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Q99501

- GA2L1_HUMAN

UniProt

Q99501 - GA2L1_HUMAN

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Protein

GAS2-like protein 1

Gene

GAS2L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Seems to be involved in the cross-linking of microtubules and microfilaments.1 Publication

GO - Molecular functioni

  1. cytoskeletal adaptor activity Source: UniProtKB
  2. microtubule binding Source: UniProtKB
  3. thyroid hormone receptor binding Source: UniProtKB

GO - Biological processi

  1. cell cycle arrest Source: UniProtKB
  2. cellular response to starvation Source: UniProtKB
  3. cellular response to thyroid hormone stimulus Source: UniProtKB
  4. microtubule bundle formation Source: UniProtKB
  5. negative regulation of cell growth Source: UniProtKB
  6. negative regulation of erythrocyte differentiation Source: UniProtKB
  7. negative regulation of gene expression Source: UniProtKB
  8. negative regulation of microtubule depolymerization Source: UniProtKB
  9. regulation of cell cycle Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
GAS2-like protein 1
Alternative name(s):
GAS2-related protein on chromosome 22
Growth arrest-specific protein 2-like 1
Gene namesi
Name:GAS2L1
Synonyms:GAR22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:16955. GAS2L1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38195.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 681680GAS2-like protein 1PRO_0000190442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei193 – 1931Phosphothreonine1 Publication
Modified residuei306 – 3061Phosphoserine2 Publications
Modified residuei352 – 3521Phosphoserine1 Publication
Modified residuei391 – 3911Phosphothreonine1 Publication
Modified residuei394 – 3941Phosphoserine1 Publication
Modified residuei492 – 4921Phosphoserine2 Publications
Modified residuei498 – 4981Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ99501.
PaxDbiQ99501.
PRIDEiQ99501.

PTM databases

PhosphoSiteiQ99501.

Expressioni

Gene expression databases

BgeeiQ99501.
CleanExiHS_GAS2L1.
GenevestigatoriQ99501.

Interactioni

Protein-protein interaction databases

BioGridi115878. 19 interactions.
STRINGi9606.ENSP00000344012.

Structurei

3D structure databases

ProteinModelPortaliQ99501.
SMRiQ99501. Positions 219-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 147121CHPROSITE-ProRule annotationAdd
BLAST
Domaini203 – 27573GARPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GAS2 family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 GAR domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG322939.
GeneTreeiENSGT00390000002205.
HOGENOMiHOG000007404.
HOVERGENiHBG079404.
InParanoidiQ99501.
OrthoDBiEOG7VTDR1.
PhylomeDBiQ99501.
TreeFamiTF323754.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
3.30.920.20. 1 hit.
InterProiIPR001715. CH-domain.
IPR003108. GAS2_dom.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF02187. GAS2. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00243. GAS2. 1 hit.
[Graphical view]
SUPFAMiSSF143575. SSF143575. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51460. GAR. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99501-1) [UniParc]FASTAAdd to Basket

Also known as: Beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADPVAGIAG SAAKSVRPFR SSEAYVEAMK EDLAEWLNAL YGLGLPGGGD
60 70 80 90 100
GFLTGLATGT TLCQHANAVT EAARALAAAR PARGVAFQAH SVVPGSFMAR
110 120 130 140 150
DNVATFIGWC RVELGVPEVL MFETEDLVLR KNEKSVVLCL LEVARRGARL
160 170 180 190 200
GLLAPRLVQF EQEIERELRA APPAPNAPAA GEDTTETAPA PGTPARGPRM
210 220 230 240 250
TPSDLRNLDE LVREILGRCT CPDQFPMIKV SEGKYRVGDS SLLIFVRVLR
260 270 280 290 300
SHVMVRVGGG WDTLEHYLDK HDPCRCSSTA HRPPQPRVCT FSPQRVSPTT
310 320 330 340 350
SPRPASPVPG SERRGSRPEM TPVSLRSTKE GPETPPRPRD QLPPHPRSRR
360 370 380 390 400
YSGDSDSSAS SAQSGPLGTR SDDTGTGPRR ERPSRRLTTG TPASPRRPPA
410 420 430 440 450
LRSQSRDRLD RGRPRGAPGG RGAQLSVPSP ARRARSQSRE EQAVLLVRRD
460 470 480 490 500
RDGQHSWVPR GRGSGGSGRS TPQTPRARSP AAPRLSRVSS PSPELGTTPA
510 520 530 540 550
SIFRTPLQLD PQQEQQLFRR LEEEFLANAR ALEAVASVTP TGPVPDPARA
560 570 580 590 600
PDPPAPDSAY CSSSSSSSSL SVLGGKCGQP GDSGRTANGL PGPRSQALSS
610 620 630 640 650
SSDEGSPCPG MGGPLDAPGS PLACTEPSRT WARGRMDTQP DRKPSRIPTP
660 670 680
RGPRRPSGPA ELGTWHALHS VTPRAEPDSW M
Length:681
Mass (Da):72,717
Last modified:August 30, 2005 - v2
Checksum:iA23A10748535D900
GO
Isoform 2 (identifier: Q99501-2) [UniParc]FASTAAdd to Basket

Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     338-681: Missing.

Show »
Length:337
Mass (Da):36,318
Checksum:i38CDE4CBA2BF5BAA
GO
Isoform 3 (identifier: Q99501-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-329: AHRPPQPRVC...MTPVSLRSTK → GPGISCPPIP...APGGSDPAGG
     330-681: Missing.

Note: No experimental confirmation available.

Show »
Length:329
Mass (Da):34,593
Checksum:i03E1DE1D5D38EE2C
GO
Isoform 4 (identifier: Q99501-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-563: Missing.

Show »
Length:454
Mass (Da):48,273
Checksum:iBB85BE498EEC3F3C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti544 – 5441V → A in BAD97322. 1 PublicationCurated
Sequence conflicti544 – 5441V → A in AAH11047. (PubMed:15489334)Curated
Sequence conflicti593 – 5931P → S in BAD97322. 1 PublicationCurated
Sequence conflicti666 – 6661H → R in BAD97322. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti490 – 4901S → G.
Corresponds to variant rs34124440 [ dbSNP | Ensembl ].
VAR_059974

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei280 – 32950AHRPP…LRSTK → GPGISCPPIPAPAATPGTVT PQPPPPRAAPLVPAVMTQAL APGGSDPAGG in isoform 3. 1 PublicationVSP_015494Add
BLAST
Alternative sequencei330 – 681352Missing in isoform 3. 1 PublicationVSP_015495Add
BLAST
Alternative sequencei337 – 563227Missing in isoform 4. CuratedVSP_055754Add
BLAST
Alternative sequencei338 – 681344Missing in isoform 2. 1 PublicationVSP_015493Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07848 Genomic DNA. Translation: CAA69176.1.
Y07846 mRNA. Translation: CAA69174.1.
AK223602 mRNA. Translation: BAD97322.1.
AC002059 Genomic DNA. No translation available.
BC001782 mRNA. Translation: AAH01782.1.
BC007624 mRNA. Translation: AAH07624.1.
BC011047 mRNA. Translation: AAH11047.1.
CCDSiCCDS63438.1. [Q99501-4]
CCDS74840.1. [Q99501-1]
RefSeqiNP_001265659.1. NM_001278730.1. [Q99501-4]
NP_006469.2. NM_006478.4.
NP_689422.1. NM_152236.2.
UniGeneiHs.322852.

Genome annotation databases

EnsembliENST00000406549; ENSP00000383995; ENSG00000185340. [Q99501-4]
ENST00000610653; ENSP00000484130; ENSG00000185340. [Q99501-2]
GeneIDi10634.
KEGGihsa:10634.
UCSCiuc003afb.1. human. [Q99501-2]

Polymorphism databases

DMDMi73915341.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07848 Genomic DNA. Translation: CAA69176.1 .
Y07846 mRNA. Translation: CAA69174.1 .
AK223602 mRNA. Translation: BAD97322.1 .
AC002059 Genomic DNA. No translation available.
BC001782 mRNA. Translation: AAH01782.1 .
BC007624 mRNA. Translation: AAH07624.1 .
BC011047 mRNA. Translation: AAH11047.1 .
CCDSi CCDS63438.1. [Q99501-4 ]
CCDS74840.1. [Q99501-1 ]
RefSeqi NP_001265659.1. NM_001278730.1. [Q99501-4 ]
NP_006469.2. NM_006478.4.
NP_689422.1. NM_152236.2.
UniGenei Hs.322852.

3D structure databases

ProteinModelPortali Q99501.
SMRi Q99501. Positions 219-275.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115878. 19 interactions.
STRINGi 9606.ENSP00000344012.

PTM databases

PhosphoSitei Q99501.

Polymorphism databases

DMDMi 73915341.

Proteomic databases

MaxQBi Q99501.
PaxDbi Q99501.
PRIDEi Q99501.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000406549 ; ENSP00000383995 ; ENSG00000185340 . [Q99501-4 ]
ENST00000610653 ; ENSP00000484130 ; ENSG00000185340 . [Q99501-2 ]
GeneIDi 10634.
KEGGi hsa:10634.
UCSCi uc003afb.1. human. [Q99501-2 ]

Organism-specific databases

CTDi 10634.
GeneCardsi GC22P029702.
HGNCi HGNC:16955. GAS2L1.
MIMi 602128. gene.
neXtProti NX_Q99501.
PharmGKBi PA38195.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322939.
GeneTreei ENSGT00390000002205.
HOGENOMi HOG000007404.
HOVERGENi HBG079404.
InParanoidi Q99501.
OrthoDBi EOG7VTDR1.
PhylomeDBi Q99501.
TreeFami TF323754.

Miscellaneous databases

GeneWikii GAS2L1.
GenomeRNAii 10634.
NextBioi 35478151.
PROi Q99501.
SOURCEi Search...

Gene expression databases

Bgeei Q99501.
CleanExi HS_GAS2L1.
Genevestigatori Q99501.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
3.30.920.20. 1 hit.
InterProi IPR001715. CH-domain.
IPR003108. GAS2_dom.
[Graphical view ]
Pfami PF00307. CH. 1 hit.
PF02187. GAS2. 1 hit.
[Graphical view ]
SMARTi SM00033. CH. 1 hit.
SM00243. GAS2. 1 hit.
[Graphical view ]
SUPFAMi SSF143575. SSF143575. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEi PS50021. CH. 1 hit.
PS51460. GAR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region."
    Zucman-Rossi J., Legoix P., Thomas G.
    Genomics 38:247-254(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2 AND 3).
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Eye.
  5. "Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules."
    Goriounov D., Leung C.L., Liem R.K.
    J. Cell Sci. 116:1045-1058(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-193; SER-306; THR-391; SER-394; SER-492 AND THR-498, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-492, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGA2L1_HUMAN
AccessioniPrimary (citable) accession number: Q99501
Secondary accession number(s): B5MCR7
, Q53EN7, Q92640, Q9BUY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 30, 2005
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3