Q99445 (GML_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycosyl-phosphatidylinositol-anchored molecule-like protein

Gene names

Name:	GML
Synonyms:	LY6DL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Potential.
Induction	By p53/TP53. Ref.1
Sequence similarities	Contains 1 UPAR/Ly6 domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Traceable author statement Ref.1. Source: ProtInc apoptotic process Traceable author statement Ref.1. Source: ProtInc negative regulation of cell proliferation Traceable author statement Ref.1. Source: ProtInc
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Traceable author statement Ref.1. Source: ProtInc plasma membrane Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 158	141	Glycosyl-phosphatidylinositol-anchored molecule-like protein		PRO_0000036166
Regions
	Domain	29 – 134	106	UPAR/Ly6
Amino acid modifications
	Disulfide bond	31 ↔ 55		By similarity
	Disulfide bond	34 ↔ 42		By similarity
	Disulfide bond	48 ↔ 73		By similarity
	Disulfide bond	77 ↔ 104		By similarity
	Disulfide bond	105 ↔ 110		By similarity
Natural variations
	Natural variant	54	1	R → C. Corresponds to variant rs3764795 [ dbSNP | Ensembl ].		VAR_020174

Sequences

	Sequence		Length	Mass (Da)
	Q99445 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 21D7F23D33DBB3B2	FASTA	158	17,730
	10 20 30 40 50 60 MLLFALLLAM ELPLVAASAT MRAQWTYSLR CHDCAVINDF NCPNIRVCPY HIRRCMTISI 70 80 90 100 110 120 RINSRELLVY KNCTNNCTFV YAAEQPPEAP GKIFKTNSFY WVCCCNSMVC NAGGPTNLER 130 140 150 DMLPDEVTEE ELPEGTVRLG VSKLLLSFAS IIVSNILP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity." Furuhata T., Tokino T., Urano T., Nakamura Y. Oncogene 13:1965-1970(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INDUCTION BY TP53.
[2]	"Genomic structure and chromosomal localization of GML (GPI-anchored molecule-like protein), a gene induced by p53." Kimura Y., Furuhata T., Urano T., Hirata K., Nakamura Y., Tokino T. Genomics 41:477-480(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D84290 mRNA. Translation: BAA12300.1. AB000381 Genomic DNA. Translation: BAA19961.1. BC074930 mRNA. Translation: AAH74930.1. BC126336 mRNA. Translation: AAI26337.1. BC126338 mRNA. Translation: AAI26339.1.
IPI	IPI00015283.
RefSeq	NP_002057.1. NM_002066.2.
UniGene	Hs.661218.
3D structure databases
ProteinModelPortal	Q99445.
SMR	Q99445. Positions 29-112.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000220940.
Polymorphism databases
DMDM	3183013.
Proteomic databases
PaxDb	Q99445.
PRIDE	Q99445.
Protocols and materials databases
DNASU	2765.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000220940; ENSP00000220940; ENSG00000104499.
GeneID	2765.
KEGG	hsa:2765.
UCSC	uc003yxg.3. human.
Organism-specific databases
CTD	2765.
GeneCards	GC08P143913.
HGNC	HGNC:4375. GML.
MIM	602370. gene.
neXtProt	NX_Q99445.
PharmGKB	PA28760.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43409.
HOGENOM	HOG000112747.
HOVERGEN	HBG005863.
InParanoid	Q99445.
OMA	NNCTFVY.
OrthoDB	EOG4M65JT.
PhylomeDB	Q99445.
Gene expression databases
ArrayExpress	Q99445.
Bgee	Q99445.
CleanEx	HS_GML.
Genevestigator	Q99445.
GermOnline	ENSG00000104499. Homo sapiens.
Family and domain databases
InterPro	IPR018363. CD59_antigen_CS. IPR016054. LY6_UPA_recep-like. [Graphical view]
SMART	SM00134. LU. 1 hit. [Graphical view]
PROSITE	PS00983. LY6_UPAR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2765.
NextBio	10876.
SOURCE	Search...

Entry information

Entry name

GML_HUMAN

Accession

Primary (citable) accession number: Q99445
Secondary accession number(s): A0AVF6, O00686, O00731

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.