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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160SAAS annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Q993B1:
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
Q993B1:
  • Virion membrane SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei455 – 476HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Host endosomeSAAS annotation, Membrane, Viral envelope proteinImported, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ993B1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 454GP120InterPro annotationAdd BLAST449
Domaini473 – 589GP41InterPro annotationAdd BLAST117

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiView protein in InterPro
IPR036377. Gp120_core_sf.
IPR000328. GP41-like.
IPR000777. HIV1_Gp120.
PfamiView protein in Pfam
PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
SUPFAMiSSF56502. SSF56502. 3 hits.

Sequencei

Sequence statusi: Fragment.

Q993B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AKAYDTEVHN VWATHACVPT DPNPQEVVLV NVTENFNMWK NDMVEQMHED
60 70 80 90 100
IISLWDQSLK PCVKLTPLCV SLKCTDLKND TNTNSSSGRM IMEKGEIKNC
110 120 130 140 150
SFNISTSKRG KVQKEYAFFY KLDIIPIDND TTSYTLTSCN TSVITQACPK
160 170 180 190 200
VSFEPIPIHY CAPAGFAILK CNNKTFNGTG PCTNVSTVQC THGIRPVVST
210 220 230 240 250
QLLLNGSLAE EEVVIRSANF TDNAKTIIVQ LNTSVEINCT RPNNNTRKKI
260 270 280 290 300
RIQRGPGRAL VTIGKIGNMR QAHCNISRAK WNATLKQIDS KLREQFGNNK
310 320 330 340 350
TIIFKQSSGG DPEIVTHSFN CGGEFFYCNS TQLFNSTWFN STWSTEGSNN
360 370 380 390 400
TEGSDTITLP CRIKQIINMW QEVGKAMYAP PISGQIRCSS NITGLLLTRD
410 420 430 440 450
GGNSNNESEI FRPGGGDMRD NWRSELYKYK VVKIEPLGVA PTKAKRRVVQ
460 470 480 490 500
REKRAVGIGA LFLGFLGAAG STMGAASMTL TVQARQLLSG IVQQQNNLLR
510 520 530 540 550
AIEAQQHLLQ LTVWGIKQLQ ARILAVERYL KDQQLLGIWG CSGKLICTTA
560 570 580
VPWNASWSNK SLEQIWNNMT WMEWDREINN YTSLIHSLI
Length:589
Mass (Da):65,753
Last modified:June 1, 2001 - v1
Checksum:i000621646924FD66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei589Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321144 Genomic DNA. Translation: AAK20292.1.
PIRiA53591.

Similar proteinsi

Entry informationi

Entry nameiQ993B1_9HIV1
AccessioniPrimary (citable) accession number: Q993B1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)