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Protein

Sialidase-1

Gene

NEU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.1 Publication

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.3 Publications

pH dependencei

Optimum pH is 4.6.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78SubstrateBy similarity1
Binding sitei97SubstrateBy similarity1
Active sitei103Proton acceptorBy similarity1
Binding sitei264SubstrateBy similarity1
Binding sitei280SubstrateBy similarity1
Binding sitei341SubstrateBy similarity1
Active sitei370NucleophileBy similarity1
Active sitei394Sequence analysis1

GO - Molecular functioni

GO - Biological processi

  • ganglioside catabolic process Source: GO_Central
  • glycosphingolipid metabolic process Source: Reactome
  • oligosaccharide catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.2.1.18. 2681.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-4085001. Sialic acid metabolism.
R-HSA-6798695. Neutrophil degranulation.
SABIO-RKQ99519.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase-1 (EC:3.2.1.18)
Alternative name(s):
Acetylneuraminyl hydrolase
G9 sialidase
Lysosomal sialidase
N-acetyl-alpha-neuraminidase 1
Gene namesi
Name:NEU1
Synonyms:NANH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:7758. NEU1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Sialidosis (SIALIDOSIS)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionLysosomal storage disease occurring as two types with various manifestations. Type 1 sialidosis (cherry red spot-myoclonus syndrome or normosomatic type) is late-onset and it is characterized by the formation of cherry red macular spots in childhood, progressive debilitating myoclonus, insiduous visual loss and rarely ataxia. The diagnosis can be confirmed by the screening of the urine for sialyloligosaccharides. Type 2 sialidosis (also known as dysmorphic type) occurs as several variants of increasing severity with earlier age of onset. It is characterized by the presence of abnormal somatic features including coarse facies and dysostosis multiplex, vertebral deformities, mental retardation, cherry-red spot/myoclonus, sialuria, cytoplasmic vacuolation of peripheral lymphocytes, bone marrow cells and conjunctival epithelial cells.
See also OMIM:256550
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01220754V → M in SIALIDOSIS; type 1; mild mutation as residual activity is still measurable. 1 Publication1
Natural variantiVAR_01220868G → V in SIALIDOSIS; type 2; less than 10% of activity. 3 Publications1
Natural variantiVAR_01746080P → L in SIALIDOSIS; type 2; no enzyme activity; retained in the endoplasmic reticulum / Golgi or rapidly degraded in the lysosomes. 1 PublicationCorresponds to variant rs104893985dbSNPEnsembl.1
Natural variantiVAR_01220991L → R in SIALIDOSIS; type 2. 2 PublicationsCorresponds to variant rs104893972dbSNPEnsembl.1
Natural variantiVAR_012210182S → G in SIALIDOSIS; type 1; normally processed. 3 PublicationsCorresponds to variant rs398123392dbSNPEnsembl.1
Natural variantiVAR_012211217V → M in SIALIDOSIS; type 1; partial transport and residual transport activity. 1 PublicationCorresponds to variant rs28940583dbSNPEnsembl.1
Natural variantiVAR_012212219G → A in SIALIDOSIS; type 1; unable to reach the lysosomes. 1 PublicationCorresponds to variant rs754068739dbSNPEnsembl.1
