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Protein

Protein disulfide isomerase MPD2

Gene

MPD2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non essential disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May be involved in glycosylation, prolyl hydroxylation and triglyceride transfer. Able to fold proteins by being directly oxidized by ERO1.1 Publication

Miscellaneous

Present with 1520 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

  • protein disulfide isomerase activity Source: SGD
  • protein disulfide oxidoreductase activity Source: SGD

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • protein folding Source: SGD
  • response to endoplasmic reticulum stress Source: GO_Central

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BioCyciYEAST:YOL088C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide isomerase MPD2 (EC:5.3.4.1)
Gene namesi
Name:MPD2
Ordered Locus Names:YOL088C
ORF Names:O0941
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL088C
SGDiS000005448 MPD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56C → S: Loss of function; when associated with S-59. 1 Publication1
Mutagenesisi59C → S: Loss of function; when associated with S-56. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003418223 – 277Protein disulfide isomerase MPD2Add BLAST255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 59Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ99316
PaxDbiQ99316
PRIDEiQ99316

Interactioni

Protein-protein interaction databases

BioGridi34314, 123 interactors
DIPiDIP-1451N
IntActiQ99316, 5 interactors
MINTiQ99316
STRINGi4932.YOL088C

Structurei

3D structure databases

ProteinModelPortaliQ99316
SMRiQ99316
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 172ThioredoxinPROSITE-ProRule annotationAdd BLAST146

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi274 – 277Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

HOGENOMiHOG000113635
InParanoidiQ99316
OMAiYTVVKYY
OrthoDBiEOG092C3SRA

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLHGFLFSV LSTCVVILPA LAYSEAVTMV KSIEQYFDIC NRNDSYTMIK
60 70 80 90 100
YYTSWCQHCK TLAPVYEELG ELYAKKANKD DTPINFLEVN CEFFGPTLCT
110 120 130 140 150
DLPGFPIIEL VKPRTKPLVL PKLDWSSMKF HERLWQRIKT WFNNPKYQLD
160 170 180 190 200
TSRVVRFEGS RNLKSLSNFI DTVRSKDTEE RFIEHIFDDS RNCNEELRSQ
210 220 230 240 250
QLLCKAGKEY YSDTLSKLYG DVNGLEKERR RLEALIKQNG DDLSKEVKEK
260 270
LKIIRLQLSL LSHIEDQLED TSSHDEL
Length:277
Mass (Da):32,401
Last modified:November 1, 1996 - v1
Checksum:iECCEA7C6CBB10488
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D34634 Genomic DNA Translation: BAA22222.1
X83121 Genomic DNA Translation: CAA58191.1
Z74830 Genomic DNA Translation: CAA99100.1
BK006948 Genomic DNA Translation: DAA10696.1
PIRiS57381
RefSeqiNP_014553.1, NM_001183342.1

Genome annotation databases

EnsemblFungiiYOL088C; YOL088C; YOL088C
GeneIDi854065
KEGGisce:YOL088C

Similar proteinsi

Entry informationi

Entry nameiMPD2_YEAST
AccessioniPrimary (citable) accession number: Q99316
Secondary accession number(s): D6W1Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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