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Protein

Transferrin receptor protein 1

Gene

Tfrc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity).By similarity

GO - Molecular functioni

  • chaperone binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • transferrin receptor activity Source: RGD

GO - Biological processi

  • acute-phase response Source: RGD
  • aging Source: RGD
  • cellular iron ion homeostasis Source: InterPro
  • positive regulation of B cell proliferation Source: UniProtKB
  • positive regulation of isotype switching Source: UniProtKB
  • positive regulation of T cell proliferation Source: UniProtKB
  • receptor internalization Source: UniProtKB
  • response to copper ion Source: RGD
  • response to hypoxia Source: RGD
  • response to inorganic substance Source: RGD
  • response to iron ion Source: RGD
  • response to manganese ion Source: RGD
  • response to nutrient Source: RGD
  • response to organic substance Source: RGD
  • response to retinoic acid Source: RGD
  • transferrin transport Source: InterPro

Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Transferrin receptor protein 1
Short name:
TR
Short name:
TfR
Short name:
TfR1
Short name:
Trfr
Alternative name(s):
CD_antigen: CD71
Gene namesi
Name:Tfrc
Synonyms:Trfr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70488. Tfrc.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type II membrane protein By similarity
  • Melanosome By similarity

GO - Cellular componenti

  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • extracellular exosome Source: RGD
  • extracellular space Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: RGD
  • mitochondrion Source: RGD
  • nucleus Source: RGD
  • plasma membrane Source: CAFA
  • recycling endosome membrane Source: RGD

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000174134‹1 – 622Transferrin receptor protein 1Add BLAST›622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi179N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi584N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi589N-linked (GlcNAc...) asparagineBy similarity1

Post-translational modificationi

N- and O-glycosylated, phosphorylated and palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ99376.
PeptideAtlasiQ99376.
PRIDEiQ99376.

PTM databases

PhosphoSitePlusiQ99376.

Expressioni

Tissue specificityi

In testis, expressed in Sertoli cells, peritubular myoid cells and in germinal cells. Highest levels in Sertoli cells.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Binds one transferrin molecule per subunit. Interacts with SH3BP4 (By similarity). Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • chaperone binding Source: RGD
  • Hsp70 protein binding Source: RGD

Protein-protein interaction databases

IntActiQ99376. 6 interactors.
MINTiMINT-246708.
STRINGi10116.ENSRNOP00000002407.

Structurei

3D structure databases

ProteinModelPortaliQ99376.
SMRiQ99376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 175PAAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni431 – 622Ligand-bindingBy similarityAdd BLAST192

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi508 – 510Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the peptidase M28 family. M28B subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane

Phylogenomic databases

eggNOGiKOG2195. Eukaryota.
COG2234. LUCA.
HOGENOMiHOG000124067.
HOVERGENiHBG023177.
InParanoidiQ99376.
PhylomeDBiQ99376.

Family and domain databases

Gene3Di1.20.930.40. 1 hit.
InterProiView protein in InterPro
IPR003137. PA_domain.
IPR007484. Peptidase_M28.
IPR029513. TfR.
IPR007365. TFR-like_dimer_dom.
PANTHERiPTHR10404:SF54. PTHR10404:SF54. 1 hit.
PfamiView protein in Pfam
PF02225. PA. 1 hit.
PF04389. Peptidase_M28. 1 hit.
PF04253. TFR_dimer. 1 hit.
SUPFAMiSSF47672. SSF47672. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q99376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IEFTDIIKQL SQNTYTPREA GSQKDENLAY YIENLFHDFK FSKVWRDEHY
60 70 80 90 100
VKIQVKNSVS QNLVTINSGS NIDPVEAPEG YVAFSKAGEV TGKLVHANFG
110 120 130 140 150
TKKDFEELNY SVNGSLVIVR AGKITFAEKV ANAQSFNAIG VLIYMDRNTF
160 170 180 190 200
PVVEADLQFF GHAHLGTGDP YTPGFPSFNH TQFPPSQSSG LPSIPVQTIS
210 220 230 240 250
RAPAEKLFKN MEGNCPPSWN IDSSCKLELS QNQNVKLTVN NVLKETRILN
260 270 280 290 300
IFGVIKGYEE PDRYIVVGAQ RDAWGPGVAK SSVGTGLLLK LAQVFSDMIS
310 320 330 340 350
KDGFRPSRSI IFASWTAGDY GAVGPTEWLE GYLSSLHLKA FTYINLDKVV
360 370 380 390 400
LGTSNFKVSA SPLLYTLMGK IMQDVKHPID GKYLYRNSNW ISKIEELSLD
410 420 430 440 450
NAAFPFLAYS GIPAVSFCFC EDEDYPYLGT KLDTYEILIQ KVPQLNQMVR
460 470 480 490 500
TAAEVAGQFI IKLTHDIELT LDYEMYNSKL LSFMKDLNQF KADIKDMGLS
510 520 530 540 550
LQWLYSARGD YFRATSRLTT DFHNAEKTNR FVMREINDRI MKVEYHFLSP
560 570 580 590 600
YVSPRESPFR HIFWGSGSHT LSALVENLRL RQKNITAFNE TLFRNQLALA
610 620
TWTIQGVANA LSGDIWNIDN EF
Length:622
Mass (Da):70,153
Last modified:November 1, 1996 - v1
Checksum:i831E4FC16DE55703
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58040 mRNA. Translation: AAA42273.1.
PIRiA34549.
UniGeneiRn.98672.

Genome annotation databases

UCSCiRGD:70488. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58040 mRNA. Translation: AAA42273.1.
PIRiA34549.
UniGeneiRn.98672.

3D structure databases

ProteinModelPortaliQ99376.
SMRiQ99376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99376. 6 interactors.
MINTiMINT-246708.
STRINGi10116.ENSRNOP00000002407.

PTM databases

PhosphoSitePlusiQ99376.

Proteomic databases

PaxDbiQ99376.
PeptideAtlasiQ99376.
PRIDEiQ99376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:70488. rat.

Organism-specific databases

RGDi70488. Tfrc.

Phylogenomic databases

eggNOGiKOG2195. Eukaryota.
COG2234. LUCA.
HOGENOMiHOG000124067.
HOVERGENiHBG023177.
InParanoidiQ99376.
PhylomeDBiQ99376.

Family and domain databases

Gene3Di1.20.930.40. 1 hit.
InterProiView protein in InterPro
IPR003137. PA_domain.
IPR007484. Peptidase_M28.
IPR029513. TfR.
IPR007365. TFR-like_dimer_dom.
PANTHERiPTHR10404:SF54. PTHR10404:SF54. 1 hit.
PfamiView protein in Pfam
PF02225. PA. 1 hit.
PF04389. Peptidase_M28. 1 hit.
PF04253. TFR_dimer. 1 hit.
SUPFAMiSSF47672. SSF47672. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTFR1_RAT
AccessioniPrimary (citable) accession number: Q99376
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.