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Protein

Histone H4-like protein type G

Gene

HIST1H4G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi17 – 215By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4-like protein type G
Gene namesi
Name:HIST1H4G
Synonyms:H4/L, H4FL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4792. HIST1H4G.

Subcellular locationi

  1. Nucleus By similarity
  2. Chromosome By similarity

GO - Cellular componenti

  1. nucleosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29167.

Polymorphism and mutation databases

BioMutaiHIST1H4G.
DMDMi74752149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Histone H4-like protein type GPRO_0000324392Add
BLAST

Proteomic databases

PaxDbiQ99525.
PRIDEiQ99525.

PTM databases

PhosphoSiteiQ99525.

Expressioni

Gene expression databases

BgeeiQ99525.
CleanExiHS_HIST1H4G.
GenevestigatoriQ99525.

Organism-specific databases

HPAiHPA042201.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-10294329,EBI-741181

Protein-protein interaction databases

BioGridi113965. 5 interactions.
IntActiQ99525. 1 interaction.
MINTiMINT-6630741.
STRINGi9606.ENSP00000244537.

Structurei

3D structure databases

ProteinModelPortaliQ99525.
SMRiQ99525. Positions 9-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiCOG2036.
GeneTreeiENSGT00760000119019.
HOGENOMiHOG000234654.
HOVERGENiHBG051878.
InParanoidiQ99525.
KOiK11254.
OMAiCHRKVLS.
OrthoDBiEOG71P2DH.
PhylomeDBiQ99525.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001951. Histone_H4.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q99525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRGKAGKG LGKGGAKCHR KVLSDNIQGI TKCTIRRLAR HGGVKRILGL
60 70 80 90
IYEETRRVFK VFLENVIWYA VTNTEHAKRK TVTAMAVVYV LKRQGRTL
Length:98
Mass (Da):11,009
Last modified:May 1, 1997 - v1
Checksum:iB76078AC96AE4DEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z80788 Genomic DNA. Translation: CAB02550.1.
AY128660 Genomic DNA. Translation: AAN01445.1.
AL031777 Genomic DNA. Translation: CAB39187.1.
CH471087 Genomic DNA. Translation: EAW55550.1.
BC126276 mRNA. Translation: AAI26277.1.
BC126278 mRNA. Translation: AAI26279.1.
CCDSiCCDS4599.1.
RefSeqiNP_003538.1. NM_003547.2.
UniGeneiHs.553507.

Genome annotation databases

EnsembliENST00000611444; ENSP00000477870; ENSG00000275663.
GeneIDi8369.
KEGGihsa:8369.
UCSCiuc003nhf.3. human.

Polymorphism and mutation databases

BioMutaiHIST1H4G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z80788 Genomic DNA. Translation: CAB02550.1.
AY128660 Genomic DNA. Translation: AAN01445.1.
AL031777 Genomic DNA. Translation: CAB39187.1.
CH471087 Genomic DNA. Translation: EAW55550.1.
BC126276 mRNA. Translation: AAI26277.1.
BC126278 mRNA. Translation: AAI26279.1.
CCDSiCCDS4599.1.
RefSeqiNP_003538.1. NM_003547.2.
UniGeneiHs.553507.

3D structure databases

ProteinModelPortaliQ99525.
SMRiQ99525. Positions 9-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113965. 5 interactions.
IntActiQ99525. 1 interaction.
MINTiMINT-6630741.
STRINGi9606.ENSP00000244537.

PTM databases

PhosphoSiteiQ99525.

Polymorphism and mutation databases

BioMutaiHIST1H4G.
DMDMi74752149.

Proteomic databases

PaxDbiQ99525.
PRIDEiQ99525.

Protocols and materials databases

DNASUi8369.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611444; ENSP00000477870; ENSG00000275663.
GeneIDi8369.
KEGGihsa:8369.
UCSCiuc003nhf.3. human.

Organism-specific databases

CTDi8369.
GeneCardsiGC06M026438.
HGNCiHGNC:4792. HIST1H4G.
HPAiHPA042201.
MIMi602832. gene.
neXtProtiNX_Q99525.
PharmGKBiPA29167.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2036.
GeneTreeiENSGT00760000119019.
HOGENOMiHOG000234654.
HOVERGENiHBG051878.
InParanoidiQ99525.
KOiK11254.
OMAiCHRKVLS.
OrthoDBiEOG71P2DH.
PhylomeDBiQ99525.

Miscellaneous databases

GeneWikiiHIST1H4G.
GenomeRNAii8369.
NextBioi31348.
PROiQ99525.
SOURCEiSearch...

Gene expression databases

BgeeiQ99525.
CleanExiHS_HIST1H4G.
GenevestigatoriQ99525.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001951. Histone_H4.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human histone gene organization: nonregular arrangement within a large cluster."
    Albig W., Kioschis P., Poustka A., Meergans K., Doenecke D.
    Genomics 40:314-322(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The human and mouse replication-dependent histone genes."
    Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J.
    Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiH4G_HUMAN
AccessioniPrimary (citable) accession number: Q99525
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 1997
Last modified: April 29, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.