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Protein

Glycosyl-phosphatidylinositol-anchored molecule-like protein

Gene

GML

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage.

GO - Biological processi

  • apoptotic process Source: ProtInc
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: ProtInc
  • negative regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosyl-phosphatidylinositol-anchored molecule-like protein
Gene namesi
Name:GML
Synonyms:LY6DL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:4375. GML.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extrinsic component of membrane Source: ProtInc
  • intracellular Source: GOC
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28760.

Polymorphism and mutation databases

BioMutaiGML.
DMDMi3183013.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 158141Glycosyl-phosphatidylinositol-anchored molecule-like proteinPRO_0000036166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 55By similarity
Disulfide bondi34 ↔ 42By similarity
Disulfide bondi48 ↔ 73By similarity
Disulfide bondi77 ↔ 104By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ99445.
PRIDEiQ99445.

Expressioni

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiQ99445.
CleanExiHS_GML.
ExpressionAtlasiQ99445. baseline and differential.
GenevisibleiQ99445. HS.

Interactioni

Protein-protein interaction databases

BioGridi109027. 24 interactions.
STRINGi9606.ENSP00000220940.

Structurei

3D structure databases

ProteinModelPortaliQ99445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 134106UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ1W. Eukaryota.
ENOG41116UW. LUCA.
GeneTreeiENSGT00430000031094.
HOGENOMiHOG000112747.
HOVERGENiHBG005863.
InParanoidiQ99445.
OMAiCNAGGPT.
PhylomeDBiQ99445.
TreeFamiTF336908.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99445-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFALLLAM ELPLVAASAT MRAQWTYSLR CHDCAVINDF NCPNIRVCPY
60 70 80 90 100
HIRRCMTISI RINSRELLVY KNCTNNCTFV YAAEQPPEAP GKIFKTNSFY
110 120 130 140 150
WVCCCNSMVC NAGGPTNLER DMLPDEVTEE ELPEGTVRLG VSKLLLSFAS

IIVSNILP
Length:158
Mass (Da):17,730
Last modified:May 1, 1997 - v1
Checksum:i21D7F23D33DBB3B2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541R → C.
Corresponds to variant rs3764795 [ dbSNP | Ensembl ].
VAR_020174

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84290 mRNA. Translation: BAA12300.1.
AB000381 Genomic DNA. Translation: BAA19961.1.
BC074930 mRNA. Translation: AAH74930.1.
BC126336 mRNA. Translation: AAI26337.1.
BC126338 mRNA. Translation: AAI26339.1.
CCDSiCCDS6391.1.
RefSeqiNP_002057.1. NM_002066.2.
XP_011515273.1. XM_011516971.1.
XP_011515274.1. XM_011516972.1.
UniGeneiHs.661218.

Genome annotation databases

EnsembliENST00000220940; ENSP00000220940; ENSG00000104499.
GeneIDi2765.
KEGGihsa:2765.
UCSCiuc003yxg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84290 mRNA. Translation: BAA12300.1.
AB000381 Genomic DNA. Translation: BAA19961.1.
BC074930 mRNA. Translation: AAH74930.1.
BC126336 mRNA. Translation: AAI26337.1.
BC126338 mRNA. Translation: AAI26339.1.
CCDSiCCDS6391.1.
RefSeqiNP_002057.1. NM_002066.2.
XP_011515273.1. XM_011516971.1.
XP_011515274.1. XM_011516972.1.
UniGeneiHs.661218.

3D structure databases

ProteinModelPortaliQ99445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109027. 24 interactions.
STRINGi9606.ENSP00000220940.

Polymorphism and mutation databases

BioMutaiGML.
DMDMi3183013.

Proteomic databases

PaxDbiQ99445.
PRIDEiQ99445.

Protocols and materials databases

DNASUi2765.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220940; ENSP00000220940; ENSG00000104499.
GeneIDi2765.
KEGGihsa:2765.
UCSCiuc003yxg.3. human.

Organism-specific databases

CTDi2765.
GeneCardsiGML.
HGNCiHGNC:4375. GML.
MIMi602370. gene.
neXtProtiNX_Q99445.
PharmGKBiPA28760.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ1W. Eukaryota.
ENOG41116UW. LUCA.
GeneTreeiENSGT00430000031094.
HOGENOMiHOG000112747.
HOVERGENiHBG005863.
InParanoidiQ99445.
OMAiCNAGGPT.
PhylomeDBiQ99445.
TreeFamiTF336908.

Miscellaneous databases

GenomeRNAii2765.
PROiQ99445.
SOURCEiSearch...

Gene expression databases

BgeeiQ99445.
CleanExiHS_GML.
ExpressionAtlasiQ99445. baseline and differential.
GenevisibleiQ99445. HS.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity."
    Furuhata T., Tokino T., Urano T., Nakamura Y.
    Oncogene 13:1965-1970(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INDUCTION BY TP53.
  2. "Genomic structure and chromosomal localization of GML (GPI-anchored molecule-like protein), a gene induced by p53."
    Kimura Y., Furuhata T., Urano T., Hirata K., Nakamura Y., Tokino T.
    Genomics 41:477-480(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiGML_HUMAN
AccessioniPrimary (citable) accession number: Q99445
Secondary accession number(s): A0AVF6, O00686, O00731
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.