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Q99457

- NP1L3_HUMAN

UniProt

Q99457 - NP1L3_HUMAN

Protein

Nucleosome assembly protein 1-like 3

Gene

NAP1L3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. nucleosome assembly Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleosome assembly protein 1-like 3
    Gene namesi
    Name:NAP1L3
    Synonyms:BNAP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:7639. NAP1L3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31441.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Nucleosome assembly protein 1-like 3PRO_0000185657Add
    BLAST

    Proteomic databases

    PaxDbiQ99457.
    PRIDEiQ99457.

    PTM databases

    PhosphoSiteiQ99457.

    Expressioni

    Gene expression databases

    BgeeiQ99457.
    CleanExiHS_NAP1L3.
    GenevestigatoriQ99457.

    Organism-specific databases

    HPAiHPA026075.

    Interactioni

    Protein-protein interaction databases

    IntActiQ99457. 1 interaction.
    STRINGi9606.ENSP00000362171.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99457.
    SMRiQ99457. Positions 274-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi24 – 7249Ser-richAdd
    BLAST
    Compositional biasi154 – 254101Glu-richAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG258492.
    HOGENOMiHOG000171827.
    HOVERGENiHBG052653.
    InParanoidiQ99457.
    KOiK11281.
    OMAiNASFFNF.
    OrthoDBiEOG7W1541.
    PhylomeDBiQ99457.
    TreeFamiTF314349.

    Family and domain databases

    InterProiIPR002164. NAP_family.
    [Graphical view]
    PANTHERiPTHR11875. PTHR11875. 1 hit.
    PfamiPF00956. NAP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q99457-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEADFKMVS EPVAHGVAEE EMASSTSDSG EESDSSSSSS STSDSSSSSS    50
    TSGSSSGSGS SSSSSGSTSS RSRLYRKKRV PEPSRRARRA PLGTNFVDRL 100
    PQAVRNRVQA LRNIQDECDK VDTLFLKAIH DLERKYAELN KPLYDRRFQI 150
    INAEYEPTEE ECEWNSEDEE FSSDEEVQDN TPSEMPPLEG EEEENPKENP 200
    EVKAEEKEVP KEIPEVKDEE KEVPKEIPEV KAEEKADSKD CMEATPEVKE 250
    DPKEVPQVKA DDKEQPKATE AKARAAVRET HKRVPEERLQ DSVDLKRARK 300
    GKPKREDPKG IPDYWLIVLK NVDKLGPMIQ KYDEPILKFL SDVSLKFSKP 350
    GQPVSYTFEF HFLPNPYFRN EVLVKTYIIK AKPDHNDPFF SWGWEIEDCK 400
    GCKIDWRRGK DVTVTTTQSR TTATGEIEIQ PRVVPNASFF NFFSPPEIPM 450
    IGKLEPREDA ILDEDFEIGQ ILHDNVILKS IYYYTGEVNG TYYQFGKHYG 500
    NKKYRK 506
    Length:506
    Mass (Da):57,593
    Last modified:March 1, 2005 - v2
    Checksum:iA63672CBC2F98A87
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti290 – 2901Q → R in BAA08904. (PubMed:8976385)Curated
    Sequence conflicti406 – 4061W → R in BAA08904. (PubMed:8976385)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti224 – 2241P → A.2 Publications
    Corresponds to variant rs1045686 [ dbSNP | Ensembl ].
    VAR_024545

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50370 mRNA. Translation: BAA08904.1.
    AK315176 mRNA. Translation: BAG37617.1.
    AL009173 Genomic DNA. Translation: CAA15661.1.
    CCDSiCCDS14465.1.
    RefSeqiNP_004529.2. NM_004538.5.
    UniGeneiHs.21365.
    Hs.732006.

    Genome annotation databases

    EnsembliENST00000373079; ENSP00000362171; ENSG00000186310.
    GeneIDi4675.
    KEGGihsa:4675.
    UCSCiuc004efq.3. human.

    Polymorphism databases

    DMDMi60416442.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50370 mRNA. Translation: BAA08904.1 .
    AK315176 mRNA. Translation: BAG37617.1 .
    AL009173 Genomic DNA. Translation: CAA15661.1 .
    CCDSi CCDS14465.1.
    RefSeqi NP_004529.2. NM_004538.5.
    UniGenei Hs.21365.
    Hs.732006.

    3D structure databases

    ProteinModelPortali Q99457.
    SMRi Q99457. Positions 274-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99457. 1 interaction.
    STRINGi 9606.ENSP00000362171.

    PTM databases

    PhosphoSitei Q99457.

    Polymorphism databases

    DMDMi 60416442.

    Proteomic databases

    PaxDbi Q99457.
    PRIDEi Q99457.

    Protocols and materials databases

    DNASUi 4675.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373079 ; ENSP00000362171 ; ENSG00000186310 .
    GeneIDi 4675.
    KEGGi hsa:4675.
    UCSCi uc004efq.3. human.

    Organism-specific databases

    CTDi 4675.
    GeneCardsi GC0XM092925.
    H-InvDB HIX0016910.
    HGNCi HGNC:7639. NAP1L3.
    HPAi HPA026075.
    MIMi 300117. gene.
    neXtProti NX_Q99457.
    PharmGKBi PA31441.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258492.
    HOGENOMi HOG000171827.
    HOVERGENi HBG052653.
    InParanoidi Q99457.
    KOi K11281.
    OMAi NASFFNF.
    OrthoDBi EOG7W1541.
    PhylomeDBi Q99457.
    TreeFami TF314349.

    Miscellaneous databases

    GenomeRNAii 4675.
    NextBioi 18020.
    PROi Q99457.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99457.
    CleanExi HS_NAP1L3.
    Genevestigatori Q99457.

    Family and domain databases

    InterProi IPR002164. NAP_family.
    [Graphical view ]
    PANTHERi PTHR11875. PTHR11875. 1 hit.
    Pfami PF00956. NAP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression pattern and mapping to Xq of NAP1L3, a gene encoding a peptide homologous to human and yeast nucleosome assembly proteins."
      Watanabe T.K., Fujiwara T., Nakamura Y., Hirai Y., Maekawa H., Takahashi E.
      Cytogenet. Cell Genet. 74:281-285(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-224.
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-224.
      Tissue: Heart.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNP1L3_HUMAN
    AccessioniPrimary (citable) accession number: Q99457
    Secondary accession number(s): B2RCM0, O60788
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3