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Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

Gene

AGAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.4 Publications

Enzyme regulationi

GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi413 – 420GTPSequence analysis8
Nucleotide bindingi457 – 461GTPSequence analysis5
Nucleotide bindingi515 – 518GTPSequence analysis4
Zinc fingeri946 – 969C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of protein catabolic process Source: MGI
  • protein transport Source: UniProtKB-KW
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135439-MONOMER.
ReactomeiR-HSA-373752. Netrin-1 signaling.
SignaLinkiQ99490.
SIGNORiQ99490.

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Short name:
AGAP-2
Alternative name(s):
Centaurin-gamma-1
Short name:
Cnt-g1
GTP-binding and GTPase-activating protein 2
Short name:
GGAP2
Phosphatidylinositol 3-kinase enhancer
Short name:
PIKE
Gene namesi
Name:AGAP2
Synonyms:CENTG1, KIAA0167
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16921. AGAP2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • mitochondrion Source: HPA
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi116986.
OpenTargetsiENSG00000135439.
PharmGKBiPA26411.

Polymorphism and mutation databases

BioMutaiAGAP2.
DMDMi97535883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000742171 – 1192Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2Add BLAST1192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113PhosphoserineBy similarity1
Modified residuei128PhosphoserineBy similarity1
Modified residuei149PhosphoserineBy similarity1
Modified residuei638PhosphoserineCombined sources1
Modified residuei750PhosphoserineBy similarity1
Modified residuei752PhosphoserineBy similarity1
Modified residuei808PhosphoserineBy similarity1
Modified residuei927PhosphoserineBy similarity1
Modified residuei985PhosphoserineBy similarity1
Modified residuei1178PhosphoserineBy similarity1
Isoform 2 (identifier: Q99490-2)
Modified residuei682Phosphotyrosine1 Publication1
Modified residuei774Phosphotyrosine1 Publication1

Post-translational modificationi

Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99490.
PaxDbiQ99490.
PeptideAtlasiQ99490.
PRIDEiQ99490.

PTM databases

iPTMnetiQ99490.
PhosphoSitePlusiQ99490.

Expressioni

Tissue specificityi

Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart.5 Publications

Gene expression databases

BgeeiENSG00000135439.
CleanExiHS_AGAP2.
ExpressionAtlasiQ99490. baseline and differential.
GenevisibleiQ99490. HS.

Organism-specific databases

HPAiHPA023474.

Interactioni

Subunit structurei

Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity). Isoform 2 interacts with activated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
INSRP062132EBI-2361824,EBI-475899
PrlrQ085012EBI-7737644,EBI-7737664From a different organism.
STAT5AP422293EBI-7737644,EBI-749537
Stat5aP422302EBI-7737644,EBI-617434From a different organism.

Protein-protein interaction databases

BioGridi125549. 8 interactors.
IntActiQ99490. 8 interactors.
MINTiMINT-3037505.
STRINGi9606.ENSP00000449241.

Structurei

Secondary structure

11192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi406 – 412Combined sources7
Helixi415 – 417Combined sources3
Helixi419 – 428Combined sources10
Beta strandi438 – 448Combined sources11
Beta strandi451 – 459Combined sources9
Beta strandi461 – 463Combined sources3
Helixi466 – 471Combined sources6
Beta strandi473 – 480Combined sources8
Helixi484 – 501Combined sources18
Beta strandi503 – 505Combined sources3
Beta strandi509 – 515Combined sources7
Beta strandi521 – 523Combined sources3
Helixi529 – 539Combined sources11
Beta strandi540 – 548Combined sources9
Turni549 – 552Combined sources4
Helixi555 – 574Combined sources20
Beta strandi677 – 686Combined sources10
Beta strandi695 – 703Combined sources9
Turni704 – 706Combined sources3
Beta strandi707 – 713Combined sources7
Helixi714 – 719Combined sources6
Beta strandi724 – 730Combined sources7
Beta strandi732 – 734Combined sources3
Beta strandi878 – 881Combined sources4
Beta strandi887 – 894Combined sources8
Helixi895 – 913Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BMJX-ray2.10A402-577[»]
2IWRX-ray1.50A402-577[»]
2RLONMR-A674-914[»]
ProteinModelPortaliQ99490.
SMRiQ99490.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99490.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini676 – 910PHPROSITE-ProRule annotationAdd BLAST235
Domaini931 – 1051Arf-GAPPROSITE-ProRule annotationAdd BLAST121
Repeati1090 – 1119ANK 1Add BLAST30
Repeati1123 – 1152ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 23Interaction with EPB41L1By similarityAdd BLAST23
Regioni180 – 225Interactions with HOMER1 and NF2By similarityAdd BLAST46
Regioni267 – 390Interaction with PLCG1By similarityAdd BLAST124
Regioni405 – 572G domainAdd BLAST168

Domaini

G domain binds GTP and has GTPase activity.
Arf-GAP domain interacts with G domain and may regulate its GTPase activity.
Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the cytosol. PH domain of isoform 2 is required for binding to AP-1.

Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri946 – 969C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0705. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000007233.
HOVERGENiHBG054045.
InParanoidiQ99490.
KOiK17848.
PhylomeDBiQ99490.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99490-1) [UniParc]FASTAAdd to basket
Also known as: PIKE-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRGAGALQR RTTTYLISLT LVKLESVPPP PPSPSAAAVG APGARGSEPR
60 70 80 90 100
DPGSPRGAEE PGKKRHERLF HRQDALWIST SSAGAGGAEP PALSPAPASP
110 120 130 140 150
ARPVSPAPGR RLSLWAAPPG PPLSGGLSPD SKPGGAPSSS RRPLLSSPSW
160 170 180 190 200
GGPEPEGRTG GGVPGSSSPH PGTGSRRLKV APPPPAPKPC KTVTTSGAKA
210 220 230 240 250
GGGKGAGSRL SWPESEGKPR VKGSKSSAGT GASVSAAATA AAAGGGGSTA
260 270 280 290 300
STSGGVGAGA GARGKLSPRK GKSKTLDNSD LHPGPPAGSP PPLTLPPTPS
310 320 330 340 350
PATAVTAASA QPPGPAPPIT LEPPAPGLKR GREGGRASTR DRKMLKFISG
360 370 380 390 400
IFTKSTGGPP GSGPLPGPPS LSSGSGSREL LGAELRASPK AVINSQEWTL
410 420 430 440 450
SRSIPELRLG VLGDARSGKS SLIHRFLTGS YQVLEKTESE QYKKEMLVDG
460 470 480 490 500
QTHLVLIREE AGAPDAKFSG WADAVIFVFS LEDENSFQAV SRLHGQLSSL
510 520 530 540 550
RGEGRGGLAL ALVGTQDRIS ASSPRVVGDA RARALCADMK RCSYYETCAT
560 570 580 590 600
YGLNVDRVFQ EVAQKVVTLR KQQQLLAACK SLPSSPSHSA ASTPVAGQAS
610 620 630 640 650
NGGHTSDYSS SLPSSPNVGH RELRAEAAAV AGLSTPGSLH RAAKRRTSLF
660 670 680 690 700
ANRRGSDSEK RSLDSRGETT GSGRAIPIKQ SFLLKRSGNS LNKEWKKKYV
710 720 730 740 750
TLSSNGFLLY HPSINDYIHS THGKEMDLLR TTVKVPGKRP PRAISAFGPS
760 770 780 790 800
ASINGLVKDM STVQMGEGLE ATTPMPSPSP SPSSLQPPPD QTSKHLLKPD
810 820 830 840 850
RNLARALSTD CTPSGDLSPL SREPPPSPMV KKQRRKKLTT PSKTEGSAGQ
860 870 880 890 900
AEAKRKMWKL KSFGSLRNIY KAEENFEFLI VSSTGQTWHF EAASFEERDA
910 920 930 940 950
WVQAIESQIL ASLQCCESSK VKLRTDSQSE AVAIQAIRNA KGNSICVDCG
960 970 980 990 1000
APNPTWASLN LGALICIECS GIHRNLGTHL SRVRSLDLDD WPRELTLVLT
1010 1020 1030 1040 1050
AIGNDTANRV WESDTRGRAK PSRDSSREER ESWIRAKYEQ LLFLAPLSTS
1060 1070 1080 1090 1100
EEPLGRQLWA AVQAQDVATV LLLLAHARHG PLDTSVEDPQ LRSPLHLAAE
1110 1120 1130 1140 1150
LAHVVITQLL LWYGADVAAR DAQGRTALFY ARQAGSQLCA DILLQHGCPG
1160 1170 1180 1190
EGGSAATTPS AATTPSITAT PSPRRRSSAA SVGRADAPVA LV
Length:1,192
Mass (Da):124,674
Last modified:May 16, 2006 - v2
Checksum:i8DA53707C0127984
GO
Isoform 2 (identifier: Q99490-2) [UniParc]FASTAAdd to basket
Also known as: PIKE-A

The sequence of this isoform differs from the canonical sequence as follows:
     1-336: Missing.
     337-390: ASTRDRKMLK...LGAELRASPK → MHAQRQFVVA...IQASLDSIRE
     853-872: Missing.

