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Q99525

- H4G_HUMAN

UniProt

Q99525 - H4G_HUMAN

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Protein
Histone H4-like protein type G
Gene
HIST1H4G, H4/L, H4FL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi17 – 215 By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleosome assembly Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4-like protein type G
Gene namesi
Synonyms:H4/L, H4FL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4792. HIST1H4G.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. nucleosome Source: UniProtKB-KW
  2. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29167.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Histone H4-like protein type G
PRO_0000324392Add
BLAST

Proteomic databases

PaxDbiQ99525.
PRIDEiQ99525.

PTM databases

PhosphoSiteiQ99525.

Expressioni

Gene expression databases

BgeeiQ99525.
CleanExiHS_HIST1H4G.
GenevestigatoriQ99525.

Organism-specific databases

HPAiHPA042201.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA By similarity.

Protein-protein interaction databases

BioGridi113965. 3 interactions.
MINTiMINT-6630741.
STRINGi9606.ENSP00000244537.

Structurei

3D structure databases

ProteinModelPortaliQ99525.
SMRiQ99525. Positions 9-98.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.

Phylogenomic databases

eggNOGiCOG2036.
HOGENOMiHOG000234654.
HOVERGENiHBG051878.
InParanoidiQ99525.
KOiK11254.
OMAiCHRKVLS.
OrthoDBiEOG71P2DH.
PhylomeDBiQ99525.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001951. Histone_H4.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99525-1 [UniParc]FASTAAdd to Basket

« Hide

MSVRGKAGKG LGKGGAKCHR KVLSDNIQGI TKCTIRRLAR HGGVKRILGL   50
IYEETRRVFK VFLENVIWYA VTNTEHAKRK TVTAMAVVYV LKRQGRTL 98
Length:98
Mass (Da):11,009
Last modified:May 1, 1997 - v1
Checksum:iB76078AC96AE4DEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z80788 Genomic DNA. Translation: CAB02550.1.
AY128660 Genomic DNA. Translation: AAN01445.1.
AL031777 Genomic DNA. Translation: CAB39187.1.
CH471087 Genomic DNA. Translation: EAW55550.1.
BC126276 mRNA. Translation: AAI26277.1.
BC126278 mRNA. Translation: AAI26279.1.
CCDSiCCDS4599.1.
RefSeqiNP_003538.1. NM_003547.2.
UniGeneiHs.553507.

Genome annotation databases

EnsembliENST00000244537; ENSP00000244537; ENSG00000124578.
GeneIDi8369.
KEGGihsa:8369.
UCSCiuc003nhf.3. human.

Polymorphism databases

DMDMi74752149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z80788 Genomic DNA. Translation: CAB02550.1 .
AY128660 Genomic DNA. Translation: AAN01445.1 .
AL031777 Genomic DNA. Translation: CAB39187.1 .
CH471087 Genomic DNA. Translation: EAW55550.1 .
BC126276 mRNA. Translation: AAI26277.1 .
BC126278 mRNA. Translation: AAI26279.1 .
CCDSi CCDS4599.1.
RefSeqi NP_003538.1. NM_003547.2.
UniGenei Hs.553507.

3D structure databases

ProteinModelPortali Q99525.
SMRi Q99525. Positions 9-98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113965. 3 interactions.
MINTi MINT-6630741.
STRINGi 9606.ENSP00000244537.

PTM databases

PhosphoSitei Q99525.

Polymorphism databases

DMDMi 74752149.

Proteomic databases

PaxDbi Q99525.
PRIDEi Q99525.

Protocols and materials databases

DNASUi 8369.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000244537 ; ENSP00000244537 ; ENSG00000124578 .
GeneIDi 8369.
KEGGi hsa:8369.
UCSCi uc003nhf.3. human.

Organism-specific databases

CTDi 8369.
GeneCardsi GC06M026409.
HGNCi HGNC:4792. HIST1H4G.
HPAi HPA042201.
MIMi 602832. gene.
neXtProti NX_Q99525.
PharmGKBi PA29167.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2036.
HOGENOMi HOG000234654.
HOVERGENi HBG051878.
InParanoidi Q99525.
KOi K11254.
OMAi CHRKVLS.
OrthoDBi EOG71P2DH.
PhylomeDBi Q99525.

Miscellaneous databases

GeneWikii HIST1H4G.
GenomeRNAii 8369.
NextBioi 31348.
PROi Q99525.
SOURCEi Search...

Gene expression databases

Bgeei Q99525.
CleanExi HS_HIST1H4G.
Genevestigatori Q99525.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
InterProi IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001951. Histone_H4.
[Graphical view ]
Pfami PF00125. Histone. 1 hit.
[Graphical view ]
PRINTSi PR00623. HISTONEH4.
SMARTi SM00417. H4. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human histone gene organization: nonregular arrangement within a large cluster."
    Albig W., Kioschis P., Poustka A., Meergans K., Doenecke D.
    Genomics 40:314-322(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The human and mouse replication-dependent histone genes."
    Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J.
    Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiH4G_HUMAN
AccessioniPrimary (citable) accession number: Q99525
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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