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Protein

Stromal cell-derived factor 2

Gene

SDF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: ProtInc

GO - Biological processi

  • ER-associated misfolded protein catabolic process Source: GO_Central
  • protein glycosylation Source: ProtInc

Enzyme and pathway databases

SignaLinkiQ99470.

Names & Taxonomyi

Protein namesi
Recommended name:
Stromal cell-derived factor 2
Short name:
SDF-2
Gene namesi
Name:SDF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10675. SDF2.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: GO_Central
  • extracellular space Source: ProtInc

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6388.
OpenTargetsiENSG00000132581.
PharmGKBiPA35603.

Chemistry databases

DrugBankiDB02201. Malonate Ion.

Polymorphism and mutation databases

BioMutaiSDF2.
DMDMi116242785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisCombined sourcesAdd BLAST18
ChainiPRO_000003195519 – 211Stromal cell-derived factor 2Add BLAST193

Proteomic databases

EPDiQ99470.
MaxQBiQ99470.
PaxDbiQ99470.
PeptideAtlasiQ99470.
PRIDEiQ99470.
TopDownProteomicsiQ99470.

PTM databases

iPTMnetiQ99470.
PhosphoSitePlusiQ99470.

Expressioni

Gene expression databases

BgeeiENSG00000132581.
CleanExiHS_SDF2.
ExpressionAtlasiQ99470. baseline and differential.
GenevisibleiQ99470. HS.

Organism-specific databases

HPAiHPA042799.

Interactioni

Protein-protein interaction databases

BioGridi112289. 14 interactors.
IntActiQ99470. 5 interactors.
STRINGi9606.ENSP00000247020.

Structurei

3D structure databases

ProteinModelPortaliQ99470.
SMRiQ99470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 75MIR 1PROSITE-ProRule annotationAdd BLAST55
Domaini83 – 138MIR 2PROSITE-ProRule annotationAdd BLAST56
Domaini139 – 193MIR 3PROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3358. Eukaryota.
ENOG410ZBU3. LUCA.
GeneTreeiENSGT00510000046663.
HOGENOMiHOG000236354.
HOVERGENiHBG024385.
InParanoidiQ99470.
OMAiMAQPSQN.
OrthoDBiEOG091G0MFB.
PhylomeDBiQ99470.
TreeFamiTF314557.

Family and domain databases

InterProiView protein in InterPro
IPR027005. GlyclTrfase_39-like.
IPR016093. MIR_motif.
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiView protein in Pfam
PF02815. MIR. 1 hit.
SMARTiView protein in SMART
SM00472. MIR. 3 hits.
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiView protein in PROSITE
PS50919. MIR. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVPLLLLG GLWSAVGASS LGVVTCGSVV KLLNTRHNVR LHSHDVRYGS
60 70 80 90 100
GSGQQSVTGV TSVDDSNSYW RIRGKSATVC ERGTPIKCGQ PIRLTHVNTG
110 120 130 140 150
RNLHSHHFTS PLSGNQEVSA FGEEGEGDYL DDWTVLCNGP YWVRDGEVRF
160 170 180 190 200
KHSSTEVLLS VTGEQYGRPI SGQKEVHGMA QPSQNNYWKA MEGIFMKPSE
210
LLKAEAHHAE L
Length:211
Mass (Da):23,026
Last modified:October 17, 2006 - v2
Checksum:i5EFC91C62E7B61E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51G → S in BAA09312 (PubMed:8918255).Curated1
Sequence conflicti74G → R in BAA09312 (PubMed:8918255).Curated1
Sequence conflicti119S → T in BAA09312 (PubMed:8918255).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05191315A → T. Corresponds to variant dbSNP:rs35404078Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50645 mRNA. Translation: BAA09312.1.
BC000500 mRNA. Translation: AAH00500.1.
BC001406 mRNA. Translation: AAH01406.1.
CCDSiCCDS11238.1.
PIRiJC5106.
RefSeqiNP_008854.2. NM_006923.3.
UniGeneiHs.514036.

Genome annotation databases

EnsembliENST00000247020; ENSP00000247020; ENSG00000132581.
GeneIDi6388.
KEGGihsa:6388.
UCSCiuc002hbw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSDF2_HUMAN
AccessioniPrimary (citable) accession number: Q99470
Secondary accession number(s): Q9BQ79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: October 17, 2006
Last modified: August 30, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot