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Q993M1

- RDRP_GGNNV

UniProt

Q993M1 - RDRP_GGNNV

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Protein
RNA-directed RNA polymerase
Gene
N/A
Organism
Greasy grouper nervous necrosis virus (GGNNV) (Epinephelus tauvina nervous necrosis virus)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2 Reviewed prediction.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RdRp
Alternative name(s):
RNA replicase
Short name:
Protein A
OrganismiGreasy grouper nervous necrosis virus (GGNNV) (Epinephelus tauvina nervous necrosis virus)
Taxonomic identifieri143921 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeBetanodavirus
Virus hostiEpinephelus tauvina (Greasy grouper) (Perca tauvina) [TaxID: 203262]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982RNA-directed RNA polymerase
PRO_0000222447Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ993M1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini579 – 701123RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR001788. Tymovirus_RNA-dep_RNA_pol.
[Graphical view]
PfamiPF00978. RdRP_2. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q993M1-1 [UniParc]FASTAAdd to Basket

« Hide

MRRFEFALAR MSGAAFCVYT GYRLLTSKWL ADRVEDYRQR IIAEKKQILR    50
DAAMIRTQIQ REMELVRISV RKGHSHQEAA TERNSATETM LGVVEKCGYE 100
PYVISPSPRE VGYHGSRQFY SLADFRQDYR RDDITDRHII VMTDVDYYVD 150
MHELIGLGVP ILLYTFQPST VSGEVKDGYF TITDDSVHYR VAGGKDVRHR 200
IWNYNHDTMY VCSRPRGFWA NLMQILRDIT GVTAICSFLY TKLGIAPFGD 250
PVTMFTVDQF KMGEHRNIVS IVPFATCRSN LLKISEYGAE LEYMRYQQRN 300
NIANFNAVTY ISENGPLISL GLEGNFASVQ LPLQDFENIR TAYELSKTNN 350
LSDTVRRSGR PCKEAAIIHK CLQAECAVVS EVVHKPGDLA RHYQAVGSAY 400
DTDPAEQGKC YAREYAPGPL TQTAVFPSES RSNELATIDG RIAGPQAKAK 450
SREHITPKMR KVARDFVHHL VPIAGTGRPY PLTYVEEQQT KPLQRARNDA 500
NRYHDEFTMM VKAFQKKEAY NAPNYPRNIS TVPHTQNVKL SSYTYAFKAS 550
VLQHVPWYMP THTPAEIADA VQNLAASSTE LVETDYSKFD GTFLRFMREC 600
VEFAIYKRWV HLDHLPELTT LLANEIQAPA VTRLGIKYDP DCSRLSGSAL 650
TTDGNSIANA FVSYLAGRMA GMDDDEAWSW IGIVYGDDGL RSGNVSNELL 700
TNTASSLGFD LKIVNRAPRG SPVTFLSRVY LDPWSSPASV QSPLRTLLKL 750
HTTCDTQSEI DDIGWAKTQA YLVTDSKTPF IGHWCRAYQR NCTARVVQYA 800
DYADIPFWVK NDDHVGNSWP QSESDDWNDI VANELGVTTA ELLKHLALLD 850
AYAGPISGLP RLTTSIDLEP KMSVALDGEI QAGPSQNKTS KDGTNPTSDR 900
SAPRRARAAL PGDDGHARRS RRSDRDPGKR DAHVRDKRPR RSSPPTRPVT 950
PVPTPSSGDR GTDGDGLGRA AVRQRQRRRT QV 982
Length:982
Mass (Da):110,395
Last modified:June 1, 2001 - v1
Checksum:iCC61FB47B75CE0DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF319555 mRNA. Translation: AAK21877.1.
RefSeqiNP_689433.1. NC_004137.1.

Genome annotation databases

GeneIDi984290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF319555 mRNA. Translation: AAK21877.1 .
RefSeqi NP_689433.1. NC_004137.1.

3D structure databases

ProteinModelPortali Q993M1.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 984290.

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR001788. Tymovirus_RNA-dep_RNA_pol.
[Graphical view ]
Pfami PF00978. RdRP_2. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Determination of the complete nucleotide sequences of RNA1 and RNA2 from greasy grouper (Epinephelus tauvina) nervous necrosis virus, Singapore strain."
    Tan C., Huang B., Chang S.F., Ngoh G.H., Munday B., Chen S.C., Kwang J.
    J. Gen. Virol. 82:647-653(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Singapore.

Entry informationi

Entry nameiRDRP_GGNNV
AccessioniPrimary (citable) accession number: Q993M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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