Receptor-type adenylate cyclase GRESAG 4.1 - Trypanosoma brucei brucei

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Reviewed, UniProtKB/Swiss-Prot Q99279 (CY41_TRYBB)

Last modified October 13, 2009. Version 57. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Receptor-type adenylate cyclase GRESAG 4.1
    EC=4.6.1.1
Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase

Gene names

Name:

GRESAG 4.1

Organism

Trypanosoma brucei brucei

Taxonomic identifier

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma

Protein attributes

Sequence length	1242 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Could act as a receptor for a unknown ligand.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 1 magnesium ion per subunit.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the adenylyl cyclase class-3 family. Contains 1 guanylate cyclase domain.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Membrane
Domain	Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase Receptor
PTM	Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cAMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW intracellular signaling cascade Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1242

Receptor-type adenylate cyclase GRESAG 4.1

PRO_0000195737

Regions

Topological domain

39

Cytoplasmic Potential

Transmembrane

21

Potential

Topological domain

802

Extracellular Potential

Transmembrane

21

Potential

Topological domain

359

Cytoplasmic Potential

Sites

Metal binding

1

Magnesium

Metal binding

1

Magnesium

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Secondary structure

1

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1242

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

Q99279-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 452F8B22FFC0A2E3
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1,242

138,158

        10         20         30         40         50         60 
MHWQEGGGRG CVYTHGNCRR NLTARALQAL QHVEALTCHY CVSLLHLLPL LLMWMPPVCA 

        70         80         90        100        110        120 
DDSAVTVNVL SMMYNPEYYV EKVNAINAGF DASLSAHGWK TGSGATISVI RPPSYNTTAE 

       130        140        150        160        170        180 
DIFQLGVKQS EGKLLVVFGP LGTDPVVWVR DKLKENDLVA IAPIAYSSEV RGWNPHLYSI 

       190        200        210        220        230        240 
SVEPNAELLA LIRYAVVYLG LPRVGLMYAK GNGFDKESYE FTMRIMEIMG RKPCGVFAVE 

       250        260        270        280        290        300 
SSGGRDVLEG QLNTKWGQFV ATRPQAVLLF SSLEEETTGW FVKKIAQDNR TVDMYLLAPS 

       310        320        330        340        350        360 
SFQHFLIKTW SDALVSLNRT FTPGQLITTG TVPLASDNRS SMVRHFQRDM DNYLDTNSDW 

       370        380        390        400        410        420 
KGFAKPEHYL KDDKLGEMMV FGWLAGEVLF EALNNAPQLT NRTSFMESLY KQRRYVIDDF 

       430        440        450        460        470        480 
VVGDFGGECD EALHYRVPCV IAIKAAAWTH MRVVDDSLSL KPMKKGSVTW SVSECSSANV 

       490        500        510        520        530        540 
QVSAPLIGLY VVLTDDKVAQ RASMRWSLGA RSIEEADDVD KRIFFHSLKV NLKNLTQSLE 

       550        560        570        580        590        600 
QVRDTKAVAA VLGVTADILS VPNMTFIGPI PLFPRLNKFW RNVIHLQPLL AHELYVLAVY 

       610        620        630        640        650        660 
LSNTSSTGVK ALVRGGEASE VVDTLDKSLV TFGVSLDSSK TLGDGDPMSS YLSGNGDVFC 

       670        680        690        700        710        720 
IGLTPPDVAA VARHLQTHLR ARVFVPFNDI LLFYQEFVAG FNASKESIAS SEGLLFATSF 

       730        740        750        760        770        780 
PHWGKKNRKS DMVARFHRHV NESHWDPLTF LGFATTRLLQ VVISNMRKVN AEPLADRIYT 

       790        800        810        820        830        840 
ESNIRVDDVG FGPFSDAECV SGTSVSANEC ASNFGATNIS VWSMGACAEF KLAQDTGWDD 

       850        860        870        880        890        900 
TVYGLCYSAR GSTHTVTDSW NNFWVCIRLV IIYCPWCVPT HLPAERRNNN RAPKEPTDPV 

       910        920        930        940        950        960 
TLIFTDIESS TALWAAHPDL MPDAVAAHHR MVRSLIGRYK CYEVKTVGDS FMIASKSPFA 

       970        980        990       1000       1010       1020 
AVQLAQELQL CFLHHDWGTN ALDDSYREFE EQRAEGECEY TPPTAHMDPE VYSRLWNGLR 

      1030       1040       1050       1060       1070       1080 
VRVGIHTGLC DIIRHDEVTK GYDYYGRTPN MAARTESVAN GGQVLMTHAA YMSLSAEDRK 

      1090       1100       1110       1120       1130       1140 
QIDVTALGDV ALRGVSDPVK MYQLNTVPSR NFAALRLDRE YFFDEGEDGT TTSTSDHSSS 

      1150       1160       1170       1180       1190       1200 
RADVSESGQI IATALQSLLS TFKTAHREKL LLPYCERWRV PLPRKAASEW DDAYCEEVVR 

      1210       1220       1230       1240 
RIAVKVGRVA DHGADSGSES SSTQGSSSII IVPFYDMHLQ EY

References

[1]	"Differential expression of a family of putative adenylate/guanylate cyclase genes in Trypanosoma brucei." Alexandre S., Paindavione P., Tebabi P., Pays A., Halleux S., Steinert M., Pays E. Mol. Biochem. Parasitol. 43:279-288(1990) [PubMed: 1982555] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: EATRO 1125.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X52119 mRNA. Translation: CAA36364.1.

PIR

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FX2	X-ray	1.46	A	888-1122	[»]

ModBase

Enzyme and pathway databases

BRENDA

4.6.1.1. 74165.

Family and domain databases

InterPro

IPR001054. A/G_cyclase.
[Graphical view]

Gene3D

G3DSA:3.30.70.1230. A/G_cyclase. 1 hit.

Pfam

PF00211. Guanylate_cyc. 1 hit.
[Graphical view]

SMART

SM00044. CYCc. 1 hit.
[Graphical view]

PROSITE

PS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]

ProtoNet

Entry information

Entry name

CY41_TRYBB

Accession

Primary (citable) accession number: Q99279

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	October 13, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents