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Protein

Sphingosine 1-phosphate receptor 3

Gene

S1PR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • integrin binding Source: UniProtKB
  • lipid binding Source: ProtInc
  • sphingosine-1-phosphate receptor activity Source: InterPro

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  • anatomical structure morphogenesis Source: ProtInc
  • cytokine production Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • inflammatory response Source: ProtInc
  • negative regulation of establishment of endothelial barrier Source: UniProtKB
  • Notch signaling pathway Source: Ensembl
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc
  • regulation of interleukin-1 beta production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.
SIGNORiQ99500.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 3
Short name:
S1P receptor 3
Short name:
S1P3
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 3
Sphingosine 1-phosphate receptor Edg-3
Short name:
S1P receptor Edg-3
Gene namesi
Name:S1PR3
Synonyms:EDG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:3167. S1PR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularBy similarityAdd
BLAST
Transmembranei41 – 6525Helical; Name=1By similarityAdd
BLAST
Topological domaini66 – 727CytoplasmicBy similarity
Transmembranei73 – 10129Helical; Name=2By similarityAdd
BLAST
Topological domaini102 – 11514ExtracellularBy similarityAdd
BLAST
Transmembranei116 – 13419Helical; Name=3By similarityAdd
BLAST
Topological domaini135 – 15319CytoplasmicBy similarityAdd
BLAST
Transmembranei154 – 17926Helical; Name=4By similarityAdd
BLAST
Topological domaini180 – 19516ExtracellularBy similarityAdd
BLAST
Transmembranei196 – 21621Helical; Name=5By similarityAdd
BLAST
Topological domaini217 – 24327CytoplasmicBy similarityAdd
BLAST
Transmembranei244 – 26522Helical; Name=6By similarityAdd
BLAST
Topological domaini266 – 28116ExtracellularBy similarityAdd
BLAST
Transmembranei282 – 30221Helical; Name=7By similarityAdd
BLAST
Topological domaini303 – 37876CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402362.

Chemistry

ChEMBLiCHEMBL2363041.
GuidetoPHARMACOLOGYi277.

Polymorphism and mutation databases

BioMutaiS1PR3.
DMDMi42560554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Sphingosine 1-phosphate receptor 3PRO_0000069421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence analysis
Modified residuei326 – 3261PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ99500.
PaxDbiQ99500.
PeptideAtlasiQ99500.
PRIDEiQ99500.

PTM databases

iPTMnetiQ99500.
PhosphoSiteiQ99500.

Expressioni

Tissue specificityi

Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.

Gene expression databases

BgeeiENSG00000213694.
CleanExiHS_S1PR3.
GenevisibleiQ99500. HS.

Organism-specific databases

HPAiHPA059513.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB4P161443EBI-10634734,EBI-948678

GO - Molecular functioni

  • integrin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108227. 1 interaction.
IntActiQ99500. 5 interactions.
STRINGi9606.ENSP00000350878.

Chemistry

BindingDBiQ99500.

Structurei

3D structure databases

ProteinModelPortaliQ99500.
SMRiQ99500. Positions 16-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIA7. Eukaryota.
ENOG410XQD3. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ99500.
KOiK04290.
OMAiIGMCWLI.
OrthoDBiEOG091G0DD4.
PhylomeDBiQ99500.
TreeFamiTF330052.

Family and domain databases

InterProiIPR004062. EDG3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01524. EDG3RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATALPPRLQ PVRGNETLRE HYQYVGKLAG RLKEASEGST LTTVLFLVIC
60 70 80 90 100
SFIVLENLMV LIAIWKNNKF HNRMYFFIGN LALCDLLAGI AYKVNILMSG
110 120 130 140 150
KKTFSLSPTV WFLREGSMFV ALGASTCSLL AIAIERHLTM IKMRPYDANK
160 170 180 190 200
RHRVFLLIGM CWLIAFTLGA LPILGWNCLH NLPDCSTILP LYSKKYIAFC
210 220 230 240 250
ISIFTAILVT IVILYARIYF LVKSSSRKVA NHNNSERSMA LLRTVVIVVS
260 270 280 290 300
VFIACWSPLF ILFLIDVACR VQACPILFKA QWFIVLAVLN SAMNPVIYTL
310 320 330 340 350
ASKEMRRAFF RLVCNCLVRG RGARASPIQP ALDPSRSKSS SSNNSSHSPK
360 370
VKEDLPHTAP SSCIMDKNAA LQNGIFCN
Length:378
Mass (Da):42,250
Last modified:February 16, 2004 - v2
Checksum:i79A00300968F439F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti359 – 3591A → D in CAA58744 (PubMed:8878560).Curated
Sequence conflicti359 – 3591A → D in AAC51906 (PubMed:9409733).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti243 – 2431R → Q.
Corresponds to variant rs34075341 [ dbSNP | Ensembl ].
VAR_033465

