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Q99469 (STAC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH3 and cysteine-rich domain-containing protein
Alternative name(s):
Src homology 3 and cysteine-rich domain-containing protein
Gene names
Name:STAC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably involved in a neuron-specific signal transduction.

Subcellular location

Cytoplasm.

Sequence similarities

Contains 1 phorbol-ester/DAG-type zinc finger.

Contains 1 SH3 domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402SH3 and cysteine-rich domain-containing protein
PRO_0000072235

Regions

Domain285 – 34460SH3
Zinc finger107 – 15953Phorbol-ester/DAG-type

Natural variations

Natural variant2621N → S.
Corresponds to variant rs7634545 [ dbSNP | Ensembl ].
VAR_034505

Secondary structure

........... 402
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q99469 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 211688D178E4F905

FASTA40244,554
        10         20         30         40         50         60 
MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK SLRSKSADNF 

        70         80         90        100        110        120 
FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG LHPGGKAHAF QEYIFKKPTF 

       130        140        150        160        170        180 
CDVCNHMIVG TNAKHGLRCK ACKMSIHHKC TDGLAPQRCM GKLPKGFRRY YSSPLLIHEQ 

       190        200        210        220        230        240 
FGCIKEVMPI ACGNKVDPVY ETLRFGTSLA QRTKKGSSGS GSDSPHRTST SDLVEVPEEA 

       250        260        270        280        290        300 
NGPGGGYDLR KRSNSVFTYP ENGTDDFRDP AKNINHQGSL SKDPLQMNTY VALYKFVPQE 

       310        320        330        340        350        360 
NEDLEMRPGD IITLLEDSNE DWWKGKIQDR IGFFPANFVQ RLQQNEKIFR CVRTFIGCKE 

       370        380        390        400 
QGQITLKENQ ICVSSEEEQD GFIRVLSGKK KGLIPLDVLE NI 

« Hide

References

« Hide 'large scale' references
[1]"Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains."
Suzuki H., Kawai J., Taga C., Yaoi T., Hara A., Hirose K., Hayashizaki Y., Watanabe S.
Biochem. Biophys. Res. Commun. 229:902-909(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Solution structure of the first SH3 domain of STAC protein."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 288-342.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D86640 mRNA. Translation: BAA13152.1.
AK313493 mRNA. Translation: BAG36275.1.
CH471055 Genomic DNA. Translation: EAW64474.1.
CCDSCCDS2662.1.
PIRJC5270.
RefSeqNP_003140.1. NM_003149.2.
UniGeneHs.56045.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DL4NMR-A288-342[»]
ProteinModelPortalQ99469.
SMRQ99469. Positions 106-161, 288-342, 347-402.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112646. 9 interactions.
IntActQ99469. 7 interactions.
MINTMINT-7188364.
STRING9606.ENSP00000273183.

PTM databases

PhosphoSiteQ99469.

Polymorphism databases

DMDM12229989.

Proteomic databases

PaxDbQ99469.
PeptideAtlasQ99469.
PRIDEQ99469.

Protocols and materials databases

DNASU6769.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000273183; ENSP00000273183; ENSG00000144681.
GeneID6769.
KEGGhsa:6769.
UCSCuc003cgh.1. human.

Organism-specific databases

CTD6769.
GeneCardsGC03P036397.
H-InvDBHIX0119145.
HGNCHGNC:11353. STAC.
HPAHPA035143.
MIM602317. gene.
neXtProtNX_Q99469.
PharmGKBPA36175.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG82046.
HOGENOMHOG000230980.
HOVERGENHBG017859.
InParanoidQ99469.
OMANSVFTYP.
OrthoDBEOG7XM2ZF.
PhylomeDBQ99469.
TreeFamTF332878.

Gene expression databases

ArrayExpressQ99469.
BgeeQ99469.
CleanExHS_STAC.
GenevestigatorQ99469.

Family and domain databases

InterProIPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PfamPF00130. C1_1. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTSM00109. C1. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ99469.
GenomeRNAi6769.
NextBio26416.
PROQ99469.
SOURCESearch...

Entry information

Entry nameSTAC_HUMAN
AccessionPrimary (citable) accession number: Q99469
Secondary accession number(s): B2R8S8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM