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Q992I2

- SIGC_ARVS1

UniProt

Q992I2 - SIGC_ARVS1

Protein

Sigma-C capsid protein

Gene

ORF3

Organism
Avian reovirus (strain S1133) (ARV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Structural protein responsible for cell attachment. Induces cell apoptosis.1 Publication

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. viral entry into host cell Source: UniProtKB-KW
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sigma-C capsid protein
    Alternative name(s):
    Sigma-3 protein
    Gene namesi
    ORF Names:ORF3
    OrganismiAvian reovirus (strain S1133) (ARV)
    Taxonomic identifieri38171 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]

    Subcellular locationi

    Virion Curated

    GO - Cellular componenti

    1. viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Sigma-C capsid proteinPRO_0000222758Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.

    Structurei

    Secondary structure

    1
    326
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi123 – 15331
    Turni156 – 1594
    Beta strandi166 – 1694
    Beta strandi172 – 1754
    Turni179 – 1813
    Beta strandi182 – 1909
    Beta strandi196 – 20914
    Beta strandi213 – 22311
    Beta strandi226 – 23914
    Beta strandi241 – 2499
    Helixi250 – 2523
    Beta strandi253 – 2553
    Helixi260 – 2634
    Helixi267 – 2704
    Beta strandi274 – 2829
    Beta strandi285 – 29713
    Beta strandi300 – 3067
    Beta strandi308 – 32518

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BSFX-ray2.10A151-326[»]
    2BT7X-ray2.35A157-326[»]
    2BT8X-ray3.00A157-326[»]
    2JJLX-ray2.30A117-326[»]
    2VRSX-ray1.75A/B/C117-326[»]
    ProteinModelPortaliQ992I2.
    SMRiQ992I2. Positions 151-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ992I2.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili60 – 8021Sequence AnalysisAdd
    BLAST

    Domaini

    The C-terminus is important for the induction of cellular apoptosis.

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Family and domain databases

    InterProiIPR007662. Capsid_sigmaC_reovir.
    [Graphical view]
    PfamiPF04582. Reo_sigmaC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q992I2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLNPSQRR EVVSLILSLT SNVNISHGDL TPIYERLTNL EASTELLHRS    50
    ISDISTTVSN ISANLQDMTH TLDDVTANLD GLRTTVTALQ DSVSILSTNV 100
    TDLTNRSSAH AAILSSLQTT VDGNSTAISN LKSDISSNGL AITDLQDRVK 150
    SLESTASHGL SFSPPLSVAD GVVSLDMDPY FCSQRVSLTS YSAEAQLMQF 200
    RWMARGTNGS SDTIDMTVNA HCHGRRTDYM MSSTGNLTVT SNVVLLTFDL 250
    SDITHIPSDL ARLVPSAGFQ AASFPVDVSF TRDSATHAYQ AYGVYSSSRV 300
    FTITFPTGGD GTANIRSLTV RTGIDT 326
    Length:326
    Mass (Da):34,856
    Last modified:June 1, 2001 - v1
    Checksum:i7E2A0D3ADDEAC153
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571T → S in AAC42113. (PubMed:7782781)Curated
    Sequence conflicti97 – 971S → P in AAC42113. (PubMed:7782781)Curated
    Sequence conflicti162 – 1621F → L in AAC42113. (PubMed:7782781)Curated
    Sequence conflicti193 – 1931A → E in AAC42113. (PubMed:7782781)Curated
    Sequence conflicti204 – 2041A → E in AAC42113. (PubMed:7782781)Curated
    Sequence conflicti221 – 2211H → Y in AAC42113. (PubMed:7782781)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L39002 Genomic RNA. Translation: AAC42113.1.
    AF330703 Genomic RNA. Translation: AAK18188.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L39002 Genomic RNA. Translation: AAC42113.1 .
    AF330703 Genomic RNA. Translation: AAK18188.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BSF X-ray 2.10 A 151-326 [» ]
    2BT7 X-ray 2.35 A 157-326 [» ]
    2BT8 X-ray 3.00 A 157-326 [» ]
    2JJL X-ray 2.30 A 117-326 [» ]
    2VRS X-ray 1.75 A/B/C 117-326 [» ]
    ProteinModelPortali Q992I2.
    SMRi Q992I2. Positions 151-326.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q992I2.

    Family and domain databases

    InterProi IPR007662. Capsid_sigmaC_reovir.
    [Graphical view ]
    Pfami PF04582. Reo_sigmaC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and expression of the S1 gene of avian reovirus."
      Shapouri M.R., Kane M., Letarte M., Bergeron J., Arella M., Silim A.
      J. Gen. Virol. 76:1515-1520(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "The avian reovirus genome segment S1 is a functionally tricistronic gene that expresses one structural and two nonstructural proteins in infected cells."
      Bodelon G., Labrada L., Martinez-Costas J., Benavente J.
      Virology 290:181-191(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "Subunit composition and conformational stability of the oligomeric form of the avian reovirus cell-attachment protein sigmaC."
      Grande A., Costas C., Benavente J.
      J. Gen. Virol. 83:131-139(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    4. "Avian reovirus sigmaC protein induces apoptosis in cultured cells."
      Shih W.L., Hsu H.W., Liao M.H., Lee L.H., Liu H.J.
      Virology 321:65-74(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiSIGC_ARVS1
    AccessioniPrimary (citable) accession number: Q992I2
    Secondary accession number(s): Q84141
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 9, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3