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Q993A8

- Q993A8_9HIV1

UniProt

Q993A8 - Q993A8_9HIV1

Protein
Submitted name:

Envelope glycoprotein

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.SAAS annotation
    The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Envelope glycoproteinImported
    Gene namesi
    Name:envImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell endosome membrane Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endosomeSAAS annotation, Viral envelope proteinUniRule annotationImported, Virion

    Pathology & Biotechi

    Keywords - Diseasei

    AIDSUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi31 – 311N-linked (GlcNAc...)Imported
    Glycosylationi298 – 2981N-linked (GlcNAc...)Imported

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2NY1X-ray1.99A26-435[»]
    2NY3X-ray2.00A26-435[»]
    ProteinModelPortaliQ993A8.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ993A8.

    Family & Domainsi

    Family and domain databases

    Gene3Di2.170.40.20. 2 hits.
    InterProiIPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view]
    PfamiPF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view]
    SUPFAMiSSF56502. SSF56502. 3 hits.

    Sequencei

    Sequence statusi: Fragment.

    Q993A8-1 [UniParc]FASTAAdd to Basket

    « Hide

    AKAYDTEVHN VWATHACVPT DPNPQEVVLV NVTENFNMWK NDMVEQMHED    50
    IISLWDQSLK PCVKLTPLCV SLKCTDLKND TNTNSSSGRM IMEKGEIKNC 100
    SFNISTSIRG KVQKEYAFFY KLDIIPIDND TTSYTLTSCN TSVITQACPK 150
    VSFEPIPIHY CAPAGFAILK CNNKTFNGTG PCTNVSTVQC THGIRPVVST 200
    QLLLNGSLAE EEVVIRSVNF TDNAKTIIVQ LNTSVEINCT RPNNNTRKKI 250
    RIQRGPGRAF VTIGKIGNMR QAHCNISRAK WNATLKQIAS KLREQFGNNK 300
    TIIFKQSSGG DPEIVTHSFN CGGEFFYCNS TQLFNSTWFN STWSTEGSNN 350
    TEGSDTITLP CRIKQIINMW QEVGKAMYAP PISGQIRCSS NITGLLLTRD 400
    GGNSNNESEI FRPGGGDMRD NWRSELYKYK VVKIEPLGVA PTKAKRRVVQ 450
    REKRAVGIGA LFLGFLGAAG STMGAASMTL TVQARQLLSG IVQQQNNLLR 500
    AIEAQQHLLQ LTVWGIKQLQ ARILAVERYL KDQQLLGIWG CSGKLICTTA 550
    VPWNASWSNK SLEQIWNNMT WMEWDREINN YTSLIHSL 588
    Length:588
    Mass (Da):65,643
    Last modified:June 1, 2001 - v1
    Checksum:i47475A5780240AE8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei588 – 5881Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321147 Genomic DNA. Translation: AAK20295.1.
    PIRiA53591.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321147 Genomic DNA. Translation: AAK20295.1 .
    PIRi A53591.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2NY1 X-ray 1.99 A 26-435 [» ]
    2NY3 X-ray 2.00 A 26-435 [» ]
    ProteinModelPortali Q993A8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q993A8.

    Family and domain databases

    Gene3Di 2.170.40.20. 2 hits.
    InterProi IPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view ]
    Pfami PF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56502. SSF56502. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. DCosta S.S., Hurwitz J.L.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Structural features of HIV envelope defined by antibody escape mutant analysis."
      D'Costa S., Slobod K.S., Webster R.G., White S.W., Hurwitz J.L.
      AIDS Res. Hum. Retroviruses 17:1205-1209(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 26-435, GLYCOSYLATION AT ASN-31; ASN-140; ASN-173; ASN-177; ASN-184; ASN-205; ASN-219; ASN-232 AND ASN-238.

    Entry informationi

    Entry nameiQ993A8_9HIV1
    AccessioniPrimary (citable) accession number: Q993A8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3