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Q99417

- MYCBP_HUMAN

UniProt

Q99417 - MYCBP_HUMAN

Protein

C-Myc-binding protein

Gene

MYCBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB
    2. spermatogenesis Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-Myc-binding protein
    Alternative name(s):
    Associate of Myc 1
    Short name:
    AMY-1
    Gene namesi
    Name:MYCBP
    Synonyms:AMY1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:7554. MYCBP.

    Subcellular locationi

    Cytoplasm. Nucleus. Mitochondrion
    Note: Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.

    GO - Cellular componenti

    1. centrosome Source: HPA
    2. cytoplasm Source: UniProtKB
    3. mitochondrion Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31354.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 103102C-Myc-binding proteinPRO_0000220980Add
    BLAST

    Proteomic databases

    MaxQBiQ99417.
    PaxDbiQ99417.
    PeptideAtlasiQ99417.
    PRIDEiQ99417.

    PTM databases

    PhosphoSiteiQ99417.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.

    Gene expression databases

    BgeeiQ99417.
    CleanExiHS_MYCBP.
    GenevestigatoriQ99417.

    Organism-specific databases

    HPAiHPA041188.

    Interactioni

    Subunit structurei

    Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AKAP1Q92667-22EBI-716185,EBI-2120060
    ARFGEF1Q9Y6D63EBI-716185,EBI-1044254
    ARFGEF2Q9Y6D55EBI-716185,EBI-2837511
    MAATS1Q7Z4T9-45EBI-716185,EBI-2119735
    MYCBPAPQ8TBZ24EBI-716185,EBI-1391585

    Protein-protein interaction databases

    BioGridi117673. 24 interactions.
    IntActiQ99417. 21 interactions.
    MINTiMINT-1367805.
    STRINGi9606.ENSP00000380702.

    Structurei

    Secondary structure

    1
    103
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi60 – 9031
    Turni91 – 933

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YY0X-ray2.40A/B/C/D42-94[»]
    ProteinModelPortaliQ99417.
    SMRiQ99417. Positions 42-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ99417.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AMY1 family.Curated

    Phylogenomic databases

    eggNOGiNOG68420.
    HOGENOMiHOG000260967.
    HOVERGENiHBG052546.
    InParanoidiQ99417.
    OMAiAQYEPLQ.
    OrthoDBiEOG7Q8CNC.
    PhylomeDBiQ99417.
    TreeFamiTF329224.

    Family and domain databases

    InterProiIPR026060. AMY1.
    [Graphical view]
    PANTHERiPTHR13168. PTHR13168. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99417-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHYKAADSK REQFRRYLEK SGVLDTLTKV LVALYEEPEK PNSALDFLKH    50
    HLGAATPENP EIELLRLELA EMKEKYEAIV EENKKLKAKL AQYEPPQEEK 100
    RAE 103
    Length:103
    Mass (Da):11,967
    Last modified:January 23, 2007 - v3
    Checksum:i72B9BD179A6808D0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti65 – 651L → V in BAA09338. (PubMed:9797456)Curated
    Sequence conflicti65 – 651L → V in BAA22408. (PubMed:9797456)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50692 mRNA. Translation: BAA09338.1.
    BT007109 mRNA. Translation: AAP35773.1.
    AB007191 mRNA. Translation: BAA22408.1.
    AB451287 mRNA. Translation: BAG70101.1.
    AB451419 mRNA. Translation: BAG70233.1.
    AK311886 mRNA. Translation: BAG34827.1.
    AL139260 Genomic DNA. Translation: CAI23050.1.
    BC008686 mRNA. Translation: AAH08686.1.
    CCDSiCCDS431.1.
    RefSeqiNP_036465.2. NM_012333.4.
    UniGeneiHs.591506.

    Genome annotation databases

    EnsembliENST00000397572; ENSP00000380702; ENSG00000214114.
    GeneIDi26292.
    KEGGihsa:26292.
    UCSCiuc001ccs.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50692 mRNA. Translation: BAA09338.1 .
    BT007109 mRNA. Translation: AAP35773.1 .
    AB007191 mRNA. Translation: BAA22408.1 .
    AB451287 mRNA. Translation: BAG70101.1 .
    AB451419 mRNA. Translation: BAG70233.1 .
    AK311886 mRNA. Translation: BAG34827.1 .
    AL139260 Genomic DNA. Translation: CAI23050.1 .
    BC008686 mRNA. Translation: AAH08686.1 .
    CCDSi CCDS431.1.
    RefSeqi NP_036465.2. NM_012333.4.
    UniGenei Hs.591506.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YY0 X-ray 2.40 A/B/C/D 42-94 [» ]
    ProteinModelPortali Q99417.
    SMRi Q99417. Positions 42-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117673. 24 interactions.
    IntActi Q99417. 21 interactions.
    MINTi MINT-1367805.
    STRINGi 9606.ENSP00000380702.

    PTM databases

    PhosphoSitei Q99417.

    Proteomic databases

    MaxQBi Q99417.
    PaxDbi Q99417.
    PeptideAtlasi Q99417.
    PRIDEi Q99417.

    Protocols and materials databases

    DNASUi 26292.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397572 ; ENSP00000380702 ; ENSG00000214114 .
    GeneIDi 26292.
    KEGGi hsa:26292.
    UCSCi uc001ccs.3. human.

    Organism-specific databases

    CTDi 26292.
    GeneCardsi GC01M039328.
    HGNCi HGNC:7554. MYCBP.
    HPAi HPA041188.
    MIMi 606535. gene.
    neXtProti NX_Q99417.
    PharmGKBi PA31354.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68420.
    HOGENOMi HOG000260967.
    HOVERGENi HBG052546.
    InParanoidi Q99417.
    OMAi AQYEPLQ.
    OrthoDBi EOG7Q8CNC.
    PhylomeDBi Q99417.
    TreeFami TF329224.

    Miscellaneous databases

    EvolutionaryTracei Q99417.
    GeneWikii MYCBP.
    GenomeRNAii 26292.
    NextBioi 48639.
    PROi Q99417.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q99417.
    CleanExi HS_MYCBP.
    Genevestigatori Q99417.

    Family and domain databases

    InterProi IPR026060. AMY1.
    [Graphical view ]
    PANTHERi PTHR13168. PTHR13168. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC."
      Taira T., Maeda J., Ohishi T., Kitaura H., Yoshida S., Kato H., Ikeda M., Tamai K., Iguchi-Ariga S.M.M., Ariga H.
      Genes Cells 3:549-565(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
      , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
      Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-11.
      Tissue: Platelet.
    8. "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase."
      Furusawa M., Ohnishi T., Taira T., Iguchi-Ariga S.M.M., Ariga H.
      J. Biol. Chem. 276:36647-36651(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AKAP1.
    9. "AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis."
      Yukitake H., Furusawa M., Taira T., Iguchi-Ariga S.M.M., Ariga H.
      Biochim. Biophys. Acta 1577:126-132(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MYCBPAP.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Crystal structure of c-myc-1 binding protein domain from Homo sapiens."
      RIKEN structural genomics initiative (RSGI)
      Submitted (APR-2008) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 42-94.

    Entry informationi

    Entry nameiMYCBP_HUMAN
    AccessioniPrimary (citable) accession number: Q99417
    Secondary accession number(s): B2R4N0, Q5TA64, Q96HE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3