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Protein

Receptor-type adenylate cyclase GRESAG 4.3

Gene

GRESAG 4.3

Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Could act as a receptor for an unknown ligand.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+Note: Binds 1 Mg2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi894Magnesium1
Metal bindingi937Magnesium1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase, Receptor

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type adenylate cyclase GRESAG 4.3 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene namesi
Name:GRESAG 4.3
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 845ExtracellularSequence analysisAdd BLAST800
Transmembranei846 – 866HelicalSequence analysisAdd BLAST21
Topological domaini867 – 1229CytoplasmicSequence analysisAdd BLAST363

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001957391 – 1229Receptor-type adenylate cyclase GRESAG 4.3Add BLAST1229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi626N-linked (GlcNAc...)Sequence analysis1
Glycosylationi693N-linked (GlcNAc...)Sequence analysis1
Glycosylationi768N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

11229
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi888 – 895Combined sources8
Helixi898 – 904Combined sources7
Turni906 – 908Combined sources3
Helixi909 – 926Combined sources18
Beta strandi930 – 935Combined sources6
Beta strandi938 – 944Combined sources7
Helixi946 – 962Combined sources17
Helixi969 – 984Combined sources16
Beta strandi985 – 987Combined sources3
Helixi997 – 1003Combined sources7
Beta strandi1009 – 1016Combined sources8
Beta strandi1019 – 1022Combined sources4
Turni1024 – 1026Combined sources3
Beta strandi1029 – 1033Combined sources5
Helixi1034 – 1045Combined sources12
Beta strandi1051 – 1054Combined sources4
Helixi1055 – 1060Combined sources6
Helixi1063 – 1067Combined sources5
Beta strandi1071 – 1077Combined sources7
Beta strandi1086 – 1091Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FX4X-ray1.90A876-1106[»]
ProteinModelPortaliQ99280.
SMRiQ99280.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99280.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini889 – 1043Guanylate cyclasePROSITE-ProRule annotationAdd BLAST155

Sequence similaritiesi

Belongs to the adenylyl cyclase class-3 family.Curated
Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIARVCRLTK HSKPPHLPIT LTTPTLFLVV LVLLQLHPIC VLVNVDDGGG
60 70 80 90 100
VTVKAISLLY SRKWNVKVIN AVNAGLNASL AARNWTVAPG VNVEVVRPPS
110 120 130 140 150
YDIDPAQFLD VYLKVLNDDK SLLVVLGPMG NDDAEKLYDT LEENRLVGFG
160 170 180 190 200
PMTVSTRHEG YMPHLYFLRP EATGESYCPS TLCGESLRVL RQGFMYLDGL
210 220 230 240 250
LGGSEAYDHA VDFISRMGYS FCCVFTVEDK AGGQGGSSEE FDAVWDEFAG
260 270 280 290 300
GNPQAVIMFA TMKPDAKKFL VRLVSDPRTE DTFVLTPIFL QKSIVSIWKE
310 320 330 340 350
TLEEANVPLH PHRVIQTGSN PLAKEDYIDA IKRFQTEMRN YLTEYKEWSG
360 370 380 390 400
FNDADHFLKN DADGELMVNG WIAGEVLRRA LRSHGWMNTA TAFLESLYEQ
410 420 430 440 450
RRYVIDDIVV GDFGGECDSF TSANGATCRC NRGGKNVYMR EIAEDYRLQP
460 470 480 490 500
LVGGHIMTTP LQCHIDPSIL RPPLTGLTVD MEDHEELLRG STQFETGVST
510 520 530 540 550
TTSSGKAGEM NSFFLQKVVT DTQKVSNELN TLRQERIVTA VFGIVTKAVL
560 570 580 590 600
GLPGLTFIDP ITPTPHLNSF SRNVIHLSPT LEQQLYVLVN YLSSIRADFP
610 620 630 640 650
NCVIRGGEAP AIIDALRKTL VTFGLNLSST VVLTPGDTVG EHLPKSGITF
660 670 680 690 700
IIGLAVDDIV VIEEHLRIHT KARVLVQFSD IALLYNEFVQ AFNNSDGAKH
710 720 730 740 750
LLFATSLPHW ADVDTTSETV RRFHEAVREV EKWTPLSLLG FTTGRLIQEN
760 770 780 790 800
LQNMERVTSD LLVDLFFNQT VITIDDMHYG PYKHYDCIIN GVVTADDCMA
810 820 830 840 850
NFGATDISVW SMARALRSDE PLLQNPMSPS LVYTVPNGNA LTPAQLAGVV
860 870 880 890 900
GGSLFVVALA ICLSVLACFT LRGTRDNDSA PKEPTGPVTL IFTDIESSTA
910 920 930 940 950
LWAAHPDLMP DAVATHHRLI RSLITRYECY EVKTVGDSFM IASKSPFAAV
960 970 980 990 1000
QLAQELQLRF LRLDWETNAL DESYREFEEQ RAEGECEYTP PTAHMDPEVY
1010 1020 1030 1040 1050
SRLWNGLRVR VGIHTGLCDI RYDEVTKGYD YYGRTSNMAA RTESVANGGQ
1060 1070 1080 1090 1100
VLMTHAAYMS LSGEDRNQLD VTTLGATVLR GVPEPVRMYQ LNAVPGRNFA
1110 1120 1130 1140 1150
ALRLDRELFN DGEDETTTSC SDHSSLRAEL SIAAQTIAAS LQSLLGTFTP
1160 1170 1180 1190 1200
AQRQKALTPF CERCGVTLPR KMGHVWDNDS CQEVIRRIAA KVGHVVDRHA
1210 1220
AETRERSVCT LSSGSVIIIS NDLSDMIRV
Length:1,229
Mass (Da):136,142
Last modified:November 1, 1996 - v1
Checksum:i2B2AA575C62AC288
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52121 mRNA. Translation: CAA36366.1.
PIRiS14199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52121 mRNA. Translation: CAA36366.1.
PIRiS14199.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FX4X-ray1.90A876-1106[»]
ProteinModelPortaliQ99280.
SMRiQ99280.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ99280.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCY43_TRYBB
AccessioniPrimary (citable) accession number: Q99280
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.