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Reviewed, UniProtKB/Swiss-Prot Q99467 (CD180_HUMAN)

Last modified January 19, 2010. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    CD180 antigen
Alternative name(s):
    Lymphocyte antigen 64
    Radioprotective 105 kDa protein
    CD_antigen=CD180
Gene names
Name: CD180
Synonyms: LY64, RP105
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length661 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells By similarity.

Subunit structure

Binds to MD-1. Ref.6

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.

Sequence similarities

Belongs to the Toll-like receptor family.

Contains 17 LRR (leucine-rich) repeats.

Ontologies

Keywords
   Biological processImmune response
Inflammatory response
Innate immunity
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainLeucine-rich repeat
Repeat
Signal
Transmembrane
   Molecular functionReceptor
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processinflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding Ref.1

Traceable author statement. Source: ProtInc

receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.5
Chain24 – 661638CD180 antigen
PRO_0000034741

Regions

Topological domain24 – 626603Extracellular Potential
Transmembrane627 – 65024 Potential
Topological domain651 – 66111Cytoplasmic Potential
Repeat51 – 7525LRR 1
Repeat76 – 9924LRR 2
Repeat101 – 12323LRR 3
Repeat148 – 17225LRR 4
Repeat174 – 19522LRR 5
Repeat198 – 22124LRR 6
Repeat273 – 29624LRR 7
Repeat297 – 32024LRR 8
Repeat323 – 34624LRR 9
Repeat353 – 36917LRR 10
Repeat370 – 39223LRR 11
Repeat395 – 41824LRR 12
Repeat420 – 44324LRR 13
Repeat468 – 49427LRR 14
Repeat496 – 51823LRR 15
Repeat519 – 54022LRR 16
Repeat541 – 56525LRR 17

Amino acid modifications

Glycosylation341N-linked (GlcNAc...) Potential
Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation781N-linked (GlcNAc...) Ref.7
Glycosylation2011N-linked (GlcNAc...) Potential
Glycosylation2341N-linked (GlcNAc...) Potential
Glycosylation2441N-linked (GlcNAc...) Potential
Glycosylation3941N-linked (GlcNAc...) Potential
Glycosylation4021N-linked (GlcNAc...) Potential
Glycosylation4511N-linked (GlcNAc...) Potential
Glycosylation5731N-linked (GlcNAc...) Potential

Natural variations

Natural variant201V → L: dbSNP rs5744463.
VAR_057298
Natural variant531N → K: dbSNP rs16875312.
VAR_021978
Natural variant991S → R: dbSNP rs2230520.
VAR_021979
Natural variant2591D → N: dbSNP rs5744525.
VAR_057299
Natural variant3561V → M: dbSNP rs56752081.
VAR_061859
Natural variant4301T → A: dbSNP rs2230523.
VAR_057300
Natural variant6481F → L: dbSNP rs2230524.
VAR_057301

Sequences

Sequence LengthMass (Da)Tools
Q99467-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: C08F2A5EBDE5A607

FASTA66174,165
        10         20         30         40         50         60 
MAFDVSCFFW VVLFSAGCKV ITSWDQMCIE KEANKTYNCE NLGLSEIPDT LPNTTEFLEF 

        70         80         90        100        110        120 
SFNFLPTIHN RTFSRLMNLT FLDLTRCQIN WIHEDTFQSH HQLSTLVLTG NPLIFMAETS 

       130        140        150        160        170        180 
LNGPKSLKHL FLIQTGISNL EFIPVHNLEN LESLYLGSNH ISSIKFPKDF PARNLKVLDF 

       190        200        210        220        230        240 
QNNAIHYISR EDMRSLEQAI NLSLNFNGNN VKGIELGAFD STVFQSLNFG GTPNLSVIFN 

       250        260        270        280        290        300 
GLQNSTTQSL WLGTFEDIDD EDISSAMLKG LCEMSVESLN LQEHRFSDIS STTFQCFTQL 

       310        320        330        340        350        360 
QELDLTATHL KGLPSGMKGL NLLKKLVLSV NHFDQLCQIS AANFPSLTHL YIRGNVKKLH 

       370        380        390        400        410        420 
LGVGCLEKLG NLQTLDLSHN DIEASDCCSL QLKNLSHLQT LNLSHNEPLG LQSQAFKECP 

       430        440        450        460        470        480 
QLELLDLAFT RLHINAPQSP FQNLHFLQVL NLTYCFLDTS NQHLLAGLPV LRHLNLKGNH 

       490        500        510        520        530        540 
FQDGTITKTN LLQTVGSLEV LILSSCGLLS IDQQAFHSLG KMSHVDLSHN SLTCDSIDSL 

       550        560        570        580        590        600 
SHLKGIYLNL AANSINIISP RLLPILSQQS TINLSHNPLD CTCSNIHFLT WYKENLHKLE 

       610        620        630        640        650        660 
GSEETTCANP PSLRGVKLSD VKLSCGITAI GIFFLIVFLL LLAILLFFAV KYLLRWKYQH 


I 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)."
Miura Y., Miyake K., Yamashita Y., Shimazu R., Copeland N.G., Gilbert D.J., Jenkins N.A., Inazawa J., Abe T., Kimoto M.
Genomics 38:299-304(1996) [PubMed: 8975706] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: B-cell lymphoma.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-38.
[6]"RP105 is associated with MD-1 and transmits an activation signal in human B cells."
Miura Y., Shimazu R., Miyake K., Akashi S., Ogata H., Yamashita Y., Narisawa Y., Kimoto M.
Blood 92:2815-2822(1998) [PubMed: 9763566] [Abstract]
Cited for: INTERACTION WITH MD-1.
[7]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78, MASS SPECTROMETRY.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D83597 mRNA. Translation: BAA12019.1.
AK313177 mRNA. Translation: BAG35994.1.
CH471137 Genomic DNA. Translation: EAW51318.1.
BC109069 mRNA. Translation: AAI09070.1.
BC109070 mRNA. Translation: AAI09071.1.
IPIIPI00023722.
RefSeqNP_005573.2.
UniGeneHs.87205

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ99467.

PTM databases

PhosphoSiteQ99467.

Proteomic databases

PRIDEQ99467.

Genome annotation databases

EnsemblENST00000256447; ENSP00000256447; ENSG00000134061; Homo sapiens. [Genome view]
GeneID4064.
KEGGhsa:4064.

Organism-specific databases

CTD4064.
GeneCardsGC05M066514.
H-InvDBHIX0032100.
HGNCHGNC:6726. CD180.
HPAHPA003740.
MIM602226. gene.
PharmGKBPA30490.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG19333.
HOGENOMHBG281016.
HOVERGENQ99467.
InParanoidQ99467.

Gene expression databases

ArrayExpressQ99467.
BgeeQ99467.
CleanExHS_CD180.
GenevestigatorQ99467.
GermOnlineENSG00000134061. Homo sapiens.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamPF00560. LRR_1. 3 hits.
[Graphical view]
SMARTSM00082. LRRCT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio15932.
SOURCESearch...

Entry information

Entry nameCD180_HUMAN
AccessionPrimary (citable) accession number: Q99467
Secondary accession number(s): B2R7Z7, Q32MM5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 1997
Last modified: January 19, 2010
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents