Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q99437

- VATO_HUMAN

UniProt

Q99437 - VATO_HUMAN

Protein

V-type proton ATPase 21 kDa proteolipid subunit

Gene

ATP6V0B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei98 – 981Essential for proton translocationBy similarity

    GO - Molecular functioni

    1. hydrogen ion transmembrane transporter activity Source: InterPro
    2. transporter activity Source: ProtInc

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: InterPro
    2. cellular iron ion homeostasis Source: Reactome
    3. insulin receptor signaling pathway Source: Reactome
    4. interaction with host Source: Reactome
    5. phagosome maturation Source: Reactome
    6. proton transport Source: ProtInc
    7. transferrin transport Source: Reactome
    8. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000117410-MONOMER.
    ReactomeiREACT_1109. Insulin receptor recycling.
    REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_25283. Transferrin endocytosis and recycling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase 21 kDa proteolipid subunit
    Short name:
    V-ATPase 21 kDa proteolipid subunit
    Alternative name(s):
    Vacuolar proton pump 21 kDa proteolipid subunit
    hATPL
    Gene namesi
    Name:ATP6V0B
    Synonyms:ATP6F
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:861. ATP6V0B.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome membrane Source: Reactome
    2. integral component of membrane Source: ProtInc
    3. phagocytic vesicle membrane Source: Reactome
    4. proton-transporting V-type ATPase, V0 domain Source: InterPro
    5. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25148.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205V-type proton ATPase 21 kDa proteolipid subunitPRO_0000071777Add
    BLAST

    Proteomic databases

    PRIDEiQ99437.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ99437.
    BgeeiQ99437.
    CleanExiHS_ATP6V0B.
    GenevestigatoriQ99437.

    Organism-specific databases

    HPAiHPA044281.

    Interactioni

    Subunit structurei

    Interacts with IFITM3.By similarity

    Protein-protein interaction databases

    BioGridi107016. 5 interactions.
    IntActiQ99437. 3 interactions.
    STRINGi9606.ENSP00000236067.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99437.
    SMRiQ99437. Positions 49-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 33LumenalSequence Analysis
    Topological domaini25 – 5127CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini73 – 9018LumenalSequence AnalysisAdd
    BLAST
    Topological domaini112 – 13726CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 17517LumenalSequence AnalysisAdd
    BLAST
    Topological domaini197 – 2059CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0636.
    HOGENOMiHOG000056522.
    HOVERGENiHBG105033.
    InParanoidiQ99437.
    KOiK03661.
    OrthoDBiEOG7MD4RZ.
    PhylomeDBiQ99437.
    TreeFamiTF314946.

    Family and domain databases

    InterProiIPR002379. ATPase_proteolipid_c_like_dom.
    IPR000245. ATPase_proteolipid_csu.
    [Graphical view]
    PfamiPF00137. ATP-synt_C. 2 hits.
    [Graphical view]
    PRINTSiPR00122. VACATPASE.
    SUPFAMiSSF81333. SSF81333. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q99437-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTGLALLYSG VFVAFWACAL AVGVCYTIFD LGFRFDVAWF LTETSPFMWS    50
    NLGIGLAISL SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV 100
    AIYGIIMAIV ISNMAEPFSA TDPKAIGHRN YHAGYSMFGA GLTVGLSNLF 150
    CGVCVGIVGS GAALADAQNP SLFVKILIVE IFGSAIGLFG VIVAILQTSR 200
    VKMGD 205
    Length:205
    Mass (Da):21,406
    Last modified:May 1, 1997 - v1
    Checksum:iF17C688D068A2785
    GO
    Isoform 2 (identifier: Q99437-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-47: Missing.

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:158
    Mass (Da):16,206
    Checksum:i93A67D6350A62D34
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti155 – 1551V → M in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035703

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4747Missing in isoform 2. CuratedVSP_046288Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89052 mRNA. Translation: BAA13753.1.
    BT007151 mRNA. Translation: AAP35815.1.
    CR456972 mRNA. Translation: CAG33253.1.
    AL357079 Genomic DNA. Translation: CAI16801.1.
    CH471059 Genomic DNA. Translation: EAX07066.1.
    CH471059 Genomic DNA. Translation: EAX07067.1.
    CH471059 Genomic DNA. Translation: EAX07068.1.
    BC000423 mRNA. Translation: AAH00423.1.
    BC005876 mRNA. Translation: AAH05876.1.
    CCDSiCCDS41315.1. [Q99437-2]
    CCDS505.1. [Q99437-1]
    RefSeqiNP_001034546.1. NM_001039457.1. [Q99437-2]
    NP_004038.1. NM_004047.3. [Q99437-1]
    UniGeneiHs.596514.

