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Protein

Prefoldin subunit 5

Gene

PFDN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.1 Publication

GO - Molecular functioni

  • transcription corepressor activity Source: ProtInc
  • unfolded protein binding Source: InterPro

GO - Biological processi

  • negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: BHF-UCL
  • protein folding Source: InterPro
  • regulation of transcription, DNA-templated Source: ProtInc
  • retina development in camera-type eye Source: Ensembl

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 5
Alternative name(s):
Myc modulator 1
c-Myc-binding protein Mm-1
Gene namesi
Name:PFDN5
Synonyms:MM1, PFD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000123349.13.
HGNCiHGNC:8869. PFDN5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5204.
OpenTargetsiENSG00000123349.
PharmGKBiPA33210.

Polymorphism and mutation databases

BioMutaiPFDN5.
DMDMi12231038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001536612 – 154Prefoldin subunit 5Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei42N6-acetyllysineCombined sources1
Modified residuei56PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99471.
MaxQBiQ99471.
PaxDbiQ99471.
PeptideAtlasiQ99471.
PRIDEiQ99471.
TopDownProteomicsiQ99471-1. [Q99471-1]
Q99471-3. [Q99471-3]

2D gel databases

OGPiQ99471.

PTM databases

iPTMnetiQ99471.
PhosphoSitePlusiQ99471.

Expressioni

Tissue specificityi

Highly expressed in pancreas and skeletal muscle and moderately in other tissues.

Gene expression databases

BgeeiENSG00000123349.
CleanExiHS_PFDN5.
ExpressionAtlasiQ99471. baseline and differential.
GenevisibleiQ99471. HS.

Organism-specific databases

HPAiHPA008587.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to MYC; interacts with its N-terminal domain.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111226. 78 interactors.
CORUMiQ99471.
DIPiDIP-28155N.
IntActiQ99471. 142 interactors.
MINTiMINT-5003456.
STRINGi9606.ENSP00000334188.

Structurei

3D structure databases

ProteinModelPortaliQ99471.
SMRiQ99471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

eggNOGiKOG3048. Eukaryota.
COG1730. LUCA.
GeneTreeiENSGT00390000008783.
HOGENOMiHOG000207562.
HOVERGENiHBG004539.
InParanoidiQ99471.
KOiK04797.
OMAiFQPDWEN.
OrthoDBiEOG091G0TVG.
PhylomeDBiQ99471.
TreeFamiTF106509.

Family and domain databases

HAMAPiMF_00308. PfdA. 1 hit.
InterProiView protein in InterPro
IPR011599. PFD_alpha_archaea.
IPR004127. Prefoldin_subunit_alpha.
PfamiView protein in Pfam
PF02996. Prefoldin. 1 hit.
TIGRFAMsiTIGR00293. TIGR00293. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q99471-1) [UniParc]FASTAAdd to basket
Also known as: MM1-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL
60 70 80 90 100
NVLNKSNEGK ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK
110 120 130 140 150
DFFKRKIDFL TKQMEKIQPA LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA

TAKA
Length:154
Mass (Da):17,328
Last modified:January 11, 2001 - v2
Checksum:i0DA1F3644548CB14
GO
Isoform 2 (identifier: Q99471-2) [UniParc]FASTAAdd to basket
Also known as: MM1-beta

The sequence of this isoform differs from the canonical sequence as follows:
     59-154: GKELLVPLTS...LGAAQATAKA → DVCPWEAA

Note: Does not repress transcription activity of MYC.
Show »
Length:66
Mass (Da):7,481
Checksum:iC07E3472E5BD2A76
GO
Isoform 3 (identifier: Q99471-3) [UniParc]FASTAAdd to basket
Also known as: MM1-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     25-69: Missing.

Show »
Length:109
Mass (Da):12,379
Checksum:i899AFF472DCC00D7
GO

Sequence cautioni

The sequence BAA14006 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04310325 – 69Missing in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_04310459 – 154GKELL…ATAKA → DVCPWEAA in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89667 mRNA. Translation: BAA14006.1. Different initiation.
AB055802 Genomic DNA. Translation: BAB32643.1.
AB055803 mRNA. Translation: BAB32644.1.
AB055804 mRNA. Translation: BAB32645.1.
AB055805 mRNA. Translation: BAB32646.1.
BT007195 mRNA. Translation: AAP35859.1.
AK292623 mRNA. Translation: BAF85312.1.
AC073611 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96683.1.
CH471054 Genomic DNA. Translation: EAW96685.1.
BC003373 mRNA. No translation available.
BC062671 mRNA. Translation: AAH62671.1.
CCDSiCCDS8853.1. [Q99471-1]
CCDS8854.1. [Q99471-3]
RefSeqiNP_002615.2. NM_002624.3. [Q99471-1]
NP_665904.1. NM_145897.2. [Q99471-3]
UniGeneiHs.655327.

Genome annotation databases

EnsembliENST00000243040; ENSP00000243040; ENSG00000123349. [Q99471-2]
ENST00000334478; ENSP00000334188; ENSG00000123349. [Q99471-1]
ENST00000351500; ENSP00000266964; ENSG00000123349. [Q99471-3]
ENST00000551018; ENSP00000447942; ENSG00000123349. [Q99471-1]
GeneIDi5204.
KEGGihsa:5204.
UCSCiuc001scl.5. human. [Q99471-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPFD5_HUMAN
AccessioniPrimary (citable) accession number: Q99471
Secondary accession number(s): A8K9A8
, Q54AA8, Q9C083, Q9C084
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: October 25, 2017
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families