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Protein

CD180 antigen

Gene

CD180

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134061-MONOMER.
ReactomeiR-HSA-166016. Toll Like Receptor 4 (TLR4) Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
CD180 antigen
Alternative name(s):
Lymphocyte antigen 64
Radioprotective 105 kDa protein
CD_antigen: CD180
Gene namesi
Name:CD180
Synonyms:LY64, RP105
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6726. CD180.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 626ExtracellularSequence analysisAdd BLAST603
Transmembranei627 – 650HelicalSequence analysisAdd BLAST24
Topological domaini651 – 661CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4064.
OpenTargetsiENSG00000134061.
PharmGKBiPA30490.

Polymorphism and mutation databases

BioMutaiCD180.
DMDMi296434437.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000003474124 – 661CD180 antigenAdd BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi78N-linked (GlcNAc...)1 Publication1
Glycosylationi201N-linked (GlcNAc...)Sequence analysis1
Glycosylationi234N-linked (GlcNAc...)Sequence analysis1
Glycosylationi244N-linked (GlcNAc...)Sequence analysis1
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1
Glycosylationi402N-linked (GlcNAc...)1 Publication1
Glycosylationi451N-linked (GlcNAc...)1 Publication1
Glycosylationi573N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ99467.
PaxDbiQ99467.
PeptideAtlasiQ99467.
PRIDEiQ99467.

PTM databases

iPTMnetiQ99467.
PhosphoSitePlusiQ99467.

Expressioni

Tissue specificityi

Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.

Gene expression databases

BgeeiENSG00000134061.
CleanExiHS_CD180.
GenevisibleiQ99467. HS.

Organism-specific databases

HPAiHPA003740.

Interactioni

Subunit structurei

M-shaped tetramer of two CD180-LY86 heterodimers.1 Publication

Protein-protein interaction databases

BioGridi110242. 1 interactor.
DIPiDIP-59104N.
STRINGi9606.ENSP00000256447.

Structurei

Secondary structure

1661
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 32Combined sources4
Turni33 – 35Combined sources3
Beta strandi36 – 38Combined sources3
Beta strandi57 – 59Combined sources3
Beta strandi66 – 68Combined sources3
Turni70 – 75Combined sources6
Beta strandi80 – 83Combined sources4
Turni94 – 99Combined sources6
Beta strandi105 – 107Combined sources3
Turni118 – 121Combined sources4
Beta strandi129 – 131Combined sources3
Helixi140 – 142Combined sources3
Beta strandi153 – 155Combined sources3
Beta strandi177 – 179Combined sources3
Helixi190 – 194Combined sources5
Turni195 – 198Combined sources4
Beta strandi200 – 205Combined sources6
Turni216 – 221Combined sources6
Beta strandi223 – 228Combined sources6
Helixi235 – 241Combined sources7
Turni242 – 244Combined sources3
Beta strandi246 – 251Combined sources6
Turni265 – 268Combined sources4
Helixi269 – 273Combined sources5
Beta strandi274 – 280Combined sources7
Beta strandi286 – 288Combined sources3
Turni291 – 294Combined sources4
Helixi296 – 299Combined sources4
Beta strandi301 – 304Combined sources4
Beta strandi325 – 327Combined sources3
Helixi336 – 339Combined sources4
Helixi341 – 343Combined sources3
Beta strandi349 – 351Combined sources3
Turni365 – 368Combined sources4
Beta strandi374 – 376Combined sources3
Beta strandi384 – 388Combined sources5
Turni389 – 391Combined sources3
Beta strandi400 – 402Combined sources3
Beta strandi409 – 411Combined sources3
Turni413 – 418Combined sources6
Beta strandi424 – 426Combined sources3
Turni440 – 443Combined sources4
Beta strandi449 – 451Combined sources3
Turni462 – 467Combined sources6
Beta strandi473 – 475Combined sources3
Helixi482 – 484Combined sources3
Helixi491 – 494Combined sources4
Beta strandi500 – 502Combined sources3
Turni513 – 518Combined sources6
Beta strandi524 – 526Combined sources3
Helixi534 – 540Combined sources7
Beta strandi547 – 549Combined sources3
Helixi563 – 567Combined sources5
Beta strandi569 – 573Combined sources5
Helixi583 – 585Combined sources3
Helixi586 – 594Combined sources9
Beta strandi598 – 600Combined sources3
Beta strandi607 – 613Combined sources7
Turni618 – 620Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B2DX-ray2.80A/B24-626[»]
ProteinModelPortaliQ99467.
SMRiQ99467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 53LRRNTAdd BLAST21
Repeati54 – 75LRR 1Add BLAST22
Repeati78 – 99LRR 2Add BLAST22
Repeati102 – 123LRR 3Add BLAST22
Repeati126 – 147LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati201 – 221LRR 7Add BLAST21
Repeati275 – 296LRR 8Add BLAST22
Repeati299 – 320LRR 9Add BLAST22
Repeati322 – 343LRR 10Add BLAST22
Repeati346 – 366LRR 11Add BLAST21
Repeati371 – 391LRR 12Add BLAST21
Repeati397 – 418LRR 13Add BLAST22
Repeati421 – 442LRR 14Add BLAST22
Repeati446 – 466LRR 15Add BLAST21
Repeati470 – 493LRR 16Add BLAST24
Repeati497 – 518LRR 17Add BLAST22
Repeati521 – 544LRR 18Add BLAST24
Repeati546 – 564LRR 19Add BLAST19
Domaini577 – 627LRRCTAdd BLAST51

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 19 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000146395.
HOVERGENiHBG050848.
InParanoidiQ99467.
KOiK06555.
OMAiNNAIHYI.
OrthoDBiEOG091G01RC.
PhylomeDBiQ99467.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFDVSCFFW VVLFSAGCKV ITSWDQMCIE KEANKTYNCE NLGLSEIPDT
60 70 80 90 100
LPNTTEFLEF SFNFLPTIHN RTFSRLMNLT FLDLTRCQIN WIHEDTFQSH
110 120 130 140 150
HQLSTLVLTG NPLIFMAETS LNGPKSLKHL FLIQTGISNL EFIPVHNLEN
160 170 180 190 200
LESLYLGSNH ISSIKFPKDF PARNLKVLDF QNNAIHYISR EDMRSLEQAI
210 220 230 240 250
NLSLNFNGNN VKGIELGAFD STIFQSLNFG GTPNLSVIFN GLQNSTTQSL
260 270 280 290 300
WLGTFEDIDD EDISSAMLKG LCEMSVESLN LQEHRFSDIS STTFQCFTQL
310 320 330 340 350
QELDLTATHL KGLPSGMKGL NLLKKLVLSV NHFDQLCQIS AANFPSLTHL
360 370 380 390 400
YIRGNVKKLH LGVGCLEKLG NLQTLDLSHN DIEASDCCSL QLKNLSHLQT
410 420 430 440 450
LNLSHNEPLG LQSQAFKECP QLELLDLAFT RLHINAPQSP FQNLHFLQVL
460 470 480 490 500
NLTYCFLDTS NQHLLAGLPV LRHLNLKGNH FQDGTITKTN LLQTVGSLEV
510 520 530 540 550
LILSSCGLLS IDQQAFHSLG KMSHVDLSHN SLTCDSIDSL SHLKGIYLNL
560 570 580 590 600
AANSINIISP RLLPILSQQS TINLSHNPLD CTCSNIHFLT WYKENLHKLE
610 620 630 640 650
GSEETTCANP PSLRGVKLSD VKLSCGITAI GIFFLIVFLL LLAILLFFAV
660
KYLLRWKYQH I
Length:661
Mass (Da):74,179
Last modified:May 18, 2010 - v2
Checksum:i93DE3178594B3383
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223I → V in BAA12019 (PubMed:8975706).Curated1
Sequence conflicti223I → V in BAG35994 (PubMed:14702039).Curated1
Sequence conflicti223I → V in EAW51318 (Ref. 4) Curated1
Sequence conflicti223I → V in AAI09070 (PubMed:15489334).Curated1
Sequence conflicti223I → V in AAI09071 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05729820V → L.Corresponds to variant rs5744463dbSNPEnsembl.1
Natural variantiVAR_02197853N → K.Corresponds to variant rs16875312dbSNPEnsembl.1
Natural variantiVAR_02197999S → R.Corresponds to variant rs2230520dbSNPEnsembl.1
Natural variantiVAR_057299259D → N.Corresponds to variant rs5744525dbSNPEnsembl.1
Natural variantiVAR_061859356V → M.Corresponds to variant rs56752081dbSNPEnsembl.1
Natural variantiVAR_057300430T → A.Corresponds to variant rs2230523dbSNPEnsembl.1
Natural variantiVAR_057301648F → L.Corresponds to variant rs2230524dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83597 mRNA. Translation: BAA12019.1.
AK313177 mRNA. Translation: BAG35994.1.
AC026445 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51318.1.
BC109069 mRNA. Translation: AAI09070.1.
BC109070 mRNA. Translation: AAI09071.1.
CCDSiCCDS3992.1.
RefSeqiNP_005573.2. NM_005582.2.
UniGeneiHs.87205.

