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Protein

Nucleosome assembly protein 1-like 3

Gene

NAP1L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. nucleosome assembly Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 3
Gene namesi
Name:NAP1L3
Synonyms:BNAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:7639. NAP1L3.

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31441.

Polymorphism and mutation databases

BioMutaiNAP1L3.
DMDMi60416442.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Nucleosome assembly protein 1-like 3PRO_0000185657Add
BLAST

Proteomic databases

PaxDbiQ99457.
PRIDEiQ99457.

PTM databases

PhosphoSiteiQ99457.

Expressioni

Gene expression databases

BgeeiQ99457.
CleanExiHS_NAP1L3.
ExpressionAtlasiQ99457. baseline and differential.
GenevestigatoriQ99457.

Organism-specific databases

HPAiHPA026075.

Interactioni

Protein-protein interaction databases

BioGridi110756. 4 interactions.
IntActiQ99457. 1 interaction.
STRINGi9606.ENSP00000362171.

Structurei

3D structure databases

ProteinModelPortaliQ99457.
SMRiQ99457. Positions 274-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 7249Ser-richAdd
BLAST
Compositional biasi154 – 254101Glu-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG258492.
GeneTreeiENSGT00480000042668.
HOGENOMiHOG000171827.
HOVERGENiHBG052653.
InParanoidiQ99457.
KOiK11281.
OMAiNASFFNF.
OrthoDBiEOG7W1541.
PhylomeDBiQ99457.
TreeFamiTF314349.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEADFKMVS EPVAHGVAEE EMASSTSDSG EESDSSSSSS STSDSSSSSS
60 70 80 90 100
TSGSSSGSGS SSSSSGSTSS RSRLYRKKRV PEPSRRARRA PLGTNFVDRL
110 120 130 140 150
PQAVRNRVQA LRNIQDECDK VDTLFLKAIH DLERKYAELN KPLYDRRFQI
160 170 180 190 200
INAEYEPTEE ECEWNSEDEE FSSDEEVQDN TPSEMPPLEG EEEENPKENP
210 220 230 240 250
EVKAEEKEVP KEIPEVKDEE KEVPKEIPEV KAEEKADSKD CMEATPEVKE
260 270 280 290 300
DPKEVPQVKA DDKEQPKATE AKARAAVRET HKRVPEERLQ DSVDLKRARK
310 320 330 340 350
GKPKREDPKG IPDYWLIVLK NVDKLGPMIQ KYDEPILKFL SDVSLKFSKP
360 370 380 390 400
GQPVSYTFEF HFLPNPYFRN EVLVKTYIIK AKPDHNDPFF SWGWEIEDCK
410 420 430 440 450
GCKIDWRRGK DVTVTTTQSR TTATGEIEIQ PRVVPNASFF NFFSPPEIPM
460 470 480 490 500
IGKLEPREDA ILDEDFEIGQ ILHDNVILKS IYYYTGEVNG TYYQFGKHYG

NKKYRK
Length:506
Mass (Da):57,593
Last modified:March 1, 2005 - v2
Checksum:iA63672CBC2F98A87
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti290 – 2901Q → R in BAA08904 (PubMed:8976385).Curated
Sequence conflicti406 – 4061W → R in BAA08904 (PubMed:8976385).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti224 – 2241P → A.2 Publications
Corresponds to variant rs1045686 [ dbSNP | Ensembl ].
VAR_024545

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50370 mRNA. Translation: BAA08904.1.
AK315176 mRNA. Translation: BAG37617.1.
AL009173 Genomic DNA. Translation: CAA15661.1.
CCDSiCCDS14465.1.
RefSeqiNP_004529.2. NM_004538.5.
UniGeneiHs.21365.
Hs.732006.

Genome annotation databases

EnsembliENST00000373079; ENSP00000362171; ENSG00000186310.
GeneIDi4675.
KEGGihsa:4675.
UCSCiuc004efq.3. human.

Polymorphism and mutation databases

BioMutaiNAP1L3.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50370 mRNA. Translation: BAA08904.1.
AK315176 mRNA. Translation: BAG37617.1.
AL009173 Genomic DNA. Translation: CAA15661.1.
CCDSiCCDS14465.1.
RefSeqiNP_004529.2. NM_004538.5.
UniGeneiHs.21365.
Hs.732006.

3D structure databases

ProteinModelPortaliQ99457.
SMRiQ99457. Positions 274-486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110756. 4 interactions.
IntActiQ99457. 1 interaction.
STRINGi9606.ENSP00000362171.

PTM databases

PhosphoSiteiQ99457.

Polymorphism and mutation databases

BioMutaiNAP1L3.
DMDMi60416442.

Proteomic databases

PaxDbiQ99457.
PRIDEiQ99457.

Protocols and materials databases

DNASUi4675.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373079; ENSP00000362171; ENSG00000186310.
GeneIDi4675.
KEGGihsa:4675.
UCSCiuc004efq.3. human.

Organism-specific databases

CTDi4675.
GeneCardsiGC0XM092925.
H-InvDBHIX0016910.
HGNCiHGNC:7639. NAP1L3.
HPAiHPA026075.
MIMi300117. gene.
neXtProtiNX_Q99457.
PharmGKBiPA31441.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG258492.
GeneTreeiENSGT00480000042668.
HOGENOMiHOG000171827.
HOVERGENiHBG052653.
InParanoidiQ99457.
KOiK11281.
OMAiNASFFNF.
OrthoDBiEOG7W1541.
PhylomeDBiQ99457.
TreeFamiTF314349.

Miscellaneous databases

ChiTaRSiNAP1L3. human.
GenomeRNAii4675.
NextBioi18020.
PROiQ99457.
SOURCEiSearch...

Gene expression databases

BgeeiQ99457.
CleanExiHS_NAP1L3.
ExpressionAtlasiQ99457. baseline and differential.
GenevestigatoriQ99457.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression pattern and mapping to Xq of NAP1L3, a gene encoding a peptide homologous to human and yeast nucleosome assembly proteins."
    Watanabe T.K., Fujiwara T., Nakamura Y., Hirai Y., Maekawa H., Takahashi E.
    Cytogenet. Cell Genet. 74:281-285(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-224.
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-224.
    Tissue: Heart.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNP1L3_HUMAN
AccessioniPrimary (citable) accession number: Q99457
Secondary accession number(s): B2RCM0, O60788
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 1, 2005
Last modified: April 29, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.