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Q993A8 (Q993A8_9HIV1) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:env EMBL AAK20295.1
OrganismHuman immunodeficiency virus 1 EMBL AAK20295.1
Taxonomic identifier11676 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length588 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity. SAAS SAAS000328

The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity.

Subcellular location

Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein By similarity SAAS SAAS000328.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Glycosylation311N-linked (GlcNAc...) PDB 2NY1 PDB 2NY3
Glycosylation2981N-linked (GlcNAc...) PDB 2NY1 PDB 2NY3

Experimental info

Non-terminal residue11 EMBL AAK20295.1
Non-terminal residue5881 EMBL AAK20295.1

Sequences

Sequence LengthMass (Da)Tools
Q993A8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 47475A5780240AE8

FASTA58865,643
        10         20         30         40         50         60 
AKAYDTEVHN VWATHACVPT DPNPQEVVLV NVTENFNMWK NDMVEQMHED IISLWDQSLK 

        70         80         90        100        110        120 
PCVKLTPLCV SLKCTDLKND TNTNSSSGRM IMEKGEIKNC SFNISTSIRG KVQKEYAFFY 

       130        140        150        160        170        180 
KLDIIPIDND TTSYTLTSCN TSVITQACPK VSFEPIPIHY CAPAGFAILK CNNKTFNGTG 

       190        200        210        220        230        240 
PCTNVSTVQC THGIRPVVST QLLLNGSLAE EEVVIRSVNF TDNAKTIIVQ LNTSVEINCT 

       250        260        270        280        290        300 
RPNNNTRKKI RIQRGPGRAF VTIGKIGNMR QAHCNISRAK WNATLKQIAS KLREQFGNNK 

       310        320        330        340        350        360 
TIIFKQSSGG DPEIVTHSFN CGGEFFYCNS TQLFNSTWFN STWSTEGSNN TEGSDTITLP 

       370        380        390        400        410        420 
CRIKQIINMW QEVGKAMYAP PISGQIRCSS NITGLLLTRD GGNSNNESEI FRPGGGDMRD 

       430        440        450        460        470        480 
NWRSELYKYK VVKIEPLGVA PTKAKRRVVQ REKRAVGIGA LFLGFLGAAG STMGAASMTL 

       490        500        510        520        530        540 
TVQARQLLSG IVQQQNNLLR AIEAQQHLLQ LTVWGIKQLQ ARILAVERYL KDQQLLGIWG 

       550        560        570        580 
CSGKLICTTA VPWNASWSNK SLEQIWNNMT WMEWDREINN YTSLIHSL 

« Hide

References

[1]DCosta S.S., Hurwitz J.L.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Structural features of HIV envelope defined by antibody escape mutant analysis."
D'Costa S., Slobod K.S., Webster R.G., White S.W., Hurwitz J.L.
AIDS Res. Hum. Retroviruses 17:1205-1209(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Structural definition of a conserved neutralization epitope on HIV-1 gp120."
Zhou T., Xu L., Dey B., Hessell A.J., Van Ryk D., Xiang S.H., Yang X., Zhang M.Y., Zwick M.B., Arthos J., Burton D.R., Dimitrov D.S., Sodroski J., Wyatt R., Nabel G.J., Kwong P.D.
Nature 445:732-737(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 26-435, GLYCOSYLATION AT ASN-31; ASN-140; ASN-173; ASN-177; ASN-184; ASN-205; ASN-219; ASN-232 AND ASN-238.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF321147 Genomic DNA. Translation: AAK20295.1.
PIRA53591.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2NY1X-ray1.99A26-435[»]
2NY3X-ray2.00A26-435[»]
ProteinModelPortalQ993A8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.170.40.20. 2 hits.
InterProIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMSSF56502. SSF56502. 3 hits.
ProtoNetSearch...

Other

EvolutionaryTraceQ993A8.

Entry information

Entry nameQ993A8_9HIV1
AccessionPrimary (citable) accession number: Q993A8
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)