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Q99469

- STAC_HUMAN

UniProt

Q99469 - STAC_HUMAN

Protein

SH3 and cysteine-rich domain-containing protein

Gene

STAC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Probably involved in a neuron-specific signal transduction.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri107 – 15953Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cellular response to heat Source: Ensembl
    2. intracellular signal transduction Source: InterPro
    3. signal transduction Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH3 and cysteine-rich domain-containing protein
    Alternative name(s):
    Src homology 3 and cysteine-rich domain-containing protein
    Gene namesi
    Name:STAC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11353. STAC.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36175.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 402402SH3 and cysteine-rich domain-containing proteinPRO_0000072235Add
    BLAST

    Proteomic databases

    PaxDbiQ99469.
    PeptideAtlasiQ99469.
    PRIDEiQ99469.

    PTM databases

    PhosphoSiteiQ99469.

    Expressioni

    Gene expression databases

    ArrayExpressiQ99469.
    BgeeiQ99469.
    CleanExiHS_STAC.
    GenevestigatoriQ99469.

    Organism-specific databases

    HPAiHPA035143.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PARP2Q9UGN52EBI-2652799,EBI-2795348
    YWHAEP622582EBI-2652799,EBI-356498

    Protein-protein interaction databases

    BioGridi112646. 9 interactions.
    IntActiQ99469. 8 interactions.
    MINTiMINT-7188364.
    STRINGi9606.ENSP00000273183.

    Structurei

    Secondary structure

    1
    402
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi289 – 2946
    Beta strandi311 – 3166
    Beta strandi320 – 3267
    Beta strandi331 – 3355
    Turni336 – 3383
    Beta strandi339 – 3413

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DL4NMR-A288-342[»]
    ProteinModelPortaliQ99469.
    SMRiQ99469. Positions 106-161, 288-342, 347-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ99469.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini285 – 34460SH3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri107 – 15953Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    SH3 domain, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG82046.
    HOGENOMiHOG000230980.
    HOVERGENiHBG017859.
    InParanoidiQ99469.
    OMAiNSVFTYP.
    OrthoDBiEOG7XM2ZF.
    PhylomeDBiQ99469.
    TreeFamiTF332878.

    Family and domain databases

    InterProiIPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    IPR013315. Spectrin_alpha_SH3.
    [Graphical view]
    PfamiPF00130. C1_1. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    PR01887. SPECTRNALPHA.
    SMARTiSM00109. C1. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99469-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK    50
    SLRSKSADNF FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG 100
    LHPGGKAHAF QEYIFKKPTF CDVCNHMIVG TNAKHGLRCK ACKMSIHHKC 150
    TDGLAPQRCM GKLPKGFRRY YSSPLLIHEQ FGCIKEVMPI ACGNKVDPVY 200
    ETLRFGTSLA QRTKKGSSGS GSDSPHRTST SDLVEVPEEA NGPGGGYDLR 250
    KRSNSVFTYP ENGTDDFRDP AKNINHQGSL SKDPLQMNTY VALYKFVPQE 300
    NEDLEMRPGD IITLLEDSNE DWWKGKIQDR IGFFPANFVQ RLQQNEKIFR 350
    CVRTFIGCKE QGQITLKENQ ICVSSEEEQD GFIRVLSGKK KGLIPLDVLE 400
    NI 402
    Length:402
    Mass (Da):44,554
    Last modified:May 1, 1997 - v1
    Checksum:i211688D178E4F905
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti262 – 2621N → S.
    Corresponds to variant rs7634545 [ dbSNP | Ensembl ].
    VAR_034505

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86640 mRNA. Translation: BAA13152.1.
    AK313493 mRNA. Translation: BAG36275.1.
    CH471055 Genomic DNA. Translation: EAW64474.1.
    CCDSiCCDS2662.1.
    PIRiJC5270.
    RefSeqiNP_003140.1. NM_003149.2.
    UniGeneiHs.56045.

    Genome annotation databases

    EnsembliENST00000273183; ENSP00000273183; ENSG00000144681.
    GeneIDi6769.
    KEGGihsa:6769.
    UCSCiuc003cgh.1. human.

    Polymorphism databases

    DMDMi12229989.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86640 mRNA. Translation: BAA13152.1 .
    AK313493 mRNA. Translation: BAG36275.1 .
    CH471055 Genomic DNA. Translation: EAW64474.1 .
    CCDSi CCDS2662.1.
    PIRi JC5270.
    RefSeqi NP_003140.1. NM_003149.2.
    UniGenei Hs.56045.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DL4 NMR - A 288-342 [» ]
    ProteinModelPortali Q99469.
    SMRi Q99469. Positions 106-161, 288-342, 347-402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112646. 9 interactions.
    IntActi Q99469. 8 interactions.
    MINTi MINT-7188364.
    STRINGi 9606.ENSP00000273183.

    PTM databases

    PhosphoSitei Q99469.

    Polymorphism databases

    DMDMi 12229989.

    Proteomic databases

    PaxDbi Q99469.
    PeptideAtlasi Q99469.
    PRIDEi Q99469.

    Protocols and materials databases

    DNASUi 6769.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273183 ; ENSP00000273183 ; ENSG00000144681 .
    GeneIDi 6769.
    KEGGi hsa:6769.
    UCSCi uc003cgh.1. human.

    Organism-specific databases

    CTDi 6769.
    GeneCardsi GC03P036397.
    H-InvDB HIX0119145.
    HGNCi HGNC:11353. STAC.
    HPAi HPA035143.
    MIMi 602317. gene.
    neXtProti NX_Q99469.
    PharmGKBi PA36175.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG82046.
    HOGENOMi HOG000230980.
    HOVERGENi HBG017859.
    InParanoidi Q99469.
    OMAi NSVFTYP.
    OrthoDBi EOG7XM2ZF.
    PhylomeDBi Q99469.
    TreeFami TF332878.

    Miscellaneous databases

    EvolutionaryTracei Q99469.
    GenomeRNAii 6769.
    NextBioi 26416.
    PROi Q99469.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99469.
    Bgeei Q99469.
    CleanExi HS_STAC.
    Genevestigatori Q99469.

    Family and domain databases

    InterProi IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    IPR013315. Spectrin_alpha_SH3.
    [Graphical view ]
    Pfami PF00130. C1_1. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    PR01887. SPECTRNALPHA.
    SMARTi SM00109. C1. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains."
      Suzuki H., Kawai J., Taga C., Yaoi T., Hara A., Hirose K., Hayashizaki Y., Watanabe S.
      Biochem. Biophys. Res. Commun. 229:902-909(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Solution structure of the first SH3 domain of STAC protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 288-342.

    Entry informationi

    Entry nameiSTAC_HUMAN
    AccessioniPrimary (citable) accession number: Q99469
    Secondary accession number(s): B2R8S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3