Natural variantiVAR_018076225R → P in SIALIDOSIS; type 2; impaired enzyme folding. 1 PublicationCorresponds to variant rs28940584dbSNPEnsembl.1
Natural variantiVAR_012213227G → R in SIALIDOSIS; type 1 and juvenile type 2; catalytically inactive; retained in pre-lysosomal compartments. 3 PublicationsCorresponds to variant rs769765227dbSNPEnsembl.1
Natural variantiVAR_012214231L → H in SIALIDOSIS; type 1; unable to reach the lysosomes. 1 PublicationCorresponds to variant rs762400331dbSNPEnsembl.1
Natural variantiVAR_012215240W → R in SIALIDOSIS; type 2; no enzyme activity; retained in the endoplasmic reticulum / Golgi or rapidly degraded in the lysosomes. 2 PublicationsCorresponds to variant rs104893978dbSNPEnsembl.1
Natural variantiVAR_012216243G → R in SIALIDOSIS; type 1; no enzyme activity and no transport to the lysosome. 1 PublicationCorresponds to variant rs104893983dbSNPEnsembl.1
Natural variantiVAR_012217260F → Y in SIALIDOSIS; infantile type 2; catalytically inactive; rapid intralysosomal degradation. 4 PublicationsCorresponds to variant rs104893977dbSNPEnsembl.1
Natural variantiVAR_012219270L → F in SIALIDOSIS; type 2; reduction in enzyme activity; rapid intralysosomal degradation. 2 Publications1
Natural variantiVAR_012218270L → P in SIALIDOSIS. 1 Publication1
Natural variantiVAR_012220294R → S in SIALIDOSIS; type 1; mild mutation as residual activity is still measurable. 1 PublicationCorresponds to variant rs190549838dbSNPEnsembl.1
Natural variantiVAR_012221298A → V in SIALIDOSIS; type 2; less than 10% of activity; rapid intralysosomal degradation; impaired enzyme folding. 4 PublicationsCorresponds to variant rs104893981dbSNPEnsembl.1
Natural variantiVAR_017461316P → S in SIALIDOSIS; type 1; no enzyme activity; retained in the endoplasmic reticulum / Golgi or rapidly degraded in the lysosomes. 1 PublicationCorresponds to variant rs104893979dbSNPEnsembl.1
Natural variantiVAR_012222328G → S in SIALIDOSIS; type 1; reduction in enzyme activity. 3 PublicationsCorresponds to variant rs534846786dbSNPEnsembl.1
Natural variantiVAR_012223335P → Q in SIALIDOSIS; type 2; unable to reach the lysosomes. 1 PublicationCorresponds to variant rs749996046dbSNPEnsembl.1
Natural variantiVAR_018077341R → G in SIALIDOSIS; type 2; affects substrate binding or catalysis. 1 PublicationCorresponds to variant rs751458617dbSNPEnsembl.1
Natural variantiVAR_012224363L → P in SIALIDOSIS; infantile type 2; unable to reach the lysosomes. 4 PublicationsCorresponds to variant rs193922915dbSNPEnsembl.1
Natural variantiVAR_012225370Y → C in SIALIDOSIS; infantile type 2; catalytically inactive. 1 Publication1
Natural variantiVAR_012226400Y → YHY in SIALIDOSIS; type 1; mild mutation as residual activity is still measurable. 1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi412Y → A: Correct sorting to the plasma membrane but no endocytosis and internalization. 1 Publication1
Mutagenesisi413G → A: Correct sorting to the plasma membrane but no endocytosis and internalization. 1 Publication1
Mutagenesisi415L → A: Correct sorting to the plasma membrane but no endocytosis and internalization. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4758.
MalaCardsiNEU1.
MIMi256550. phenotype.
OpenTargetsiENSG00000184494.
ENSG00000204386.
ENSG00000223957.
ENSG00000227129.
ENSG00000227315.
ENSG00000228691.
ENSG00000234343.
ENSG00000234846.
Orphaneti93400. Congenital sialidosis type 2.
93399. Juvenile sialidosis type 2.
812. Sialidosis type 1.
PharmGKBiPA31560.

