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Protein

Sigma-C capsid protein

Gene

ORF3

Organism
Avian reovirus (strain S1133) (ARV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Structural protein responsible for cell attachment. Induces cell apoptosis.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Sigma-C capsid protein
Alternative name(s):
Sigma-3 protein
Gene namesi
ORF Names:ORF3
OrganismiAvian reovirus (strain S1133) (ARV)
Taxonomic identifieri38171 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002227581 – 326Sigma-C capsid proteinAdd BLAST326

Interactioni

Subunit structurei

Homotrimer.

Structurei

Secondary structure

1326
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi118 – 121Combined sources4
Helixi123 – 153Combined sources31
Turni156 – 159Combined sources4
Beta strandi166 – 169Combined sources4
Beta strandi172 – 175Combined sources4
Turni179 – 181Combined sources3
Beta strandi182 – 190Combined sources9
Beta strandi196 – 209Combined sources14
Beta strandi213 – 223Combined sources11
Beta strandi226 – 239Combined sources14
Beta strandi241 – 249Combined sources9
Helixi250 – 252Combined sources3
Beta strandi253 – 255Combined sources3
Helixi260 – 263Combined sources4
Helixi267 – 270Combined sources4
Beta strandi274 – 282Combined sources9
Beta strandi285 – 297Combined sources13
Beta strandi300 – 306Combined sources7
Beta strandi308 – 325Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BSFX-ray2.10A151-326[»]
2BT7X-ray2.35A157-326[»]
2BT8X-ray3.00A157-326[»]
2JJLX-ray2.30A117-326[»]
2VRSX-ray1.75A/B/C117-326[»]
ProteinModelPortaliQ992I2.
SMRiQ992I2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ992I2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili60 – 80Sequence analysisAdd BLAST21

Domaini

The C-terminus is important for the induction of cellular apoptosis.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR007662. Capsid_sigmaC_reovir.
[Graphical view]
PfamiPF04582. Reo_sigmaC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q992I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLNPSQRR EVVSLILSLT SNVNISHGDL TPIYERLTNL EASTELLHRS
60 70 80 90 100
ISDISTTVSN ISANLQDMTH TLDDVTANLD GLRTTVTALQ DSVSILSTNV
110 120 130 140 150
TDLTNRSSAH AAILSSLQTT VDGNSTAISN LKSDISSNGL AITDLQDRVK
160 170 180 190 200
SLESTASHGL SFSPPLSVAD GVVSLDMDPY FCSQRVSLTS YSAEAQLMQF
210 220 230 240 250
RWMARGTNGS SDTIDMTVNA HCHGRRTDYM MSSTGNLTVT SNVVLLTFDL
260 270 280 290 300
SDITHIPSDL ARLVPSAGFQ AASFPVDVSF TRDSATHAYQ AYGVYSSSRV
310 320
FTITFPTGGD GTANIRSLTV RTGIDT
Length:326
Mass (Da):34,856
Last modified:June 1, 2001 - v1
Checksum:i7E2A0D3ADDEAC153
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57T → S in AAC42113 (PubMed:7782781).Curated1
Sequence conflicti97S → P in AAC42113 (PubMed:7782781).Curated1
Sequence conflicti162F → L in AAC42113 (PubMed:7782781).Curated1
Sequence conflicti193A → E in AAC42113 (PubMed:7782781).Curated1
Sequence conflicti204A → E in AAC42113 (PubMed:7782781).Curated1
Sequence conflicti221H → Y in AAC42113 (PubMed:7782781).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39002 Genomic RNA. Translation: AAC42113.1.
AF330703 Genomic RNA. Translation: AAK18188.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39002 Genomic RNA. Translation: AAC42113.1.
AF330703 Genomic RNA. Translation: AAK18188.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BSFX-ray2.10A151-326[»]
2BT7X-ray2.35A157-326[»]
2BT8X-ray3.00A157-326[»]
2JJLX-ray2.30A117-326[»]
2VRSX-ray1.75A/B/C117-326[»]
ProteinModelPortaliQ992I2.
SMRiQ992I2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ992I2.

Family and domain databases

InterProiIPR007662. Capsid_sigmaC_reovir.
[Graphical view]
PfamiPF04582. Reo_sigmaC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIGC_ARVS1
AccessioniPrimary (citable) accession number: Q992I2
Secondary accession number(s): Q84141
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.