Q99435 (NELL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein kinase C-binding protein NELL2

Alternative name(s):
NEL-like protein 2
Nel-related protein 2

Gene names

Name:	NELL2
Synonyms:	NRP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	816 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Homotrimer. Binds to PKC beta-1 By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Contains 6 EGF-like domains. Contains 1 laminin G-like domain. Contains 3 VWFC domains.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal
Ligand	Calcium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Non-traceable author statement. Source: UniProtKB
Cellular_component	extracellular region Non-traceable author statement. Source: UniProtKB
Molecular_function	calcium ion binding Non-traceable author statement. Source: UniProtKB structural molecule activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GFI1B	Q5VTD9	2	EBI-946274,EBI-946212

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q99435-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q99435-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSIRRLLILILKIGRRWTELIRTM

Note: No experimental confirmation available.

Isoform 3 (identifier: Q99435-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGFPPLLKGQASATRSSLASCSWVVFFLSCLSRHAPEIEGGRRWTELIRTM

Note: No experimental confirmation available.

Isoform 4 (identifier: Q99435-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MESRVLLRTFCLIFGLGA → METGLGAPLFKAWLLIS

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.7
	Chain	22 – 816	795	Protein kinase C-binding protein NELL2		PRO_0000007666
Regions
	Domain	64 – 228	165	Laminin G-like
	Domain	272 – 331	60	VWFC 1
	Domain	397 – 439	43	EGF-like 1
	Domain	440 – 481	42	EGF-like 2; calcium-binding Potential
	Domain	482 – 522	41	EGF-like 3; calcium-binding Potential
	Domain	523 – 553	31	EGF-like 4
	Domain	555 – 601	47	EGF-like 5; calcium-binding Potential
	Domain	602 – 637	36	EGF-like 6; calcium-binding Potential
	Domain	638 – 693	56	VWFC 2
	Domain	698 – 756	59	VWFC 3
Amino acid modifications
	Glycosylation	53	1	N-linked (GlcNAc...) Potential
	Glycosylation	225	1	N-linked (GlcNAc...) Potential
	Glycosylation	293	1	N-linked (GlcNAc...) Potential
	Glycosylation	298	1	N-linked (GlcNAc...) Potential
	Glycosylation	517	1	N-linked (GlcNAc...) Potential
	Glycosylation	615	1	N-linked (GlcNAc...) Potential
	Glycosylation	635	1	N-linked (GlcNAc...) Potential
	Disulfide bond	401 ↔ 413		By similarity
	Disulfide bond	407 ↔ 422		By similarity
	Disulfide bond	424 ↔ 438		By similarity
	Disulfide bond	444 ↔ 457		By similarity
	Disulfide bond	451 ↔ 466		By similarity
	Disulfide bond	468 ↔ 480		By similarity
	Disulfide bond	486 ↔ 499		By similarity
	Disulfide bond	493 ↔ 508		By similarity
	Disulfide bond	510 ↔ 521		By similarity
	Disulfide bond	525 ↔ 535		By similarity
	Disulfide bond	529 ↔ 541		By similarity
	Disulfide bond	543 ↔ 552		By similarity
	Disulfide bond	559 ↔ 572		By similarity
	Disulfide bond	566 ↔ 581		By similarity
	Disulfide bond	583 ↔ 600		By similarity
	Disulfide bond	606 ↔ 619		By similarity
	Disulfide bond	613 ↔ 628		By similarity
	Disulfide bond	630 ↔ 636		By similarity
Natural variations
	Alternative sequence	1 – 18	18	MESRV…FGLGA → METGLGAPLFKAWLLIS in isoform 4.		VSP_043869
	Alternative sequence	1	1	M → MSIRRLLILILKIGRRWTEL IRTM in isoform 2.		VSP_043801
	Alternative sequence	1	1	M → MGFPPLLKGQASATRSSLAS CSWVVFFLSCLSRHAPEIEG GRRWTELIRTM in isoform 3.		VSP_043802
	Natural variant	5	1	V → I. Corresponds to variant rs2658973 [ dbSNP | Ensembl ].		VAR_048987
	Natural variant	347	1	N → D. Corresponds to variant rs17574839 [ dbSNP | Ensembl ].		VAR_048988
	Natural variant	631	1	P → L. Corresponds to variant rs1050710 [ dbSNP | Ensembl ].		VAR_048989
Experimental info
	Sequence conflict	353	1	S → P in BAH12990. Ref.3
	Sequence conflict	454	1	N → D in BAH12990. Ref.3
	Sequence conflict	489	1	N → D in BAH14331. Ref.3
	Sequence conflict	636	1	C → S in BAH14331. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 89370B987DC7A324	FASTA	816	91,346
	10 20 30 40 50 60 MESRVLLRTF CLIFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG LHNGTKAFLF 70 80 90 100 110 120 QDTPRSIKAS TATAEQFFQK LRNKHEFTIL VTLKQTHLNS GVILSIHHLD HRYLELESSG 130 140 150 160 170 180 HRNEVRLHYR SGSHRPHTEV FPYILADDKW HKLSLAISAS HLILHIDCNK IYERVVEKPS 190 200 210 220 230 240 TDLPLGTTFW LGQRNNAHGY FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK 250 260 270 280 290 300 IMELQDILAK TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWIDG CKNCTCLNGT 310 320 330 340 350 360 IQCETLICPN PDCPLKSALA YVDGKCCKEC KSICQFQGRT YFEGERNTVY SSSGVCVLYE 370 380 390 400 410 420 CKDQTMKLVE SSGCPALDCP ESHQITLSHS CCKVCKGYDF CSERHNCMEN SICRNLNDRA 430 440 450 460 470 480 VCSCRDGFRA LREDNAYCED IDECAEGRHY CRENTMCVNT PGSFMCICKT GYIRIDDYSC 490 500 510 520 530 540 TEHDECITNQ HNCDENALCF NTVGGHNCVC KPGYTGNGTT CKAFCKDGCR NGGACIAANV 550 560 570 580 590 600 CACPQGFTGP SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC 610 620 630 640 650 660 EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKVKHNG QIWVLENDRC 670 680 690 700 710 720 SVCSCQNGFV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC LHQNGETLYN SGDTWVQNCQ 730 740 750 760 770 780 QCRCLQGEVD CWPLPCPDVE CEFSILPENE CCPRCVTDPC QADTIRNDIT KTCLDEMNVV 790 800 810 RFTGSSWIKH GTECTLCQCK NGHICCSVDP QCLQEL
	Isoform 2 [UniParc]. Checksum: E7A4531EAB965749	FASTA	839	94,180
	10 20 30 40 50 60 MSIRRLLILI LKIGRRWTEL IRTMESRVLL RTFCLIFGLG AVWGLGVDPS LQIDVLTELE 70 80 90 100 110 120 LGESTTGVRQ VPGLHNGTKA FLFQDTPRSI KASTATAEQF FQKLRNKHEF TILVTLKQTH 130 140 150 160 170 180 LNSGVILSIH HLDHRYLELE SSGHRNEVRL HYRSGSHRPH TEVFPYILAD DKWHKLSLAI 190 200 210 220 230 240 SASHLILHID CNKIYERVVE KPSTDLPLGT TFWLGQRNNA HGYFKGIMQD VQLLVMPQGF 250 260 270 280 290 300 IAQCPDLNRT CPTCNDFHGL VQKIMELQDI LAKTSAKLSR AEQRMNRLDQ CYCERTCTMK 310 320 330 340 350 360 GTTYREFESW IDGCKNCTCL NGTIQCETLI CPNPDCPLKS ALAYVDGKCC KECKSICQFQ 370 380 390 400 410 420 GRTYFEGERN TVYSSSGVCV LYECKDQTMK LVESSGCPAL DCPESHQITL SHSCCKVCKG 430 440 450 460 470 480 YDFCSERHNC MENSICRNLN DRAVCSCRDG FRALREDNAY CEDIDECAEG RHYCRENTMC 490 500 510 520 530 540 VNTPGSFMCI CKTGYIRIDD YSCTEHDECI TNQHNCDENA LCFNTVGGHN CVCKPGYTGN 550 560 570 580 590 600 GTTCKAFCKD GCRNGGACIA ANVCACPQGF TGPSCETDID ECSDGFVQCD SRANCINLPG 610 620 630 640 650 660 WYHCECRDGY HDNGMFSPSG ESCEDIDECG TGRHSCANDT ICFNLDGGYD CRCPHGKNCT 670 680 690 700 710 720 GDCIHDGKVK HNGQIWVLEN DRCSVCSCQN GFVMCRRMVC DCENPTVDLF CCPECDPRLS 730 740 750 760 770 780 SQCLHQNGET LYNSGDTWVQ NCQQCRCLQG EVDCWPLPCP DVECEFSILP ENECCPRCVT 790 800 810 820 830 DPCQADTIRN DITKTCLDEM NVVRFTGSSW IKHGTECTLC QCKNGHICCS VDPQCLQEL
