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Protein

C-Myc-binding protein

Gene

MYCBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.

GO - Molecular functioni

  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • spermatogenesis Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
C-Myc-binding protein
Alternative name(s):
Associate of Myc 1
Short name:
AMY-1
Gene namesi
Name:MYCBP
Synonyms:AMY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7554. MYCBP.

Subcellular locationi

  • Cytoplasm
  • Nucleus
  • Mitochondrion

  • Note: Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • mitochondrion Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26292.
OpenTargetsiENSG00000214114.
PharmGKBiPA31354.

Polymorphism and mutation databases

BioMutaiMYCBP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002209802 – 103C-Myc-binding proteinAdd BLAST102

Proteomic databases

EPDiQ99417.
MaxQBiQ99417.
PaxDbiQ99417.
PeptideAtlasiQ99417.
PRIDEiQ99417.
TopDownProteomicsiQ99417.

PTM databases

iPTMnetiQ99417.
PhosphoSitePlusiQ99417.

Expressioni

Tissue specificityi

Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.

Gene expression databases

BgeeiENSG00000214114.
CleanExiHS_MYCBP.
ExpressionAtlasiQ99417. baseline and differential.
GenevisibleiQ99417. HS.

Organism-specific databases

HPAiHPA041188.

Interactioni

Subunit structurei

Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AKAP1Q92667-22EBI-716185,EBI-2120060
ARFGEF1Q9Y6D63EBI-716185,EBI-1044254
ARFGEF2Q9Y6D55EBI-716185,EBI-2837511
MAATS1Q7Z4T9-45EBI-716185,EBI-2119735
MYCBPAPQ8TBZ24EBI-716185,EBI-1391585

Protein-protein interaction databases

BioGridi117673. 32 interactors.
IntActiQ99417. 23 interactors.
MINTiMINT-1367805.
STRINGi9606.ENSP00000380702.

Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi43 – 50Combined sources8
Beta strandi51 – 54Combined sources4
Helixi60 – 90Combined sources31
Turni91 – 93Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YY0X-ray2.40A/B/C/D42-94[»]
ProteinModelPortaliQ99417.
SMRiQ99417.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99417.

Family & Domainsi

Sequence similaritiesi

Belongs to the AMY1 family.Curated

Phylogenomic databases

eggNOGiENOG410J2G0. Eukaryota.
ENOG41126S1. LUCA.
GeneTreeiENSGT00390000017974.
HOGENOMiHOG000260967.
HOVERGENiHBG052546.
InParanoidiQ99417.
OrthoDBiEOG091G166C.
PhylomeDBiQ99417.
TreeFamiTF329224.

Family and domain databases

InterProiIPR026060. AMY1.
[Graphical view]
PANTHERiPTHR13168. PTHR13168. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHYKAADSK REQFRRYLEK SGVLDTLTKV LVALYEEPEK PNSALDFLKH
60 70 80 90 100
HLGAATPENP EIELLRLELA EMKEKYEAIV EENKKLKAKL AQYEPPQEEK

RAE
Length:103
Mass (Da):11,967
Last modified:January 23, 2007 - v3
Checksum:i72B9BD179A6808D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65L → V in BAA09338 (PubMed:9797456).Curated1
Sequence conflicti65L → V in BAA22408 (PubMed:9797456).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50692 mRNA. Translation: BAA09338.1.
BT007109 mRNA. Translation: AAP35773.1.
AB007191 mRNA. Translation: BAA22408.1.
AB451287 mRNA. Translation: BAG70101.1.
AB451419 mRNA. Translation: BAG70233.1.
AK311886 mRNA. Translation: BAG34827.1.
AL139260 Genomic DNA. Translation: CAI23050.1.
BC008686 mRNA. Translation: AAH08686.1.
CCDSiCCDS431.1.
RefSeqiNP_036465.2. NM_012333.4.
UniGeneiHs.591506.

Genome annotation databases

EnsembliENST00000397572; ENSP00000380702; ENSG00000214114.
GeneIDi26292.
KEGGihsa:26292.
UCSCiuc001ccs.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50692 mRNA. Translation: BAA09338.1.
BT007109 mRNA. Translation: AAP35773.1.
AB007191 mRNA. Translation: BAA22408.1.
AB451287 mRNA. Translation: BAG70101.1.
AB451419 mRNA. Translation: BAG70233.1.
AK311886 mRNA. Translation: BAG34827.1.
AL139260 Genomic DNA. Translation: CAI23050.1.
BC008686 mRNA. Translation: AAH08686.1.
CCDSiCCDS431.1.
RefSeqiNP_036465.2. NM_012333.4.
UniGeneiHs.591506.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YY0X-ray2.40A/B/C/D42-94[»]
ProteinModelPortaliQ99417.
SMRiQ99417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117673. 32 interactors.
IntActiQ99417. 23 interactors.
MINTiMINT-1367805.
STRINGi9606.ENSP00000380702.

PTM databases

iPTMnetiQ99417.
PhosphoSitePlusiQ99417.

Polymorphism and mutation databases

BioMutaiMYCBP.

Proteomic databases

EPDiQ99417.
MaxQBiQ99417.
PaxDbiQ99417.
PeptideAtlasiQ99417.
PRIDEiQ99417.
TopDownProteomicsiQ99417.

Protocols and materials databases

DNASUi26292.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397572; ENSP00000380702; ENSG00000214114.
GeneIDi26292.
KEGGihsa:26292.
UCSCiuc001ccs.4. human.

Organism-specific databases

CTDi26292.
DisGeNETi26292.
GeneCardsiMYCBP.
HGNCiHGNC:7554. MYCBP.
HPAiHPA041188.
MIMi606535. gene.
neXtProtiNX_Q99417.
OpenTargetsiENSG00000214114.
PharmGKBiPA31354.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2G0. Eukaryota.
ENOG41126S1. LUCA.
GeneTreeiENSGT00390000017974.
HOGENOMiHOG000260967.
HOVERGENiHBG052546.
InParanoidiQ99417.
OrthoDBiEOG091G166C.
PhylomeDBiQ99417.
TreeFamiTF329224.

Miscellaneous databases

EvolutionaryTraceiQ99417.
GeneWikiiMYCBP.
GenomeRNAii26292.
PROiQ99417.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000214114.
CleanExiHS_MYCBP.
ExpressionAtlasiQ99417. baseline and differential.
GenevisibleiQ99417. HS.

Family and domain databases

InterProiIPR026060. AMY1.
[Graphical view]
PANTHERiPTHR13168. PTHR13168. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMYCBP_HUMAN
AccessioniPrimary (citable) accession number: Q99417
Secondary accession number(s): B2R4N0, Q5TA64, Q96HE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.