adenocarcinoma (at protein level). Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen.6 Publications

Inductioni

Up-regulated by EGF and TGF-alpha in endometrial, ovarian and breast tumor cells. Up-regulated by progestin and by phorbol 12-myristate 13-acetate (PMA) in breast cancer cell lines.2 Publications

Gene expression databases

ArrayExpressiQ99527.
BgeeiQ99527.
CleanExiHS_GPER.
GenevestigatoriQ99527.

Organism-specific databases

HPAiHPA027052.

Interactioni

Subunit structurei

Homodimer Inferred. Heterodimer; heterodimerizes with other G-protein-coupled receptor (GPCRs) like CRHR1, HTR1A and PAQR8. Interacts (via C-terminus tail motif) with DLG4 (via N-terminus tandem pair of PDZ domains); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner By similarity. Interacts with RAMP3. Interacts with KRT7 and KRT8. Interacts with EGFR; the interaction increases after agonist-induced stimulation in cancer-associated fibroblasts (CAF). Interacts with EGFR and ESR1.4 Publications

Protein-protein interaction databases

IntActiQ99527. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ99527.
SMRiQ99527. Positions 19-338.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151076.
HOVERGENiHBG005351.
KOiK04246.
OMAiQHARLSC.
OrthoDBiEOG7WX08J.
PhylomeDBiQ99527.
TreeFamiTF333506.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99527-1 [UniParc]FASTAAdd to Basket

« Hide

MDVTSQARGV GLEMYPGTAQ PAAPNTTSPE LNLSHPLLGT ALANGTGELS    50
EHQQYVIGLF LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN 100
LAVADLILVA DSLIEVFNLH ERYYDIAVLC TFMSLFLQVN MYSSVFFLTW 150
MSFDRYIALA RAMRCSLFRT KHHARLSCGL IWMASVSATL VPFTAVHLQH 200
TDEACFCFAD VREVQWLEVT LGFIVPFAII GLCYSLIVRV LVRAHRHRGL 250
RPRRQKALRM ILAVVLVFFV CWLPENVFIS VHLLQRTQPG AAPCKQSFRH 300
AHPLTGHIVN LAAFSNSCLN PLIYSFLGET FRDKLRLYIE QKTNLPALNR 350
FCHAALKAVI PDSTEQSDVR FSSAV 375
Length:375
Mass (Da):42,248
Last modified:May 1, 1997 - v1
Checksum:i0A54EED8A698F075
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161P → L.2 Publications
Corresponds to variant rs11544331 [ dbSNP | Ensembl ].
VAR_033319

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 212QP → HA in AAC52027. 1 Publication
Sequence conflicti32 – 4918Missing in AAB02736. 1 PublicationAdd
BLAST
Sequence conflicti104 – 1041A → G in AAB02736. 1 Publication
Sequence conflicti140 – 1467NMYSSVF → QHVQAASS in AAB02736. 1 Publication
Sequence conflicti179 – 1791G → A in AAB02736. 1 Publication
Sequence conflicti184 – 1841A → S in AAB02736. 1 Publication
Sequence conflicti312 – 3121A → T in AAC51173. 1 Publication
Sequence conflicti320 – 3201N → T in AAB02736. 1 Publication
Sequence conflicti355 – 3551A → V in AAB02736. 1 Publication
Sequence conflicti358 – 3581A → V in AAB02736. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08162 mRNA. Translation: CAA69354.1.
U77827 Genomic DNA. Translation: AAC51173.1.
AF015257 mRNA. Translation: AAC51904.1.
X98510 mRNA. Translation: CAA67133.1.
U63917 mRNA. Translation: AAB88017.1.
AF027956 Genomic DNA. Translation: AAC52027.1.
U58828 mRNA. Translation: AAB02736.1.
CR541741 mRNA. Translation: CAG46541.1.
AK291590 mRNA. Translation: BAF84279.1.
AB451427 mRNA. Translation: BAG70241.1.
CH236953 Genomic DNA. Translation: EAL23938.1.
CH471144 Genomic DNA. Translation: EAW87194.1.
BC011634 mRNA. Translation: AAH11634.1.
CCDSiCCDS5322.1.
PIRiG02670.
JC5069.
RefSeqiNP_001035055.1. NM_001039966.1.
NP_001091671.1. NM_001098201.1.
NP_001496.1. NM_001505.2.
UniGeneiHs.20961.

Genome annotation databases

EnsembliENST00000297469; ENSP00000297469; ENSG00000164850.
ENST00000397088; ENSP00000380277; ENSG00000164850.
ENST00000397092; ENSP00000380281; ENSG00000164850.
ENST00000401670; ENSP00000385151; ENSG00000164850.
GeneIDi2852.
KEGGihsa:2852.
UCSCiuc003sjz.1. human.