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83864 Genomic DNA. Translation: CAA58744.1.
AF022139 mRNA. Translation: AAC51906.1.
AY322540 Genomic DNA. Translation: AAP84353.1.
AK312798 mRNA. Translation: BAG35658.1.
AL772202 Genomic DNA. Translation: CAI16743.1.
CH471089 Genomic DNA. Translation: EAW62758.1.
BC060827 mRNA. Translation: AAH60827.1.
BC069579 mRNA. Translation: AAH69579.1.
CCDSiCCDS6680.1.
PIRiJC5245.
RefSeqiNP_005217.2. NM_005226.3.
UniGeneiHs.585118.

Genome annotation databases

EnsembliENST00000358157; ENSP00000350878; ENSG00000213694.
ENST00000375846; ENSP00000365006; ENSG00000213694.
GeneIDi1903.
KEGGihsa:1903.
UCSCiuc004aqe.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83864 Genomic DNA. Translation: CAA58744.1.
AF022139 mRNA. Translation: AAC51906.1.
AY322540 Genomic DNA. Translation: AAP84353.1.
AK312798 mRNA. Translation: BAG35658.1.
AL772202 Genomic DNA. Translation: CAI16743.1.
CH471089 Genomic DNA. Translation: EAW62758.1.
BC060827 mRNA. Translation: AAH60827.1.
BC069579 mRNA. Translation: AAH69579.1.
CCDSiCCDS6680.1.
PIRiJC5245.
RefSeqiNP_005217.2. NM_005226.3.
UniGeneiHs.585118.

3D structure databases

ProteinModelPortaliQ99500.
SMRiQ99500. Positions 16-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108227. 1 interaction.
IntActiQ99500. 5 interactions.
STRINGi9606.ENSP00000350878.

Chemistry

BindingDBiQ99500.
ChEMBLiCHEMBL2363041.
GuidetoPHARMACOLOGYi277.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ99500.
PhosphoSiteiQ99500.

Polymorphism and mutation databases

BioMutaiS1PR3.
DMDMi42560554.

Proteomic databases

MaxQBiQ99500.
PaxDbiQ99500.
PeptideAtlasiQ99500.
PRIDEiQ99500.

Protocols and materials databases

DNASUi1903.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358157; ENSP00000350878; ENSG00000213694.
ENST00000375846; ENSP00000365006; ENSG00000213694.
GeneIDi1903.
KEGGihsa:1903.
UCSCiuc004aqe.5. human.

Organism-specific databases

CTDi1903.
GeneCardsiS1PR3.
HGNCiHGNC:3167. S1PR3.
HPAiHPA059513.
MIMi601965. gene.
neXtProtiNX_Q99500.
PharmGKBiPA162402362.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIA7. Eukaryota.
ENOG410XQD3. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ99500.
KOiK04290.
OMAiIGMCWLI.
OrthoDBiEOG091G0DD4.
PhylomeDBiQ99500.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.
SIGNORiQ99500.

Miscellaneous databases

GeneWikiiS1PR3.
GenomeRNAii1903.
PROiQ99500.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213694.
CleanExiHS_S1PR3.
GenevisibleiQ99500. HS.

Family and domain databases

InterProiIPR004062. EDG3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01524. EDG3RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS1PR3_HUMAN
AccessioniPrimary (citable) accession number: Q99500
Secondary accession number(s): Q5SQD8, Q7Z5I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 16, 2004
Last modified: September 7, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.