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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160SAAS annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endosomeSAAS annotation, MembraneSAAS annotation, Viral envelope proteinUniRule annotationImported, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Combined sources
Disulfide bondi62 ↔ 148Combined sources
Disulfide bondi69 ↔ 139Combined sources
Disulfide bondi161 ↔ 190Combined sources
Disulfide bondi171 ↔ 182Combined sources
Disulfide bondi239 ↔ 274Combined sources
Glycosylationi298 – 2981N-linked (GlcNAc...)Combined sources
Disulfide bondi321 ↔ 388Combined sources
Disulfide bondi328 ↔ 361Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NY1X-ray1.99A26-435[»]
2NY3X-ray2.00A26-435[»]
ProteinModelPortaliQ993A8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ993A8.

Family & Domainsi

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 3 hits.

Sequencei

Sequence statusi: Fragment.

Q993A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AKAYDTEVHN VWATHACVPT DPNPQEVVLV NVTENFNMWK NDMVEQMHED
60 70 80 90 100
IISLWDQSLK PCVKLTPLCV SLKCTDLKND TNTNSSSGRM IMEKGEIKNC
110 120 130 140 150
SFNISTSIRG KVQKEYAFFY KLDIIPIDND TTSYTLTSCN TSVITQACPK
160 170 180 190 200
VSFEPIPIHY CAPAGFAILK CNNKTFNGTG PCTNVSTVQC THGIRPVVST
210 220 230 240 250
QLLLNGSLAE EEVVIRSVNF TDNAKTIIVQ LNTSVEINCT RPNNNTRKKI
260 270 280 290 300
RIQRGPGRAF VTIGKIGNMR QAHCNISRAK WNATLKQIAS KLREQFGNNK
310 320 330 340 350
TIIFKQSSGG DPEIVTHSFN CGGEFFYCNS TQLFNSTWFN STWSTEGSNN
360 370 380 390 400
TEGSDTITLP CRIKQIINMW QEVGKAMYAP PISGQIRCSS NITGLLLTRD
410 420 430 440 450
GGNSNNESEI FRPGGGDMRD NWRSELYKYK VVKIEPLGVA PTKAKRRVVQ
460 470 480 490 500
REKRAVGIGA LFLGFLGAAG STMGAASMTL TVQARQLLSG IVQQQNNLLR
510 520 530 540 550
AIEAQQHLLQ LTVWGIKQLQ ARILAVERYL KDQQLLGIWG CSGKLICTTA
560 570 580
VPWNASWSNK SLEQIWNNMT WMEWDREINN YTSLIHSL
Length:588
Mass (Da):65,643
Last modified:June 1, 2001 - v1
Checksum:i47475A5780240AE8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei588 – 5881Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321147 Genomic DNA. Translation: AAK20295.1.
PIRiA53591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321147 Genomic DNA. Translation: AAK20295.1.
PIRiA53591.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NY1X-ray1.99A26-435[»]
2NY3X-ray2.00A26-435[»]
ProteinModelPortaliQ993A8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ993A8.

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. DCosta S.S., Hurwitz J.L.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structural features of HIV envelope defined by antibody escape mutant analysis."
    D'Costa S., Slobod K.S., Webster R.G., White S.W., Hurwitz J.L.
    AIDS Res. Hum. Retroviruses 17:1205-1209(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 26-435, DISULFIDE BONDS, GLYCOSYLATION AT ASN-31 AND ASN-298.

Entry informationi

Entry nameiQ993A8_9HIV1
AccessioniPrimary (citable) accession number: Q993A8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 27, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.