Chemistry databases

ChEMBLiCHEMBL2726.
DrugBankiDB00198. Oseltamivir.

Polymorphism and mutation databases

BioMutaiNEU1.
DMDMi17368612.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 471 PublicationAdd BLAST47
ChainiPRO_000001202648 – 415Sialidase-1Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Glycosylationi343N-linked (GlcNAc...)Sequence analysis1
Glycosylationi352N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

N-glycosylated.3 Publications
Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ99519.
MaxQBiQ99519.
PaxDbiQ99519.
PeptideAtlasiQ99519.
PRIDEiQ99519.

PTM databases

iPTMnetiQ99519.
PhosphoSitePlusiQ99519.

Expressioni

Tissue specificityi

Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain.2 Publications

Gene expression databases

BgeeiENSG00000184494.
CleanExiHS_NEU1.
ExpressionAtlasiQ99519. baseline and differential.
GenevisibleiQ99519. HS.

Organism-specific databases

HPAiHPA015634.
HPA021506.

Interactioni

Subunit structurei

Interacts with cathepsin A (protective protein), beta-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.

Protein-protein interaction databases

BioGridi110831. 12 interactors.
IntActiQ99519. 7 interactors.
MINTiMINT-1389413.
STRINGi9606.ENSP00000364782.

Chemistry databases

BindingDBiQ99519.

Structurei

3D structure databases

ProteinModelPortaliQ99519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati112 – 123BNR 1Add BLAST12
Repeati172 – 183BNR 2Add BLAST12
Repeati231 – 242BNR 3Add BLAST12
Repeati347 – 358BNR 4Add BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi77 – 80FRIP motif4
Motifi412 – 415Internalization signal4

Domaini

A C-terminal internalization signal (YGTL) appears to allow the targeting of plasma membrane proteins to endosomes.

