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Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Greasy grouper nervous necrosis virus (GGNNV) (Epinephelus tauvina nervous necrosis virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RdRp
Alternative name(s):
RNA replicase
Short name:
Protein A
OrganismiGreasy grouper nervous necrosis virus (GGNNV) (Epinephelus tauvina nervous necrosis virus)
Taxonomic identifieri143921 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeBetanodavirus
Virus hostiEpinephelus tauvina (Greasy grouper) (Perca tauvina) [TaxID: 203262]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982RNA-directed RNA polymerasePRO_0000222447Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ993M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini579 – 701123RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the nodaviridae RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR001788. Tymovirus_RNA-dep_RNA_pol.
[Graphical view]
PfamiPF00978. RdRP_2. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q993M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRFEFALAR MSGAAFCVYT GYRLLTSKWL ADRVEDYRQR IIAEKKQILR
60 70 80 90 100
DAAMIRTQIQ REMELVRISV RKGHSHQEAA TERNSATETM LGVVEKCGYE
110 120 130 140 150
PYVISPSPRE VGYHGSRQFY SLADFRQDYR RDDITDRHII VMTDVDYYVD
160 170 180 190 200
MHELIGLGVP ILLYTFQPST VSGEVKDGYF TITDDSVHYR VAGGKDVRHR
210 220 230 240 250
IWNYNHDTMY VCSRPRGFWA NLMQILRDIT GVTAICSFLY TKLGIAPFGD
260 270 280 290 300
PVTMFTVDQF KMGEHRNIVS IVPFATCRSN LLKISEYGAE LEYMRYQQRN
310 320 330 340 350
NIANFNAVTY ISENGPLISL GLEGNFASVQ LPLQDFENIR TAYELSKTNN
360 370 380 390 400
LSDTVRRSGR PCKEAAIIHK CLQAECAVVS EVVHKPGDLA RHYQAVGSAY
410 420 430 440 450
DTDPAEQGKC YAREYAPGPL TQTAVFPSES RSNELATIDG RIAGPQAKAK
460 470 480 490 500
SREHITPKMR KVARDFVHHL VPIAGTGRPY PLTYVEEQQT KPLQRARNDA
510 520 530 540 550
NRYHDEFTMM VKAFQKKEAY NAPNYPRNIS TVPHTQNVKL SSYTYAFKAS
560 570 580 590 600
VLQHVPWYMP THTPAEIADA VQNLAASSTE LVETDYSKFD GTFLRFMREC
610 620 630 640 650
VEFAIYKRWV HLDHLPELTT LLANEIQAPA VTRLGIKYDP DCSRLSGSAL
660 670 680 690 700
TTDGNSIANA FVSYLAGRMA GMDDDEAWSW IGIVYGDDGL RSGNVSNELL
710 720 730 740 750
TNTASSLGFD LKIVNRAPRG SPVTFLSRVY LDPWSSPASV QSPLRTLLKL
760 770 780 790 800
HTTCDTQSEI DDIGWAKTQA YLVTDSKTPF IGHWCRAYQR NCTARVVQYA
810 820 830 840 850
DYADIPFWVK NDDHVGNSWP QSESDDWNDI VANELGVTTA ELLKHLALLD
860 870 880 890 900
AYAGPISGLP RLTTSIDLEP KMSVALDGEI QAGPSQNKTS KDGTNPTSDR
910 920 930 940 950
SAPRRARAAL PGDDGHARRS RRSDRDPGKR DAHVRDKRPR RSSPPTRPVT
960 970 980
PVPTPSSGDR GTDGDGLGRA AVRQRQRRRT QV
Length:982
Mass (Da):110,395
Last modified:June 1, 2001 - v1
Checksum:iCC61FB47B75CE0DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319555 mRNA. Translation: AAK21877.1.
RefSeqiNP_689433.1. NC_004137.1.

Genome annotation databases

GeneIDi984290.
KEGGivg:984290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319555 mRNA. Translation: AAK21877.1.
RefSeqiNP_689433.1. NC_004137.1.

3D structure databases

ProteinModelPortaliQ993M1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi984290.
KEGGivg:984290.

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR001788. Tymovirus_RNA-dep_RNA_pol.
[Graphical view]
PfamiPF00978. RdRP_2. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Determination of the complete nucleotide sequences of RNA1 and RNA2 from greasy grouper (Epinephelus tauvina) nervous necrosis virus, Singapore strain."
    Tan C., Huang B., Chang S.F., Ngoh G.H., Munday B., Chen S.C., Kwang J.
    J. Gen. Virol. 82:647-653(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Singapore.

Entry informationi

Entry nameiRDRP_GGNNV
AccessioniPrimary (citable) accession number: Q993M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: April 1, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.