Reviewed,
UniProtKB/Swiss-Prot Q99424 (ACOX2_HUMAN)
Last modified
November 3, 2009.
Version 89.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Peroxisomal acyl-coenzyme A oxidase 2 EC=1.17.99.3 Alternative name(s): 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase Trihydroxycoprostanoyl-CoA oxidase Short name=THCA-CoA oxidase Short name=THCCox | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 681 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids. |
| Catalytic activity | (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor. |
| Cofactor | FAD By similarity. |
| Subunit structure | Heterodimer By similarity. |
| Subcellular location | |
| Tissue specificity | Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney. |
| Sequence similarities | Belongs to the acyl-CoA oxidase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 681 | 681 | Peroxisomal acyl-coenzyme A oxidase 2 | PRO_0000204681 | |||||
Regions | |||||||||
| Motif | 679 – 681 | 3 | Microbody targeting signal Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 3 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 417 | 1 | Phosphotyrosine Ref.7 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger's syndrome." Baumgart E., Vanhooren J.C.T., Fransen M., Marynen P., Puype M., Vandekerckhove J., Leunissen J.A.M., Fahimi H.D., Mannaerts G.P., Van Veldhoven P.P. Proc. Natl. Acad. Sci. U.S.A. 93:13748-13753(1996) [PubMed: 8943006] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 8-14; 271-282; 337-346; 450-468 AND 656-664. Tissue: Liver. |
| [2] | "Genomic sequence of peroxisomal human branched chain acyl-CoA oxidase." Fournier B., Baumgart E., Fahimi D., Mannaerts G.P., Van Veldhoven P.P. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [4] | "The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. Gibbs R.A.Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon. |
| [7] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-417, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| X95190 mRNA. Translation: CAA64489.1. AJ001541 AJ001548 Genomic DNA. Translation: CAB65596.1. AK313512 mRNA. Translation: BAG36292.1. AC116036 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW65375.1. BC047700 mRNA. Translation: AAH47700.1. | |
| IPI | IPI00293125. |
| RefSeq | NP_003491.1. |
| UniGene | Hs.444959 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IS2 based on UniProtKB P07872. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q99424. |
PTM databases | |
| PhosphoSite | Q99424. |
Proteomic databases | |
| PRIDE | Q99424. |
Genome annotation databases | |
| Ensembl | ENST00000302819; ENSP00000307697; ENSG00000168306; Homo sapiens. [Genome view] |
| GeneID | 8309. |
| KEGG | hsa:8309. |
| UCSC | uc003dkl.1. human. |
Organism-specific databases | |
| CTD | 8309. |
| GeneCards | GC03M058465. |
| H-InvDB | HIX0024326. |
| HGNC | HGNC:120. ACOX2. |
| MIM | 601641. gene. |
| PharmGKB | PA24444. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q99424. |
| OMA | ETEATYD. |
Enzyme and pathway databases | |
| BRENDA | 1.17.99.3. 247. |
| Reactome | REACT_602. Metabolism of lipids and lipoproteins. |
Gene expression databases | |
| ArrayExpress | Q99424. |
| Bgee | Q99424. |
| CleanEx | HS_ACOX2. |
| Genevestigator | Q99424. |
| GermOnline | ENSG00000168306. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006091. Acyl-CoA_Oxase/DH_M. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view] |
| Gene3D | G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits. |
| PANTHER | PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit. |
| Pfam | PF01756. ACOX. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view] |
| PIRSF | PIRSF000168. Acyl-CoA_oxidase. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 31117. |
| SOURCE | Search... |
Entry information
| Entry name | ACOX2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q99424 Secondary accession number(s): A6NF16, B2R8U5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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