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Q99467 (CD180_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD180 antigen
Alternative name(s):
Lymphocyte antigen 64
Radioprotective 105 kDa protein
CD_antigen=CD180
Gene names
Name:CD180
Synonyms:LY64, RP105
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length661 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells By similarity.

Subunit structure

M-shaped tetramer of two CD180-LY86 heterodimers. Ref.9

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.

Sequence similarities

Belongs to the Toll-like receptor family.

Contains 19 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.6
Chain24 – 661638CD180 antigen
PRO_0000034741

Regions

Topological domain24 – 626603Extracellular Potential
Transmembrane627 – 65024Helical; Potential
Topological domain651 – 66111Cytoplasmic Potential
Domain33 – 5321LRRNT
Repeat54 – 7522LRR 1
Repeat78 – 9922LRR 2
Repeat102 – 12322LRR 3
Repeat126 – 14722LRR 4
Repeat150 – 17122LRR 5
Repeat174 – 19522LRR 6
Repeat201 – 22121LRR 7
Repeat275 – 29622LRR 8
Repeat299 – 32022LRR 9
Repeat322 – 34322LRR 10
Repeat346 – 36621LRR 11
Repeat371 – 39121LRR 12
Repeat397 – 41822LRR 13
Repeat421 – 44222LRR 14
Repeat446 – 46621LRR 15
Repeat470 – 49324LRR 16
Repeat497 – 51822LRR 17
Repeat521 – 54424LRR 18
Repeat546 – 56419LRR 19
Domain577 – 62751LRRCT

Amino acid modifications

Glycosylation341N-linked (GlcNAc...) Potential
Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation781N-linked (GlcNAc...) Ref.8
Glycosylation2011N-linked (GlcNAc...) Potential
Glycosylation2341N-linked (GlcNAc...) Potential
Glycosylation2441N-linked (GlcNAc...) Potential
Glycosylation3941N-linked (GlcNAc...) Potential
Glycosylation4021N-linked (GlcNAc...) Ref.9
Glycosylation4511N-linked (GlcNAc...) Ref.9
Glycosylation5731N-linked (GlcNAc...) Potential

Natural variations

Natural variant201V → L.
Corresponds to variant rs5744463 [ dbSNP | Ensembl ].
VAR_057298
Natural variant531N → K.
Corresponds to variant rs16875312 [ dbSNP | Ensembl ].
VAR_021978
Natural variant991S → R.
Corresponds to variant rs2230520 [ dbSNP | Ensembl ].
VAR_021979
Natural variant2591D → N.
Corresponds to variant rs5744525 [ dbSNP | Ensembl ].
VAR_057299
Natural variant3561V → M.
Corresponds to variant rs56752081 [ dbSNP | Ensembl ].
VAR_061859
Natural variant4301T → A.
Corresponds to variant rs2230523 [ dbSNP | Ensembl ].
VAR_057300
Natural variant6481F → L.
Corresponds to variant rs2230524 [ dbSNP | Ensembl ].
VAR_057301

Experimental info

Sequence conflict2231I → V in BAA12019. Ref.1
Sequence conflict2231I → V in BAG35994. Ref.2
Sequence conflict2231I → V in EAW51318. Ref.4
Sequence conflict2231I → V in AAI09070. Ref.5
Sequence conflict2231I → V in AAI09071. Ref.5

Secondary structure

............................................................................................................... 661
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q99467 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 93DE3178594B3383

FASTA66174,179
        10         20         30         40         50         60 
MAFDVSCFFW VVLFSAGCKV ITSWDQMCIE KEANKTYNCE NLGLSEIPDT LPNTTEFLEF 

        70         80         90        100        110        120 
SFNFLPTIHN RTFSRLMNLT FLDLTRCQIN WIHEDTFQSH HQLSTLVLTG NPLIFMAETS 

       130        140        150        160        170        180 
LNGPKSLKHL FLIQTGISNL EFIPVHNLEN LESLYLGSNH ISSIKFPKDF PARNLKVLDF 

       190        200        210        220        230        240 
QNNAIHYISR EDMRSLEQAI NLSLNFNGNN VKGIELGAFD STIFQSLNFG GTPNLSVIFN 

