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Q993M1

- RDRP_GGNNV

UniProt

Q993M1 - RDRP_GGNNV

Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Greasy grouper nervous necrosis virus (GGNNV) (Epinephelus tauvina nervous necrosis virus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Short name:
    RdRp
    Alternative name(s):
    RNA replicase
    Short name:
    Protein A
    OrganismiGreasy grouper nervous necrosis virus (GGNNV) (Epinephelus tauvina nervous necrosis virus)
    Taxonomic identifieri143921 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeBetanodavirus
    Virus hostiEpinephelus tauvina (Greasy grouper) (Perca tauvina) [TaxID: 203262]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 982982RNA-directed RNA polymerasePRO_0000222447Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ993M1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini579 – 701123RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the nodaviridae RNA polymerase family.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR001788. Tymovirus_RNA-dep_RNA_pol.
    [Graphical view]
    PfamiPF00978. RdRP_2. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q993M1-1 [UniParc]FASTAAdd to Basket

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    MRRFEFALAR MSGAAFCVYT GYRLLTSKWL ADRVEDYRQR IIAEKKQILR    50
    DAAMIRTQIQ REMELVRISV RKGHSHQEAA TERNSATETM LGVVEKCGYE 100
    PYVISPSPRE VGYHGSRQFY SLADFRQDYR RDDITDRHII VMTDVDYYVD 150
    MHELIGLGVP ILLYTFQPST VSGEVKDGYF TITDDSVHYR VAGGKDVRHR 200
    IWNYNHDTMY VCSRPRGFWA NLMQILRDIT GVTAICSFLY TKLGIAPFGD 250
    PVTMFTVDQF KMGEHRNIVS IVPFATCRSN LLKISEYGAE LEYMRYQQRN 300
    NIANFNAVTY ISENGPLISL GLEGNFASVQ LPLQDFENIR TAYELSKTNN 350
    LSDTVRRSGR PCKEAAIIHK CLQAECAVVS EVVHKPGDLA RHYQAVGSAY 400
    DTDPAEQGKC YAREYAPGPL TQTAVFPSES RSNELATIDG RIAGPQAKAK 450
    SREHITPKMR KVARDFVHHL VPIAGTGRPY PLTYVEEQQT KPLQRARNDA 500
    NRYHDEFTMM VKAFQKKEAY NAPNYPRNIS TVPHTQNVKL SSYTYAFKAS 550
    VLQHVPWYMP THTPAEIADA VQNLAASSTE LVETDYSKFD GTFLRFMREC 600
    VEFAIYKRWV HLDHLPELTT LLANEIQAPA VTRLGIKYDP DCSRLSGSAL 650
    TTDGNSIANA FVSYLAGRMA GMDDDEAWSW IGIVYGDDGL RSGNVSNELL 700
    TNTASSLGFD LKIVNRAPRG SPVTFLSRVY LDPWSSPASV QSPLRTLLKL 750
    HTTCDTQSEI DDIGWAKTQA YLVTDSKTPF IGHWCRAYQR NCTARVVQYA 800
    DYADIPFWVK NDDHVGNSWP QSESDDWNDI VANELGVTTA ELLKHLALLD 850
    AYAGPISGLP RLTTSIDLEP KMSVALDGEI QAGPSQNKTS KDGTNPTSDR 900
    SAPRRARAAL PGDDGHARRS RRSDRDPGKR DAHVRDKRPR RSSPPTRPVT 950
    PVPTPSSGDR GTDGDGLGRA AVRQRQRRRT QV 982
    Length:982
    Mass (Da):110,395
    Last modified:June 1, 2001 - v1
    Checksum:iCC61FB47B75CE0DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF319555 mRNA. Translation: AAK21877.1.
    RefSeqiNP_689433.1. NC_004137.1.

    Genome annotation databases

    GeneIDi984290.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF319555 mRNA. Translation: AAK21877.1 .
    RefSeqi NP_689433.1. NC_004137.1.

    3D structure databases

    ProteinModelPortali Q993M1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 984290.

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR001788. Tymovirus_RNA-dep_RNA_pol.
    [Graphical view ]
    Pfami PF00978. RdRP_2. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Determination of the complete nucleotide sequences of RNA1 and RNA2 from greasy grouper (Epinephelus tauvina) nervous necrosis virus, Singapore strain."
      Tan C., Huang B., Chang S.F., Ngoh G.H., Munday B., Chen S.C., Kwang J.
      J. Gen. Virol. 82:647-653(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Singapore.

    Entry informationi

    Entry nameiRDRP_GGNNV
    AccessioniPrimary (citable) accession number: Q993M1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3