Q992J0 (RDRP_BOOLV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: RNA-directed RNA polymerase Short name=RdRp EC=2.7.7.48 Alternative name(s): RNA replicase Short name=Protein A
Organism	Boolarra virus (BoV)
Taxonomic identifier	12286 [NCBI]
Taxonomic lineage	Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Nodaviridae › Alphanodavirus
Virus host	Hepialidae (ghost moths) [TaxID: 41021]

Protein attributes

Sequence length	998 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2 Potential.
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Sequence similarities	Belongs to the nodaviridae RNA polymerase family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase RNA-directed RNA polymerase Transferase
Gene Ontology (GO)
Molecular_function	RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 998	998	RNA-directed RNA polymerase		PRO_0000222445

Sequences

	Sequence		Length	Mass (Da)
	Q992J0 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 7FAFFE4FC7329253	FASTA	998	111,204
	10 20 30 40 50 60 MTIKIILGEH QITRTELLGG IVIVSGCGAV AYCISKFWGY GAIAPYPQSG GNRVTRALQR 70 80 90 100 110 120 AVIDKTKTPI KTHFYPLDSL RTVTPRRASD NGHAVSGAVR DAARRLINES IETVGGSKFE 130 140 150 160 170 180 LNPNPNSTMG PRNHFHFAVG DLAQNFRDDQ PAADAFIVGV DVDYYITEPD VLLEHMRPLV 190 200 210 220 230 240 LHTFNPKKVS GFDADSPFTI NNNLVEYKVS GGAAWVHPVW DWCEAGEFIA SRVRSSWFEW 250 260 270 280 290 300 LLQLPLRCLG LERVGYHKIH HCRPWTDCPD RALVYTIPQH TVWRFTWIDT EIHTRKLKRI 310 320 330 340 350 360 TYQDNTKPGW NRLEHVSDNN QLLVSIGREG EHMQITIEKD KLEMLSGLGA TQSVNARLIG 370 380 390 400 410 420 MGHKDPLYTS MIVQYYTGKK VVLSVAPTVY RPTMPRVHWP VTSDADVPEV SARQYTKPII 430 440 450 460 470 480 SDCMMMPMIK RWETMSESIE RRVTFVANNK KPSDAVAKIA AEFVSLMNGP FIDLEPLTIE 490 500 510 520 530 540 ETVERLNKPS QQLQLRAVFE IMGVEPRQVI ESFNKNEPGM KSSRIISAFP DILFIVKVSR 550 560 570 580 590 600 YTLAYSDAVL HAEHNQHWYY PGRTPVGITD GVCEFVSDCD GQVIETDFSN LDGRVSGWMQ 610 620 630 640 650 660 RNIAQKAMVQ AFRAEYRDEI ISFMDTIINC PAKAKRFGFR YEPGMGVKSG SPTTTPHNTQ 670 680 690 700 710 720 YNACVEYTAL KFEYPDANPE DLFSLLGPKC GDDGLARATI QKTINRAAKC YGLELKVEKY 730 740 750 760 770 780 NPEVGLCFLS RVFVDPLNTP TTIQDPLRTL RKLHITTRDP TIPIADAACD RVEGYLCTDA 790 800 810 820 830 840 HTPLISEYCR MVQRLYGPKT STRDVREARR SRNKEKPYWL TCDGSWPQHP QDALLMKQIV 850 860 870 880 890 900 VSRTGIDEDT VDKLIGRFAA MKDVWEPITL ESEESKAAQT IDEEGVAPGS VDESLLKLND 910 920 930 940 950 960 AKQTRSNSGT SGPHTKGGGS GTGNELPRST KQRAKGPRQS AGLPKQGKAN SKPNGNVAAG 970 980 990 QAQHGGIPRG KTPSGGKTNA RRAPPKAGAQ PGAPTNPK

References

[1]	"Comparisons among the larger genome segments of six nodaviruses and their encoded RNA replicases." Johnson K.N., Johnson K.L., Dasgupta R., Gratsch T., Ball L.A. J. Gen. Virol. 82:1855-1866(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF329080 Genomic RNA. Translation: AAK15751.1.
RefSeq	NP_689439.1. NC_004142.1.
3D structure databases
ProteinModelPortal	Q992J0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	956656.
Family and domain databases
InterPro	IPR020237. RNA-dir_pol_C_nodavirus. [Graphical view]
ProDom	PD029982. RNA-dir_pol_nodavirus. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

RDRP_BOOLV

Accession

Primary (citable) accession number: Q992J0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program