Reviewed,
UniProtKB/Swiss-Prot Q99471 (PFD5_HUMAN)
Last modified
December 15, 2009.
Version 79.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Prefoldin subunit 5 Alternative name(s): C-myc-binding protein Mm-1 Myc modulator 1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 154 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Ref.7 |
| Subunit structure | Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to c-Myc; interacts with its N-terminal domain. Represses the transcriptional activity of c-Myc. |
| Tissue specificity | Highly expressed in pancreas and skeletal muscle and moderately in other tissues. |
| Sequence similarities | Belongs to the prefoldin subunit alpha family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Chaperone |
| PTM | Acetylation |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein folding Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | cytoskeleton Inferred from direct assay. Source: HPA nucleus Ref.1Traceable author statement. Source: ProtInc prefoldin complexInferred from electronic annotation. Source: InterPro |
| Molecular function | transcription corepressor activity Ref.1 Traceable author statement. Source: ProtInc unfolded protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| vIRF-3 | Q9DUN1 | 5 | EBI-1047551,EBI-1647907 | From a different organism. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | ||||||
| Chain | 2 – 154 | 153 | Prefoldin subunit 5 | PRO_0000153661 | |||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine | ||||||
| Modified residue | 42 | 1 | N6-acetyllysine Ref.10 | ||||||
| Modified residue | 112 | 1 | N6-acetyllysine Ref.10 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc." Mori K., Maeda Y., Kitaura H., Taira T., Iguchi-Ariga S.M., Ariga H. J. Biol. Chem. 273:29794-29800(1998) [PubMed: 9792694] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer." Fujioka Y., Taira T., Maeda Y., Tanaka S., Nishihara H., Iguchi-Ariga S.M.M., Nagashima K., Ariga H. J. Biol. Chem. 276:45137-45144(2001) [PubMed: 11567024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Blood and Fibroblast. |
| [3] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [7] | "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin." Vainberg I.E., Lewis S.A., Rommelaere H., Ampe C., Vandekerckhove J., Klein H.L., Cowan N.J. Cell 93:863-873(1998) [PubMed: 9630229] [Abstract] Cited for: FUNCTION. |
| [8] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [9] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. |
| [10] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-42 AND LYS-112, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D89667 mRNA. Translation: BAA14006.1. Different initiation. AB055802 Genomic DNA. Translation: BAB32643.1. AB055803 mRNA. Translation: BAB32644.1. BT007195 mRNA. Translation: AAP35859.1. AK292623 mRNA. Translation: BAF85312.1. CH471054 Genomic DNA. Translation: EAW96683.1. BC003373 mRNA. No translation available. BC062671 mRNA. Translation: AAH62671.1. | |
| IPI | IPI00015361. |
| RefSeq | NP_002615.2. |
| UniGene | Hs.655327 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-28155N. |
| IntAct | Q99471. 6 interactions. |
| STRING | Q99471. |
PTM databases | |
| PhosphoSite | Q99471. |
2-D gel databases | |
| OGP | Q99471. |
Proteomic databases | |
| PeptideAtlas | Q99471. |
| PRIDE | Q99471. |
Genome annotation databases | |
| Ensembl | ENST00000334478; ENSP00000334188; ENSG00000123349; Homo sapiens. [Genome view] |
| GeneID | 5204. |
| KEGG | hsa:5204. |
| UCSC | uc001scl.1. human. |
Organism-specific databases | |
| CTD | 5204. |
| GeneCards | GC12P051975. |
| H-InvDB | HIX0010679. |
| HGNC | HGNC:8869. PFDN5. |
| HPA | HPA008587. |
| MIM | 604899. gene. |
| PharmGKB | PA33210. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG522331. |
| HOVERGEN | Q99471. |
| InParanoid | Q99471. |
| OMA | KRRTRAY. |
| OrthoDB | EOG9KD95M. |
Enzyme and pathway databases | |
| Reactome | REACT_17015. Metabolism of proteins. |
Gene expression databases | |
| ArrayExpress | Q99471. |
| Bgee | Q99471. |
| CleanEx | HS_PFDN5. |
| Genevestigator | Q99471. |
| GermOnline | ENSG00000123349. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011599. PFD_alpha. IPR004127. PFD_alpha-like. IPR009053. Prefoldin. [Graphical view] |
| Pfam | PF02996. Prefoldin. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 20126. |
| SOURCE | Search... |
Entry information
| Entry name | PFD5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q99471 Secondary accession number(s): A8K9A8, Q54AA8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


