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Q99525

- H4G_HUMAN

UniProt

Q99525 - H4G_HUMAN

Protein

Histone H4-like protein type G

Gene

HIST1H4G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi17 – 215By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleosome assembly Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone H4-like protein type G
    Gene namesi
    Name:HIST1H4G
    Synonyms:H4/L, H4FL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4792. HIST1H4G.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. nucleosome Source: UniProtKB-KW
    2. nucleus Source: UniProt

    Keywords - Cellular componenti

    Chromosome, Nucleosome core, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29167.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9898Histone H4-like protein type GPRO_0000324392Add
    BLAST

    Proteomic databases

    PaxDbiQ99525.
    PRIDEiQ99525.

    PTM databases

    PhosphoSiteiQ99525.

    Expressioni

    Gene expression databases

    BgeeiQ99525.
    CleanExiHS_HIST1H4G.
    GenevestigatoriQ99525.

    Organism-specific databases

    HPAiHPA042201.

    Interactioni

    Subunit structurei

    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA By similarity.By similarity

    Protein-protein interaction databases

    BioGridi113965. 4 interactions.
    MINTiMINT-6630741.
    STRINGi9606.ENSP00000244537.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99525.
    SMRiQ99525. Positions 9-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone H4 family.Curated

    Phylogenomic databases

    eggNOGiCOG2036.
    HOGENOMiHOG000234654.
    HOVERGENiHBG051878.
    InParanoidiQ99525.
    KOiK11254.
    OMAiCHRKVLS.
    OrthoDBiEOG71P2DH.
    PhylomeDBiQ99525.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR001951. Histone_H4.
    [Graphical view]
    PfamiPF00125. Histone. 1 hit.
    [Graphical view]
    PRINTSiPR00623. HISTONEH4.
    SMARTiSM00417. H4. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q99525-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVRGKAGKG LGKGGAKCHR KVLSDNIQGI TKCTIRRLAR HGGVKRILGL   50
    IYEETRRVFK VFLENVIWYA VTNTEHAKRK TVTAMAVVYV LKRQGRTL 98
    Length:98
    Mass (Da):11,009
    Last modified:May 1, 1997 - v1
    Checksum:iB76078AC96AE4DEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z80788 Genomic DNA. Translation: CAB02550.1.
    AY128660 Genomic DNA. Translation: AAN01445.1.
    AL031777 Genomic DNA. Translation: CAB39187.1.
    CH471087 Genomic DNA. Translation: EAW55550.1.
    BC126276 mRNA. Translation: AAI26277.1.
    BC126278 mRNA. Translation: AAI26279.1.
    CCDSiCCDS4599.1.
    RefSeqiNP_003538.1. NM_003547.2.
    UniGeneiHs.553507.

    Genome annotation databases

    GeneIDi8369.
    KEGGihsa:8369.
    UCSCiuc003nhf.3. human.

    Polymorphism databases

    DMDMi74752149.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z80788 Genomic DNA. Translation: CAB02550.1 .
    AY128660 Genomic DNA. Translation: AAN01445.1 .
    AL031777 Genomic DNA. Translation: CAB39187.1 .
    CH471087 Genomic DNA. Translation: EAW55550.1 .
    BC126276 mRNA. Translation: AAI26277.1 .
    BC126278 mRNA. Translation: AAI26279.1 .
    CCDSi CCDS4599.1.
    RefSeqi NP_003538.1. NM_003547.2.
    UniGenei Hs.553507.

    3D structure databases

    ProteinModelPortali Q99525.
    SMRi Q99525. Positions 9-98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113965. 4 interactions.
    MINTi MINT-6630741.
    STRINGi 9606.ENSP00000244537.

    PTM databases

    PhosphoSitei Q99525.

    Polymorphism databases

    DMDMi 74752149.

    Proteomic databases

    PaxDbi Q99525.
    PRIDEi Q99525.

    Protocols and materials databases

    DNASUi 8369.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8369.
    KEGGi hsa:8369.
    UCSCi uc003nhf.3. human.

    Organism-specific databases

    CTDi 8369.
    GeneCardsi GC06M026409.
    HGNCi HGNC:4792. HIST1H4G.
    HPAi HPA042201.
    MIMi 602832. gene.
    neXtProti NX_Q99525.
    PharmGKBi PA29167.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2036.
    HOGENOMi HOG000234654.
    HOVERGENi HBG051878.
    InParanoidi Q99525.
    KOi K11254.
    OMAi CHRKVLS.
    OrthoDBi EOG71P2DH.
    PhylomeDBi Q99525.

    Miscellaneous databases

    GeneWikii HIST1H4G.
    GenomeRNAii 8369.
    NextBioi 31348.
    PROi Q99525.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99525.
    CleanExi HS_HIST1H4G.
    Genevestigatori Q99525.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR001951. Histone_H4.
    [Graphical view ]
    Pfami PF00125. Histone. 1 hit.
    [Graphical view ]
    PRINTSi PR00623. HISTONEH4.
    SMARTi SM00417. H4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Human histone gene organization: nonregular arrangement within a large cluster."
      Albig W., Kioschis P., Poustka A., Meergans K., Doenecke D.
      Genomics 40:314-322(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The human and mouse replication-dependent histone genes."
      Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J.
      Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiH4G_HUMAN
    AccessioniPrimary (citable) accession number: Q99525
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3