CD180 antigen precursor - Homo sapiens (Human)

Names and origin

Protein names

Recommended name:
    CD180 antigen
Alternative name(s):
    Lymphocyte antigen 64
    Radioprotective 105 kDa protein
    CD_antigen=CD180

Gene names

Name:	CD180
Synonyms:	LY64, RP105

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	661 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells By similarity.
Subunit structure	Binds to MD-1. Ref.6
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
Sequence similarities	Belongs to the Toll-like receptor family. Contains 17 LRR (leucine-rich) repeats.

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Ontologies

Keywords
Biological process	Immune response Inflammatory response Innate immunity
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Leucine-rich repeat Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Ref.1 Traceable author statement. Source: ProtInc receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Ref.5

Chain

24 – 661

638

CD180 antigen

PRO_0000034741

Regions

Topological domain

24 – 626

603

Extracellular Potential

Transmembrane

627 – 650

24

Potential

Topological domain

651 – 661

11

Cytoplasmic Potential

Repeat

51 – 75

25

LRR 1

Repeat

76 – 99

24

LRR 2

Repeat

101 – 123

23

LRR 3

Repeat

148 – 172

25

LRR 4

Repeat

174 – 195

22

LRR 5

Repeat

198 – 221

24

LRR 6

Repeat

273 – 296

24

LRR 7

Repeat

297 – 320

24

LRR 8

Repeat

323 – 346

24

LRR 9

Repeat

353 – 369

17

LRR 10

Repeat

370 – 392

23

LRR 11

Repeat

395 – 418

24

LRR 12

Repeat

420 – 443

24

LRR 13

Repeat

468 – 494

27

LRR 14

Repeat

496 – 518

23

LRR 15

Repeat

519 – 540

22

LRR 16

Repeat

541 – 565

25

LRR 17

Amino acid modifications

Glycosylation

34

1

N-linked (GlcNAc...) Potential

Glycosylation

53

1

N-linked (GlcNAc...) Potential

Glycosylation

70

1

N-linked (GlcNAc...) Potential

Glycosylation

78

1

N-linked (GlcNAc...) Ref.7

Glycosylation

201

1

N-linked (GlcNAc...) Potential

Glycosylation

234

1

N-linked (GlcNAc...) Potential

Glycosylation

244

1

N-linked (GlcNAc...) Potential

Glycosylation

394

1

N-linked (GlcNAc...) Potential

Glycosylation

402

1

N-linked (GlcNAc...) Potential

Glycosylation

451

1

N-linked (GlcNAc...) Potential

Glycosylation

573

1

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

20

1

V → L: dbSNP rs5744463.

VAR_057298

Natural variant

53

1

N → K: dbSNP rs16875312.

VAR_021978

Natural variant

99

1

S → R: dbSNP rs2230520.

VAR_021979

Natural variant

259

1

D → N: dbSNP rs5744525.

VAR_057299

Natural variant

356

1

V → M: dbSNP rs56752081.

VAR_061859

Natural variant

430

1

T → A: dbSNP rs2230523.

VAR_057300

Natural variant

648

1

F → L: dbSNP rs2230524.

VAR_057301

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Sequences

Sequence

Length

Mass (Da)

Tools

Q99467-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: C08F2A5EBDE5A607
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FASTA

661

74,165

        10         20         30         40         50         60 
MAFDVSCFFW VVLFSAGCKV ITSWDQMCIE KEANKTYNCE NLGLSEIPDT LPNTTEFLEF 

        70         80         90        100        110        120 
SFNFLPTIHN RTFSRLMNLT FLDLTRCQIN WIHEDTFQSH HQLSTLVLTG NPLIFMAETS 

       130        140        150        160        170        180 
LNGPKSLKHL FLIQTGISNL EFIPVHNLEN LESLYLGSNH ISSIKFPKDF PARNLKVLDF 

       190        200        210        220        230        240 
QNNAIHYISR EDMRSLEQAI NLSLNFNGNN VKGIELGAFD STVFQSLNFG GTPNLSVIFN 

       250        260        270        280        290        300 
GLQNSTTQSL WLGTFEDIDD EDISSAMLKG LCEMSVESLN LQEHRFSDIS STTFQCFTQL 

       310        320        330        340        350        360 
QELDLTATHL KGLPSGMKGL NLLKKLVLSV NHFDQLCQIS AANFPSLTHL YIRGNVKKLH 

       370        380        390        400        410        420 
LGVGCLEKLG NLQTLDLSHN DIEASDCCSL QLKNLSHLQT LNLSHNEPLG LQSQAFKECP 

       430        440        450        460        470        480 
QLELLDLAFT RLHINAPQSP FQNLHFLQVL NLTYCFLDTS NQHLLAGLPV LRHLNLKGNH 

       490        500        510        520        530        540 
FQDGTITKTN LLQTVGSLEV LILSSCGLLS IDQQAFHSLG KMSHVDLSHN SLTCDSIDSL 

       550        560        570        580        590        600 
SHLKGIYLNL AANSINIISP RLLPILSQQS TINLSHNPLD CTCSNIHFLT WYKENLHKLE 

       610        620        630        640        650        660 
GSEETTCANP PSLRGVKLSD VKLSCGITAI GIFFLIVFLL LLAILLFFAV KYLLRWKYQH 


I

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)." Miura Y., Miyake K., Yamashita Y., Shimazu R., Copeland N.G., Gilbert D.J., Jenkins N.A., Inazawa J., Abe T., Kimoto M. Genomics 38:299-304(1996) [PubMed: 8975706] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: B-cell lymphoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-38.
[6]	"RP105 is associated with MD-1 and transmits an activation signal in human B cells." Miura Y., Shimazu R., Miyake K., Akashi S., Ogata H., Yamashita Y., Narisawa Y., Kimoto M. Blood 92:2815-2822(1998) [PubMed: 9763566] [Abstract] Cited for: INTERACTION WITH MD-1.
[7]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	D83597 mRNA. Translation: BAA12019.1. AK313177 mRNA. Translation: BAG35994.1. CH471137 Genomic DNA. Translation: EAW51318.1. BC109069 mRNA. Translation: AAI09070.1. BC109070 mRNA. Translation: AAI09071.1.
IPI	IPI00023722.
RefSeq	NP_005573.2.
UniGene	Hs.87205
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q99467.
PTM databases
PhosphoSite	Q99467.
Proteomic databases
PRIDE	Q99467.
Genome annotation databases
Ensembl	ENST00000256447; ENSP00000256447; ENSG00000134061; Homo sapiens. [Genome view]
GeneID	4064.
KEGG	hsa:4064.
Organism-specific databases
CTD	4064.
GeneCards	GC05M066514.
H-InvDB	HIX0032100.
HGNC	HGNC:6726. CD180.
HPA	HPA003740.
MIM	602226. gene.
PharmGKB	PA30490.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19333.
HOGENOM	HBG281016.
HOVERGEN	Q99467.
InParanoid	Q99467.
Gene expression databases
ArrayExpress	Q99467.
Bgee	Q99467.
CleanEx	HS_CD180.
Genevestigator	Q99467.
GermOnline	ENSG00000134061. Homo sapiens.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. [Graphical view]
Pfam	PF00560. LRR_1. 3 hits. [Graphical view]
SMART	SM00082. LRRCT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	15932.
SOURCE	Search...

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Entry information

Entry name

CD180_HUMAN

Accession

Primary (citable) accession number: Q99467
Secondary accession number(s): B2R7Z7, Q32MM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	May 1, 1997
Last modified:	January 19, 2010
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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