    Genome annotation databases

    EnsembliENST00000236067; ENSP00000236067; ENSG00000117410. [Q99437-2]
    ENST00000472174; ENSP00000431605; ENSG00000117410. [Q99437-1]
    ENST00000498664; ENSP00000434094; ENSG00000117410. [Q99437-2]
    GeneIDi533.
    KEGGihsa:533.
    UCSCiuc001cld.3. human. [Q99437-1]

    Polymorphism databases

    DMDMi6136172.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89052 mRNA. Translation: BAA13753.1 .
    BT007151 mRNA. Translation: AAP35815.1 .
    CR456972 mRNA. Translation: CAG33253.1 .
    AL357079 Genomic DNA. Translation: CAI16801.1 .
    CH471059 Genomic DNA. Translation: EAX07066.1 .
    CH471059 Genomic DNA. Translation: EAX07067.1 .
    CH471059 Genomic DNA. Translation: EAX07068.1 .
    BC000423 mRNA. Translation: AAH00423.1 .
    BC005876 mRNA. Translation: AAH05876.1 .
    CCDSi CCDS41315.1. [Q99437-2 ]
    CCDS505.1. [Q99437-1 ]
    RefSeqi NP_001034546.1. NM_001039457.1. [Q99437-2 ]
    NP_004038.1. NM_004047.3. [Q99437-1 ]
    UniGenei Hs.596514.

    3D structure databases

    ProteinModelPortali Q99437.
    SMRi Q99437. Positions 49-114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107016. 5 interactions.
    IntActi Q99437. 3 interactions.
    STRINGi 9606.ENSP00000236067.

    Polymorphism databases

    DMDMi 6136172.

    Proteomic databases

    PRIDEi Q99437.

    Protocols and materials databases

    DNASUi 533.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000236067 ; ENSP00000236067 ; ENSG00000117410 . [Q99437-2 ]
    ENST00000472174 ; ENSP00000431605 ; ENSG00000117410 . [Q99437-1 ]
    ENST00000498664 ; ENSP00000434094 ; ENSG00000117410 . [Q99437-2 ]
    GeneIDi 533.
    KEGGi hsa:533.
    UCSCi uc001cld.3. human. [Q99437-1 ]

    Organism-specific databases

    CTDi 533.
    GeneCardsi GC01P044440.
    HGNCi HGNC:861. ATP6V0B.
    HPAi HPA044281.
    MIMi 603717. gene.
    neXtProti NX_Q99437.
    PharmGKBi PA25148.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0636.
    HOGENOMi HOG000056522.
    HOVERGENi HBG105033.
    InParanoidi Q99437.
    KOi K03661.
    OrthoDBi EOG7MD4RZ.
    PhylomeDBi Q99437.
    TreeFami TF314946.

    Enzyme and pathway databases

    BioCyci MetaCyc:ENSG00000117410-MONOMER.
    Reactomei REACT_1109. Insulin receptor recycling.
    REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_25283. Transferrin endocytosis and recycling.

    Miscellaneous databases

    ChiTaRSi ATP6V0B. human.
    GeneWikii ATP6V0B.
    GenomeRNAii 533.
    NextBioi 2211.
    PROi Q99437.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q99437.
    Bgeei Q99437.
    CleanExi HS_ATP6V0B.
    Genevestigatori Q99437.

    Family and domain databases

    InterProi IPR002379. ATPase_proteolipid_c_like_dom.
    IPR000245. ATPase_proteolipid_csu.
    [Graphical view ]
    Pfami PF00137. ATP-synt_C. 2 hits.
    [Graphical view ]
    PRINTSi PR00122. VACATPASE.
    SUPFAMi SSF81333. SSF81333. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F)."
      Nishigori H., Yamada S., Tomura H., Fernald A.A., le Beau M.M., Takeuchi T., Takeda J.
      Genomics 50:222-228(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Muscle.
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-155.

    Entry informationi

    Entry nameiVATO_HUMAN
    AccessioniPrimary (citable) accession number: Q99437
    Secondary accession number(s): D3DPY5, Q6IB32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3