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Protein

Mitochondrial 2-oxodicarboxylate carrier 2

Gene

ODC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate. The main physiological role is probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.

GO - Molecular functioni

  • dicarboxylic acid transmembrane transporter activity Source: SGD

GO - Biological processi

  • dicarboxylic acid transport Source: GOC
  • mitochondrial transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33721-MONOMER.
ReactomeiR-SCE-71064. Lysine catabolism.

Protein family/group databases

TCDBi2.A.29.2.5. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier 2
Gene namesi
Name:ODC2
Ordered Locus Names:YOR222W
ORF Names:YOR50-12
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR222W.
SGDiS000005748. ODC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei76 – 9520Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei122 – 14221Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei171 – 19121Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei215 – 23521Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei280 – 30021Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Mitochondrial 2-oxodicarboxylate carrier 2PRO_0000090649Add
BLAST

Proteomic databases

MaxQBiQ99297.
PeptideAtlasiQ99297.

Interactioni

Protein-protein interaction databases

BioGridi34616. 37 interactions.
DIPiDIP-5386N.
MINTiMINT-492942.

Structurei

3D structure databases

ProteinModelPortaliQ99297.
SMRiQ99297. Positions 8-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati10 – 10697Solcar 1Add
BLAST
Repeati116 – 20085Solcar 2Add
BLAST
Repeati209 – 29991Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000111119.
HOGENOMiHOG000168307.
InParanoidiQ99297.
KOiK15110.
OMAiFASNDFW.
OrthoDBiEOG72ZCR5.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDSNAKPL PFIYQFISGA VAGISELTVM YPLDVVKTRF QLEVTTPTAA
60 70 80 90 100
AVGKQVERYN GVIDCLKKIV KKEGFSRLYR GISSPMLMEA PKRATKFACN
110 120 130 140 150
DQYQKIFKNL FNTNETTQKI SIAAGASAGM TEAAVIVPFE LIKIRMQDVK
160 170 180 190 200
SSYLGPMDCL KKTIKNEGIM GLYKGIESTM WRNALWNGGY FGVIYQVRNS
210 220 230 240 250
MPVAKTKGQK TRNDLIAGAI GGTVGTMLNT PFDVVKSRIQ SVDAVSSAVK
260 270 280 290 300
KYNWCLPSLL VIYREEGFRA LYKGFVPKVC RLAPGGSLML VVFTGMMNFF

RDLKYGH
Length:307
Mass (Da):34,007
Last modified:November 1, 1996 - v1
Checksum:i4089082A64DBA97C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92441 Genomic DNA. Translation: CAA63185.1.
Z75130 Genomic DNA. Translation: CAA99440.1.
Z75131 Genomic DNA. Translation: CAA99442.2.
BK006948 Genomic DNA. Translation: DAA10993.1.
PIRiS60949.
RefSeqiNP_014865.1. NM_001183641.1.

Genome annotation databases

EnsemblFungiiYOR222W; YOR222W; YOR222W.
GeneIDi854397.
KEGGisce:YOR222W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92441 Genomic DNA. Translation: CAA63185.1.
Z75130 Genomic DNA. Translation: CAA99440.1.
Z75131 Genomic DNA. Translation: CAA99442.2.
BK006948 Genomic DNA. Translation: DAA10993.1.
PIRiS60949.
RefSeqiNP_014865.1. NM_001183641.1.

3D structure databases

ProteinModelPortaliQ99297.
SMRiQ99297. Positions 8-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34616. 37 interactions.
DIPiDIP-5386N.
MINTiMINT-492942.

Protein family/group databases

TCDBi2.A.29.2.5. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBiQ99297.
PeptideAtlasiQ99297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR222W; YOR222W; YOR222W.
GeneIDi854397.
KEGGisce:YOR222W.

Organism-specific databases

EuPathDBiFungiDB:YOR222W.
SGDiS000005748. ODC2.

Phylogenomic databases

GeneTreeiENSGT00730000111119.
HOGENOMiHOG000168307.
InParanoidiQ99297.
KOiK15110.
OMAiFASNDFW.
OrthoDBiEOG72ZCR5.

Enzyme and pathway databases

BioCyciYEAST:G3O-33721-MONOMER.
ReactomeiR-SCE-71064. Lysine catabolism.

Miscellaneous databases

NextBioi976565.
PROiQ99297.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of a 33 kb fragment from the right arm of chromosome XV of the yeast Saccharomyces cerevisiae."
    Galisson F., Dujon B.
    Yeast 12:877-885(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Identification in Saccharomyces cerevisiae of two isoforms of a novel mitochondrial transporter for 2-oxoadipate and 2-oxoglutarate."
    Palmieri L., Agrimi G., Runswick M.J., Fearnley I.M., Palmieri F., Walker J.E.
    J. Biol. Chem. 276:1916-1922(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiODC2_YEAST
AccessioniPrimary (citable) accession number: Q99297
Secondary accession number(s): D6W2S7, O13594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.