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Q99469

- STAC_HUMAN

UniProt

Q99469 - STAC_HUMAN

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Protein

SH3 and cysteine-rich domain-containing protein

Gene

STAC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probably involved in a neuron-specific signal transduction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri107 – 15953Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to heat Source: Ensembl
  2. intracellular signal transduction Source: InterPro
  3. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and cysteine-rich domain-containing protein
Alternative name(s):
Src homology 3 and cysteine-rich domain-containing protein
Gene namesi
Name:STAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11353. STAC.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36175.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402SH3 and cysteine-rich domain-containing proteinPRO_0000072235Add
BLAST

Proteomic databases

MaxQBiQ99469.
PaxDbiQ99469.
PeptideAtlasiQ99469.
PRIDEiQ99469.

PTM databases

PhosphoSiteiQ99469.

Expressioni

Gene expression databases

BgeeiQ99469.
CleanExiHS_STAC.
ExpressionAtlasiQ99469. baseline and differential.
GenevestigatoriQ99469.

Organism-specific databases

HPAiHPA035143.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PARP2Q9UGN52EBI-2652799,EBI-2795348
YWHAEP622582EBI-2652799,EBI-356498

Protein-protein interaction databases

BioGridi112646. 12 interactions.
IntActiQ99469. 8 interactions.
MINTiMINT-7188364.
STRINGi9606.ENSP00000273183.

Structurei

Secondary structure

1
402
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi289 – 2946
Beta strandi311 – 3166
Beta strandi320 – 3267
Beta strandi331 – 3355
Turni336 – 3383
Beta strandi339 – 3413

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DL4NMR-A288-342[»]
ProteinModelPortaliQ99469.
SMRiQ99469. Positions 106-161, 288-342.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99469.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 34460SH3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri107 – 15953Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiNOG82046.
GeneTreeiENSGT00390000008822.
HOGENOMiHOG000230980.
HOVERGENiHBG017859.
InParanoidiQ99469.
OMAiNSVFTYP.
OrthoDBiEOG7XM2ZF.
PhylomeDBiQ99469.
TreeFamiTF332878.

Family and domain databases

InterProiIPR002219. PE/DAG-bd.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00109. C1. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99469-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK
60 70 80 90 100
SLRSKSADNF FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG
110 120 130 140 150
LHPGGKAHAF QEYIFKKPTF CDVCNHMIVG TNAKHGLRCK ACKMSIHHKC
160 170 180 190 200
TDGLAPQRCM GKLPKGFRRY YSSPLLIHEQ FGCIKEVMPI ACGNKVDPVY
210 220 230 240 250
ETLRFGTSLA QRTKKGSSGS GSDSPHRTST SDLVEVPEEA NGPGGGYDLR
260 270 280 290 300
KRSNSVFTYP ENGTDDFRDP AKNINHQGSL SKDPLQMNTY VALYKFVPQE
310 320 330 340 350
NEDLEMRPGD IITLLEDSNE DWWKGKIQDR IGFFPANFVQ RLQQNEKIFR
360 370 380 390 400
CVRTFIGCKE QGQITLKENQ ICVSSEEEQD GFIRVLSGKK KGLIPLDVLE

NI
Length:402
Mass (Da):44,554
Last modified:May 1, 1997 - v1
Checksum:i211688D178E4F905
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti262 – 2621N → S.
Corresponds to variant rs7634545 [ dbSNP | Ensembl ].
VAR_034505

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86640 mRNA. Translation: BAA13152.1.
AK313493 mRNA. Translation: BAG36275.1.
CH471055 Genomic DNA. Translation: EAW64474.1.
CCDSiCCDS2662.1.
PIRiJC5270.
RefSeqiNP_003140.1. NM_003149.2.
UniGeneiHs.56045.

Genome annotation databases

EnsembliENST00000273183; ENSP00000273183; ENSG00000144681.
GeneIDi6769.
KEGGihsa:6769.
UCSCiuc003cgh.1. human.

Polymorphism databases

DMDMi12229989.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86640 mRNA. Translation: BAA13152.1 .
AK313493 mRNA. Translation: BAG36275.1 .
CH471055 Genomic DNA. Translation: EAW64474.1 .
CCDSi CCDS2662.1.
PIRi JC5270.
RefSeqi NP_003140.1. NM_003149.2.
UniGenei Hs.56045.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DL4 NMR - A 288-342 [» ]
ProteinModelPortali Q99469.
SMRi Q99469. Positions 106-161, 288-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112646. 12 interactions.
IntActi Q99469. 8 interactions.
MINTi MINT-7188364.
STRINGi 9606.ENSP00000273183.

PTM databases

PhosphoSitei Q99469.

Polymorphism databases

DMDMi 12229989.

Proteomic databases

MaxQBi Q99469.
PaxDbi Q99469.
PeptideAtlasi Q99469.
PRIDEi Q99469.

Protocols and materials databases

DNASUi 6769.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273183 ; ENSP00000273183 ; ENSG00000144681 .
GeneIDi 6769.
KEGGi hsa:6769.
UCSCi uc003cgh.1. human.

Organism-specific databases

CTDi 6769.
GeneCardsi GC03P036421.
H-InvDB HIX0119145.
HGNCi HGNC:11353. STAC.
HPAi HPA035143.
MIMi 602317. gene.
neXtProti NX_Q99469.
PharmGKBi PA36175.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82046.
GeneTreei ENSGT00390000008822.
HOGENOMi HOG000230980.
HOVERGENi HBG017859.
InParanoidi Q99469.
OMAi NSVFTYP.
OrthoDBi EOG7XM2ZF.
PhylomeDBi Q99469.
TreeFami TF332878.

Miscellaneous databases

EvolutionaryTracei Q99469.
GenomeRNAii 6769.
NextBioi 26416.
PROi Q99469.
SOURCEi Search...

Gene expression databases

Bgeei Q99469.
CleanExi HS_STAC.
ExpressionAtlasi Q99469. baseline and differential.
Genevestigatori Q99469.

Family and domain databases

InterProi IPR002219. PE/DAG-bd.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view ]
Pfami PF00130. C1_1. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTi SM00109. C1. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains."
    Suzuki H., Kawai J., Taga C., Yaoi T., Hara A., Hirose K., Hayashizaki Y., Watanabe S.
    Biochem. Biophys. Res. Commun. 229:902-909(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Solution structure of the first SH3 domain of STAC protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 288-342.

Entry informationi

Entry nameiSTAC_HUMAN
AccessioniPrimary (citable) accession number: Q99469
Secondary accession number(s): B2R8S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3