Show »
Length:836
Mass (Da):90,537
Checksum:iB8E42631BC06D5DC
GO

Sequence cautioni

The sequence BAA11484 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1137Q → H in AAC39522 (PubMed:9192850).Curated1
Sequence conflicti1147G → A in AAC39522 (PubMed:9192850).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036183339T → A in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_026438455V → A in a glioblastoma cell line. 1 Publication1
Natural variantiVAR_022046507G → S.Corresponds to variant rs2301553dbSNPEnsembl.1
Natural variantiVAR_026439518R → G in a sarcoma cell line. 1 Publication1
Natural variantiVAR_026440568T → I in a neuroblastoma cell line. 1 Publication1
Natural variantiVAR_026441651A → V in a glioblastoma cell line. 1 Publication1
Natural variantiVAR_026442767E → V in a glioblastoma cell line. 1 Publication1
Natural variantiVAR_036184816D → Y in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_026443939N → D in a glioblastoma cell line. 1 Publication1
Natural variantiVAR_026444947V → M in a sarcoma cell line. 1 Publication1
Natural variantiVAR_0264451022S → P in a glioblastoma cell line. 1 Publication1
Natural variantiVAR_0555321124G → V.1 PublicationCorresponds to variant rs238521dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0185311 – 336Missing in isoform 2. 5 PublicationsAdd BLAST336
Alternative sequenceiVSP_018532337 – 390ASTRD…RASPK → MHAQRQFVVAAVRAEVRRHE VAKQALNRLRKLAERVDDPE LQDSIQASLDSIRE in isoform 2. 5 PublicationsAdd BLAST54
Alternative sequenceiVSP_018533853 – 872Missing in isoform 2. 5 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81031 Genomic DNA. Translation: AAC39522.2.
AF384128 mRNA. Translation: AAO39848.1.
AY128689 mRNA. Translation: AAM97540.1.
D79989 mRNA. Translation: BAA11484.2. Different initiation.
AF413077 mRNA. Translation: AAL04171.1.
AK292672 mRNA. Translation: BAF85361.1.
CH471054 Genomic DNA. Translation: EAW97049.1.
BC028020 mRNA. Translation: AAH28020.1.
CCDSiCCDS44932.1. [Q99490-1]
CCDS8951.1. [Q99490-2]
RefSeqiNP_001116244.1. NM_001122772.2.
NP_055585.1. NM_014770.3. [Q99490-2]
UniGeneiHs.302435.

Genome annotation databases

EnsembliENST00000257897; ENSP00000257897; ENSG00000135439. [Q99490-2]
GeneIDi116986.
KEGGihsa:116986.
UCSCiuc001spr.4. human. [Q99490-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81031 Genomic DNA. Translation: AAC39522.2.
AF384128 mRNA. Translation: AAO39848.1.
AY128689 mRNA. Translation: AAM97540.1.
D79989 mRNA. Translation: BAA11484.2. Different initiation.
AF413077 mRNA. Translation: AAL04171.1.
AK292672 mRNA. Translation: BAF85361.1.
CH471054 Genomic DNA. Translation: EAW97049.1.
BC028020 mRNA. Translation: AAH28020.1.
CCDSiCCDS44932.1. [Q99490-1]
CCDS8951.1. [Q99490-2]
RefSeqiNP_001116244.1. NM_001122772.2.
NP_055585.1. NM_014770.3. [Q99490-2]
UniGeneiHs.302435.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BMJX-ray2.10A402-577[»]
2IWRX-ray1.50A402-577[»]
2RLONMR-A674-914[»]
ProteinModelPortaliQ99490.
SMRiQ99490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125549. 8 interactors.
IntActiQ99490. 8 interactors.
MINTiMINT-3037505.
STRINGi9606.ENSP00000449241.

PTM databases

iPTMnetiQ99490.
PhosphoSitePlusiQ99490.

Polymorphism and mutation databases

BioMutaiAGAP2.
DMDMi97535883.

Proteomic databases

MaxQBiQ99490.
PaxDbiQ99490.
PeptideAtlasiQ99490.
PRIDEiQ99490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257897; ENSP00000257897; ENSG00000135439. [Q99490-2]
GeneIDi116986.
KEGGihsa:116986.
UCSCiuc001spr.4. human. [Q99490-1]

Organism-specific databases

CTDi116986.
DisGeNETi116986.
GeneCardsiAGAP2.
H-InvDBHIX0201900.
HGNCiHGNC:16921. AGAP2.
HPAiHPA023474.
MIMi605476. gene.
neXtProtiNX_Q99490.
OpenTargetsiENSG00000135439.
PharmGKBiPA26411.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0705. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000007233.
HOVERGENiHBG054045.
InParanoidiQ99490.
KOiK17848.
PhylomeDBiQ99490.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135439-MONOMER.
ReactomeiR-HSA-373752. Netrin-1 signaling.
SignaLinkiQ99490.
SIGNORiQ99490.

Miscellaneous databases

ChiTaRSiAGAP2. human.
EvolutionaryTraceiQ99490.
GeneWikiiCENTG1.
GenomeRNAii116986.
PROiQ99490.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135439.
CleanExiHS_AGAP2.
ExpressionAtlasiQ99490. baseline and differential.
GenevisibleiQ99490. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGAP2_HUMAN
AccessioniPrimary (citable) accession number: Q99490
Secondary accession number(s): A8K9F7
, O00578, Q548E0, Q8IWU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 16, 2006
Last modified: November 2, 2016
This is version 181 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.