Genome annotation databases

EnsembliENST00000256447; ENSP00000256447; ENSG00000134061.
GeneIDi4064.
KEGGihsa:4064.
UCSCiuc003juy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83597 mRNA. Translation: BAA12019.1.
AK313177 mRNA. Translation: BAG35994.1.
AC026445 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51318.1.
BC109069 mRNA. Translation: AAI09070.1.
BC109070 mRNA. Translation: AAI09071.1.
CCDSiCCDS3992.1.
RefSeqiNP_005573.2. NM_005582.2.
UniGeneiHs.87205.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B2DX-ray2.80A/B24-626[»]
ProteinModelPortaliQ99467.
SMRiQ99467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110242. 1 interactor.
DIPiDIP-59104N.
STRINGi9606.ENSP00000256447.

PTM databases

iPTMnetiQ99467.
PhosphoSitePlusiQ99467.

Polymorphism and mutation databases

BioMutaiCD180.
DMDMi296434437.

Proteomic databases

MaxQBiQ99467.
PaxDbiQ99467.
PeptideAtlasiQ99467.
PRIDEiQ99467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256447; ENSP00000256447; ENSG00000134061.
GeneIDi4064.
KEGGihsa:4064.
UCSCiuc003juy.3. human.

Organism-specific databases

CTDi4064.
DisGeNETi4064.
GeneCardsiCD180.
H-InvDBHIX0032100.
HGNCiHGNC:6726. CD180.
HPAiHPA003740.
MIMi602226. gene.
neXtProtiNX_Q99467.
OpenTargetsiENSG00000134061.
PharmGKBiPA30490.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000146395.
HOVERGENiHBG050848.
InParanoidiQ99467.
KOiK06555.
OMAiNNAIHYI.
OrthoDBiEOG091G01RC.
PhylomeDBiQ99467.
TreeFamiTF351113.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134061-MONOMER.
ReactomeiR-HSA-166016. Toll Like Receptor 4 (TLR4) Cascade.

Miscellaneous databases

ChiTaRSiCD180. human.
GeneWikiiCD180.
GenomeRNAii4064.
PROiQ99467.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134061.
CleanExiHS_CD180.
GenevisibleiQ99467. HS.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD180_HUMAN
AccessioniPrimary (citable) accession number: Q99467
Secondary accession number(s): B2R7Z7, Q32MM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.