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Protein

Sortilin

Gene

SORT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.10 Publications

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • nerve growth factor binding Source: BHF-UCL
  • nerve growth factor receptor activity Source: BHF-UCL
  • neurotensin receptor activity, non-G-protein coupled Source: BHF-UCL

GO - Biological processi

  • endocytosis Source: BHF-UCL
  • endosome to lysosome transport Source: BHF-UCL
  • endosome transport via multivesicular body sorting pathway Source: BHF-UCL
  • extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
  • glucose import Source: BHF-UCL
  • Golgi to endosome transport Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • multicellular organism development Source: UniProtKB-KW
  • myotube differentiation Source: BHF-UCL
  • negative regulation of fat cell differentiation Source: Ensembl
  • negative regulation of lipoprotein lipase activity Source: BHF-UCL
  • neuropeptide signaling pathway Source: BHF-UCL
  • neurotrophin TRK receptor signaling pathway Source: BHF-UCL
  • ossification Source: UniProtKB-KW
  • plasma membrane to endosome transport Source: BHF-UCL
  • positive regulation of epithelial cell apoptotic process Source: Ensembl
  • regulation of gene expression Source: BHF-UCL
  • response to insulin Source: BHF-UCL
  • vesicle organization Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Differentiation, Endocytosis, Osteogenesis, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134243-MONOMER.
ReactomeiR-HSA-432722. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Sortilin
Alternative name(s):
100 kDa NT receptor
Glycoprotein 95
Short name:
Gp95
Neurotensin receptor 3
Short name:
NT3
Short name:
NTR3
Gene namesi
Name:SORT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11186. SORT1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini78 – 755ExtracellularSequence analysisAdd BLAST678
Transmembranei756 – 778HelicalSequence analysisAdd BLAST23
Topological domaini779 – 831CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • clathrin-coated pit Source: BHF-UCL
  • clathrin-coated vesicle Source: BHF-UCL
  • cytoplasmic, membrane-bounded vesicle Source: BHF-UCL
  • cytosol Source: GOC
  • dendrite Source: Ensembl
  • early endosome Source: BHF-UCL
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: BHF-UCL
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: BHF-UCL
  • lysosomal membrane Source: UniProtKB-SubCell
  • neuronal cell body Source: Ensembl
  • nuclear membrane Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: BHF-UCL
  • plasma membrane Source: BHF-UCL
  • trans-Golgi network transport vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

A common polymorphism located in a non-coding region between CELSR2 and PSRC1 alters a CEBP transcription factor binding site and is responsible for changes in hepatic expression of SORT1. Altered SORT1 expression in liver affects low density lipoprotein cholesterol levels in plasma and is associated with susceptibility to myocardial infarction.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi74 – 77RWRR → GWRA: Abrogates propeptide cleavage. 1 Publication4
Mutagenesisi76 – 77RR → GG: Abrogates propeptide cleavage. 1 Publication2
Mutagenesisi792Y → A: Reduces endocytosis and Golgi to endosome sorting; when associated with A-795. 1 Publication1
Mutagenesisi795L → A: Reduces endocytosis and Golgi to endosome sorting; when associated with A-792. 1 Publication1
Mutagenesisi823 – 824DD → NN: Reduces interaction with GGA1. 1 Publication2
Mutagenesisi825S → A: Reduces interaction with GGA1. 1 Publication1
Mutagenesisi826 – 828DED → NQN: Abrogates interaction with GGA1 and impairs localization to the Golgi. 1 Publication3
Mutagenesisi829 – 830LL → AA: Abrogates interaction with GGA1 and impairs localization to the Golgi. 2 Publications2
Mutagenesisi829 – 830Missing : Abrogates interaction with GGA2. Reduces endocytosis and Golgi to endosome sorting; when associated with A-792 and A-795. 2 Publications2

Organism-specific databases

DisGeNETi6272.
MIMi613589. phenotype.
OpenTargetsiENSG00000134243.
PharmGKBiPA36023.

Chemistry databases

ChEMBLiCHEMBL3091.

Polymorphism and mutation databases

BioMutaiSORT1.
DMDMi84028263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33By similarityAdd BLAST33
PropeptideiPRO_000003316234 – 77Removed in mature form1 PublicationAdd BLAST44
ChainiPRO_000003316378 – 831SortilinAdd BLAST754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi86 ↔ 556
Glycosylationi98N-linked (GlcNAc...)Curated1
Glycosylationi162N-linked (GlcNAc...)2 Publications1
Glycosylationi163N-linked (GlcNAc...); atypical1 Publication1
Disulfide bondi257 ↔ 277
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1
Glycosylationi406N-linked (GlcNAc...)1 Publication1
Disulfide bondi448 ↔ 458
Glycosylationi582N-linked (GlcNAc...)1 Publication1
Disulfide bondi612 ↔ 651
Disulfide bondi634 ↔ 666
Disulfide bondi668 ↔ 723
Disulfide bondi675 ↔ 688
Glycosylationi684N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi702 ↔ 740
Modified residuei814PhosphoserineCombined sources1
Modified residuei819PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1

Post-translational modificationi

The N-terminal propeptide is cleaved by furin and possibly other homologous proteases.2 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ99523.
MaxQBiQ99523.
PaxDbiQ99523.
PeptideAtlasiQ99523.
PRIDEiQ99523.

PTM databases

iPTMnetiQ99523.
PhosphoSitePlusiQ99523.
SwissPalmiQ99523.

Expressioni

Tissue specificityi

Expressed in brain and prostate (at protein level). Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver.2 Publications

Inductioni

During osteoblast differentiation.1 Publication

Gene expression databases

BgeeiENSG00000134243.
CleanExiHS_SORT1.
ExpressionAtlasiQ99523. baseline and differential.
GenevisibleiQ99523. HS.

Organism-specific databases

HPAiCAB011498.
HPA006889.

Interactioni

Subunit structurei

Interacts with LPL and SLC2A4 (By similarity). Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP, GM2A and NTS. Forms a complex with NGFR which binds specifically to the precursor forms of NGFB (proNGFB) and BDNF (proBDNF). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; may regulate their anterograde axonal transport and signaling. Interacts with CLN5 (PubMed:22431521). Interacts with PSAP (PubMed:22431521, PubMed:14657016).By similarity13 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GGA1Q9UJY52EBI-1057058,EBI-447141
LPLP111516EBI-1057058,EBI-8794090From a different organism.
NGFP011384EBI-1057058,EBI-1028250
NTRK1P046293EBI-1057058,EBI-1028226
NTRK3Q162882EBI-1057058,EBI-3936704

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • nerve growth factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi112180. 128 interactors.
DIPiDIP-41798N.
IntActiQ99523. 136 interactors.
MINTiMINT-197682.
STRINGi9606.ENSP00000256637.

Chemistry databases

BindingDBiQ99523.

Structurei

Secondary structure

1831
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi92 – 97Combined sources6
Beta strandi100 – 106Combined sources7
Beta strandi110 – 116Combined sources7
Beta strandi118 – 121Combined sources4
Beta strandi124 – 130Combined sources7
Beta strandi136 – 138Combined sources3
Beta strandi141 – 149Combined sources9
Helixi158 – 161Combined sources4
Helixi168 – 170Combined sources3
Beta strandi172 – 174Combined sources3
Beta strandi182 – 186Combined sources5
Beta strandi196 – 202Combined sources7
Beta strandi208 – 211Combined sources4
Beta strandi216 – 218Combined sources3
Beta strandi221 – 223Combined sources3
Beta strandi226 – 234Combined sources9
Beta strandi239 – 244Combined sources6
Beta strandi247 – 261Combined sources15
Helixi263 – 265Combined sources3
Beta strandi267 – 271Combined sources5
Beta strandi273 – 275Combined sources3
Turni277 – 282Combined sources6
Beta strandi283 – 291Combined sources9
Beta strandi297 – 309Combined sources13
Beta strandi312 – 318Combined sources7
Beta strandi320 – 322Combined sources3
Beta strandi325 – 332Combined sources8
Beta strandi351 – 356Combined sources6
Beta strandi361 – 366Combined sources6
Beta strandi368 – 370Combined sources3
Beta strandi372 – 379Combined sources8
Beta strandi385 – 395Combined sources11
Turni397 – 399Combined sources3
Beta strandi414 – 419Combined sources6
Beta strandi421 – 423Combined sources3
Beta strandi425 – 432Combined sources8
Beta strandi438 – 441Combined sources4
Beta strandi453 – 456Combined sources4
Beta strandi459 – 462Combined sources4
Helixi465 – 469Combined sources5
Beta strandi488 – 497Combined sources10
Beta strandi504 – 510Combined sources7
Beta strandi516 – 521Combined sources6
Beta strandi523 – 528Combined sources6
Helixi529 – 531Combined sources3
Beta strandi533 – 538Combined sources6
Beta strandi546 – 552Combined sources7
Beta strandi558 – 561Combined sources4
Beta strandi567 – 573Combined sources7
Beta strandi581 – 590Combined sources10
Beta strandi595 – 603Combined sources9
Helixi604 – 606Combined sources3
Helixi614 – 616Combined sources3
Beta strandi617 – 621Combined sources5
Turni630 – 633Combined sources4
Beta strandi638 – 645Combined sources8
Beta strandi661 – 665Combined sources5
Helixi670 – 672Combined sources3
Beta strandi673 – 675Combined sources3
Beta strandi683 – 685Combined sources3
Helixi696 – 704Combined sources9
Helixi707 – 710Combined sources4
Beta strandi714 – 717Combined sources4
Beta strandi724 – 726Combined sources3
Beta strandi734 – 736Combined sources3
Helixi737 – 740Combined sources4
Helixi741 – 743Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F6KX-ray2.00A78-756[»]
3G2UX-ray2.30C/D819-831[»]
3G2VX-ray2.10C/D819-831[»]
4MSLX-ray2.70A78-756[»]
4N7EX-ray2.70A78-756[»]
4PO7X-ray2.66A78-756[»]
ProteinModelPortaliQ99523.
SMRiQ99523.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99523.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati145 – 156BNR 1Add BLAST12
Repeati198 – 209BNR 2Add BLAST12
Repeati240 – 251BNR 3Add BLAST12
Repeati287 – 298BNR 4Add BLAST12
Repeati328 – 339BNR 5Add BLAST12
Repeati377 – 388BNR 6Add BLAST12
Repeati428 – 439BNR 7Add BLAST12
Repeati506 – 517BNR 8Add BLAST12
Repeati548 – 559BNR 9Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 61Intrachain binding of the propeptide and the extracellular domainAdd BLAST12
Regioni612 – 756Interactions with LRPAP1 and NGFBAdd BLAST145
Regioni779 – 831Golgi to endosome transport and interactions with GGA1 and GGA2Add BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi787 – 792Endocytosis signalCurated6

Domaini

The N-terminal propeptide may facilitate precursor transport within the Golgi stack. Intrachain binding of the N-terminal propeptide and the extracellular domain may also inhibit premature ligand binding.
The extracellular domain may be shed following protease cleavage in some cell types.

Sequence similaritiesi

Contains 9 BNR repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISX8. Eukaryota.
ENOG410ZJ6Q. LUCA.
GeneTreeiENSGT00510000046443.
HOGENOMiHOG000231347.
HOVERGENiHBG080235.
InParanoidiQ99523.
KOiK12388.
OMAiCDSTAKN.
OrthoDBiEOG091G0ETU.
PhylomeDBiQ99523.
TreeFamiTF324918.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR031777. Sortilin_C.
IPR031778. Sortilin_N.
IPR006581. VPS10.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF15902. Sortilin-Vps10. 1 hit.
PF15901. Sortilin_C. 1 hit.
[Graphical view]
SMARTiSM00602. VPS10. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99523-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERPWGAADG LSRWPHGLGL LLLLQLLPPS TLSQDRLDAP PPPAAPLPRW
60 70 80 90 100
SGPIGVSWGL RAAAAGGAFP RGGRWRRSAP GEDEECGRVR DFVAKLANNT
110 120 130 140 150
HQHVFDDLRG SVSLSWVGDS TGVILVLTTF HVPLVIMTFG QSKLYRSEDY
160 170 180 190 200
GKNFKDITDL INNTFIRTEF GMAIGPENSG KVVLTAEVSG GSRGGRIFRS
210 220 230 240 250
SDFAKNFVQT DLPFHPLTQM MYSPQNSDYL LALSTENGLW VSKNFGGKWE
260 270 280 290 300
EIHKAVCLAK WGSDNTIFFT TYANGSCKAD LGALELWRTS DLGKSFKTIG
310 320 330 340 350
VKIYSFGLGG RFLFASVMAD KDTTRRIHVS TDQGDTWSMA QLPSVGQEQF
360 370 380 390 400
YSILAANDDM VFMHVDEPGD TGFGTIFTSD DRGIVYSKSL DRHLYTTTGG
410 420 430 440 450
ETDFTNVTSL RGVYITSVLS EDNSIQTMIT FDQGGRWTHL RKPENSECDA
460 470 480 490 500
TAKNKNECSL HIHASYSISQ KLNVPMAPLS EPNAVGIVIA HGSVGDAISV
510 520 530 540 550
MVPDVYISDD GGYSWTKMLE GPHYYTILDS GGIIVAIEHS SRPINVIKFS
560 570 580 590 600
TDEGQCWQTY TFTRDPIYFT GLASEPGARS MNISIWGFTE SFLTSQWVSY
610 620 630 640 650
TIDFKDILER NCEEKDYTIW LAHSTDPEDY EDGCILGYKE QFLRLRKSSV
660 670 680 690 700
CQNGRDYVVT KQPSICLCSL EDFLCDFGYY RPENDSKCVE QPELKGHDLE
710 720 730 740 750
FCLYGREEHL TTNGYRKIPG DKCQGGVNPV REVKDLKKKC TSNFLSPEKQ
760 770 780 790 800
NSKSNSVPII LAIVGLMLVT VVAGVLIVKK YVCGGRFLVH RYSVLQQHAE
810 820 830
ANGVDGVDAL DTASHTNKSG YHDDSDEDLL E
Length:831
Mass (Da):92,068
Last modified:December 20, 2005 - v3
Checksum:i91F96A3035A4B43A
GO
Isoform 2 (identifier: Q99523-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.
     278-279: KA → T

Note: No experimental confirmation available.
Show »
Length:694
Mass (Da):77,375
Checksum:i4F80EC724C360750
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti650V → M in CAA66904 (PubMed:9013611).Curated1

Polymorphismi

Genetic variations in SORT1 influence low density lipoprotein cholesterol (LDL-C) variability and contribute to the low density lipoprotein cholesterol level quantitative trait locus 6 (LDLCQ6) [MIMi:613589].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053681358D → Y.Corresponds to variant rs2228605dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0462391 – 136Missing in isoform 2. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_046240278 – 279KA → T in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98248 mRNA. Translation: CAA66904.2.
FJ525881 Genomic DNA. Translation: ACN81319.1.
AK301548 mRNA. Translation: BAG63045.1.
AL390252 Genomic DNA. Translation: CAI13180.1.
BC023542 mRNA. Translation: AAH23542.1.
CCDSiCCDS55618.1. [Q99523-2]
CCDS798.1. [Q99523-1]
RefSeqiNP_001192157.1. NM_001205228.1. [Q99523-2]
NP_002950.3. NM_002959.6. [Q99523-1]
UniGeneiHs.485195.
Hs.703487.

