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Q99489

- OXDD_HUMAN

UniProt

Q99489 - OXDD_HUMAN

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Protein

D-aspartate oxidase

Gene

DDO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.

Catalytic activityi

D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei166 – 1661FAD; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei183 – 1831FADBy similarity
Binding sitei223 – 2231SubstrateBy similarity
Binding sitei278 – 2781SubstrateBy similarity
Binding sitei312 – 3121FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 2015FADBy similarityAdd
BLAST
Nucleotide bindingi36 – 372FADBy similarity
Nucleotide bindingi43 – 442FADBy similarity
Nucleotide bindingi48 – 503FADBy similarity
Nucleotide bindingi307 – 3115FADBy similarity

GO - Molecular functioni

  1. cofactor binding Source: UniProtKB
  2. D-aspartate oxidase activity Source: UniProtKB
  3. receptor binding Source: UniProtKB

GO - Biological processi

  1. aspartate catabolic process Source: UniProtKB
  2. aspartate metabolic process Source: Ensembl
  3. D-amino acid catabolic process Source: UniProtKB
  4. grooming behavior Source: Ensembl
  5. hormone metabolic process Source: Ensembl
  6. insemination Source: Ensembl
  7. oxidation-reduction process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

SABIO-RKQ99489.

Names & Taxonomyi

Protein namesi
Recommended name:
D-aspartate oxidase (EC:1.4.3.1)
Short name:
DASOX
Short name:
DDO
Gene namesi
Name:DDO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:2727. DDO.

Subcellular locationi

GO - Cellular componenti

  1. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27194.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341D-aspartate oxidasePRO_0000162770Add
BLAST

Proteomic databases

MaxQBiQ99489.
PaxDbiQ99489.
PRIDEiQ99489.

PTM databases

PhosphoSiteiQ99489.

Expressioni

Gene expression databases

BgeeiQ99489.
CleanExiHS_DDO.
ExpressionAtlasiQ99489. baseline and differential.
GenevestigatoriQ99489.

Organism-specific databases

HPAiHPA037525.
HPA037526.

Interactioni

Protein-protein interaction databases

BioGridi114098. 3 interactions.
IntActiQ99489. 1 interaction.
STRINGi9606.ENSP00000357920.

Structurei

3D structure databases

ProteinModelPortaliQ99489.
SMRiQ99489. Positions 5-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi339 – 3413Microbody targeting signalSequence Analysis

Sequence similaritiesi

Belongs to the DAMOX/DASOX family.Curated

Phylogenomic databases

eggNOGiCOG0665.
GeneTreeiENSGT00390000018635.
HOGENOMiHOG000046303.
HOVERGENiHBG003493.
InParanoidiQ99489.
KOiK00272.
OMAiNFIRDGD.
OrthoDBiEOG7B31NB.
PhylomeDBiQ99489.
TreeFamiTF313887.

Family and domain databases

InterProiIPR023209. D-aa_oxidase.
IPR006181. D-amino_acid_oxidase_CS.
IPR006076. FAD-dep_OxRdtase.
[Graphical view]
PANTHERiPTHR11530. PTHR11530. 1 hit.
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PIRSFiPIRSF000189. D-aa_oxidase. 1 hit.
PROSITEiPS00677. DAO. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform DDO-1 (identifier: Q99489-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTARIAVVG AGVVGLSTAV CISKLVPRCS VTIISDKFTP DTTSDVAAGM
60 70 80 90 100
LIPHTYPDTP IHTQKQWFRE TFNHLFAIAN SAEAGDAGVH LVSGWQIFQS
110 120 130 140 150
TPTEEVPFWA DVVLGFRKMT EAELKKFPQY VFGQAFTTLK CECPAYLPWL
160 170 180 190 200
EKRIKGSGGW TLTRRIEDLW ELHPSFDIVV NCSGLGSRQL AGDSKIFPVR
210 220 230 240 250
GQVLQVQAPW VEHFIRDGSG LTYIYPGTSH VTLGGTRQKG DWNLSPDAEN
260 270 280 290 300
SREILSRCCA LEPSLHGACN IREKVGLRPY RPGVRLQTEL LARDGQRLPV
310 320 330 340
VHHYGHGSGG ISVHWGTALE AARLVSECVH ALRTPIPKSN L
Length:341
Mass (Da):37,535
Last modified:May 1, 1997 - v1
Checksum:i8CAE7501FB7F215C
GO
Isoform DDO-2 (identifier: Q99489-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-153: Missing.

Show »
Length:282
Mass (Da):30,522
Checksum:iDBD01D57E5B72F7A
GO
Isoform 3 (identifier: Q99489-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRPARHWETRFGARDFGGFQDCFFRDRLM

Show »
Length:369
Mass (Da):40,993
Checksum:i4E4C372EE90DD7C5
GO
Isoform 4 (identifier: Q99489-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRPARHWETRFGARDFGGFQDCFFRDRLM
     95-153: Missing.

Show »
Length:310
Mass (Da):33,980
Checksum:iE74BBF6D27BE5CB3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti278 – 2781R → S in BAF85718. (PubMed:14702039)Curated
Isoform 4 (identifier: Q99489-4)
Sequence conflicti9 – 91T → N in DN990727. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361F → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_036244
Natural varianti189 – 1891Q → E.
Corresponds to variant rs17622 [ dbSNP | Ensembl ].
VAR_014939
Natural varianti230 – 2301H → Y.
Corresponds to variant rs17621 [ dbSNP | Ensembl ].
VAR_014940
Natural varianti255 – 2551L → R.
Corresponds to variant rs17623 [ dbSNP | Ensembl ].
VAR_014941

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MRPARHWETRFGARDFGGFQ DCFFRDRLM in isoform 3 and isoform 4. 3 PublicationsVSP_037664
Alternative sequencei95 – 15359Missing in isoform DDO-2 and isoform 4. 2 PublicationsVSP_001269Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89858 mRNA. Translation: BAA14031.1.
AK293029 mRNA. Translation: BAF85718.1.
AL050350 Genomic DNA. Translation: CAI42511.1.
AL050350 Genomic DNA. Translation: CAI42509.1.
AL050350 Genomic DNA. Translation: CAI42510.1.
CH471051 Genomic DNA. Translation: EAW48316.1.
CH471051 Genomic DNA. Translation: EAW48317.1.
BC032786 mRNA. Translation: AAH32786.3.
DN990727 mRNA. No translation available.
CCDSiCCDS5082.1. [Q99489-3]
CCDS5083.1. [Q99489-4]
PIRiJC5438.
JC5439.
RefSeqiNP_003640.2. NM_003649.2. [Q99489-3]
NP_004023.2. NM_004032.2. [Q99489-4]
UniGeneiHs.591348.

Genome annotation databases

EnsembliENST00000368923; ENSP00000357919; ENSG00000203797. [Q99489-4]
ENST00000368924; ENSP00000357920; ENSG00000203797. [Q99489-3]
GeneIDi8528.
KEGGihsa:8528.
UCSCiuc003puc.3. human. [Q99489-3]
uc003pud.3. human. [Q99489-4]

Polymorphism databases

DMDMi2494037.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89858 mRNA. Translation: BAA14031.1 .
AK293029 mRNA. Translation: BAF85718.1 .
AL050350 Genomic DNA. Translation: CAI42511.1 .
AL050350 Genomic DNA. Translation: CAI42509.1 .
AL050350 Genomic DNA. Translation: CAI42510.1 .
CH471051 Genomic DNA. Translation: EAW48316.1 .
CH471051 Genomic DNA. Translation: EAW48317.1 .
BC032786 mRNA. Translation: AAH32786.3 .
DN990727 mRNA. No translation available.
CCDSi CCDS5082.1. [Q99489-3 ]
CCDS5083.1. [Q99489-4 ]
PIRi JC5438.
JC5439.
RefSeqi NP_003640.2. NM_003649.2. [Q99489-3 ]
NP_004023.2. NM_004032.2. [Q99489-4 ]
UniGenei Hs.591348.

3D structure databases

ProteinModelPortali Q99489.
SMRi Q99489. Positions 5-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114098. 3 interactions.
IntActi Q99489. 1 interaction.
STRINGi 9606.ENSP00000357920.

Chemistry

BindingDBi Q99489.
ChEMBLi CHEMBL5887.

PTM databases

PhosphoSitei Q99489.

Polymorphism databases

DMDMi 2494037.

Proteomic databases

MaxQBi Q99489.
PaxDbi Q99489.
PRIDEi Q99489.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368923 ; ENSP00000357919 ; ENSG00000203797 . [Q99489-4 ]
ENST00000368924 ; ENSP00000357920 ; ENSG00000203797 . [Q99489-3 ]
GeneIDi 8528.
KEGGi hsa:8528.
UCSCi uc003puc.3. human. [Q99489-3 ]
uc003pud.3. human. [Q99489-4 ]

Organism-specific databases

CTDi 8528.
GeneCardsi GC06M110672.
HGNCi HGNC:2727. DDO.
HPAi HPA037525.
HPA037526.
MIMi 124450. gene.
neXtProti NX_Q99489.
PharmGKBi PA27194.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0665.
GeneTreei ENSGT00390000018635.
HOGENOMi HOG000046303.
HOVERGENi HBG003493.
InParanoidi Q99489.
KOi K00272.
OMAi NFIRDGD.
OrthoDBi EOG7B31NB.
PhylomeDBi Q99489.
TreeFami TF313887.

Enzyme and pathway databases

SABIO-RK Q99489.

Miscellaneous databases

GeneWikii DDO_(gene).
GenomeRNAii 8528.
NextBioi 31934.
PROi Q99489.
SOURCEi Search...

Gene expression databases

Bgeei Q99489.
CleanExi HS_DDO.
ExpressionAtlasi Q99489. baseline and differential.
Genevestigatori Q99489.

Family and domain databases

InterProi IPR023209. D-aa_oxidase.
IPR006181. D-amino_acid_oxidase_CS.
IPR006076. FAD-dep_OxRdtase.
[Graphical view ]
PANTHERi PTHR11530. PTHR11530. 1 hit.
Pfami PF01266. DAO. 1 hit.
[Graphical view ]
PIRSFi PIRSF000189. D-aa_oxidase. 1 hit.
PROSITEi PS00677. DAO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and functional characterization of the human brain D-aspartate oxidase."
    Setoyama C., Miura R.
    J. Biochem. 121:798-803(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS DDO-1 AND DDO-2).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Uterus.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  6. "High-throughput cloning of full-length human cDNAs directly from cDNA libraries optimized for large and rare transcripts."
    Birkett C., Cho J., Gau Y., Hamer R., Kelly S., Kovacs K., Liu L., Liu X., Porter J., Sachs A., Shu Y., Sun Z., Wong J., Wu M., Zhang X., Jay G., He W.
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-206 (ISOFORM 4).
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-136.

Entry informationi

Entry nameiOXDD_HUMAN
AccessioniPrimary (citable) accession number: Q99489
Secondary accession number(s): A8KAG4
, Q5JXM4, Q5JXM5, Q5JXM6, Q8N552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3