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Protein

Mitochondrial 2-oxodicarboxylate carrier 2

Gene

ODC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate. The main physiological role is probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.

GO - Molecular functioni

  • dicarboxylic acid transmembrane transporter activity Source: SGD

GO - Biological processi

  • mitochondrial transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-33721-MONOMER
ReactomeiR-SCE-71064 Lysine catabolism

Protein family/group databases

TCDBi2.A.29.2.5 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier 2
Gene namesi
Name:ODC2
Ordered Locus Names:YOR222W
ORF Names:YOR50-12
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR222W
SGDiS000005748 ODC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei76 – 95Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei122 – 142Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei171 – 191Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei280 – 300Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906491 – 307Mitochondrial 2-oxodicarboxylate carrier 2Add BLAST307

Proteomic databases

MaxQBiQ99297
PaxDbiQ99297
PRIDEiQ99297

Interactioni

Protein-protein interaction databases

BioGridi34616, 94 interactors
DIPiDIP-5386N
STRINGi4932.YOR222W

Structurei

3D structure databases

ProteinModelPortaliQ99297
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 106Solcar 1Add BLAST97
Repeati116 – 200Solcar 2Add BLAST85
Repeati209 – 299Solcar 3Add BLAST91

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000111119
HOGENOMiHOG000168307
InParanoidiQ99297
KOiK15110
OMAiLESTMWR
OrthoDBiEOG092C3CGH

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q99297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDSNAKPL PFIYQFISGA VAGISELTVM YPLDVVKTRF QLEVTTPTAA
60 70 80 90 100
AVGKQVERYN GVIDCLKKIV KKEGFSRLYR GISSPMLMEA PKRATKFACN
110 120 130 140 150
DQYQKIFKNL FNTNETTQKI SIAAGASAGM TEAAVIVPFE LIKIRMQDVK
160 170 180 190 200
SSYLGPMDCL KKTIKNEGIM GLYKGIESTM WRNALWNGGY FGVIYQVRNS
210 220 230 240 250
MPVAKTKGQK TRNDLIAGAI GGTVGTMLNT PFDVVKSRIQ SVDAVSSAVK
260 270 280 290 300
KYNWCLPSLL VIYREEGFRA LYKGFVPKVC RLAPGGSLML VVFTGMMNFF

RDLKYGH
Length:307
Mass (Da):34,007
Last modified:November 1, 1996 - v1
Checksum:i4089082A64DBA97C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92441 Genomic DNA Translation: CAA63185.1
Z75130 Genomic DNA Translation: CAA99440.1
Z75131 Genomic DNA Translation: CAA99442.2
BK006948 Genomic DNA Translation: DAA10993.1
PIRiS60949
RefSeqiNP_014865.1, NM_001183641.1

Genome annotation databases

EnsemblFungiiYOR222W; YOR222W; YOR222W
GeneIDi854397
KEGGisce:YOR222W

Similar proteinsi

Entry informationi

Entry nameiODC2_YEAST
AccessioniPrimary (citable) accession number: Q99297
Secondary accession number(s): D6W2S7, O13594
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health