Genome annotation databases

EnsembliENST00000256637; ENSP00000256637; ENSG00000134243. [Q99523-1]
ENST00000538502; ENSP00000438597; ENSG00000134243. [Q99523-2]
GeneIDi6272.
KEGGihsa:6272.
UCSCiuc001dxm.3. human. [Q99523-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98248 mRNA. Translation: CAA66904.2.
FJ525881 Genomic DNA. Translation: ACN81319.1.
AK301548 mRNA. Translation: BAG63045.1.
AL390252 Genomic DNA. Translation: CAI13180.1.
BC023542 mRNA. Translation: AAH23542.1.
CCDSiCCDS55618.1. [Q99523-2]
CCDS798.1. [Q99523-1]
RefSeqiNP_001192157.1. NM_001205228.1. [Q99523-2]
NP_002950.3. NM_002959.6. [Q99523-1]
UniGeneiHs.485195.
Hs.703487.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F6KX-ray2.00A78-756[»]
3G2UX-ray2.30C/D819-831[»]
3G2VX-ray2.10C/D819-831[»]
4MSLX-ray2.70A78-756[»]
4N7EX-ray2.70A78-756[»]
4PO7X-ray2.66A78-756[»]
ProteinModelPortaliQ99523.
SMRiQ99523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112180. 128 interactors.
DIPiDIP-41798N.
IntActiQ99523. 136 interactors.
MINTiMINT-197682.
STRINGi9606.ENSP00000256637.

Chemistry databases

BindingDBiQ99523.
ChEMBLiCHEMBL3091.

PTM databases

iPTMnetiQ99523.
PhosphoSitePlusiQ99523.
SwissPalmiQ99523.

Polymorphism and mutation databases

BioMutaiSORT1.
DMDMi84028263.

Proteomic databases

EPDiQ99523.
MaxQBiQ99523.
PaxDbiQ99523.
PeptideAtlasiQ99523.
PRIDEiQ99523.

Protocols and materials databases

DNASUi6272.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256637; ENSP00000256637; ENSG00000134243. [Q99523-1]
ENST00000538502; ENSP00000438597; ENSG00000134243. [Q99523-2]
GeneIDi6272.
KEGGihsa:6272.
UCSCiuc001dxm.3. human. [Q99523-1]

Organism-specific databases

CTDi6272.
DisGeNETi6272.
GeneCardsiSORT1.
HGNCiHGNC:11186. SORT1.
HPAiCAB011498.
HPA006889.
MIMi602458. gene.
613589. phenotype.
neXtProtiNX_Q99523.
OpenTargetsiENSG00000134243.
PharmGKBiPA36023.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISX8. Eukaryota.
ENOG410ZJ6Q. LUCA.
GeneTreeiENSGT00510000046443.
HOGENOMiHOG000231347.
HOVERGENiHBG080235.
InParanoidiQ99523.
KOiK12388.
OMAiCDSTAKN.
OrthoDBiEOG091G0ETU.
PhylomeDBiQ99523.
TreeFamiTF324918.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134243-MONOMER.
ReactomeiR-HSA-432722. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSiSORT1. human.
EvolutionaryTraceiQ99523.
GeneWikiiSortilin_1.
GenomeRNAii6272.
PROiQ99523.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134243.
CleanExiHS_SORT1.
ExpressionAtlasiQ99523. baseline and differential.
GenevisibleiQ99523. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR031777. Sortilin_C.
IPR031778. Sortilin_N.
IPR006581. VPS10.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF15902. Sortilin-Vps10. 1 hit.
PF15901. Sortilin_C. 1 hit.
[Graphical view]
SMARTiSM00602. VPS10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSORT_HUMAN
AccessioniPrimary (citable) accession number: Q99523
Secondary accession number(s): B4DWI3, C0JYZ0, Q8IZ49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 164 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.