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated
Contains 4 BNR repeats.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IE33. Eukaryota.
COG4409. LUCA.
GeneTreeiENSGT00720000108878.
HOGENOMiHOG000007651.
HOVERGENiHBG057314.
InParanoidiQ99519.
KOiK01186.
OMAiRNQYTES.
OrthoDBiEOG091G0HAW.
PhylomeDBiQ99519.
TreeFamiTF331063.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF13088. BNR_2. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGERPSTAL PDRRWGPRIL GFWGGCRVWV FAAIFLLLSL AASWSKAEND
60 70 80 90 100
FGLVQPLVTM EQLLWVSGRQ IGSVDTFRIP LITATPRGTL LAFAEARKMS
110 120 130 140 150
SSDEGAKFIA LRRSMDQGST WSPTAFIVND GDVPDGLNLG AVVSDVETGV
160 170 180 190 200
VFLFYSLCAH KAGCQVASTM LVWSKDDGVS WSTPRNLSLD IGTEVFAPGP
210 220 230 240 250
GSGIQKQREP RKGRLIVCGH GTLERDGVFC LLSDDHGASW RYGSGVSGIP
260 270 280 290 300
YGQPKQENDF NPDECQPYEL PDGSVVINAR NQNNYHCHCR IVLRSYDACD
310 320 330 340 350
TLRPRDVTFD PELVDPVVAA GAVVTSSGIV FFSNPAHPEF RVNLTLRWSF
360 370 380 390 400
SNGTSWRKET VQLWPGPSGY SSLATLEGSM DGEEQAPQLY VLYEKGRNHY
410
TESISVAKIS VYGTL
Length:415
Mass (Da):45,467
Last modified:May 1, 1997 - v1
Checksum:i360E60A256DEA07F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01220754V → M in SIALIDOSIS; type 1; mild mutation as residual activity is still measurable. 1 Publication1
Natural variantiVAR_01220868G → V in SIALIDOSIS; type 2; less than 10% of activity. 3 Publications1
Natural variantiVAR_01746080P → L in SIALIDOSIS; type 2; no enzyme activity; retained in the endoplasmic reticulum / Golgi or rapidly degraded in the lysosomes. 1 PublicationCorresponds to variant rs104893985dbSNPEnsembl.1
Natural variantiVAR_04920388G → A.Corresponds to variant rs34712643dbSNPEnsembl.1
Natural variantiVAR_01220991L → R in SIALIDOSIS; type 2. 2 PublicationsCorresponds to variant rs104893972dbSNPEnsembl.1
Natural variantiVAR_012210182S → G in SIALIDOSIS; type 1; normally processed. 3 PublicationsCorresponds to variant rs398123392dbSNPEnsembl.1
Natural variantiVAR_012211217V → M in SIALIDOSIS; type 1; partial transport and residual transport activity. 1 PublicationCorresponds to variant rs28940583dbSNPEnsembl.1
Natural variantiVAR_012212219G → A in SIALIDOSIS; type 1; unable to reach the lysosomes. 1 PublicationCorresponds to variant rs754068739dbSNPEnsembl.1
Natural variantiVAR_018076225R → P in SIALIDOSIS; type 2; impaired enzyme folding. 1 PublicationCorresponds to variant rs28940584dbSNPEnsembl.1
Natural variantiVAR_012213227G → R in SIALIDOSIS; type 1 and juvenile type 2; catalytically inactive; retained in pre-lysosomal compartments. 3 PublicationsCorresponds to variant rs769765227dbSNPEnsembl.1
Natural variantiVAR_012214231L → H in SIALIDOSIS; type 1; unable to reach the lysosomes. 1 PublicationCorresponds to variant rs762400331dbSNPEnsembl.1
Natural variantiVAR_012215240W → R in SIALIDOSIS; type 2; no enzyme activity; retained in the endoplasmic reticulum / Golgi or rapidly degraded in the lysosomes. 2 PublicationsCorresponds to variant rs104893978dbSNPEnsembl.1
Natural variantiVAR_012216243G → R in SIALIDOSIS; type 1; no enzyme activity and no transport to the lysosome. 1 PublicationCorresponds to variant rs104893983dbSNPEnsembl.1
Natural variantiVAR_012217260F → Y in SIALIDOSIS; infantile type 2; catalytically inactive; rapid intralysosomal degradation. 4 PublicationsCorresponds to variant rs104893977dbSNPEnsembl.1
Natural variantiVAR_012219270L → F in SIALIDOSIS; type 2; reduction in enzyme activity; rapid intralysosomal degradation. 2 Publications1
Natural variantiVAR_012218270L → P in SIALIDOSIS. 1 Publication1
Natural variantiVAR_012220294R → S in SIALIDOSIS; type 1; mild mutation as residual activity is still measurable. 1 PublicationCorresponds to variant rs190549838dbSNPEnsembl.1
Natural variantiVAR_012221298A → V in SIALIDOSIS; type 2; less than 10% of activity; rapid intralysosomal degradation; impaired enzyme folding. 4 PublicationsCorresponds to variant rs104893981dbSNPEnsembl.1
Natural variantiVAR_017461316P → S in SIALIDOSIS; type 1; no enzyme activity; retained in the endoplasmic reticulum / Golgi or rapidly degraded in the lysosomes. 1 PublicationCorresponds to variant rs104893979dbSNPEnsembl.1
Natural variantiVAR_012222328G → S in SIALIDOSIS; type 1; reduction in enzyme activity. 3 PublicationsCorresponds to variant rs534846786dbSNPEnsembl.1
Natural variantiVAR_012223335P → Q in SIALIDOSIS; type 2; unable to reach the lysosomes. 1 PublicationCorresponds to variant rs749996046dbSNPEnsembl.1
Natural variantiVAR_018077341R → G in SIALIDOSIS; type 2; affects substrate binding or catalysis. 1 PublicationCorresponds to variant rs751458617dbSNPEnsembl.1
Natural variantiVAR_012224363L → P in SIALIDOSIS; infantile type 2; unable to reach the lysosomes. 4 PublicationsCorresponds to variant rs193922915dbSNPEnsembl.1
Natural variantiVAR_012225370Y → C in SIALIDOSIS; infantile type 2; catalytically inactive. 1 Publication1
Natural variantiVAR_012226400Y → YHY in SIALIDOSIS; type 1; mild mutation as residual activity is still measurable. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040958 mRNA. Translation: AAB96774.1.
X78687 mRNA. Translation: CAA55356.1.
U84246 mRNA. Translation: AAD09239.1.
AF134726 Genomic DNA. Translation: AAD21814.1.
BA000025 Genomic DNA. Translation: BAB63297.1.
BT007206 mRNA. Translation: AAP35870.1.
BC000722 mRNA. Translation: AAH00722.1.
BC011900 mRNA. Translation: AAH11900.1.
CCDSiCCDS4723.1.
RefSeqiNP_000425.1. NM_000434.3.
UniGeneiHs.520037.

