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Protein

Stromal cell-derived factor 2

Gene

SDF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ99470.

Names & Taxonomyi

Protein namesi
Recommended name:
Stromal cell-derived factor 2
Short name:
SDF-2
Gene namesi
Name:SDF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10675. SDF2.

Subcellular locationi

GO - Cellular componenti

  • dolichyl-phosphate-mannose-protein mannosyltransferase complex Source: GO_Central
  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35603.

Polymorphism and mutation databases

BioMutaiSDF2.
DMDMi116242785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisCombined sourcesAdd
BLAST
Chaini19 – 211193Stromal cell-derived factor 2PRO_0000031955Add
BLAST

Proteomic databases

EPDiQ99470.
MaxQBiQ99470.
PaxDbiQ99470.
PRIDEiQ99470.
TopDownProteomicsiQ99470.

PTM databases

iPTMnetiQ99470.
PhosphoSiteiQ99470.

Expressioni

Gene expression databases

BgeeiQ99470.
CleanExiHS_SDF2.
ExpressionAtlasiQ99470. baseline and differential.
GenevisibleiQ99470. HS.

Organism-specific databases

HPAiHPA042799.

Interactioni

Protein-protein interaction databases

BioGridi112289. 13 interactions.
IntActiQ99470. 4 interactions.
STRINGi9606.ENSP00000247020.

Structurei

3D structure databases

ProteinModelPortaliQ99470.
SMRiQ99470. Positions 24-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 7555MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini83 – 13856MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini139 – 19355MIR 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3358. Eukaryota.
ENOG410ZBU3. LUCA.
GeneTreeiENSGT00510000046663.
HOGENOMiHOG000236354.
HOVERGENiHBG024385.
InParanoidiQ99470.
OMAiMAQPSQN.
OrthoDBiEOG71VSV4.
PhylomeDBiQ99470.
TreeFamiTF314557.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39-like.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVPLLLLG GLWSAVGASS LGVVTCGSVV KLLNTRHNVR LHSHDVRYGS
60 70 80 90 100
GSGQQSVTGV TSVDDSNSYW RIRGKSATVC ERGTPIKCGQ PIRLTHVNTG
110 120 130 140 150
RNLHSHHFTS PLSGNQEVSA FGEEGEGDYL DDWTVLCNGP YWVRDGEVRF
160 170 180 190 200
KHSSTEVLLS VTGEQYGRPI SGQKEVHGMA QPSQNNYWKA MEGIFMKPSE
210
LLKAEAHHAE L
Length:211
Mass (Da):23,026
Last modified:October 17, 2006 - v2
Checksum:i5EFC91C62E7B61E9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511G → S in BAA09312 (PubMed:8918255).Curated
Sequence conflicti74 – 741G → R in BAA09312 (PubMed:8918255).Curated
Sequence conflicti119 – 1191S → T in BAA09312 (PubMed:8918255).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151A → T.
Corresponds to variant rs35404078 [ dbSNP | Ensembl ].
VAR_051913

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50645 mRNA. Translation: BAA09312.1.
BC000500 mRNA. Translation: AAH00500.1.
BC001406 mRNA. Translation: AAH01406.1.
CCDSiCCDS11238.1.
PIRiJC5106.
RefSeqiNP_008854.2. NM_006923.3.
UniGeneiHs.514036.

Genome annotation databases

EnsembliENST00000247020; ENSP00000247020; ENSG00000132581.
GeneIDi6388.
KEGGihsa:6388.
UCSCiuc002hbw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50645 mRNA. Translation: BAA09312.1.
BC000500 mRNA. Translation: AAH00500.1.
BC001406 mRNA. Translation: AAH01406.1.
CCDSiCCDS11238.1.
PIRiJC5106.
RefSeqiNP_008854.2. NM_006923.3.
UniGeneiHs.514036.

3D structure databases

ProteinModelPortaliQ99470.
SMRiQ99470. Positions 24-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112289. 13 interactions.
IntActiQ99470. 4 interactions.
STRINGi9606.ENSP00000247020.

PTM databases

iPTMnetiQ99470.
PhosphoSiteiQ99470.

Polymorphism and mutation databases

BioMutaiSDF2.
DMDMi116242785.

Proteomic databases

EPDiQ99470.
MaxQBiQ99470.
PaxDbiQ99470.
PRIDEiQ99470.
TopDownProteomicsiQ99470.

Protocols and materials databases

DNASUi6388.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247020; ENSP00000247020; ENSG00000132581.
GeneIDi6388.
KEGGihsa:6388.
UCSCiuc002hbw.4. human.

Organism-specific databases

CTDi6388.
GeneCardsiSDF2.
HGNCiHGNC:10675. SDF2.
HPAiHPA042799.
MIMi602934. gene.
neXtProtiNX_Q99470.
PharmGKBiPA35603.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3358. Eukaryota.
ENOG410ZBU3. LUCA.
GeneTreeiENSGT00510000046663.
HOGENOMiHOG000236354.
HOVERGENiHBG024385.
InParanoidiQ99470.
OMAiMAQPSQN.
OrthoDBiEOG71VSV4.
PhylomeDBiQ99470.
TreeFamiTF314557.

Enzyme and pathway databases

SignaLinkiQ99470.

Miscellaneous databases

GenomeRNAii6388.
PROiQ99470.
SOURCEiSearch...

Gene expression databases

BgeeiQ99470.
CleanExiHS_SDF2.
ExpressionAtlasiQ99470. baseline and differential.
GenevisibleiQ99470. HS.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39-like.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method."
    Hamada T., Tashiro K., Tada H., Inazawa J., Shirozu M., Shibahara K., Nakamura T., Martina N., Nakano T., Honjo T.
    Gene 176:211-214(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Glioblastoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Ovary.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: CLEAVAGE OF SIGNAL PEPTIDE [LARGE SCALE ANALYSIS] AFTER ALA-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSDF2_HUMAN
AccessioniPrimary (citable) accession number: Q99470
Secondary accession number(s): Q9BQ79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: October 17, 2006
Last modified: June 8, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.