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Q992I2

- SIGC_ARVS1

UniProt

Q992I2 - SIGC_ARVS1

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Protein

Sigma-C capsid protein

Gene
ORF3
Organism
Avian reovirus (strain S1133) (ARV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Structural protein responsible for cell attachment. Induces cell apoptosis.1 Publication

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. viral entry into host cell Source: UniProtKB-KW
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Sigma-C capsid protein
Alternative name(s):
Sigma-3 protein
Gene namesi
ORF Names:ORF3
OrganismiAvian reovirus (strain S1133) (ARV)
Taxonomic identifieri38171 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Subcellular locationi

Virion Reviewed prediction

GO - Cellular componenti

  1. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Sigma-C capsid proteinPRO_0000222758Add
BLAST

Interactioni

Subunit structurei

Homotrimer.

Structurei

Secondary structure

1
326
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi123 – 15331
Turni156 – 1594
Beta strandi166 – 1694
Beta strandi172 – 1754
Turni179 – 1813
Beta strandi182 – 1909
Beta strandi196 – 20914
Beta strandi213 – 22311
Beta strandi226 – 23914
Beta strandi241 – 2499
Helixi250 – 2523
Beta strandi253 – 2553
Helixi260 – 2634
Helixi267 – 2704
Beta strandi274 – 2829
Beta strandi285 – 29713
Beta strandi300 – 3067
Beta strandi308 – 32518

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BSFX-ray2.10A151-326[»]
2BT7X-ray2.35A157-326[»]
2BT8X-ray3.00A157-326[»]
2JJLX-ray2.30A117-326[»]
2VRSX-ray1.75A/B/C117-326[»]
ProteinModelPortaliQ992I2.
SMRiQ992I2. Positions 151-326.

Miscellaneous databases

EvolutionaryTraceiQ992I2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili60 – 8021 Reviewed predictionAdd
BLAST

Domaini

The C-terminus is important for the induction of cellular apoptosis.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR007662. Capsid_sigmaC_reovir.
[Graphical view]
PfamiPF04582. Reo_sigmaC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q992I2-1 [UniParc]FASTAAdd to Basket

« Hide

MAGLNPSQRR EVVSLILSLT SNVNISHGDL TPIYERLTNL EASTELLHRS    50
ISDISTTVSN ISANLQDMTH TLDDVTANLD GLRTTVTALQ DSVSILSTNV 100
TDLTNRSSAH AAILSSLQTT VDGNSTAISN LKSDISSNGL AITDLQDRVK 150
SLESTASHGL SFSPPLSVAD GVVSLDMDPY FCSQRVSLTS YSAEAQLMQF 200
RWMARGTNGS SDTIDMTVNA HCHGRRTDYM MSSTGNLTVT SNVVLLTFDL 250
SDITHIPSDL ARLVPSAGFQ AASFPVDVSF TRDSATHAYQ AYGVYSSSRV 300
FTITFPTGGD GTANIRSLTV RTGIDT 326
Length:326
Mass (Da):34,856
Last modified:June 1, 2001 - v1
Checksum:i7E2A0D3ADDEAC153
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571T → S in AAC42113. 1 Publication
Sequence conflicti97 – 971S → P in AAC42113. 1 Publication
Sequence conflicti162 – 1621F → L in AAC42113. 1 Publication
Sequence conflicti193 – 1931A → E in AAC42113. 1 Publication
Sequence conflicti204 – 2041A → E in AAC42113. 1 Publication
Sequence conflicti221 – 2211H → Y in AAC42113. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L39002 Genomic RNA. Translation: AAC42113.1.
AF330703 Genomic RNA. Translation: AAK18188.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L39002 Genomic RNA. Translation: AAC42113.1 .
AF330703 Genomic RNA. Translation: AAK18188.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BSF X-ray 2.10 A 151-326 [» ]
2BT7 X-ray 2.35 A 157-326 [» ]
2BT8 X-ray 3.00 A 157-326 [» ]
2JJL X-ray 2.30 A 117-326 [» ]
2VRS X-ray 1.75 A/B/C 117-326 [» ]
ProteinModelPortali Q992I2.
SMRi Q992I2. Positions 151-326.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q992I2.

Family and domain databases

InterProi IPR007662. Capsid_sigmaC_reovir.
[Graphical view ]
Pfami PF04582. Reo_sigmaC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, sequencing and expression of the S1 gene of avian reovirus."
    Shapouri M.R., Kane M., Letarte M., Bergeron J., Arella M., Silim A.
    J. Gen. Virol. 76:1515-1520(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "The avian reovirus genome segment S1 is a functionally tricistronic gene that expresses one structural and two nonstructural proteins in infected cells."
    Bodelon G., Labrada L., Martinez-Costas J., Benavente J.
    Virology 290:181-191(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Subunit composition and conformational stability of the oligomeric form of the avian reovirus cell-attachment protein sigmaC."
    Grande A., Costas C., Benavente J.
    J. Gen. Virol. 83:131-139(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. "Avian reovirus sigmaC protein induces apoptosis in cultured cells."
    Shih W.L., Hsu H.W., Liao M.H., Lee L.H., Liu H.J.
    Virology 321:65-74(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSIGC_ARVS1
AccessioniPrimary (citable) accession number: Q992I2
Secondary accession number(s): Q84141
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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