Genome annotation databases

EnsembliENST00000229725; ENSP00000229725; ENSG00000184494.
ENST00000375631; ENSP00000364782; ENSG00000204386.
ENST00000411774; ENSP00000399309; ENSG00000234846.
ENST00000422978; ENSP00000408957; ENSG00000227129.
ENST00000423382; ENSP00000401067; ENSG00000228691.
ENST00000434496; ENSP00000409489; ENSG00000234343.
ENST00000437432; ENSP00000403720; ENSG00000223957.
ENST00000439648; ENSP00000408207; ENSG00000227315.
GeneIDi4758.
KEGGihsa:4758.
UCSCiuc003nxq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Neuraminidase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040958 mRNA. Translation: AAB96774.1.
X78687 mRNA. Translation: CAA55356.1.
U84246 mRNA. Translation: AAD09239.1.
AF134726 Genomic DNA. Translation: AAD21814.1.
BA000025 Genomic DNA. Translation: BAB63297.1.
BT007206 mRNA. Translation: AAP35870.1.
BC000722 mRNA. Translation: AAH00722.1.
BC011900 mRNA. Translation: AAH11900.1.
CCDSiCCDS4723.1.
RefSeqiNP_000425.1. NM_000434.3.
UniGeneiHs.520037.

3D structure databases

ProteinModelPortaliQ99519.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110831. 12 interactors.
IntActiQ99519. 7 interactors.
MINTiMINT-1389413.
STRINGi9606.ENSP00000364782.

Chemistry databases

BindingDBiQ99519.
ChEMBLiCHEMBL2726.
DrugBankiDB00198. Oseltamivir.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

PTM databases

iPTMnetiQ99519.
PhosphoSitePlusiQ99519.

Polymorphism and mutation databases

BioMutaiNEU1.
DMDMi17368612.

Proteomic databases

EPDiQ99519.
MaxQBiQ99519.
PaxDbiQ99519.
PeptideAtlasiQ99519.
PRIDEiQ99519.

Protocols and materials databases

DNASUi4758.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229725; ENSP00000229725; ENSG00000184494.
ENST00000375631; ENSP00000364782; ENSG00000204386.
ENST00000411774; ENSP00000399309; ENSG00000234846.
ENST00000422978; ENSP00000408957; ENSG00000227129.
ENST00000423382; ENSP00000401067; ENSG00000228691.
ENST00000434496; ENSP00000409489; ENSG00000234343.
ENST00000437432; ENSP00000403720; ENSG00000223957.
ENST00000439648; ENSP00000408207; ENSG00000227315.
GeneIDi4758.
KEGGihsa:4758.
UCSCiuc003nxq.5. human.

Organism-specific databases

CTDi4758.
DisGeNETi4758.
GeneCardsiNEU1.
HGNCiHGNC:7758. NEU1.
HPAiHPA015634.
HPA021506.
MalaCardsiNEU1.
MIMi256550. phenotype.
608272. gene.
neXtProtiNX_Q99519.
OpenTargetsiENSG00000184494.
ENSG00000204386.
ENSG00000223957.
ENSG00000227129.
ENSG00000227315.
ENSG00000228691.
ENSG00000234343.
ENSG00000234846.
Orphaneti93400. Congenital sialidosis type 2.
93399. Juvenile sialidosis type 2.
812. Sialidosis type 1.
PharmGKBiPA31560.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE33. Eukaryota.
COG4409. LUCA.
GeneTreeiENSGT00720000108878.
HOGENOMiHOG000007651.
HOVERGENiHBG057314.
InParanoidiQ99519.
KOiK01186.
OMAiRNQYTES.
OrthoDBiEOG091G0HAW.
PhylomeDBiQ99519.
TreeFamiTF331063.

Enzyme and pathway databases

BRENDAi3.2.1.18. 2681.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-4085001. Sialic acid metabolism.
R-HSA-6798695. Neutrophil degranulation.
SABIO-RKQ99519.

Miscellaneous databases

ChiTaRSiNEU1. human.
GeneWikiiNEU1.
GenomeRNAii4758.
PROiQ99519.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184494.
CleanExiHS_NEU1.
ExpressionAtlasiQ99519. baseline and differential.
GenevisibleiQ99519. HS.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF13088. BNR_2. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNEUR1_HUMAN
AccessioniPrimary (citable) accession number: Q99519
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 174 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.