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Q993M1 (RDRP_GGNNV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase

Short name=RdRp
EC=2.7.7.48
Alternative name(s):
RNA replicase
Short name=Protein A
OrganismGreasy grouper nervous necrosis virus (GGNNV) (Epinephelus tauvina nervous necrosis virus)
Taxonomic identifier143921 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeBetanodavirus
Virus hostEpinephelus tauvina (Greasy grouper) (Perca tauvina) [TaxID: 203262]

Protein attributes

Sequence length982 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2 Potential.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the nodaviridae RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 982982RNA-directed RNA polymerase
PRO_0000222447

Regions

Domain579 – 701123RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
Q993M1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: CC61FB47B75CE0DA

FASTA982110,395
        10         20         30         40         50         60 
MRRFEFALAR MSGAAFCVYT GYRLLTSKWL ADRVEDYRQR IIAEKKQILR DAAMIRTQIQ 

        70         80         90        100        110        120 
REMELVRISV RKGHSHQEAA TERNSATETM LGVVEKCGYE PYVISPSPRE VGYHGSRQFY 

       130        140        150        160        170        180 
SLADFRQDYR RDDITDRHII VMTDVDYYVD MHELIGLGVP ILLYTFQPST VSGEVKDGYF 

       190        200        210        220        230        240 
TITDDSVHYR VAGGKDVRHR IWNYNHDTMY VCSRPRGFWA NLMQILRDIT GVTAICSFLY 

       250        260        270        280        290        300 
TKLGIAPFGD PVTMFTVDQF KMGEHRNIVS IVPFATCRSN LLKISEYGAE LEYMRYQQRN 

       310        320        330        340        350        360 
NIANFNAVTY ISENGPLISL GLEGNFASVQ LPLQDFENIR TAYELSKTNN LSDTVRRSGR 

       370        380        390        400        410        420 
PCKEAAIIHK CLQAECAVVS EVVHKPGDLA RHYQAVGSAY DTDPAEQGKC YAREYAPGPL 

       430        440        450        460        470        480 
TQTAVFPSES RSNELATIDG RIAGPQAKAK SREHITPKMR KVARDFVHHL VPIAGTGRPY 

       490        500        510        520        530        540 
PLTYVEEQQT KPLQRARNDA NRYHDEFTMM VKAFQKKEAY NAPNYPRNIS TVPHTQNVKL 

       550        560        570        580        590        600 
SSYTYAFKAS VLQHVPWYMP THTPAEIADA VQNLAASSTE LVETDYSKFD GTFLRFMREC 

       610        620        630        640        650        660 
VEFAIYKRWV HLDHLPELTT LLANEIQAPA VTRLGIKYDP DCSRLSGSAL TTDGNSIANA 

       670        680        690        700        710        720 
FVSYLAGRMA GMDDDEAWSW IGIVYGDDGL RSGNVSNELL TNTASSLGFD LKIVNRAPRG 

       730        740        750        760        770        780 
SPVTFLSRVY LDPWSSPASV QSPLRTLLKL HTTCDTQSEI DDIGWAKTQA YLVTDSKTPF 

       790        800        810        820        830        840 
IGHWCRAYQR NCTARVVQYA DYADIPFWVK NDDHVGNSWP QSESDDWNDI VANELGVTTA 

       850        860        870        880        890        900 
ELLKHLALLD AYAGPISGLP RLTTSIDLEP KMSVALDGEI QAGPSQNKTS KDGTNPTSDR 

       910        920        930        940        950        960 
SAPRRARAAL PGDDGHARRS RRSDRDPGKR DAHVRDKRPR RSSPPTRPVT PVPTPSSGDR 

       970        980 
GTDGDGLGRA AVRQRQRRRT QV 

« Hide

References

[1]"Determination of the complete nucleotide sequences of RNA1 and RNA2 from greasy grouper (Epinephelus tauvina) nervous necrosis virus, Singapore strain."
Tan C., Huang B., Chang S.F., Ngoh G.H., Munday B., Chen S.C., Kwang J.
J. Gen. Virol. 82:647-653(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Singapore.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF319555 mRNA. Translation: AAK21877.1.
RefSeqNP_689433.1. NC_004137.1.

3D structure databases

ProteinModelPortalQ993M1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID984290.

Family and domain databases

InterProIPR007094. RNA-dir_pol_PSvirus.
IPR001788. Tymovirus_RNA-dep_RNA_pol.
[Graphical view]
PfamPF00978. RdRP_2. 1 hit.
[Graphical view]
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_GGNNV
AccessionPrimary (citable) accession number: Q993M1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families