       250        260        270        280        290        300 
GLQNSTTQSL WLGTFEDIDD EDISSAMLKG LCEMSVESLN LQEHRFSDIS STTFQCFTQL 

       310        320        330        340        350        360 
QELDLTATHL KGLPSGMKGL NLLKKLVLSV NHFDQLCQIS AANFPSLTHL YIRGNVKKLH 

       370        380        390        400        410        420 
LGVGCLEKLG NLQTLDLSHN DIEASDCCSL QLKNLSHLQT LNLSHNEPLG LQSQAFKECP 

       430        440        450        460        470        480 
QLELLDLAFT RLHINAPQSP FQNLHFLQVL NLTYCFLDTS NQHLLAGLPV LRHLNLKGNH 

       490        500        510        520        530        540 
FQDGTITKTN LLQTVGSLEV LILSSCGLLS IDQQAFHSLG KMSHVDLSHN SLTCDSIDSL 

       550        560        570        580        590        600 
SHLKGIYLNL AANSINIISP RLLPILSQQS TINLSHNPLD CTCSNIHFLT WYKENLHKLE 

       610        620        630        640        650        660 
GSEETTCANP PSLRGVKLSD VKLSCGITAI GIFFLIVFLL LLAILLFFAV KYLLRWKYQH 


I 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)."
Miura Y., Miyake K., Yamashita Y., Shimazu R., Copeland N.G., Gilbert D.J., Jenkins N.A., Inazawa J., Abe T., Kimoto M.
Genomics 38:299-304(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: B-cell lymphoma.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-38.
[7]"RP105 is associated with MD-1 and transmits an activation signal in human B cells."
Miura Y., Shimazu R., Miyake K., Akashi S., Ogata H., Yamashita Y., Narisawa Y., Kimoto M.
Blood 92:2815-2822(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH LY86.
[8]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78.
Tissue: Liver.
[9]"Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family."
Ohto U., Miyake K., Shimizu T.
J. Mol. Biol. 413:815-825(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 24-626 IN COMPLEX WITH LY86, SUBUNIT, GLYCOSYLATION AT ASN-402 AND ASN-451.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D83597 mRNA. Translation: BAA12019.1.
AK313177 mRNA. Translation: BAG35994.1.
AC026445 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51318.1.
BC109069 mRNA. Translation: AAI09070.1.
BC109070 mRNA. Translation: AAI09071.1.
CCDSCCDS3992.1.
RefSeqNP_005573.2. NM_005582.2.
UniGeneHs.87205.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3B2DX-ray2.80A/B24-626[»]
ProteinModelPortalQ99467.
SMRQ99467. Positions 26-626.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110242. 2 interactions.
DIPDIP-59104N.
STRING9606.ENSP00000256447.

PTM databases

PhosphoSiteQ99467.

Polymorphism databases

DMDM296434437.

Proteomic databases

MaxQBQ99467.
PaxDbQ99467.
PRIDEQ99467.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256447; ENSP00000256447; ENSG00000134061.
GeneID4064.
KEGGhsa:4064.
UCSCuc003juy.2. human.

Organism-specific databases

CTD4064.
GeneCardsGC05M066514.
H-InvDBHIX0032100.
HGNCHGNC:6726. CD180.
HPAHPA003740.
MIM602226. gene.
neXtProtNX_Q99467.
PharmGKBPA30490.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG319009.
HOGENOMHOG000146395.
HOVERGENHBG050848.
InParanoidQ99467.
KOK06555.
OMAKGLCEMS.
OrthoDBEOG7ZKS9G.
PhylomeDBQ99467.
TreeFamTF351113.

Gene expression databases

BgeeQ99467.
CleanExHS_CD180.
GenevestigatorQ99467.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTSM00082. LRRCT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCD180. human.
GeneWikiCD180.
GenomeRNAi4064.
NextBio15932.
PROQ99467.
SOURCESearch...

Entry information

Entry nameCD180_HUMAN
AccessionPrimary (citable) accession number: Q99467
Secondary accession number(s): B2R7Z7, Q32MM5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries