Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prefoldin subunit 5

Gene

PFDN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.1 Publication

GO - Molecular functioni

  • transcription corepressor activity Source: ProtInc
  • unfolded protein binding Source: InterPro

GO - Biological processi

  • negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: BHF-UCL
  • protein folding Source: InterPro
  • regulation of transcription, DNA-templated Source: ProtInc
  • retina development in camera-type eye Source: Ensembl

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 5
Alternative name(s):
Myc modulator 1
c-Myc-binding protein Mm-1
Gene namesi
Name:PFDN5
Synonyms:MM1, PFD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000123349.13
HGNCiHGNC:8869 PFDN5
MIMi604899 gene
neXtProtiNX_Q99471

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5204
OpenTargetsiENSG00000123349
PharmGKBiPA33210

Polymorphism and mutation databases

BioMutaiPFDN5
DMDMi12231038

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001536612 – 154Prefoldin subunit 5Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei42N6-acetyllysineCombined sources1
Modified residuei56PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99471
MaxQBiQ99471
PaxDbiQ99471
PeptideAtlasiQ99471
PRIDEiQ99471
TopDownProteomicsiQ99471-1 [Q99471-1]
Q99471-3 [Q99471-3]

2D gel databases

OGPiQ99471

PTM databases

iPTMnetiQ99471
PhosphoSitePlusiQ99471

Expressioni

Tissue specificityi

Highly expressed in pancreas and skeletal muscle and moderately in other tissues.

Gene expression databases

BgeeiENSG00000123349
CleanExiHS_PFDN5
ExpressionAtlasiQ99471 baseline and differential
GenevisibleiQ99471 HS

Organism-specific databases

HPAiHPA008587

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to MYC; interacts with its N-terminal domain.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111226, 80 interactors
CORUMiQ99471
DIPiDIP-28155N
IntActiQ99471, 143 interactors
MINTiQ99471
STRINGi9606.ENSP00000334188

Structurei

3D structure databases

ProteinModelPortaliQ99471
SMRiQ99471
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

eggNOGiKOG3048 Eukaryota
COG1730 LUCA
GeneTreeiENSGT00390000008783
HOGENOMiHOG000207562
HOVERGENiHBG004539
InParanoidiQ99471
KOiK04797
OMAiFQPDWEN
OrthoDBiEOG091G0TVG
PhylomeDBiQ99471
TreeFamiTF106509

Family and domain databases

Gene3Di1.10.287.370, 1 hit
HAMAPiMF_00308 PfdA, 1 hit
InterProiView protein in InterPro
IPR011599 PFD_alpha_archaea
IPR009053 Prefoldin
IPR004127 Prefoldin_subunit_alpha
PfamiView protein in Pfam
PF02996 Prefoldin, 1 hit
TIGRFAMsiTIGR00293 TIGR00293, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q99471-1) [UniParc]FASTAAdd to basket
Also known as: MM1-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL
60 70 80 90 100
NVLNKSNEGK ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK
110 120 130 140 150
DFFKRKIDFL TKQMEKIQPA LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA

TAKA
Length:154
Mass (Da):17,328
Last modified:January 11, 2001 - v2
Checksum:i0DA1F3644548CB14
GO
Isoform 2 (identifier: Q99471-2) [UniParc]FASTAAdd to basket
Also known as: MM1-beta

The sequence of this isoform differs from the canonical sequence as follows:
     59-154: GKELLVPLTS...LGAAQATAKA → DVCPWEAA

Note: Does not repress transcription activity of MYC.
Show »
Length:66
Mass (Da):7,481
Checksum:iC07E3472E5BD2A76
GO
Isoform 3 (identifier: Q99471-3) [UniParc]FASTAAdd to basket
Also known as: MM1-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     25-69: Missing.

Show »
Length:109
Mass (Da):12,379
Checksum:i899AFF472DCC00D7
GO

Sequence cautioni

The sequence BAA14006 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04310325 – 69Missing in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_04310459 – 154GKELL…ATAKA → DVCPWEAA in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89667 mRNA Translation: BAA14006.1 Different initiation.
AB055802 Genomic DNA Translation: BAB32643.1
AB055803 mRNA Translation: BAB32644.1
AB055804 mRNA Translation: BAB32645.1
AB055805 mRNA Translation: BAB32646.1
BT007195 mRNA Translation: AAP35859.1
AK292623 mRNA Translation: BAF85312.1
AC073611 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96683.1
CH471054 Genomic DNA Translation: EAW96685.1
BC003373 mRNA No translation available.
BC062671 mRNA Translation: AAH62671.1
CCDSiCCDS8853.1 [Q99471-1]
CCDS8854.1 [Q99471-3]
RefSeqiNP_002615.2, NM_002624.3 [Q99471-1]
NP_665904.1, NM_145897.2 [Q99471-3]
UniGeneiHs.655327

Genome annotation databases

EnsembliENST00000243040; ENSP00000243040; ENSG00000123349 [Q99471-2]
ENST00000334478; ENSP00000334188; ENSG00000123349 [Q99471-1]
ENST00000351500; ENSP00000266964; ENSG00000123349 [Q99471-3]
ENST00000551018; ENSP00000447942; ENSG00000123349 [Q99471-1]
GeneIDi5204
KEGGihsa:5204
UCSCiuc001scl.5 human [Q99471-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPFD5_HUMAN
AccessioniPrimary (citable) accession number: Q99471
Secondary accession number(s): A8K9A8
, Q54AA8, Q9C083, Q9C084
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health