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Q992I2 (SIGC_ARVS1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sigma-C capsid protein
Alternative name(s):
Sigma-3 protein
Gene names
ORF Names:ORF3
OrganismAvian reovirus (strain S1133) (ARV)
Taxonomic identifier38171 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Structural protein responsible for cell attachment. Induces cell apoptosis. Ref.4

Subunit structure

Homotrimer.

Subcellular location

Virion Potential.

Domain

The C-terminus is important for the induction of cellular apoptosis.

Sequence similarities

Belongs to the orthoreovirus sigma C protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Sigma-C capsid protein
PRO_0000222758

Regions

Coiled coil60 – 8021 Potential

Experimental info

Sequence conflict571T → S in AAC42113. Ref.1
Sequence conflict971S → P in AAC42113. Ref.1
Sequence conflict1621F → L in AAC42113. Ref.1
Sequence conflict1931A → E in AAC42113. Ref.1
Sequence conflict2041A → E in AAC42113. Ref.1
Sequence conflict2211H → Y in AAC42113. Ref.1

Secondary structure

.................................. 326
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q992I2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 7E2A0D3ADDEAC153

FASTA32634,856
        10         20         30         40         50         60 
MAGLNPSQRR EVVSLILSLT SNVNISHGDL TPIYERLTNL EASTELLHRS ISDISTTVSN 

        70         80         90        100        110        120 
ISANLQDMTH TLDDVTANLD GLRTTVTALQ DSVSILSTNV TDLTNRSSAH AAILSSLQTT 

       130        140        150        160        170        180 
VDGNSTAISN LKSDISSNGL AITDLQDRVK SLESTASHGL SFSPPLSVAD GVVSLDMDPY 

       190        200        210        220        230        240 
FCSQRVSLTS YSAEAQLMQF RWMARGTNGS SDTIDMTVNA HCHGRRTDYM MSSTGNLTVT 

       250        260        270        280        290        300 
SNVVLLTFDL SDITHIPSDL ARLVPSAGFQ AASFPVDVSF TRDSATHAYQ AYGVYSSSRV 

       310        320 
FTITFPTGGD GTANIRSLTV RTGIDT 

« Hide

References

[1]"Cloning, sequencing and expression of the S1 gene of avian reovirus."
Shapouri M.R., Kane M., Letarte M., Bergeron J., Arella M., Silim A.
J. Gen. Virol. 76:1515-1520(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"The avian reovirus genome segment S1 is a functionally tricistronic gene that expresses one structural and two nonstructural proteins in infected cells."
Bodelon G., Labrada L., Martinez-Costas J., Benavente J.
Virology 290:181-191(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"Subunit composition and conformational stability of the oligomeric form of the avian reovirus cell-attachment protein sigmaC."
Grande A., Costas C., Benavente J.
J. Gen. Virol. 83:131-139(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[4]"Avian reovirus sigmaC protein induces apoptosis in cultured cells."
Shih W.L., Hsu H.W., Liao M.H., Lee L.H., Liu H.J.
Virology 321:65-74(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L39002 Genomic RNA. Translation: AAC42113.1.
AF330703 Genomic RNA. Translation: AAK18188.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2BSFX-ray2.10A151-326[»]
2BT7X-ray2.35A157-326[»]
2BT8X-ray3.00A157-326[»]
2JJLX-ray2.30A117-326[»]
2VRSX-ray1.75A/B/C117-326[»]
ProteinModelPortalQ992I2.
SMRQ992I2. Positions 151-326.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR007662. Capsid_sigmaC_reovir.
[Graphical view]
PfamPF04582. Reo_sigmaC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ992I2.

Entry information

Entry nameSIGC_ARVS1
AccessionPrimary (citable) accession number: Q992I2
Secondary accession number(s): Q84141
Entry history
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references