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Protein

SH3 and cysteine-rich domain-containing protein

Gene

STAC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in a neuron-specific signal transduction.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 159Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST53

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144681-MONOMER.

Protein family/group databases

TCDBi8.A.34.1.2. the endophilin (endophilin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and cysteine-rich domain-containing protein
Alternative name(s):
Src homology 3 and cysteine-rich domain-containing protein
Gene namesi
Name:STAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11353. STAC.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • T-tubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6769.
OpenTargetsiENSG00000144681.
PharmGKBiPA36175.

Polymorphism and mutation databases

BioMutaiSTAC.
DMDMi12229989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722351 – 402SH3 and cysteine-rich domain-containing proteinAdd BLAST402

Proteomic databases

PaxDbiQ99469.
PeptideAtlasiQ99469.
PRIDEiQ99469.

PTM databases

iPTMnetiQ99469.
PhosphoSitePlusiQ99469.

Expressioni

Gene expression databases

BgeeiENSG00000144681.
CleanExiHS_STAC.
ExpressionAtlasiQ99469. baseline and differential.
GenevisibleiQ99469. HS.

Organism-specific databases

HPAiHPA035143.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PARP2Q9UGN52EBI-2652799,EBI-2795348
YWHAEP622582EBI-2652799,EBI-356498

Protein-protein interaction databases

BioGridi112646. 17 interactors.
IntActiQ99469. 17 interactors.
MINTiMINT-7188364.
STRINGi9606.ENSP00000273183.

Structurei

Secondary structure

1402
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi289 – 294Combined sources6
Beta strandi311 – 316Combined sources6
Beta strandi320 – 326Combined sources7
Beta strandi331 – 335Combined sources5
Turni336 – 338Combined sources3
Beta strandi339 – 341Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DL4NMR-A288-342[»]
ProteinModelPortaliQ99469.
SMRiQ99469.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99469.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 344SH3PROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 159Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF5B. Eukaryota.
ENOG410XQKX. LUCA.
GeneTreeiENSGT00390000008822.
HOGENOMiHOG000230980.
HOVERGENiHBG017859.
InParanoidiQ99469.
OMAiNSVFTYP.
OrthoDBiEOG091G085P.
PhylomeDBiQ99469.
TreeFamiTF332878.

Family and domain databases

CDDicd00029. C1. 1 hit.
InterProiIPR002219. PE/DAG-bd.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00109. C1. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK
60 70 80 90 100
SLRSKSADNF FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG
110 120 130 140 150
LHPGGKAHAF QEYIFKKPTF CDVCNHMIVG TNAKHGLRCK ACKMSIHHKC
160 170 180 190 200
TDGLAPQRCM GKLPKGFRRY YSSPLLIHEQ FGCIKEVMPI ACGNKVDPVY
210 220 230 240 250
ETLRFGTSLA QRTKKGSSGS GSDSPHRTST SDLVEVPEEA NGPGGGYDLR
260 270 280 290 300
KRSNSVFTYP ENGTDDFRDP AKNINHQGSL SKDPLQMNTY VALYKFVPQE
310 320 330 340 350
NEDLEMRPGD IITLLEDSNE DWWKGKIQDR IGFFPANFVQ RLQQNEKIFR
360 370 380 390 400
CVRTFIGCKE QGQITLKENQ ICVSSEEEQD GFIRVLSGKK KGLIPLDVLE

NI
Length:402
Mass (Da):44,554
Last modified:May 1, 1997 - v1
Checksum:i211688D178E4F905
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034505262N → S.Corresponds to variant rs7634545dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86640 mRNA. Translation: BAA13152.1.
AK313493 mRNA. Translation: BAG36275.1.
CH471055 Genomic DNA. Translation: EAW64474.1.
CCDSiCCDS2662.1.
PIRiJC5270.
RefSeqiNP_003140.1. NM_003149.2.
UniGeneiHs.56045.

Genome annotation databases

EnsembliENST00000273183; ENSP00000273183; ENSG00000144681.
GeneIDi6769.
KEGGihsa:6769.
UCSCiuc003cgh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86640 mRNA. Translation: BAA13152.1.
AK313493 mRNA. Translation: BAG36275.1.
CH471055 Genomic DNA. Translation: EAW64474.1.
CCDSiCCDS2662.1.
PIRiJC5270.
RefSeqiNP_003140.1. NM_003149.2.
UniGeneiHs.56045.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DL4NMR-A288-342[»]
ProteinModelPortaliQ99469.
SMRiQ99469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112646. 17 interactors.
IntActiQ99469. 17 interactors.
MINTiMINT-7188364.
STRINGi9606.ENSP00000273183.

Protein family/group databases

TCDBi8.A.34.1.2. the endophilin (endophilin) family.

PTM databases

iPTMnetiQ99469.
PhosphoSitePlusiQ99469.

Polymorphism and mutation databases

BioMutaiSTAC.
DMDMi12229989.

Proteomic databases

PaxDbiQ99469.
PeptideAtlasiQ99469.
PRIDEiQ99469.

Protocols and materials databases

DNASUi6769.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273183; ENSP00000273183; ENSG00000144681.
GeneIDi6769.
KEGGihsa:6769.
UCSCiuc003cgh.2. human.

Organism-specific databases

CTDi6769.
DisGeNETi6769.
GeneCardsiSTAC.
H-InvDBHIX0119145.
HGNCiHGNC:11353. STAC.
HPAiHPA035143.
MIMi602317. gene.
neXtProtiNX_Q99469.
OpenTargetsiENSG00000144681.
PharmGKBiPA36175.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF5B. Eukaryota.
ENOG410XQKX. LUCA.
GeneTreeiENSGT00390000008822.
HOGENOMiHOG000230980.
HOVERGENiHBG017859.
InParanoidiQ99469.
OMAiNSVFTYP.
OrthoDBiEOG091G085P.
PhylomeDBiQ99469.
TreeFamiTF332878.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144681-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ99469.
GenomeRNAii6769.
PROiQ99469.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144681.
CleanExiHS_STAC.
ExpressionAtlasiQ99469. baseline and differential.
GenevisibleiQ99469. HS.

Family and domain databases

CDDicd00029. C1. 1 hit.
InterProiIPR002219. PE/DAG-bd.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00109. C1. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAC_HUMAN
AccessioniPrimary (citable) accession number: Q99469
Secondary accession number(s): B2R8S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.