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Q992I2

- SIGC_ARVS1

UniProt

Q992I2 - SIGC_ARVS1

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Protein

Sigma-C capsid protein

Gene

ORF3

Organism
Avian reovirus (strain S1133) (ARV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Structural protein responsible for cell attachment. Induces cell apoptosis.1 Publication

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. viral entry into host cell Source: UniProtKB-KW
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Sigma-C capsid protein
Alternative name(s):
Sigma-3 protein
Gene namesi
ORF Names:ORF3
OrganismiAvian reovirus (strain S1133) (ARV)
Taxonomic identifieri38171 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Subcellular locationi

Virion Curated

GO - Cellular componenti

  1. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Sigma-C capsid proteinPRO_0000222758Add
BLAST

Interactioni

Subunit structurei

Homotrimer.

Structurei

Secondary structure

1
326
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi123 – 15331Combined sources
Turni156 – 1594Combined sources
Beta strandi166 – 1694Combined sources
Beta strandi172 – 1754Combined sources
Turni179 – 1813Combined sources
Beta strandi182 – 1909Combined sources
Beta strandi196 – 20914Combined sources
Beta strandi213 – 22311Combined sources
Beta strandi226 – 23914Combined sources
Beta strandi241 – 2499Combined sources
Helixi250 – 2523Combined sources
Beta strandi253 – 2553Combined sources
Helixi260 – 2634Combined sources
Helixi267 – 2704Combined sources
Beta strandi274 – 2829Combined sources
Beta strandi285 – 29713Combined sources
Beta strandi300 – 3067Combined sources
Beta strandi308 – 32518Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BSFX-ray2.10A151-326[»]
2BT7X-ray2.35A157-326[»]
2BT8X-ray3.00A157-326[»]
2JJLX-ray2.30A117-326[»]
2VRSX-ray1.75A/B/C117-326[»]
ProteinModelPortaliQ992I2.
SMRiQ992I2. Positions 151-326.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ992I2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili60 – 8021Sequence AnalysisAdd
BLAST

Domaini

The C-terminus is important for the induction of cellular apoptosis.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR007662. Capsid_sigmaC_reovir.
[Graphical view]
PfamiPF04582. Reo_sigmaC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q992I2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGLNPSQRR EVVSLILSLT SNVNISHGDL TPIYERLTNL EASTELLHRS
60 70 80 90 100
ISDISTTVSN ISANLQDMTH TLDDVTANLD GLRTTVTALQ DSVSILSTNV
110 120 130 140 150
TDLTNRSSAH AAILSSLQTT VDGNSTAISN LKSDISSNGL AITDLQDRVK
160 170 180 190 200
SLESTASHGL SFSPPLSVAD GVVSLDMDPY FCSQRVSLTS YSAEAQLMQF
210 220 230 240 250
RWMARGTNGS SDTIDMTVNA HCHGRRTDYM MSSTGNLTVT SNVVLLTFDL
260 270 280 290 300
SDITHIPSDL ARLVPSAGFQ AASFPVDVSF TRDSATHAYQ AYGVYSSSRV
310 320
FTITFPTGGD GTANIRSLTV RTGIDT
Length:326
Mass (Da):34,856
Last modified:June 1, 2001 - v1
Checksum:i7E2A0D3ADDEAC153
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571T → S in AAC42113. (PubMed:7782781)Curated
Sequence conflicti97 – 971S → P in AAC42113. (PubMed:7782781)Curated
Sequence conflicti162 – 1621F → L in AAC42113. (PubMed:7782781)Curated
Sequence conflicti193 – 1931A → E in AAC42113. (PubMed:7782781)Curated
Sequence conflicti204 – 2041A → E in AAC42113. (PubMed:7782781)Curated
Sequence conflicti221 – 2211H → Y in AAC42113. (PubMed:7782781)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39002 Genomic RNA. Translation: AAC42113.1.
AF330703 Genomic RNA. Translation: AAK18188.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39002 Genomic RNA. Translation: AAC42113.1 .
AF330703 Genomic RNA. Translation: AAK18188.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BSF X-ray 2.10 A 151-326 [» ]
2BT7 X-ray 2.35 A 157-326 [» ]
2BT8 X-ray 3.00 A 157-326 [» ]
2JJL X-ray 2.30 A 117-326 [» ]
2VRS X-ray 1.75 A/B/C 117-326 [» ]
ProteinModelPortali Q992I2.
SMRi Q992I2. Positions 151-326.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q992I2.

Family and domain databases

InterProi IPR007662. Capsid_sigmaC_reovir.
[Graphical view ]
Pfami PF04582. Reo_sigmaC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, sequencing and expression of the S1 gene of avian reovirus."
    Shapouri M.R., Kane M., Letarte M., Bergeron J., Arella M., Silim A.
    J. Gen. Virol. 76:1515-1520(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "The avian reovirus genome segment S1 is a functionally tricistronic gene that expresses one structural and two nonstructural proteins in infected cells."
    Bodelon G., Labrada L., Martinez-Costas J., Benavente J.
    Virology 290:181-191(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Subunit composition and conformational stability of the oligomeric form of the avian reovirus cell-attachment protein sigmaC."
    Grande A., Costas C., Benavente J.
    J. Gen. Virol. 83:131-139(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. "Avian reovirus sigmaC protein induces apoptosis in cultured cells."
    Shih W.L., Hsu H.W., Liao M.H., Lee L.H., Liu H.J.
    Virology 321:65-74(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSIGC_ARVS1
AccessioniPrimary (citable) accession number: Q992I2
Secondary accession number(s): Q84141
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3