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Q993A8

- Q993A8_9HIV1

UniProt

Q993A8 - Q993A8_9HIV1

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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.SAAS annotation
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160SAAS annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

  1. host cell endosome membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endosomeSAAS annotation, Viral envelope proteinUniRule annotationImported, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Imported
Glycosylationi298 – 2981N-linked (GlcNAc...)Imported

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NY1X-ray1.99A26-435[»]
2NY3X-ray2.00A26-435[»]
ProteinModelPortaliQ993A8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ993A8.

Family & Domainsi

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 3 hits.

Sequencei

Sequence statusi: Fragment.

Q993A8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AKAYDTEVHN VWATHACVPT DPNPQEVVLV NVTENFNMWK NDMVEQMHED
60 70 80 90 100
IISLWDQSLK PCVKLTPLCV SLKCTDLKND TNTNSSSGRM IMEKGEIKNC
110 120 130 140 150
SFNISTSIRG KVQKEYAFFY KLDIIPIDND TTSYTLTSCN TSVITQACPK
160 170 180 190 200
VSFEPIPIHY CAPAGFAILK CNNKTFNGTG PCTNVSTVQC THGIRPVVST
210 220 230 240 250
QLLLNGSLAE EEVVIRSVNF TDNAKTIIVQ LNTSVEINCT RPNNNTRKKI
260 270 280 290 300
RIQRGPGRAF VTIGKIGNMR QAHCNISRAK WNATLKQIAS KLREQFGNNK
310 320 330 340 350
TIIFKQSSGG DPEIVTHSFN CGGEFFYCNS TQLFNSTWFN STWSTEGSNN
360 370 380 390 400
TEGSDTITLP CRIKQIINMW QEVGKAMYAP PISGQIRCSS NITGLLLTRD
410 420 430 440 450
GGNSNNESEI FRPGGGDMRD NWRSELYKYK VVKIEPLGVA PTKAKRRVVQ
460 470 480 490 500
REKRAVGIGA LFLGFLGAAG STMGAASMTL TVQARQLLSG IVQQQNNLLR
510 520 530 540 550
AIEAQQHLLQ LTVWGIKQLQ ARILAVERYL KDQQLLGIWG CSGKLICTTA
560 570 580
VPWNASWSNK SLEQIWNNMT WMEWDREINN YTSLIHSL
Length:588
Mass (Da):65,643
Last modified:June 1, 2001 - v1
Checksum:i47475A5780240AE8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei588 – 5881Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF321147 Genomic DNA. Translation: AAK20295.1.
PIRiA53591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF321147 Genomic DNA. Translation: AAK20295.1 .
PIRi A53591.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2NY1 X-ray 1.99 A 26-435 [» ]
2NY3 X-ray 2.00 A 26-435 [» ]
ProteinModelPortali Q993A8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q993A8.

Family and domain databases

Gene3Di 2.170.40.20. 2 hits.
InterProi IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view ]
Pfami PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view ]
SUPFAMi SSF56502. SSF56502. 3 hits.
ProtoNeti Search...

Publicationsi

  1. DCosta S.S., Hurwitz J.L.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structural features of HIV envelope defined by antibody escape mutant analysis."
    D'Costa S., Slobod K.S., Webster R.G., White S.W., Hurwitz J.L.
    AIDS Res. Hum. Retroviruses 17:1205-1209(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 26-435, GLYCOSYLATION AT ASN-31; ASN-140; ASN-173; ASN-177; ASN-184; ASN-205; ASN-219; ASN-232 AND ASN-238.

Entry informationi

Entry nameiQ993A8_9HIV1
AccessioniPrimary (citable) accession number: Q993A8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3