Polymorphism databases

DMDMi3023539.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08162 mRNA. Translation: CAA69354.1 .
U77827 Genomic DNA. Translation: AAC51173.1 .
AF015257 mRNA. Translation: AAC51904.1 .
X98510 mRNA. Translation: CAA67133.1 .
U63917 mRNA. Translation: AAB88017.1 .
AF027956 Genomic DNA. Translation: AAC52027.1 .
U58828 mRNA. Translation: AAB02736.1 .
CR541741 mRNA. Translation: CAG46541.1 .
AK291590 mRNA. Translation: BAF84279.1 .
AB451427 mRNA. Translation: BAG70241.1 .
CH236953 Genomic DNA. Translation: EAL23938.1 .
CH471144 Genomic DNA. Translation: EAW87194.1 .
BC011634 mRNA. Translation: AAH11634.1 .
CCDSi CCDS5322.1.
PIRi G02670.
JC5069.
RefSeqi NP_001035055.1. NM_001039966.1.
NP_001091671.1. NM_001098201.1.
NP_001496.1. NM_001505.2.
UniGenei Hs.20961.

3D structure databases

ProteinModelPortali Q99527.
SMRi Q99527. Positions 19-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q99527. 1 interaction.

Chemistry

BindingDBi Q99527.
ChEMBLi CHEMBL5872.
GuidetoPHARMACOLOGYi 221.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 3023539.

Proteomic databases

MaxQBi Q99527.
PaxDbi Q99527.
PRIDEi Q99527.

Protocols and materials databases

DNASUi 2852.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297469 ; ENSP00000297469 ; ENSG00000164850 .
ENST00000397088 ; ENSP00000380277 ; ENSG00000164850 .
ENST00000397092 ; ENSP00000380281 ; ENSG00000164850 .
ENST00000401670 ; ENSP00000385151 ; ENSG00000164850 .
GeneIDi 2852.
KEGGi hsa:2852.
UCSCi uc003sjz.1. human.

