Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q99417

- MYCBP_HUMAN

UniProt

Q99417 - MYCBP_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

C-Myc-binding protein

Gene

MYCBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.

GO - Molecular functioni

  1. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB
  2. spermatogenesis Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
C-Myc-binding protein
Alternative name(s):
Associate of Myc 1
Short name:
AMY-1
Gene namesi
Name:MYCBP
Synonyms:AMY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:7554. MYCBP.

Subcellular locationi

Cytoplasm. Nucleus. Mitochondrion
Note: Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.

GO - Cellular componenti

  1. centrosome Source: HPA
  2. cytoplasm Source: UniProtKB
  3. mitochondrion Source: UniProtKB-KW
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 103102C-Myc-binding proteinPRO_0000220980Add
BLAST

Proteomic databases

MaxQBiQ99417.
PaxDbiQ99417.
PeptideAtlasiQ99417.
PRIDEiQ99417.

PTM databases

PhosphoSiteiQ99417.

Expressioni

Tissue specificityi

Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.

Gene expression databases

BgeeiQ99417.
CleanExiHS_MYCBP.
GenevestigatoriQ99417.

Organism-specific databases

HPAiHPA041188.

Interactioni

Subunit structurei

Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AKAP1Q92667-22EBI-716185,EBI-2120060
ARFGEF1Q9Y6D63EBI-716185,EBI-1044254
ARFGEF2Q9Y6D55EBI-716185,EBI-2837511
MAATS1Q7Z4T9-45EBI-716185,EBI-2119735
MYCBPAPQ8TBZ24EBI-716185,EBI-1391585

Protein-protein interaction databases

BioGridi117673. 24 interactions.
IntActiQ99417. 21 interactions.
MINTiMINT-1367805.
STRINGi9606.ENSP00000380702.

Structurei

Secondary structure

1
103
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi60 – 9031Combined sources
Turni91 – 933Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YY0X-ray2.40A/B/C/D42-94[»]
ProteinModelPortaliQ99417.
SMRiQ99417. Positions 42-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99417.

Family & Domainsi

Sequence similaritiesi

Belongs to the AMY1 family.Curated

Phylogenomic databases

eggNOGiNOG68420.
GeneTreeiENSGT00390000017974.
HOGENOMiHOG000260967.
HOVERGENiHBG052546.
InParanoidiQ99417.
OMAiAQYEPLQ.
OrthoDBiEOG7Q8CNC.
PhylomeDBiQ99417.
TreeFamiTF329224.

Family and domain databases

InterProiIPR026060. AMY1.
[Graphical view]
PANTHERiPTHR13168. PTHR13168. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99417-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHYKAADSK REQFRRYLEK SGVLDTLTKV LVALYEEPEK PNSALDFLKH
60 70 80 90 100
HLGAATPENP EIELLRLELA EMKEKYEAIV EENKKLKAKL AQYEPPQEEK

RAE
Length:103
Mass (Da):11,967
Last modified:January 23, 2007 - v3
Checksum:i72B9BD179A6808D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651L → V in BAA09338. (PubMed:9797456)Curated
Sequence conflicti65 – 651L → V in BAA22408. (PubMed:9797456)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50692 mRNA. Translation: BAA09338.1.
BT007109 mRNA. Translation: AAP35773.1.
AB007191 mRNA. Translation: BAA22408.1.
AB451287 mRNA. Translation: BAG70101.1.
AB451419 mRNA. Translation: BAG70233.1.
AK311886 mRNA. Translation: BAG34827.1.
AL139260 Genomic DNA. Translation: CAI23050.1.
BC008686 mRNA. Translation: AAH08686.1.
CCDSiCCDS431.1.
RefSeqiNP_036465.2. NM_012333.4.
UniGeneiHs.591506.

Genome annotation databases

EnsembliENST00000397572; ENSP00000380702; ENSG00000214114.
GeneIDi26292.
KEGGihsa:26292.
UCSCiuc001ccs.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50692 mRNA. Translation: BAA09338.1 .
BT007109 mRNA. Translation: AAP35773.1 .
AB007191 mRNA. Translation: BAA22408.1 .
AB451287 mRNA. Translation: BAG70101.1 .
AB451419 mRNA. Translation: BAG70233.1 .
AK311886 mRNA. Translation: BAG34827.1 .
AL139260 Genomic DNA. Translation: CAI23050.1 .
BC008686 mRNA. Translation: AAH08686.1 .
CCDSi CCDS431.1.
RefSeqi NP_036465.2. NM_012333.4.
UniGenei Hs.591506.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YY0 X-ray 2.40 A/B/C/D 42-94 [» ]
ProteinModelPortali Q99417.
SMRi Q99417. Positions 42-94.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117673. 24 interactions.
IntActi Q99417. 21 interactions.
MINTi MINT-1367805.
STRINGi 9606.ENSP00000380702.

PTM databases

PhosphoSitei Q99417.

Proteomic databases

MaxQBi Q99417.
PaxDbi Q99417.
PeptideAtlasi Q99417.
PRIDEi Q99417.

Protocols and materials databases

DNASUi 26292.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397572 ; ENSP00000380702 ; ENSG00000214114 .
GeneIDi 26292.
KEGGi hsa:26292.
UCSCi uc001ccs.3. human.

Organism-specific databases

CTDi 26292.
GeneCardsi GC01M039328.
HGNCi HGNC:7554. MYCBP.
HPAi HPA041188.
MIMi 606535. gene.
neXtProti NX_Q99417.
PharmGKBi PA31354.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68420.
GeneTreei ENSGT00390000017974.
HOGENOMi HOG000260967.
HOVERGENi HBG052546.
InParanoidi Q99417.
OMAi AQYEPLQ.
OrthoDBi EOG7Q8CNC.
PhylomeDBi Q99417.
TreeFami TF329224.

Miscellaneous databases

EvolutionaryTracei Q99417.
GeneWikii MYCBP.
GenomeRNAii 26292.
NextBioi 48639.
PROi Q99417.
SOURCEi Search...

Gene expression databases

Bgeei Q99417.
CleanExi HS_MYCBP.
Genevestigatori Q99417.

Family and domain databases

InterProi IPR026060. AMY1.
[Graphical view ]
PANTHERi PTHR13168. PTHR13168. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC."
    Taira T., Maeda J., Ohishi T., Kitaura H., Yoshida S., Kato H., Ikeda M., Tamai K., Iguchi-Ariga S.M.M., Ariga H.
    Genes Cells 3:549-565(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
    Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
    , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
    Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-11.
    Tissue: Platelet.
  8. "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase."
    Furusawa M., Ohnishi T., Taira T., Iguchi-Ariga S.M.M., Ariga H.
    J. Biol. Chem. 276:36647-36651(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AKAP1.
  9. "AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis."
    Yukitake H., Furusawa M., Taira T., Iguchi-Ariga S.M.M., Ariga H.
    Biochim. Biophys. Acta 1577:126-132(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYCBPAP.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Crystal structure of c-myc-1 binding protein domain from Homo sapiens."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 42-94.

Entry informationi

Entry nameiMYCBP_HUMAN
AccessioniPrimary (citable) accession number: Q99417
Secondary accession number(s): B2R4N0, Q5TA64, Q96HE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3