	Isoform 3 [UniParc]. Checksum: 87C3D940EEC2BC68	FASTA	866	96,880
	10 20 30 40 50 60 MGFPPLLKGQ ASATRSSLAS CSWVVFFLSC LSRHAPEIEG GRRWTELIRT MESRVLLRTF 70 80 90 100 110 120 CLIFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG LHNGTKAFLF QDTPRSIKAS 130 140 150 160 170 180 TATAEQFFQK LRNKHEFTIL VTLKQTHLNS GVILSIHHLD HRYLELESSG HRNEVRLHYR 190 200 210 220 230 240 SGSHRPHTEV FPYILADDKW HKLSLAISAS HLILHIDCNK IYERVVEKPS TDLPLGTTFW 250 260 270 280 290 300 LGQRNNAHGY FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK IMELQDILAK 310 320 330 340 350 360 TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWIDG CKNCTCLNGT IQCETLICPN 370 380 390 400 410 420 PDCPLKSALA YVDGKCCKEC KSICQFQGRT YFEGERNTVY SSSGVCVLYE CKDQTMKLVE 430 440 450 460 470 480 SSGCPALDCP ESHQITLSHS CCKVCKGYDF CSERHNCMEN SICRNLNDRA VCSCRDGFRA 490 500 510 520 530 540 LREDNAYCED IDECAEGRHY CRENTMCVNT PGSFMCICKT GYIRIDDYSC TEHDECITNQ 550 560 570 580 590 600 HNCDENALCF NTVGGHNCVC KPGYTGNGTT CKAFCKDGCR NGGACIAANV CACPQGFTGP 610 620 630 640 650 660 SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC EDIDECGTGR 670 680 690 700 710 720 HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKVKHNG QIWVLENDRC SVCSCQNGFV 730 740 750 760 770 780 MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC LHQNGETLYN SGDTWVQNCQ QCRCLQGEVD 790 800 810 820 830 840 CWPLPCPDVE CEFSILPENE CCPRCVTDPC QADTIRNDIT KTCLDEMNVV RFTGSSWIKH 850 860 GTECTLCQCK NGHICCSVDP QCLQEL
	Isoform 4 [UniParc]. Checksum: 907D0AC0BD4B85D1	FASTA	815	91,167
	10 20 30 40 50 60 METGLGAPLF KAWLLISVWG LGVDPSLQID VLTELELGES TTGVRQVPGL HNGTKAFLFQ 70 80 90 100 110 120 DTPRSIKAST ATAEQFFQKL RNKHEFTILV TLKQTHLNSG VILSIHHLDH RYLELESSGH 130 140 150 160 170 180 RNEVRLHYRS GSHRPHTEVF PYILADDKWH KLSLAISASH LILHIDCNKI YERVVEKPST 190 200 210 220 230 240 DLPLGTTFWL GQRNNAHGYF KGIMQDVQLL VMPQGFIAQC PDLNRTCPTC NDFHGLVQKI 250 260 270 280 290 300 MELQDILAKT SAKLSRAEQR MNRLDQCYCE RTCTMKGTTY REFESWIDGC KNCTCLNGTI 310 320 330 340 350 360 QCETLICPNP DCPLKSALAY VDGKCCKECK SICQFQGRTY FEGERNTVYS SSGVCVLYEC 370 380 390 400 410 420 KDQTMKLVES SGCPALDCPE SHQITLSHSC CKVCKGYDFC SERHNCMENS ICRNLNDRAV 430 440 450 460 470 480 CSCRDGFRAL REDNAYCEDI DECAEGRHYC RENTMCVNTP GSFMCICKTG YIRIDDYSCT 490 500 510 520 530 540 EHDECITNQH NCDENALCFN TVGGHNCVCK PGYTGNGTTC KAFCKDGCRN GGACIAANVC 550 560 570 580 590 600 ACPQGFTGPS CETDIDECSD GFVQCDSRAN CINLPGWYHC ECRDGYHDNG MFSPSGESCE 610 620 630 640 650 660 DIDECGTGRH SCANDTICFN LDGGYDCRCP HGKNCTGDCI HDGKVKHNGQ IWVLENDRCS 670 680 690 700 710 720 VCSCQNGFVM CRRMVCDCEN PTVDLFCCPE CDPRLSSQCL HQNGETLYNS GDTWVQNCQQ 730 740 750 760 770 780 CRCLQGEVDC WPLPCPDVEC EFSILPENEC CPRCVTDPCQ ADTIRNDITK TCLDEMNVVR 790 800 810 FTGSSWIKHG TECTLCQCKN GHICCSVDPQ CLQEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats." Watanabe T.K., Katagiri T., Suzuki M., Shimizu F., Fujiwara T., Kanemoto N., Nakamura Y., Hirai Y., Maekawa H., Takahashi E. Genomics 38:273-276(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Biological functions of a novel human gene, hucep-12, which is specifically expressed in the central nervous system." Yoshimoto M., Yazaki M., Takayama K., Matsumoto K. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4). Tissue: Amygdala, Brain and Hippocampus.
[4]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Duodenum.
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-36 (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D83018 mRNA. Translation: BAA11681.1. D89629 mRNA. Translation: BAB46925.1. AK295125 mRNA. Translation: BAH11983.1. AK299277 mRNA. Translation: BAH12990.1. AK315960 mRNA. Translation: BAH14331.1. AK316058 mRNA. Translation: BAH14429.1. AC018923 Genomic DNA. No translation available. AC025253 Genomic DNA. No translation available. AC079033 Genomic DNA. No translation available. AC079825 Genomic DNA. No translation available. AC090012 Genomic DNA. No translation available. CH471111 Genomic DNA. Translation: EAW57873.1. BC020544 mRNA. Translation: AAH20544.1.
IPI	IPI00015260. IPI00921881. IPI00922434. IPI01021725.
RefSeq	NP_001138579.1. NM_001145107.1. NP_001138580.1. NM_001145108.1. NP_001138581.1. NM_001145109.1. NP_001138582.1. NM_001145110.1. NP_006150.1. NM_006159.2.
UniGene	Hs.505326.
3D structure databases
ProteinModelPortal	Q99435.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99435. 7 interactions.
MINT	MINT-2856232.
STRING	9606.ENSP00000416341.
Polymorphism databases
DMDM	2494289.
Proteomic databases
PaxDb	Q99435.
PRIDE	Q99435.
Protocols and materials databases
DNASU	4753.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333837; ENSP00000327988; ENSG00000184613. ENST00000395487; ENSP00000378866; ENSG00000184613. ENST00000429094; ENSP00000390680; ENSG00000184613. ENST00000437801; ENSP00000416341; ENSG00000184613. ENST00000452445; ENSP00000394612; ENSG00000184613. ENST00000549027; ENSP00000447927; ENSG00000184613.
GeneID	4753.
KEGG	hsa:4753.
UCSC	uc001rof.3. human. uc001rog.2. human. uc010skz.1. human. uc010sla.1. human.
Organism-specific databases
CTD	4753.
GeneCards	GC12M044981.
HGNC	HGNC:7751. NELL2.
HPA	HPA035715.
MIM	602320. gene.
neXtProt	NX_Q99435.
PharmGKB	PA31553.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253557.
HOGENOM	HOG000217920.
HOVERGEN	HBG004805.
InParanoid	Q99435.
OMA	DTICFNL.
OrthoDB	EOG44TP76.
PhylomeDB	Q99435.
Gene expression databases
ArrayExpress	Q99435.
Bgee	Q99435.
CleanEx	HS_NELL2. HS_NRP2.
Genevestigator	Q99435.
GermOnline	ENSG00000184613. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR026823. cEGF. IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR001791. Laminin_G. IPR001007. VWF_C. [Graphical view]
Pfam	PF12662. cEGF. 1 hit. PF07645. EGF_CA. 2 hits. PF02210. Laminin_G_2. 1 hit. PF00093. VWC. 2 hits. [Graphical view]
SMART	SM00181. EGF. 2 hits. SM00179. EGF_CA. 3 hits. SM00282. LamG. 1 hit. SM00210. TSPN. 1 hit. SM00214. VWC. 3 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS00010. ASX_HYDROXYL. 3 hits. PS00022. EGF_1. 1 hit. PS01186. EGF_2. 4 hits. PS50026. EGF_3. 6 hits. PS01187. EGF_CA. 3 hits. PS50025. LAM_G_DOMAIN. False negative. PS01208. VWFC_1. 2 hits. PS50184. VWFC_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NELL2. human.
GenomeRNAi	4753.
NextBio	18320.
SOURCE	Search...

Entry information

Entry name

NELL2_HUMAN

Accession

Primary (citable) accession number: Q99435
Secondary accession number(s): B7Z2U7 , B7Z5Q4, B7Z9J5, B7Z9U3, Q96JS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	May 29, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.