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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160SAAS annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Q993B0:
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
Q993B0:
  • Virion membrane SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei456 – 477HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Host endosomeSAAS annotation, Membrane, Viral envelope proteinImported, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ993B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 455GP120InterPro annotationAdd BLAST449
Domaini474 – 616GP41InterPro annotationAdd BLAST143

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiView protein in InterPro
IPR036377. Gp120_core_sf.
IPR000328. GP41-like.
IPR000777. HIV1_Gp120.
PfamiView protein in Pfam
PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
SUPFAMiSSF56502. SSF56502. 3 hits.

Sequencei

Sequence statusi: Fragment.

Q993B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DAKAYDTEVH NVWATHACVP TDPNPQEVVL VNVTENFNMW KNDMVEQMHE
60 70 80 90 100
DIISLWDQSL KPCVKLTPLC VSLKCTDLKN DTNTNSSSGR MIMEKGEIKN
110 120 130 140 150
CSFNISTSKR GKVQKEYAFF YKLDIIPIDN DTTSYTLTSC NTSVITQACP
160 170 180 190 200
KVSFEPIPIH YCAPAGFAIL KCNNKTFNGT GPCTNVSTVQ CTHGIRPVVS
210 220 230 240 250
TQLLLNGSLA EEEVVIRSAN FTDNAKTIIV QLNTSVEINC TRPNNNTRKK
260 270 280 290 300
IRIQRGPGRT FVTIGKIGNM RQAHCNISRA KWNATLKQID SKLREQFGNN
310 320 330 340 350
KTIIFKQSSG GDPEIVTHSF NCGGEFFYCN STQLFNSTWF NSTWSTEGSN
360 370 380 390 400
NTEGSDTITL PCRIKQIINM WQEVGKAMYA PPISGQIRCS SNITGLLLTR
410 420 430 440 450
DGGNSNNESE IFRPGGGDMR DNWRSELYKY KVVKIEPLGV APTKAKRRVV
460 470 480 490 500
QREKRAVGIG ALFLGFLGAA GSTMGAASMT LTVQARQLLS GIVQQQNNLL
510 520 530 540 550
RAIEAQQHLL QLTVWGIKQL QARILAVERY LKDQQLLGIW GCSGKLICTT
560 570 580 590 600
AVPWNASWSN KSLEQIWNNM TWMEWDREIN NYTSLIHSLI EESQNQQEKN
610
EQELLELDKW ASLWNW
Length:616
Mass (Da):69,190
Last modified:June 1, 2001 - v1
Checksum:i57A8E20F9A580A4F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei616Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321145 Genomic DNA. Translation: AAK20293.1.
PIRiA53591.

Similar proteinsi

Entry informationi

Entry nameiQ993B0_9HIV1
AccessioniPrimary (citable) accession number: Q993B0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)