Organism-specific databases

CTDi 2852.
GeneCardsi GC07P001122.
H-InvDB HIX0167652.
HGNCi HGNC:4485. GPER1.
HPAi HPA027052.
MIMi 601805. gene.
neXtProti NX_Q99527.
PharmGKBi PA28873.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG151076.
HOVERGENi HBG005351.
KOi K04246.
OMAi QHARLSC.
OrthoDBi EOG7WX08J.
PhylomeDBi Q99527.
TreeFami TF333506.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii GPR30.
GenomeRNAii 2852.
NextBioi 11247.
PROi Q99527.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q99527.
Bgeei Q99527.
CleanExi HS_GPER.
Genevestigatori Q99527.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues."
    Owman C.S.O., Blay P., Nilsson C., Lolait S.J.
    Biochem. Biophys. Res. Commun. 228:285-292(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors."
    Feng Y., Gregor P.
    Biochem. Biophys. Res. Commun. 231:651-654(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress."
    Takada Y., Kato C., Kondo S., Korenaga R., Ando J.
    Biochem. Biophys. Res. Commun. 240:737-741(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "A novel putative G-protein-coupled receptor expressed in lung, heart and lymphoid tissue."
    Kvingedal A.M., Smeland E.B.
    FEBS Lett. 407:59-62(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer."
    Carmeci C., Thompson D.A., Ring H.Z., Francke U., Weigel R.J.
    Genomics 45:607-617(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Cloning of novel IL8-related receptors from human hepatic tissue."
    McCoy R.L., Perlmutter D.H.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  10. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
    Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
    , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
    Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-16.
  11. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-16.
    Tissue: Uterus.
  14. "Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF."
    Filardo E.J., Quinn J.A., Bland K.I., Frackelton A.R. Jr.
    Mol. Endocrinol. 14:1649-1660(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells."
    Ahola T.M., Purmonen S., Pennanen P., Zhuang Y.H., Tuohimaa P., Ylikomi T.
    Eur. J. Biochem. 269:2485-2490(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  16. "Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells."
    Thomas P., Pang Y., Filardo E.J., Dong J.
    Endocrinology 146:624-632(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ESTROGEN-BINDING, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION.
  17. "A transmembrane intracellular estrogen receptor mediates rapid cell signaling."
    Revankar C.M., Cimino D.F., Sklar L.A., Arterburn J.B., Prossnitz E.R.
    Science 307:1625-1630(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ESTROGEN-BINDING, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION.
  18. "Nature of functional estrogen receptors at the plasma membrane."
    Pedram A., Razandi M., Levin E.R.
    Mol. Endocrinol. 20:1996-2009(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF ESTROGEN-BINDING, SUBCELLULAR LOCATION.
  19. "Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane."
    Filardo E., Quinn J., Pang Y., Graeber C., Shaw S., Dong J., Thomas P.
    Endocrinology 148:3236-3245(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  20. "G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol."
    Otto C., Rohde-Schulz B., Schwarz G., Fuchs I., Klewer M., Brittain D., Langer G., Bader B., Prelle K., Nubbemeyer R., Fritzemeier K.H.
    Endocrinology 149:4846-4856(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF ESTROGEN-BINDING, SUBCELLULAR LOCATION.
  21. Cited for: FUNCTION.
  22. "Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30."
    Quinn J.A., Graeber C.T., Frackelton A.R. Jr., Kim M., Schwarzbauer J.E., Filardo E.J.
    Mol. Endocrinol. 23:1052-1064(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  23. "G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells."
    Vivacqua A., Lappano R., De Marco P., Sisci D., Aquila S., De Amicis F., Fuqua S.A., Ando S., Maggiolini M.
    Mol. Endocrinol. 23:1815-1826(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EGFR AND ESR1, INDUCTION.
  24. "Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts."
    Madeo A., Maggiolini M.
    Cancer Res. 70:6036-6046(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EGFR, ASSOCIATION WITH CHROMATIN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  25. "Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest."
    Chan Q.K., Lam H.M., Ng C.F., Lee A.Y., Chan E.S., Ng H.K., Ho S.M., Lau K.M.
    Cell Death Differ. 17:1511-1523(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  26. "Conserved estrogen binding and signaling functions of the G protein-coupled estrogen receptor 1 (GPER) in mammals and fish."
    Thomas P., Alyea R., Pang Y., Peyton C., Dong J., Berg A.H.
    Steroids 75:595-602(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ESTROGEN-BINDING, BIOPHYSICOCHEMICAL PROPERTIES.
  27. "G-1-activated membrane estrogen receptors mediate increased contractility of the human myometrium."
    Maiti K., Paul J.W., Read M., Chan E.C., Riley S.C., Nahar P., Smith R.
    Endocrinology 152:2448-2455(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
  28. "GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone."
    Gros R., Ding Q., Sklar L.A., Prossnitz E.E., Arterburn J.B., Chorazyczewski J., Feldman R.D.
    Hypertension 57:442-451(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALDOSTERONE-BINDING, FUNCTION.
  29. "Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway."
    Cheng S.B., Quinn J.A., Graeber C.T., Filardo E.J.
    J. Biol. Chem. 286:22441-22455(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, UBIQUITINATION.
  30. "G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments."
    Sanden C., Broselid S., Cornmark L., Andersson K., Daszkiewicz-Nilsson J., Martensson U.E., Olde B., Leeb-Lundberg L.M.
    Mol. Pharmacol. 79:400-410(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KRT7 AND KRT8, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  31. "Retrograde transport of the transmembrane estrogen receptor, G-protein-coupled-receptor-30 (GPR30/GPER) from the plasma membrane towards the nucleus."
    Cheng S.B., Graeber C.T., Quinn J.A., Filardo E.J.
    Steroids 76:892-896(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  32. "G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17beta-estradiol in cancer cells and cancer-associated fibroblasts."
    Santolla M.F., Lappano R., De Marco P., Pupo M., Vivacqua A., Sisci D., Abonante S., Iacopetta D., Cappello A.R., Dolce V., Maggiolini M.
    J. Biol. Chem. 287:43234-43245(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  33. "G-protein coupled receptor 30 (GPR30): a novel regulator of endothelial inflammation."
    Chakrabarti S., Davidge S.T.
    PLoS ONE 7:E52357-E52357(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  34. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  35. "Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation."
    Gros R., Ding Q., Liu B., Chorazyczewski J., Feldman R.D.
    Am. J. Physiol. 304:C532-C540(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALDOSTERONE-BINDING, FUNCTION.
  36. "G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection."
    Lenhart P.M., Broselid S., Barrick C.J., Leeb-Lundberg L.M., Caron K.M.
    J. Mol. Endocrinol. 51:191-202(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RAMP3, SUBCELLULAR LOCATION.
  37. "Position paper: The membrane estrogen receptor GPER--Clues and questions."
    Barton M.
    Steroids 77:935-942(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  38. "Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology."
    Filardo E.J., Thomas P.
    Endocrinology 153:2953-2962(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiGPER1_HUMAN
AccessioniPrimary (citable) accession number: Q99527
Secondary accession number(s): A8K6C5
, B5BUJ1, O00143, O43494, Q13631, Q6FHL1, Q96F42, Q99981
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: September 3, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Does not bind estradiol according to 1 Publication and 1 Publication.

Caution

Data is conflicting regarding whether it fulfills the criteria of a membrane-bound estrogen receptor (1 Publication, 1 Publication and PubMed:16780796) or not (PubMed:12193550, 1 Publication and 1 Publication).
Data is conflicting regarding whether it is localized either at the cell membrane (PM) (1 Publication, 1 Publication, 1 Publication, 1 Publication, 1 Publication and 1 Publication) or at the endoplasmic reticulum (ER) (1 Publication and 1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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