Q99469 (STAC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH3 and cysteine-rich domain-containing protein

Alternative name(s):
Src homology 3 and cysteine-rich domain-containing protein

Gene names

Name:

STAC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably involved in a neuron-specific signal transduction.
Subcellular location	Cytoplasm.
Sequence similarities	Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Domain	SH3 domain Zinc-finger
Ligand	Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to heat Inferred from electronic annotation. Source: Compara intracellular signal transduction Inferred from electronic annotation. Source: InterPro signal transduction Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cytosol Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 402

402

SH3 and cysteine-rich domain-containing protein

PRO_0000072235

Regions

Domain

285 – 344

60

SH3

Zinc finger

107 – 159

53

Phorbol-ester/DAG-type

Natural variations

Natural variant

262

1

N → S.
Corresponds to variant rs7634545 [ dbSNP | Ensembl ].

VAR_034505

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

402

Helix Strand Turn

Details...

Beta strand

289 – 294

6

Beta strand

311 – 316

6

Beta strand

320 – 326

7

Beta strand

331 – 335

5

Turn

336 – 338

3

Beta strand

339 – 341

3

Sequences

	Sequence		Length	Mass (Da)
	Q99469 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 211688D178E4F905	FASTA	402	44,554
	10 20 30 40 50 60 MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK SLRSKSADNF 70 80 90 100 110 120 FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG LHPGGKAHAF QEYIFKKPTF 130 140 150 160 170 180 CDVCNHMIVG TNAKHGLRCK ACKMSIHHKC TDGLAPQRCM GKLPKGFRRY YSSPLLIHEQ 190 200 210 220 230 240 FGCIKEVMPI ACGNKVDPVY ETLRFGTSLA QRTKKGSSGS GSDSPHRTST SDLVEVPEEA 250 260 270 280 290 300 NGPGGGYDLR KRSNSVFTYP ENGTDDFRDP AKNINHQGSL SKDPLQMNTY VALYKFVPQE 310 320 330 340 350 360 NEDLEMRPGD IITLLEDSNE DWWKGKIQDR IGFFPANFVQ RLQQNEKIFR CVRTFIGCKE 370 380 390 400 QGQITLKENQ ICVSSEEEQD GFIRVLSGKK KGLIPLDVLE NI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains." Suzuki H., Kawai J., Taga C., Yaoi T., Hara A., Hirose K., Hayashizaki Y., Watanabe S. Biochem. Biophys. Res. Commun. 229:902-909(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Solution structure of the first SH3 domain of STAC protein." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 288-342.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D86640 mRNA. Translation: BAA13152.1.
AK313493 mRNA. Translation: BAG36275.1.
CH471055 Genomic DNA. Translation: EAW64474.1.

IPI

IPI00015342.

PIR

JC5270.

RefSeq

NP_003140.1. NM_003149.1.

UniGene

Hs.56045.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DL4	NMR	-	A	288-342	[»]

ProteinModelPortal

Q99469.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q99469. 5 interactions.

STRING

9606.ENSP00000273183.

PTM databases

PhosphoSite

Q99469.

Polymorphism databases

DMDM

12229989.

Proteomic databases

PaxDb

Q99469.

PeptideAtlas

Q99469.

PRIDE

Q99469.

Protocols and materials databases

DNASU

6769.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000273183; ENSP00000273183; ENSG00000144681.

GeneID

6769.

KEGG

hsa:6769.

UCSC

uc003cgh.1. human.

Organism-specific databases

CTD

6769.

GeneCards

GC03P036397.

H-InvDB

HIX0119145.

HGNC

HGNC:11353. STAC.

HPA

HPA035143.

MIM

602317. gene.

neXtProt

NX_Q99469.

PharmGKB

PA36175.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG82046.

HOGENOM

HOG000230980.

HOVERGEN

HBG017859.

InParanoid

Q99469.

OMA

GYDLRKR.

OrthoDB

EOG4ZS93D.

PhylomeDB

Q99469.

Gene expression databases

ArrayExpress

Q99469.

Bgee

Q99469.

CleanEx

HS_STAC.

Genevestigator

Q99469.

GermOnline

ENSG00000144681. Homo sapiens.

Family and domain databases

InterPro

IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]

Pfam

PF00130. C1_1. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]

PRINTS

PR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.

SMART

SM00109. C1. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF50044. SH3. 1 hit.

PROSITE

PS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q99469.

GenomeRNAi

6769.

NextBio

26416.

SOURCE

Search...

Entry information

Entry name

STAC_HUMAN

Accession

Primary (citable) accession number: Q99469
Secondary accession number(s): B2R8S8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1997
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.